Genome-wide linkage of obstructive sleep apnoea and high-density lipoprotein cholesterol in a Filipino family: Bivariate linkage analysis of obstructive sleep apnoea

Journal of Sleep Research

Volumn 19, Issue 2, 2010, Pages 349-357

  Relf, Bronwyn L ^a   Larkin, Emma K ^b   Torres, Carina De ^c   Baur, Louise A ^a   Christodoulou, John ^a,c   Waters, Karen A ^a,c  

^a UNIVERSITY OF SYDNEY   (Australia)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c CHILDREN S HOSPITAL AT WESTMEAD   (Australia)

Author keywords

Bivariate; Gene; Inflammation; Metabolic syndrome; Obesity; Respiratory disturbance index

Indexed keywords

CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR; TRIACYLGLYCEROL;

ADULT; ARTICLE; ATHEROSCLEROSIS; BIVARIATE ANALYSIS; BODY MASS; CELL STRESS; CHILD; CHOLESTEROL BLOOD LEVEL; CHROMOSOME 19Q; CLINICAL ARTICLE; DIET RESTRICTION; FEMALE; FILIPINO; GENE IDENTIFICATION; GENE LOCUS; GENETIC LINKAGE; HUMAN; INFLAMMATION; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; KILLER CELL; MALE; METABOLIC SYNDROME X; PHENOTYPE; POLYSOMNOGRAPHY; PREVALENCE; PRIORITY JOURNAL; RESPIRATORY DISTURBANCE INDEX; RURAL AREA; SCORING SYSTEM; SLEEP APNEA SYNDROME; TRIACYLGLYCEROL BLOOD LEVEL; AUTOSOME; BLOOD; FAMILY; GENETIC ASSOCIATION; GENETICS; GENOTYPE; PHYSIOLOGY; SLEEP; SLEEP DISORDERED BREATHING;

ADULT; BODY MASS INDEX; CHILD; CHOLESTEROL; CHOLESTEROL, HDL; CHROMOSOMES, HUMAN, 19-20; FAMILY; FEMALE; GENETIC LINKAGE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; INSULIN; LOD SCORE; MALE; PHENOTYPE; POLYSOMNOGRAPHY; RECEPTORS, KIR; SLEEP; SLEEP APNEA, OBSTRUCTIVE; TRIGLYCERIDES;

EID: 77952607904     PISSN: 09621105     EISSN: 13652869     Source Type: Journal    
DOI: 10.1111/j.1365-2869.2009.00797.x     Document Type: Article

References (52)

1. Almasy, L. Blangero, J. Multipoint quantitative trait linkage analysis in general pedigrees. Am. J. Hum. Genet., 1998, 62 : 1198 1211.
2. Almasy, L., Dyer, T. D. Blangero, J. Bivariate quantitative trait linkage analysis: pleiotropy versus co-incident linkages. Genet. Epidemiol., 1997, 14 : 953 958.
3. American Academy of Sleep Medicine. ICSD-International Classification of Sleep Disorders, Revised: Diagnostic and Coding Manual. American Academy of Sleep Medicine
4. Amos, C., de Andrade, M. Zhu, D. Comparison of multivariate tests for genetic linkage. Hum. Hered., 2001, 51 : 133 144.
5. An, P., Freedman, B. I., Hanis, C. L. et al. Genome-wide linkage scans for fasting glucose, insulin, and insulin resistance in the National Heart, Lung, and Blood Institute Family Blood Pressure Program: evidence of linkages to chromosome 7q36 and 19q13 from meta-analysis. Diabetes, 2005, 54 : 909 914.
6. Araneta, M. R. Barrett-Connor, E. Adiponectin and ghrelin levels and body size in normoglycemic Filipino, African-American, and white women. Obesity (Silver Spring), 2007, 15 : 2454 2462.
7. Araneta, M. R., Wingard, D. L. Barrett-Connor, E. Type 2 diabetes and metabolic syndrome in Filipina-American women: a high-risk nonobese population. Diabetes Care, 2002, 25 : 494 499.
8. Bell, C. G., Benzinou, M., Siddiq, A. et al. Genome-wide linkage analysis for severe obesity in French Caucasians finds significant susceptibility locus on chromosome 19q. Diabetes, 2004, 53 : 1857 1865.
9. Chiu, Y. F., Chuang, L. M., Hsiao, C. F. et al. An autosomal genome-wide scan for loci linked to pre-diabetic phenotypes in nondiabetic Chinese subjects from the Stanford Asia-Pacific Program of Hypertension and Insulin Resistance Family Study. Diabetes, 2005, 54 : 1200 1206.
10. Coughlin, S. R., Mawdsley, L., Mugarza, J. A., Calverley, P. M. Wilding, J. P. Obstructive sleep apnea is independently associated with an increased prevalence of metabolic syndrome. Eur. Heart J., 2004, 25 : 735 741.
11. Dyugovskaya, L., Lavie, P. Lavie, L. Phenotypic and functional characterization of blood δγ T cells in sleep apnea. Am. J. Respir. Crit. Care Med., 2003, 168 : 242 249.
12. Dyugovskaya, L., Lavie, P., Hirsh, M. Lavie, L. Activated CD8 + T lymphocytes in obstructive sleep apnea. Eur. Resp. J., 2005, 25 : 820 828.
13. Elbein, S. C. Hasstedt, S. J. Quantitative trait linkage analysis of lipid-related traits in familial type 2 diabetes: evidence for linkage of triglyceride levels to chromosome 19q. Diabetes, 2002, 51 : 528 535.
14. de la Eva, R. C., Baur, L. A., Donaghue, K. C. Waters, K. A. Metabolic correlates with obstructive sleep apnea in obese subjects. J. Pediatr., 2002, 140 : 654 659.
15. Gottlieb, D. J., O'Connor, G. T. Wilk, J. B. Genome-wide association of sleep and circadian phenotypes. BMC Med. Genet., 2007, 8 (Suppl. 1 S9.
16. Gozal, D., Serpero, L. D., Sans Capdevila, O. Kheirandish-Gozal, L. Systemic inflammation in non-obese children with obstructive sleep apnea. Sleep Med., 2008, 9 : 254 259.
17. Ip, M. S., Lam, B., Ng, M. M., Lam, W. K., Tsang, K. W. Lam, K. S. Obstructive sleep apnea is independently associated with insulin resistance. Am. J. Respir. Crit. Care Med., 2002, 165 : 670 676.
18. Jacobs, R., Hintzen, G., Kemper, A. et al. CD56 bright cells differ in their KIR repertoire and cytotoxic features from CD56 dim NK cells. Eur. J. Immunol., 2001, 31 : 3121 3127.
19. Kelley, J., Walter, L. Trowsdale, J. Comparative genomics of natural killer cell receptor gene clusters. PLoS Genet., 2005, 1 : e27.
20. Khalyfa, A., Capdevila, O. S., Buazza, M. O., Serpero, L. D., Kheirandish-Gozal, L. Gozal, D. Genome-wide gene expression profiling in children with non-obese obstructive sleep apnea. Sleep Med., 2008, 10 : 66 74.
21. Kono, M., Tatsumi, K., Saibara, T. et al. Obstructive sleep apnea syndrome is associated with some components of metabolic syndrome. Chest, 2007, 131 : 1387 1392.
22. Lam, B., Lam, D. C. Ip, M. S. Obstructive sleep apnea in Asia. Int. J. Tuberc. Lung Dis., 2007, 11 : 2 11.
23. Lambert, M., Paradis, G., O'Loughlin, J., Delvin, E. E., Hanley, J. A. Levy, E. Insulin resistance syndrome in a representative sample of children and adolescents from Quebec. Int. J. Obes. Relat. Metab. Disord., 2004, 28 : 833 841. (Pubitemid 39005683)
24. Larkin, E. K., Rosen, C. L., Kirchner, H. L. et al. Variation of C-reactive protein levels in adolescents: association with sleep disordered breathing and sleep duration. Circulation, 2005, 111 : 1978 1984.
25. Larkin, E. K., Patel, S. R., Redline, S., Mignot, E., Elston, R. C. Hallmayer, J. Apolipoprotein E and obstructive sleep apnea: evaluating whether a candidate gene explains a linkage peak. Genet. Epidemiol., 2006, 30 : 101 110.
26. Larkin, E. K., Patel, S. R., Elston, R. C., Gary-McGuire, C., Zhu, X. Redline, S. Using linkage analysis to identify quantitative trait loci for sleep apnea in relationship to body mass index. Ann. Hum. Genet., 2008, 72 : 762 773.
27. Lavie, L. Obstructive sleep apnoea syndrome - an oxidative stress disorder. Sleep Med. Rev., 2003, 7 : 35 51.
28. Loos, R. J., Katzmarzyk, P. T., Rao, D. C. et al. HERITAGE Family Study Genome-wide linkage scan for the metabolic syndrome in the HERITAGE family study. J. Clin. Endocrinol. Metab., 2003, 88 : 5935 5943.
29. Malhotra, A., Elbein, S. C., Ng, M. C. et al. Meta-analysis of genome-wide linkage studies of quantitative lipid traits in families ascertained for type 2 diabetes. Diabetes, 2007, 56 : 890 896.
30. Martin, L., Cianflone, K., Zakarian, R. et al. Bivariate linkage between acylation-stimulating protein and BMI and high-density lipoproteins. Obesity Res., 2004, 12 : 669 678.
31. McArdle, N., Hillman, D., Beilin, L. Watts, G. Metabolic risk factors for vascular disease in obstructive sleep apnea: a matched control study. Am. J. Respir. Crit. Care Med., 2007, 175 : 190 195.
32. Morales, D. D., Punzalan, F. E., Paz-Pacheco, E., Sy, R.G., Duante, C. A. for the National Nutrition and Health Survey: 2003 Group. Metabolic syndrome in the Philippine general population: prevalence and risk for atherosclerotic cardiovascular disease and diabetes mellitus. Diab. Vasc. Dis. Res., 2008, 5 : 36 43.
33. Ng, M. C., So, W. Y., Lam, V. K. et al. Genome-wide scan for metabolic syndrome and related quantitative traits in Hong Kong Chinese and confirmation of a susceptibility locus on chromosome 1q21-q25. Diabetes, 2004, 53 : 2676 2683.
34. Nock, N. L., Li, L., Larkin, E. K., Patel, S. R. Redline, S. Empirical evidence for 'syndrome Z': a hierarchical 5-factor model of the metabolic syndrome incorporating sleep disturbance measures. Sleep, 2009, 32 : 615 622.
35. Palmer, L. J., Buxbaum, S. G., Larkin, E. K. et al. A whole-genome wide scan for obstructive sleep apnea and obesity. Am. J. Hum. Genet., 2003, 72 : 340 350.
36. Palmer, L. J., Buxbaum, S. G., Larkin, E. K. et al. Whole genome-wide scan for OSA in African-American families. Am. J. Respir. Crit. Care Med., 2004, 169 : 1314 1321.
37. Patel, S. R. Shared genetic risk factors for obstructive sleep apnea and obesity. J. Appl. Physiol., 2005, 99 : 1600 1606.
38. Peled, N., Kassirer, M., Shitrit, D. et al. The association of OSA with insulin resistance, inflammation and metabolic syndrome. Respir. Med., 2007, 101 : 1696 1701.
39. Redline, S., Storfer-Isser, A., Rosen, C. et al. Association between metabolic syndrome and sleep-disordered breathing in adolescents. Am. J. Respir. Crit. Care Med., 2007, 176 : 401 408. (Pubitemid 47267475)
40. Saar, K., Geller, F., Rüschendorf, F. et al. Genome scan for childhood and adolescent obesity in German families. Pediatrics, 2003, 111 : 321 327.
41. S.A.G.E. Statistical Analysis for Genetic Epidemiology 5.4.1. Computer program package available from the Department of Epidemiology and Biostatistics, Rammelkamp Center for Education and Research, MetroHealth Campus, Case Western Reserve University
42. Sambrook, J. Russell, D. Molecular Cloning: A Laboratory Manual, 3rd edn. Cold Spring Harbor Laboratory Press
43. Sasanabe, R., Banno, K., Otake, K. et al. Metabolic syndrome in Japanese patients with obstructive sleep apnea syndrome. Hypertens. Res., 2006, 29 : 315 322. (Pubitemid 43965112)
44. Srinivasan, S. R., Myers, L. Berenson, G. S. Changes in metabolic syndrome variables since childhood in prehypertensive and hypertensive subjects. Hypertension, 2006, 48 : 33 39.
45. Tam, C. S., Wong, M., McBain, R., Bailey, S. Waters, K. A. Inflammatory measures in children with obstructive sleep apnea. J. Paediatr. Child Health, 2006, 42 : 277 282.
46. van Tilburg, J. H., Sandkuijl, L. A., Strongman, E. et al. A genome-wide scan in type 2 diabetes mellitus provides independent replication of a susceptibility locus on 18p11 and suggests the existence of novel loci on 2q12 and 19q13. J. Clin. Endocrinol. Metab., 2003, 88 : 2223 2230.
47. Trowsdale, J., Barten, R., Haude, A., Stewart, C. A., Beck, S. Wilson, M. J. The genomic context of natural killer receptor extended gene families. Immunol. Rev., 2001, 181 : 20 38.
48. Uhrberg, M., Valiante, N. M., Young, N. T., Lanier, L. L., Phillips, J. H. Parham, P. The repertoire of killer cell Ig-like receptor and CD94:NKG2A receptors in T-cells: clones sharing identical alpha beta TCR rearrangement express highly diverse killer cell Ig-like receptor patterns. J. Immunol., 2001, 166 : 3923 3932.
49. Villaneuva, A. T., Buchanan, P. R., Yee, B. J. Grunstein, R. R. Ethnicity and obstructive sleep apnea. Sleep Med. Rev., 2005, 9 : 419 436.
50. Waters, K. A., Mast, B. T., Vella, S. et al. Structural equation modelling of sleep apnea, inflammation and metabolic dysfunction in children. J. Sleep Res., 2007, 16 : 388 395.
51. WHO Expert Consultation. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet, 2004, 363 : 157 163.
52. World Health Organization. Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications. Part 1. Diagnosis and Classification of Diabetes Mellitus: Report of a WHO Consultation