Pharmacological and toxicological target organelles and safe use of single-walled carbon nanotubes as drug carriers in treating Alzheimer disease

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 6, Issue 3, 2010, Pages 427-441

  Yang, Zhong ^a   Zhang, Yingge ^a   Yang, Yanlian ^b   Sun, Lan ^a   Han, Dong ^b   Li, Hong ^a   Wang, Chen ^b  

^a BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

^b NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY   (China)

Author keywords

Alzheimer disease; Lysosomes; Mitochondria; Organelles; Single walled carbon nanotubes; Target treatment

Indexed keywords

BIOLOGICAL MEMBRANES; CELL MEMBRANES; MEDICAL NANOTECHNOLOGY; MITOCHONDRIA; NANOPARTICLES; OXYGEN; SINGLE-WALLED CARBON NANOTUBES (SWCN); TARGETS; TOXICITY;

ALZHEIMER DISEASE; ALZHEIMER'S DISEASE; CELLULAR INJURY; DRUG CARRIER; ENVIRONMENTAL NANOPARTICLES; GENES ENCODING; HIGH SAFETY; LYSOSOMES; MEMBRANE PROTEINS; MITOCHONDRIAL MEMBRANE POTENTIAL; NANOMEDICINES; NANOTOXICOLOGY; PHOSPHOINOSITIDES; REACTIVE OXYGEN SPECIES; SINGLE-WALL CARBON NANOTUBES; TARGETED DELIVERY;

CARBON NANOTUBES;

ACETYLCHOLINE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CREATINE KINASE; DRUG CARRIER; LACTATE DEHYDROGENASE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN; REACTIVE OXYGEN METABOLITE; SINGLE WALLED NANOTUBE; UREA; CARBON NANOTUBE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; AUTOPHAGY; BLOOD CELL COUNT; CELL DAMAGE; CELLULAR DISTRIBUTION; CREATINE KINASE BLOOD LEVEL; DISEASE MODEL; DRUG RESPONSE; DRUG SAFETY; DRUG TARGETING; GASTROINTESTINAL ABSORPTION; INTESTINE CELL; LACTATE DEHYDROGENASE BLOOD LEVEL; LEARNING; LYSOSOME; MALE; MAZE TEST; MEMORY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NEURITE; NONHUMAN; TISSUE DISTRIBUTION; UREA NITROGEN BLOOD LEVEL; ANIMAL; ANTIBODY SPECIFICITY; BRAIN; CELL FRACTIONATION; CELL SURVIVAL; DRUG EFFECTS; HEALTH STATUS; INTESTINE ABSORPTION; METABOLISM; NANOMEDICINE; PATHOLOGY; PATHOPHYSIOLOGY; PROCEDURES; RAMAN SPECTROMETRY; REPRODUCIBILITY; TOXICITY; ULTRASTRUCTURE;

ACETYLCHOLINE; ALZHEIMER DISEASE; ANIMALS; AUTOPHAGY; BRAIN; CELL SURVIVAL; DRUG CARRIERS; HEALTH STATUS; INTESTINAL ABSORPTION; LYSOSOMES; MEMORY; MICE; MITOCHONDRIA; NANOMEDICINE; NANOTUBES, CARBON; ORGAN SPECIFICITY; REPRODUCIBILITY OF RESULTS; SPECTRUM ANALYSIS, RAMAN; SUBCELLULAR FRACTIONS;

EID: 77952678343     PISSN: 15499634     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nano.2009.11.007     Document Type: Article

References (60)

1. Porter A.E., Gass M., Muller K., Skepper J.N., Midgley P., and Welland M. Direct imaging of single-walled carbon nanotubes in cells. Nat Nanotechnol 2 (2007) 713-717
2. Tanaka M., Nishigaki Y., Fuku N., Ibi T., Sahashi K., and Koga Y. Therapeutic potential of pyruvate therapy for mitochondrial diseases. Mitochondria 7 (2007) 399-403
3. Kostarelos K., Lacerda L., Pastorin G., Wu W., Wieckowski S., Luangsivilay J., et al. Cellular uptake of functionalized carbon nanotubes is independent of functional group and cell type. Nat Nanotechnol 2 (2007) 108-113
4. Pantarotto D., Briand J.P., Prato M., and Bianco A. Translocation of bioactive peptides across cell membranes by carbon nanotubes. Chem Commun 2004 (2004) 16-17
5. Pantarotto D., Singh R., McCarthy D., Erhardt M., Briand J.-P., Prato M., et al. Functionalized carbon nanotubes for plasmid DNA gene delivery. Angew Chem Int Edn 43 (2004) 5242-5246
6. Cai D., Jennifer M.M., Qin Z.-H., Huang Z., Huang J., Chiles T.C., et al. Highly efficient molecular delivery into mammalian cells using carbon nanotube spearing. Nat Methods 2 (2005) 449-454
7. Gao L., Nie L., Wan T., Qin Y., Guo Z., Yang D., et al. Carbon nanotube delivery of the GFP gene into mammalian cells. Chem BioChem 7 (2006) 239-242
8. Liu Y., Wu D.-C., Zhang W.-D., Jiang X., He C.-B., Chung T.-S., et al. Polyethylenimine-grafted multiwalled carbon nanotubes for secure noncovalent immobilization and efficient delivery of DNA. Angew Chem Int Edn Eng 44 (2005) 4782-4785
9. Kam N.W.S., and Dai H.J. Carbon nanotubes as intracellular protein transporters: generality and biological functionality. J Am Chem Soc 127 (2005) 6021-6026
10. Cherukuri P., Bachilo S., Litovsky S., and Weisman R. Near-infrared fluorescence microscopy of single-walled carbon nanotubes in phagocytic cells. J Am Chem Soc 126 (2004) 15638-15639
11. Rouse J.G., Yang J., Barron A.R., and Monteiro-Riviere N.A. Fullerene-based amino acid nanoparticle interactions with human epidermal keratinocytes. Toxicol In Vitro 20 (2006) 1313-1320
12. Monteiro-Riviere N.A., Nemanich R.J., Inman A.O., Wang Y.Y., and Riviere J.E. Multi-walled carbon nanotube interactions with human epidermal keratinocytes. Toxicol Lett 155 (2005) 377-384
13. Shvedova A.A., Castranova V., Kisin E.R., Schwegler-Berry D., Murray A.R., Gandelsman V.Z., et al. Exposure to carbon nanotube material: assessment of nanotube cytotoxicity using human keratinocyte cells. J Toxicol Environ Health A 66 (2003) 1909-1926
14. Bottini M., Bruckner S., Nika K., Bottini N., Bellucci S., Magrini A., et al. Multi-walled carbon nanotubes induce T lymphocyte apoptosis. Toxicol Lett 160 (2006) 121-126
15. Cui D., Tian F., Ozkan C.S., Wang M., and Gao H. Effect of single wall carbon nanotubes on human HEK293 cells. Toxicol Lett 155 (2005) 73-85
16. Lam C.W., James J.T., McCluskey R., and Hunter R.L. Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation. Toxicol Sci 77 (2004) 126-134
17. Muller J., Huaux F., Moreau N., Misson P., Heilier J.F., Delos M., et al. Respiratory toxicity of multi-wall carbon nanotubes. Toxicol Appl Pharmacol 207 (2005) 221-231
18. Shvedova A.A., Kisin E.R., Mercer R., Murray A.R., Johnson V.J., Potapovich A.I., et al. Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice. Am J Physiol Lung Cell Mol Physiol 289 (2005) L698-708
19. Heller D., Baik S., Eurell T., and Strano M. Single-walled carbon nanotube spectroscopy in live cells: towards long-term labels and optical sensors. Adv Mater 17 (2005) 2793-2799
20. Sato Y., Yokoyama A., Shibata K., Akimoto Y., Ogino S., Nodasaka Y., et al. Influence of length on cytotoxicity of multi-walled carbon nanotubes against human acute monocytic leukemia cell line THP-1 in vitro and subcutaneous tissue of rats in vivo. Mol Biosyst 1 (2005) 176-182
21. Albini A., Mussi V., Parodi A., Ventura A., Principi E., Tegami S.M., et al. Interactions of single-wall carbon nanotubes with endothelial cells. Nanomedicine 6 (2010) 277-288
22. Fraczek A., Menaszek E., Paluszkiewicz C., and Blazewicz M. Comparative in vivo biocompatibility study of single- and multi-wall carbon nanotubes. Acta Biomater 4 (2008) 1593-1602
23. Amatore C., Arbault S., Cristhina D., Ferreira M., Tapsoba I., Verchier Y., et al. stimulates or attenuates reactive oxygen and nitrogen species (ROS, RNS) production depending on cell state: quantitative amperometric measurements of oxidative bursts at PLB-985 and RAW 264.7 cells at the single cell level. J Electroanal Chem 615 (2008) 34-44
24. Smart S.K., Cassady A.I., Lu G.Q., and Martin D.J. The biocompatibility of carbon nanotubes. Carbon 44 (2006) 1034-1047
25. Kagan V.E., Tyurina Y.Y., Tyurin V.A., Konduru N.V., Potapovich A.I., Osipov A.N., et al. Direct and indirect effects of single walled carbon nanotubes on RAW 264.7 macrophages: role of iron. Toxicol Lett 165 (2006) 88-100
26. Garza K.M., Soto K.F., and Murr L.E. Cytotoxicity and reactive oxygen species generation from aggregated carbon and carbonaceous nanoparticulate materials. Int J Nanomed 3 (2008) 83-94
27. Lacerda L., Soundararajan A., Pastorin G., Al-Jamal K.T., Herrero M.A., Bao A., et al. Dynamic imaging of functionalized multi-walled carbon nanotube systemic circulation and urinary excretion. Adv Mater 20 (2008) 225-230
28. Lacerda L., Herrero M.A., Venner K., Bianco A., Prato M., and Kostarelos K. Carbon-nanotube shape and individualization critical for renal excretion. Small 4 (2008) 1130-1132
29. Liu J., Rinzler A.G., Dai H.G., Hafner J.H., Bradley R.K.P., Boul J., et al. Fullerene pipes. Science 280 (1998) 1253-1256
30. Doh-Ura K., Iwaki T., and Caughey B. Lysosomotropic agents and cysteine protease inhibitors inhibit scrapie-associated prion protein accumulation. J Virol 74 (2000) 4894-4897
31. Asumendi A., Morales M.C., Alvarez A., Aréchaga J., and Pérez-Yarza G. Implication of mitochondria-derived ROS and cardiolipin peroxidation in N-(4-hydroxyphenyl) retinamide-induced apoptosis. Br J Cancer 86 (2002) 1951-1956
32. Smiley S.T., Reers M., Mottola-Hartshorn C., Lin M., Chen A., Smith T.W., et al. Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate forming lipophilic cation JC-1. Proc Natl Acad Sci USA 88 (1991) 3671-3675
33. Izquierdo L.A., Barros D.M., Medina J.H., and Izquierdo I. Novelty enhances retrieval of one-trial avoidance learning in rats 1 or 31 days after training unless the hippocampus is inactivated by different receptor antagonists and enzyme inhibitors. Behav Brain Res 117 (2000) 215-220
34. Dimitrova D.S., and Getova-Spassova D.P. Effects of galantamine and donepezil on active and passive avoidance tests in rats with induced hypoxia. J Pharmacol Sci 101 (2006) 199-204
35. Pothakos K., Kurz M.J., and Lau Y.S. Restorative effect of endurance exercise on behavioral deficits in the chronic mouse model of Parkinson's disease with severe neurodegeneration. BMC Neurosci 10 6 (2009) [Epub ahead of print]
36. Liang Z., Liu F., Grundke-Iqbal I., Iqbal K., and Gong C.X. Down-regulation of cAMP-dependent protein kinase by over-activated calpain in Alzheimer disease brain. J Neurochem 103 (2007) 2462-2470
37. Copenhaver T.W., and Mielke P.W. Quantity analysis: a quantal assay refinement. Biometrics 33 (1977) 175-186
38. Memisoglu-Bilensoy E., Doǧan A.L., and Hincal A.A. Cytotoxic evaluation of injectable cyclodextrin nanoparticles. J Pharm Pharmacol 58 (2006) 585-589
39. Seglen P.O., and Gordon P.B. 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proc Natl Acad Sci USA 79 (1982) 1889-1892
40. Majeski A.E., and Dice J.F. Mechanisms of chaperone-mediated autophagy. Int J Biochem Cell Biol 36 (2004) 2435-2444
41. Kreuter J. Nanoparticles and microparticles for drug and vaccine delivery. J Anat 189 (1996) 503-505
42. Florence A.T., Hillery A.M., Hussain N., and Jani P.U. Nanoparticles as carriers for oral peptide absorption: studies on particle uptake and fate. J Control Rel 36 (1995) 39-46
43. Johng H.M., Yoo J.S., Yoon T.J., Shin H.S., Lee B.C., Lee C.H., et al. Use of magnetic nanoparticles to visualize threadlike structures inside lymphatic vessels of rats. eCAM 4 (2007) 77-82
44. Freitas R.A. Systematic nanorobot distribution and phagocytosis. In: Freitas Jr. R.A. (Ed). Nanomedicine. Biocompatibility vol. IIA (2003), Landes Bioscience, Austin (Tex) 93-154
45. Varshosaz J. pH-sensitive polymers for cytoplasmic drug delivery. Expert Opin Ther Patents 18 (2008) 959-962
46. Heffernan M.J., and Murth N. Polyketal nanoparticles: a new pH-sensitive biodegradable drug delivery vehicle. Bioconjug Chem 16 (2005) 1340-1342
47. Bae Y., Fukushima S., Harada A., and Kataoka K. Design of environment-sensitive supramolecular assemblies for intracellular drug delivery: polymeric micelles that are responsive to intracellular pH change. Angew Chem Int Ed Eng 4640-3 (2008) 42
48. Benzi G., and Moretti A. Age- and peroxidative stress-related modifications of the cerebral enzymatic activities linked to mitochondria and the glutathione system. Free Radic Biol Med 19 (1995) 77-101
49. Vartanian L.S., and Gurevich S.M. Effect of ionol on superoxide radical metabolism in murine liver. Vopr Med Khim 45 (1999) 314-320
50. Polla B.S., Kantengwa S., Francois D., Salvioli S., Franceschi C., Marsac C., et al. Mitochondria are selective targets for the protective effects of heat shock against oxidative injury. Proc Natl Acad Sci USA 93 (1996) 6458-6463
51. Gogvadze V., Orrenius S., and Zhivotovsky B. Mitochondria in cancer cells: what is so special about them?. Trends Cell Biol 18 (2008) 165-173
52. Herholz K. Acetylcholine esterase activity in mild cognitive impairment and Alzheimer's disease. Eur J Nucl Med Mol Imaging 35 Suppl 1 (2008) S25-S29
53. Razay G., and Wilcock G.K. Galantamine in Alzheimer's disease. Expert Rev Neurother 8 (2008) 9-17
54. Lu J. Effect of surface modifications on the decoration of multi-walled carbon nanotubes with ruthenium nanoparticles. Carbon 45 (2007) 1599-1605
55. Takenaka S., Arike T., Nakagawa K., Matsune H., Kishida M., and Tanabe E. Synthesis of carbon nanotube-supported Pt nanoparticles covered with silica layers. Carbon 46 (2008) 365-368
56. Mota J.P.B., and Esteves I.A.A.C. Simplified gauge-cell method and its application to the study of capillary phase transition of propane in carbon nanotubes. Adsorption 13 (2007) 21-32
57. Sun M.L., Cheng R.M., Xu X.C., Chen Y.W., and Li M.G. Studies on adsorption of phenol and substituted phenols on carbon nanotubes. Chem Res Appl 18 (2006) 13-16
58. Murugesan S., Xie J., and Linhardt R.J. Immobilization of heparin: approaches and applications. Curr Top Med Chem 8 (2008) 80-100
59. Kane R.S., and Stroock A.D. Nanobiotechnology: protein-nanomaterial interactions. Biotechnol Prog 23 (2007) 316-319
60. Zhao M., Brunk U.T., and Eaton J.W. Delayed oxidant-induced cell death involves activation of phospholipase A2. FEBS Lett 509 (2001) 399-404