Investigation of the association of BMP gene variants with nephropathy in Type 1 diabetes mellitus

Diabetic Medicine

Volumn 27, Issue 6, 2010, Pages 624-630

  McKnight, A J ^a   Pettigrew, K A ^a   Patterson, C C ^a   Kilner, J ^a   Sadlier, D M ^b   Maxwell, A P ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

Association; Bone morphogenic protein; Genetic predisposition; Kidney; Single nucleotide polymorphism

Indexed keywords

ADENINE; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; CYTOSINE; GUANINE; INSULIN; OSTEOGENIC PROTEIN 1; TRANSFORMING GROWTH FACTOR BETA; TYROSINE;

ADULT; AMINO ACID SUBSTITUTION; ARTICLE; CAUCASIAN; CONTROLLED STUDY; DIABETIC NEPHROPATHY; FEMALE; GENE FREQUENCY; GENE LOCATION; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENETIC SCREENING; GENETIC SELECTION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HAPLOTYPE MAP; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; RISK FACTOR; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEIN 7; BONE MORPHOGENETIC PROTEINS; DIABETES MELLITUS, TYPE 1; DIABETIC NEPHROPATHIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; KIDNEY FAILURE, CHRONIC; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 77952691547     PISSN: 07423071     EISSN: 14645491     Source Type: Journal    
DOI: 10.1111/j.1464-5491.2010.02976.x     Document Type: Article

References (28)

1. Ansell D, Feehally J, Fogarty D, Tomson CRV, Williams AJ, Warwick G. UK Renal Registry Report 2008.
2. USRDS. US Renal Data System 2008 Annual Data Report. Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases
3. Ichinose K, Kawasaki E, Eguchi K. Recent advancement of understanding pathogenesis of type 1 diabetes and potential relevance to diabetic nephropathy. Am J Nephrol 2007 27 : 554 564.
4. McKnight AJ, O'Donoghue D, Maxwell AP. Annotated chromosome maps for renal disease. Hum Mutat 2009 30 : 314 320.
5. Ten Dijke P, Fu J, Schaap P, Roelen BA. Signal transduction of bone morphogenetic proteins in osteoblast differentiation. J Bone Joint Surg Am 2003 3 : 34 38. (Pubitemid 36951114)
6. Dolan V, Hensey C, Brady HR. Diabetic nephropathy: renal development gone awry? Pediatr Nephrol 2003 18 : 75 84.
7. Godin RE, Robertson EJ, Dudley AT. Role of BMP family members during kidney development. Int J Dev Biol 1999 43 : 405 411.
8. Mitu G, Hirschberg R. Bone morphogenetic protein-7 (BMP7) in chronic kidney disease. Front Biosci 2008 13 : 4726 4739.
9. Mitu GM, Wang S, Hirschberg R. BMP7 is a podocyte survival factor and rescues podocytes from diabetic injury. Am J Physiol Renal Physiol 2007 293 : F1641 F1648.
10. Wang S, de Caestecker M, Kopp J, Mitu G, Lapage J, Hirschberg R. Renal bone morphogenetic protein-7 protects against diabetic nephropathy. J Am Soc Nephrol 2006 17 : 2504 2512.
11. Wang S, Chen Q, Simon TC, Strebeck F, Chaudhary L, Morrissey J et al. Bone morphogenic protein-7 (BMP-7), a novel therapy for diabetic nephropathy. Kidney Int 2003 63 : 2037 2049.
12. Ueda H, Miyazaki Y, Matsusaka T, Utsonomiya Y, Kawamura T, Hosoya T et al. Bmp in podocytes is essential for normal glomerular capillary formation. J Am Soc Nephrol 2008 19 : 685 694.
13. Yang YL, Liu YS, Chuang LY, Guh JY, Lee TC, Liao TN et al. Bone morphogenetic protein-2 antagonizes renal interstitial fibrosis by promoting catabolism of type I transforming growth factor-β receptors. Endocrinology 2009 150 : 727 740.
14. Ghosh Choudhury G, Kim YS, Simon M, Wozney J, Harris S, Ghosh-Choudhury N et al. Bone morphogenetic protein 2 inhibits platelet-derived growth factor-induced c-fos gene transcription and DNA synthesis in mesangial cells. Involvement of mitogen-activated protein kinase. J Biol Chem 1999 274 : 10897 10902.
15. McMahon R, Murphy M, Clarkson M, Taal M, Mackenzie HS, Godson C et al. IHG-2, a mesangial cell gene induced by high glucose, is human gremlin. Regulation by extracellular glucose concentration, cyclic mechanical strain, and transforming growth factor-β1. J Biol Chem 2000 275 : 9901 9904.
16. Bowden DW, Sale M, Howard TD, Qadri A, Spray BJ, Rothschild CB et al. Linkage of genetic markers on human chromosomes 20 and 12 to NIDDM in Caucasian sib pairs with a history of diabetic nephropathy. Diabetes 1997 46 : 882 886.
17. Iyengar SK, Abboud HE, Goddard KA, Saad MF, Adler SG, Arar NH et al. Genome-wide scans for diabetic nephropathy and albuminuria in multiethnic populations: the family investigation of nephropathy and diabetes (FIND). Diabetes 2007 56 : 1577 1585.
18. Hwang SJ, Yang Q, Meigs JB, Pearce EN, Fox CS. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. BMC Med Genet 2007 8 (Suppl 1 S10.
19. McKnight AJ, Savage DA, Patterson CC, Sadlier D, Maxwell AP. Resequencing of genes for transforming growth factor β1 (TGFB1) type 1 and 2 receptors (TGFBR1, TGFBR2), and association analysis of variants with diabetic nephropathy. BMC Med Genet 2007 8 : 5.
20. McKnight AJ, Woodman AM, Parkkonen M, Patterson CC, Savage DA, Forsblom C et al. Investigation of DNA polymorphisms in SMAD genes for genetic predisposition to diabetic nephropathy in patients with type 1 diabetes mellitus. Diabetologia 2009 52 : 844 849.
21. International HapMap Consortium, Frazer KA, Ballinger DG, Cox DR, Hinds DA, Stuve LL et al. A second generation human haplotype map of over 3.1 million SNPs. Nature 2007 449 : 851 861.
22. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005 21 : 263 265.
23. de Bakker PI, Yelensky R, Pe'er I, Gabriel SB, Daly MJ, Altshuler D. Efficiency and power in genetic association studies. Nat Genet 2005 37 : 1217 1223.
24. McKnight AJ, Patterson CC, Pettigrew KA, Savage DA, Kilner J, Murphy M et al. Screening the GREM1 gene and investigating association with diabetic nephropathy. J Am Soc Nephrol 2010 in press.
25. Currie D, Maxwell AP, Sadlier D, McKnight AJ, The Warren 3/UK GoKinD Study Group. Investigation of Adducin 2 (beta) DNA polymorphisms in genetic predisposition to diabetic nephropathy in Type 1 diabetes. Diabet Med 2008 25 : 1001 1005.
26. Savage DA, Patterson CC, Deloukas P, Whittacker P, McKnight AJ, Morrison J et al. Genetic association analyses of non-synonymous single nucleotide polymorphisms in diabetic nephropathy. Diabetologia 2008 51 : 1998 2002.
27. Nolan VG, Ma Q, Cohen HT, Adewoye A, Rybicki AC, Baldwin C et al. Estimated glomerular filtration rate in sickle cell anemia is associated with polymorphisms of bone morphogenetic protein receptor 1B. Am J Hematol 2008 82 : 179 184.
28. Yeh CH, Chang CK, Cheng MF, Lin HJ, Cheng JT. The antioxidant effect of bone morphogenetic protein-7 against high glucose-induced oxidative stress in mesangial cells. Biochem Biophys Res Commun 2009 382 : 292 297.