Critical concentrations in the dilution of oral self-microemulsifying drug delivery systems

Drug Development and Industrial Pharmacy

Volumn 36, Issue 5, 2010, Pages 531-538

  Kuentz, Martin ^a   Cavegn, Martin ^a  

^a UNIVERSITY OF APPLIED SCIENCES AND ARTS NORTHWESTERN SWITZERLAND   (Switzerland)

Author keywords

Critical concentration; Dilution; Drug delivery systems; Electron paramagnetic resonance; Percolation theory; Self microemulsifying

Indexed keywords

ALCOHOL; CREMOPHOR; DRUG; MIGLYOL; POLYSORBATE; SOLUTOL HS 15;

ARTICLE; CONDUCTANCE; DILUTION; DISPERSION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; ELECTRON SPIN RESONANCE; LIGHT SCATTERING; MICELLE; MICROEMULSION; MICROENVIRONMENT;

ADMINISTRATION, ORAL; CHEMISTRY, PHARMACEUTICAL; DRUG DELIVERY SYSTEMS; ELECTRON SPIN RESONANCE SPECTROSCOPY; EMULSIFYING AGENTS; SOLUBILITY;

EID: 77952608488     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639040903311099     Document Type: Article

References (34)

1. Takagi T, Ramachandran Ch, Bermejo M, Yamashita S, Yu L, Amidon G. (2006). A provisional biopharmaceutical classification of top 200 oral drug products in the United States, Great Britain, Spain and Japan. Mol Pharm, 3 (6): 631-43.
2. Jannin V, Musakhanian J, Marchaud D. (2008). Approaches for the development of solid and semi-solid lipid-based formulations. Adv Drug Deliv Rev, 60: 734-46.
3. Porter Ch, Trevaskis N, Charman W. (2007). Lipid and lipidbased formulations: Optimizing the oral delivery of lipophilic drugs. Nat Rev Drug Discov, 6 (3) 231-48.
4. Hong JY, Kim JK, Song YK, Park JS, Kim CK. (2006). A new self-emulsifying formulation of itraconazole with improved dissolution and oral absorption. J Control Release, 110: 332-8.
5. Pouton CW. (2000). Lipid formulations for oral administration of drugs: Non-emulsifying, self-emulsifying, and self-microemulsifying drug delivery systems. Eur J Pharm Sci, 11 (2): S93-8.
6. Pouton CW. (2006). Formulation of poorly water-soluble drugs for oral administration: Physicochemical and physiological issues and the lipid formulation classification system. Eur J Pharm Sci, 29: 278-87.
7. Zhang P, Liu Y, Feng N, Xu J. (2008). Preparation and evaluation of self-microemulsifying drug delivery system of oridonin. Int J Pharm, 355: 269-76.
8. Chen Y, Li G, Wu X, Chen Z, Hang J, Qin B, et al. (2008). Self-microemulsifying drug delivery system (SMEDDS) of Vinpocetine: Formulation development and in vitro assessment. Biol Pharm Bull, 31 (1): 118-25.
9. Patel AR, Vavia PR. (2007). Preparation and in vivo evaluation of SMEDDS (self-microemulsifying drug delivery system) containing fenofibrate. AAPS J, 9 (3): E344-52.
10. Perlman ME, Murdande SB, Gumkowski MJ, Shah TS, Rodricks CM, Thornton-Manning J, et al. (2008). Development of a self-microemulsifying formulation that reduces the food effect for torcetrapib. Int J Pharm, 351: 15-22.
11. Woo JS, Song YK, Hong JY, Lim SJ, Kim CK. (2008). Reduced foodeffect and enhanced bioavailability of a self-microemulsifying formulation of itraconazole in healthy volunteers. Eur J Pharm Sci, 33: 159-65.
12. Gursoy R, Benita S. (2004). Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs. Biomed Pharmacother, 58: 173-82.
13. Gao P, Rush B, Pfund W, Huang T, Bauer J, Morozowich W, et al. (2003). Development of a supersaturable SEDDS (S-SEDDS) formulation of paclitaxel with improved oral bioavailability. J Pharm Sci, 92 (12): 2386-98.
14. Kapitza SB, Michel B, van Hoogevest P, Leigh M, Imanidis G. (2007). Absorption of poorly water soluble drugs subject to apical efflux using phospholipids as solubilizers in the Caco-2 cell model. Eur J Pharm Biopharm, 66: 146-58.
15. O'Driscoll C. (2002). Lipid-based formulations for the intestinal lymphatic delivery. Eur J Pharm Sci, 15: 405-15.
16. Dahan A, Hoffman A. (2005). Evaluation of chylomicron flow blocking approach to investigate the intestinal lymphatic transport of lipophillic drugs. Eur J Pharm Sci, 24: 381-8.
17. Kuentz M, Wyttenbach N, Kuhlmann O. (2007). Application of a statistical method to the absorption of a new model drug from micellar and lipid formulations-evaluation of qualitative excipient effects. Pharm Dev Technol, 12: 275-83.
18. Porter Ch, Charman W. (2001). In vitro assessment of oral lipid based formulations. Adv Drug Deliv Rev, 50, S127-47.
19. Brogård M, Troedsson E, Thuresson K, Ljusberg-Wahren H. (2007). A new standardized lipolysis approach for the characterization of emulsions and dispersions. J Coll Interface Sci, 308: 500-7.
20. Kossena GA, Charman W, Boyd BJ, Porter Ch. (2005). Influence of the intermediate digestion phases of common formulation lipids on the absorption of a poorly water-soluble drug. J Pharm Sci, 94 (3): 481-92.
21. Porter Ch, Kaukonen AM, Taillardat-Bertschinger A, Boyd BJ, O'Connor JM, Edwards GA, et al. (2004). Use of in vitro lipid digestion data to explain the in vivo performance of triglyceride-based oral lipid formulations of poorly watersoluble drugs: Study with halofantrine. J Pharm Sci, 93 (5): 1110-21.
22. Sek L, Porter C, Kaukonen, Charman W. (2002). Evaluation of the in-vitro digestion profiles for long and medium chain triglycerides and the phase behaviour of the lipolytic products. J Pharm Pharmacol, 54: 29-41.
23. Cuiné JF, Charman WN, Pouton C, Edwards G, Porter Ch. (2007). Increasing the proportional content of surfactants (Cremophor EL) relative to lipid in self-emulsifying lipid-based formulations of danazol reduces oral bioavailability in beagle dogs. Pharm Res, 24 (4) 748-57.
24. Fatouros DG, Nielsen FS, Douroumis D, Hdjileontiadis LJ, Müllertz A. (2008). In vitro-in vivo correlations of self-emulsifying drug delivery systems combining the dynamic lipolysis model and neuro-fuzzy networks. Eur J Pharm Biopharm, 69: 887-98.
25. Ditner C, Bravo R, Imanidis G, Kuentz M. (2009). A systematic dilution study of self-microemulsifying drug delivery systems in artificial intestinal fluid using dynamic laser light backscattering. Drug Dev Ind Pharm, 35: 199-208.
26. Pouton CW. (2005). Formulation of poorly water-soluble drugs for oral drug administration. Bull Tech Gattefossé, 39-51.
27. Lopez-Montilla JC, Herrera-Morales PE, Pandey S, Shah DO. (2002). Spontaneous emulsification: Mechanisms, physicochemical aspects, modeling, and applications. J Dispers Sci Technol, 23 (1-3): 219-68.
28. Sher H, Zallen R. (1970). Critical density in percolation processes. J Chem Phys, 53 (9): 3759-61.
29. Lagües M, Ober R, Taupin C. (1978). Study of structure and electrical conductivity in microemulsions: Evidence for percolation mechanism and phase inversion. J Phys Lett, 39 (24): L487-91.
30. Alany RG, Tucker IG, Davies NM, Rades T. (2001). Characterisation of colloidal structures of pseudoternary phase diagrams formed by oil/water/amphiphile systems. Drug Dev Ind Pharm, 27 (1): 31-8.
31. Sager W, Eicke HF. (1991). The experimentalists' kit to describe microemulsions. Colloid Surf, 57: 343-53.
32. Chakraborty I, Moulik SP. (2005). Physicochemical studies on microemulsions 9. Conductance percolation of AOT-derived W/O microemulsion with aliphatic and aromatic hydrocarbon oils. J Coll Interface Sci, 289: 530-41.
33. Fanun M. (2007). Conductivity, viscosity, NMR and diclofenac solubilisation capacity studies of mixed nonionic surfactants microemulsions. J Mol Liq, 135: 5-13.
34. Lurie DJ, Mäder K. (2005). Monitoring drug delivery processes by EPR and related techniques-principles and applications. Adv Drug Deliv Rev, 57: 1171-90.