Angiotensin II type 1 receptor blockers prevent tumor necrosis factor-α-mediated endothelial nitric oxide synthase reduction and superoxide production in human umbilical vein endothelial cells

European Journal of Pharmacology

Volumn 636, Issue 1-3, 2010, Pages 36-41

  Kataoka, Hiroki ^a   Murakami, Ryuichiro ^a   Numaguchi, Yasushi ^a   Okumura, Kenji ^a,b   Murohara, Toyoaki ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Angiotensin II type 1 receptor blocker; Endothelial nitric oxide synthase; Human umbilical vein endothelial cell; Superoxide; Tumor necrosis factor

Indexed keywords

8 ISOPROSTANE; ALPHA TOCOPHEROL; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN I; ANGIOTENSIN II; ANTIOXIDANT; CANDESARTAN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; OLMESARTAN; SUPEROXIDE; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; ARTICLE; CELL LYSATE; CONTROLLED STUDY; DRUG ACTIVITY; ENDOTHELIUM CELL; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; OXIDATIVE STRESS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; UMBILICAL VEIN; WESTERN BLOTTING;

ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; CELL DEATH; CELL LINE, TUMOR; ENDOTHELIAL CELLS; FREE RADICAL SCAVENGERS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; I-KAPPA B PROTEINS; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; PHOSPHORYLATION; SUPEROXIDES; TUMOR NECROSIS FACTOR-ALPHA; UMBILICAL VEINS;

EID: 77952671653     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.03.025     Document Type: Article

References (35)

1. Anderson H.D., Rahmutula D., Gardner D.G. Tumor necrosis factor-alpha inhibits endothelial nitric-oxide synthase gene promoter activity in bovine aortic endothelial cells. J. Biol. Chem. 2004, 279:963-969.
2. Bayraktutan U., Ulker S. Effects of angiotensin II on nitric oxide generation in proliferating and quiescent rat coronary microvascular endothelial cells. Hypertens. Res. 2003, 26:749-757.
3. Chen S., Ge Y., Si J., Rifai A., Dworkin L.D., Gong R. Candesartan suppresses chronic renal inflammation by a novel antioxidant action independent of AT1R blockade. Kidney Int. 2008, 74:1128-1138.
4. Chou T.C., Yen M.H., Li C.Y., Ding Y.A. Alterations of nitric oxide synthase expression with aging and hypertension in rats. Hypertension 1998, 31:643-648.
5. Cianchetti S., Del Fiorentino A., Colognato R., Di Stefano R., Franzoni F., Pedrinelli R. Anti-inflammatory and anti-oxidant properties of telmisartan in cultured human umbilical vein endothelial cells. Atherosclerosis 2008, 198:22-28.
6. De Lorenzo A., Del Gobbo V., Premrov M.G., Bigioni M., Galvano F., Di Renzo L. Normal-weight obese syndrome: early inflammation?. Am. J. Clin. Nutr. 2007, 85:40-45.
7. Dimmeler S., Fleming I., Fisslthaler B., Hermann C., Busse R., Zeiher A.M. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 1999, 399:601-605.
8. Garg A.K., Aggarwal B.B. Reactive oxygen intermediates in TNF signaling. Mol. Immunol. 2002, 39:509-517.
9. Kagawa T., Takao T., Horino T., Matsumoto R., Inoue K., Morita T., Hashimoto K. Angiotensin II receptor blocker inhibits tumour necrosis factor-alpha-induced cell damage in human renal proximal tubular epithelial cells. Nephrology (Carlton) 2008, 13:309-315.
10. Karin M. How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complex. Oncogene 1999, 18:6867-6874.
11. Liu H., Kitazato K.T., Uno M., Yagi K., Kanematsu Y., Tamura T., Tada Y., Kinouchi T., Nagahiro S. Protective mechanisms of the angiotensin II type 1 receptor blocker candesartan against cerebral ischemia: in-vivo and in-vitro studies. J. Hypertens. 2008, 26:1435-1445.
12. Lteif A.A., Han K., Mather K.J. Obesity, insulin resistance, and the metabolic syndrome: determinants of endothelial dysfunction in whites and blacks. Circulation 2005, 112:32-38.
13. Mohazzab K.M., Kaminski P.M., Wolin M.S. NADH oxidoreductase is a major source of superoxide anion in bovine coronary artery endothelium. Am. J. Physiol. 1994, 266:H2568-H2572.
14. Morandini R., Boeynaems J.M., Duhant X., Jacquemotte F., Kinnaert E., Ghanem G. SODs are involved in the regulation of ICAM-1 expression in human melanoma and endothelial cells. Cell. Mol. Biol. 1999, 45:1053-1063. Noisy-le-grand.
15. Murakami H., Murakami R., Kambe F., Cao X., Takahashi R., Asai T., Hirai T., Numaguchi Y., Okumura K., Seo H., Murohara T. Fenofibrate activates AMPK and increases eNOS phosphorylation in HUVEC. Biochem. Biophys. Res. Commun. 2006, 341:973-978.
16. Murphy H.S., Shayman J.A., Till G.O., Mahrougui M., Owens C.B., Ryan U.S., Ward P.A. Superoxide responses of endothelial cells to C5a and TNF-alpha: divergent signal transduction pathways. Am. J. Physiol. 1992, 263:L51-L59.
17. Nakata T., Suzuki K., Fujii J., Ishikawa M., Taniguchi N. Induction and release of manganese superoxide dismutase from mitochondria of human umbilical vein endothelial cells by tumor necrosis factor-alpha and interleukin-1 alpha. Int. J. Cancer 1993, 55:646-650.
18. Olson S., Oeckler R., Li X., Du L., Traganos F., Zhao X., Burke-Wolin T. Angiotensin II stimulates nitric oxide production in pulmonary artery endothelium via the type 2 receptor. Am. J. Physiol. 2004, 287:L559-L568.
19. Picchi A., Gao X., Belmadani S., Potter B.J., Focardi M., Chilian W.M., Zhang C. Tumor necrosis factor-alpha induces endothelial dysfunction in the prediabetic metabolic syndrome. Circ. Res. 2006, 99:69-77.
20. Prasad A., Quyyumi A.A. Renin-angiotensin system and angiotensin receptor blockers in the metabolic syndrome. Circulation 2004, 110:1507-1512.
21. Rubanyi G.M., Vanhoutte P.M. Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor. Am. J. Physiol. 1986, 250:H822-H827.
22. Saito S., Hirata Y., Emori T., Imai T., Marumo F. Angiotensin II activates endothelial constitutive nitric oxide synthase via AT1 receptors. Hypertens. Res. 1996, 19:201-206.
23. Schiffrin E.L., Park J.B., Intengan H.D., Touyz R.M. Correction of arterial structure and endothelial dysfunction in human essential hypertension by the angiotensin receptor antagonist losartan. Circulation 2000, 101:1653-1659.
24. Sethi J.K., Hotamisligil G.S. The role of TNF alpha in adipocyte metabolism. Semin. Cell Dev. Biol. 1999, 10:19-29.
25. Sohn H.Y., Raff U., Hoffmann A., Gloe T., Heermeier K., Galle J., Pohl U. Differential role of angiotensin II receptor subtypes on endothelial superoxide formation. Br. J. Pharmacol. 2000, 131:667-672.
26. Stuehr D.J. Mammalian nitric oxide synthases. Biochim. Biophys. Acta 1999, 1411:217-230.
27. Weisberg S.P., McCann D., Desai M., Rosenbaum M., Leibel R.L., Ferrante A.W. Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Invest. 2003, 112:1796-1808.
28. Wilcox J.N., Subramanian R.R., Sundell C.L., Tracey W.R., Pollock J.S., Harrison D.G., Marsden P.A. Expression of multiple isoforms of nitric oxide synthase in normal and atherosclerotic vessels. Arterioscler. Thromb. Vasc. Biol. 1997, 17:2479-2488.
29. Xia Z., Liu M., Wu Y., Sharma V., Luo T., Ouyang J., McNeill J.H. N-acetylcysteine attenuates TNF-alpha-induced human vascular endothelial cell apoptosis and restores eNOS expression. Eur. J. Pharmacol. 2006, 550:134-142.
30. Yamashita T., Sekiguchi A., Kato T., Tsuneda T., Iwasaki Y.K., Sagara K., Iinuma H., Sawada H., Aizawa T. Angiotensin type 1 receptor blockade prevents endocardial dysfunction of rapidly paced atria in rats. J. Renin Angiotensin Aldosterone Syst. 2007, 8:127-132.
31. Yan G., You B., Chen S.P., Liao J.K., Sun J. Tumor necrosis factor-alpha downregulates endothelial nitric oxide synthase mRNA stability via translation elongation factor 1-alpha 1. Circ. Res. 2008, 103:591-597.
32. Yin T., Ma X., Zhao L., Cheng K., Wang H. Angiotensin II promotes NO production, inhibits apoptosis and enhances adhesion potential of bone marrow-derived endothelial progenitor cells. Cell Res. 2008, 18:792-799.
33. Yoshizumi M., Perrella M.A., Burnett J.C., Lee M.E. Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life. Circ. Res. 1993, 73:205-209.
34. Zhao X., Li X., Trusa S., Olson S.C. Angiotensin type 1 receptor is linked to inhibition of nitric oxide production in pulmonary endothelial cells. Regul. Pept. 2005, 132:113-122.
35. Zou Y., Akazawa H., Qin Y., Sano M., Takano H., Minamino T., Makita N., Iwanaga K., Zhu W., Kudoh S., Toko H., Tamura K., Kihara M., Nagai T., Fukamizu A., Umemura S., Iiri T., Fujita T., Komuro I. Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II. Nat. Cell Biol. 2004, 6:499-506.