The impact of key amino acid substitutions in the hemagglutinin of influenza A (H3N2) viruses on vaccine production and antibody response

Vaccine

Volumn 28, Issue 24, 2010, Pages 4079-4085

  Chen, Zhongying ^a   Zhou, Helen ^a   Jin, Hong ^a  

^a MEDIMMUNE   (United States)

Author keywords

Antigenicity; Egg adaptation; Hemagglutinin; Immunogenicity; Influenza H3N2 virus

Indexed keywords

GLUTAMINE; HEMAGGLUTININ; INFLUENZA VACCINE; LEUCINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY BLOOD LEVEL; ANTIBODY RESPONSE; ANTIGENICITY; ARTICLE; COLD ACCLIMATIZATION; CONTROLLED STUDY; FERRET; HEMAGGLUTINATION INHIBITION TEST; IMMUNOGENICITY; INFLUENZA A (H3N2); NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEQUENCE ANALYSIS; VACCINE PRODUCTION; VIROGENESIS; VIRUS NEUTRALIZATION; VIRUS REPLICATION; VIRUS STRAIN;

AMINO ACID SUBSTITUTION; ANIMALS; ANTIBODIES, VIRAL; ANTIBODY FORMATION; CELL LINE; CHICKENS; DOGS; FERRETS; GENETIC DRIFT; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; INFLUENZA A VIRUS, H3N2 SUBTYPE; INFLUENZA VACCINES; ORTHOMYXOVIRIDAE INFECTIONS; REASSORTANT VIRUSES; SEQUENCE ANALYSIS, PROTEIN; VIRUS REPLICATION;

EID: 77952583993     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2010.03.078     Document Type: Article

References (46)

1. Stohr K. Influenza-WHO cares. Lancet Infect Dis 2 9 (2002) 517
2. Murphy B.R., and Coelingh K. Principles underlying the development and use of live attenuated cold-adapted influenza A and B virus vaccines. Viral Immunol 15 2 (2002) 295-323
3. Russell C.A., Jones T.C., Barr I.G., Cox N.J., Garten R.J., Gregory V., et al. Influenza vaccine strain selection and recent studies on the global migration of seasonal influenza viruses. Vaccine 26S 4 (2008) D31-D34
4. Russell C.A., Jones T.C., Barr I.G., Cox N.J., Garten R.J., Gregory V., et al. The global circulation of seasonal influenza A (H3N2) viruses. Science 320 5874 (2008) 340-346
5. Lamb R.A., and Krug R.M. Orthomyxoviridae: the viruses and their replication. In: Knipe D.M., and Howley P.M. (Eds). Fields virology (2001), Lippincott Williams & Wilkins, Philadelphia 1487-1531
6. Skehel J.J., and Wiley D.C. Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin. Annu Rev Biochem 69 (2000) 531-569
7. Weis W., Brown J.H., Cusack S., Paulson J.C., Skehel J.J., and Wiley D.C. Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid. Nature 333 6172 (1988) 426-431
8. Wiley D.C., Wilson I.A., and Skehel J.J. Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation. Nature 289 5796 (1981) 373-378
9. Wilson I.A., and Cox N.J. Structural basis of immune recognition of influenza virus hemagglutinin. Annu Rev Immunol 8 (1990) 737-771
10. Wilson I.A., Skehel J.J., and Wiley D.C. Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution. Nature 289 5796 (1981) 366-373
11. Both G.W., Sleigh M.J., Cox N.J., and Kendal A.P. Antigenic drift in influenza virus H3 hemagglutinin from 1968 to 1980: multiple evolutionary pathways and sequential amino acid changes at key antigenic sites. J Virol 48 1 (1983) 52-60
12. Plotkin J.B., Dushoff J., and Levin S.A. Hemagglutinin sequence clusters and the antigenic evolution of influenza A virus. Proc Natl Acad Sci USA 99 9 (2002) 6263-6268
13. Shih A.C., Hsiao T.C., Ho M.S., and Li W.H. Simultaneous amino acid substitutions at antigenic sites drive influenza A hemagglutinin evolution. Proc Natl Acad Sci USA 104 15 (2007) 6283-6288
14. Smith D.J., Lapedes A.S., de Jong J.C., Bestebroer T.M., Rimmelzwaan G.F., Osterhaus A.D., et al. Mapping the antigenic and genetic evolution of influenza virus. Science 305 5682 (2004) 371-376
15. Bush R.M., Bender C.A., Subbarao K., Cox N.J., and Fitch W.M. Predicting the evolution of human influenza A. Science 286 5446 (1999) 1921-1925
16. Bush R.M., Fitch W.M., Bender C.A., and Cox N.J. Positive selection on the H3 hemagglutinin gene of human influenza virus A. Mol Biol Evol 16 11 (1999) 1457-1465
17. Jin H., Zhou H., Liu H., Chan W., Adhikary L., Mahmood K., et al. Two residues in the hemagglutinin of A/Fujian/411/02-like influenza viruses are responsible for antigenic drift from A/Panama/2007/99. Virology 336 1 (2005) 113-119
18. Robertson J.S. Clinical influenza virus and the embryonated Hen's egg. Rev Med Virol 3 2 (1993) 97-106
19. Gubareva L.V., Wood J.M., Meyer W.J., Katz J.M., Robertson J.S., Major D., et al. Codominant mixtures of viruses in reference strains of influenza virus due to host cell variation. Virology 199 1 (1994) 89-97
20. Katz J.M., Naeve C.W., and Webster R.G. Host cell-mediated variation in H3N2 influenza viruses. Virology 156 2 (1987) 386-395
21. Kodihalli S., Justewicz D.M., Gubareva L.V., and Webster R.G. Selection of a single amino acid substitution in the hemagglutinin molecule by chicken eggs can render influenza A virus (H3) candidate vaccine ineffective. J Virol 69 8 (1995) 4888-4897
22. Meyer W.J., Wood J.M., Major D., Robertson J.S., Webster R.G., and Katz J.M. Influence of host cell-mediated variation on the international surveillance of influenza A (H3N2) viruses. Virology 196 1 (1993) 130-137
23. Hoffmann E., Neumann G., Kawaoka Y., Hobom G., and Webster R.G. A DNA transfection system for generation of influenza A virus from eight plasmids. Proc Natl Acad Sci USA 97 11 (2000) 6108-6113
24. Jin H., Lu B., Zhou H., Ma C., Zhao J., Yang C.F., et al. Multiple amino acid residues confer temperature sensitivity to human influenza virus vaccine strains (FluMist) derived from cold-adapted A/Ann Arbor/6/60. Virology 306 1 (2003) 18-24
25. Lu B., Zhou H., Chan W., Kemble G., and Jin H. Single amino acid substitutions in the hemagglutinin of influenza A/Singapore/21/04 (H3N2) increase virus growth in embryonated chicken eggs. Vaccine 24 44-46 (2006) 6691-6693
26. Lu B., Zhou H., Ye D., Kemble G., and Jin H. Improvement of influenza A/Fujian/411/02 (H3N2) virus growth in embryonated chicken eggs by balancing the hemagglutinin and neuraminidase activities, using reverse genetics. J Virol 79 11 (2005) 6763-6771
27. Widjaja L., Ilyushina N., Webster R.G., and Webby R.J. Molecular changes associated with adaptation of human influenza A virus in embryonated chicken eggs. Virology 350 1 (2006) 137-145
28. Hensley S.E., Das S.R., Bailey A.L., Schmidt L.M., Hickman H.D., Jayaraman A., et al. Hemagglutinin receptor binding avidity drives influenza A virus antigenic drift. Science 326 5953 (2009) 734-736
29. Lee M., Chen J.S., and Cho I. Identifying potential immunodominant amino acid positions in hemagglutinin protein of influenza A H3N2 viruses. In: Kawaoka Y. (Ed). Options for the control of influenza V (2004), Elsevier, San Diego 626-631
30. Bragstad K., Nielsen L.P., and Fomsgaard A. The evolution of human influenza A viruses from 1999 to 2006: a complete genome study. Virol J 5 (2008) 40
31. Muñoz E.T., and Deem M.W. Epitope analysis for influenza vaccine design. Vaccine 23 9 (2005) 1144-1148
32. Sato K., Morishita T., Nobusawa E., Tonegawa K., Sakae K., Nakajima S., et al. Amino-acid change on the antigenic region B1 of H3 haemagglutinin may be a trigger for the emergence of drift strain of influenza A virus. Epidemiol Infect 132 3 (2004) 399-406
33. Xiu W., Wen Y., Shen X., Xie J., Yang S., Wu B., et al. Molecular evolution of influenza A (H3N2) viruses circulated in Fujian Province, China during the 1996-2004 period. Sci China C Life Sci 51 4 (2008) 373-380
34. Plakokefalos E.T., Markoulatos P., Spyrou N., Bei T., and Vamvakopoulos N.C. Molecular and phylogenetic analysis of haemagglutinin and neuraminidase sequences from recent human influenza type A (H3N2) viral isolates in Southern Greece. Arch Virol 146 10 (2001) 1899-1918
35. Martín J., Wharton S.A., Lin Y.P., Takemoto D.K., Skehel J.J., Wiley D.C., et al. Studies of the binding properties of influenza hemagglutinin receptor-site mutants. Virology 241 1 (1998) 101-111
36. Mochalova L., Gambaryan A., Romanova J., Tuzikov A., Chinarev A., Katinger D., et al. Receptor-binding properties of modern human influenza viruses primarily isolated in Vero and MDCK cells and chicken embryonated eggs. Virology 313 2 (2003) 473-480
37. Chen Z., Wang W., Zhou H., Suguitan A.L.J., Shambaugh C., Kim L., et al. Generation of live attenuated novel influenza virus A/California/7/09 (H1N1) vaccines with high yield in embryonated chicken eggs. J Virol 84 1 (2010) 44-51
38. Xu Q, Wang W, Cheng X, Zengel J, Jin H. Influenza H1N1 A/Solomon Island/3/06 virus receptor binding specificity correlates with virus pathogenicity and immunogenicity in ferrets. J Virol; 2010. [Epub ahead of print]
39. Nobusawa E., Ishihara H., Morishita T., Sato K., and Nakajima K. Change in receptor-binding specificity of recent human influenza A viruses (H3N2): a single amino acid change in hemagglutinin altered its recognition of sialyloligosaccharides. Virology 278 2 (2000) 587-596
40. Katz J.M., and Webster R.G. Efficacy of inactivated influenza A virus (H3N2) vaccines grown in mammalian cells or embryonated eggs. J Infect Dis 160 2 (1989) 191-198
41. Robertson J.S., Cook P., Nicolson C., Newman R., and Wood J.M. Mixed populations in influenza virus vaccine strains. Vaccine 12 14 (1994) 1317-1322
42. Katz J.M., Wang M., and Webster R.G. Direct sequencing of the HA gene of influenza (H3N2) virus in original clinical samples reveals sequence identity with mammalian cell-grown virus. J Virol 64 4 (1990) 1808-1811
43. Asaoka N., Tanaka Y., Sakai T., Fujii Y., Ohuchi R., and Ohuchi M. Low growth ability of recent influenza clinical isolates in MDCK cells is due to their low receptor binding affinities. Microbes Infect 8 (2006) 511-519
44. Connor R.J., Kawaoka Y., Webster R.G., and Paulson J.C. Receptor specificity in human, avian, and equine H2 and H3 influenza virus isolates. Virology 205 1 (1994) 17-23
45. Rogers G.N., Paulson J.C., Daniels R.S., Skehel J.J., Wilson I.A., and Wiley D.C. Single amino acid substitutions in influenza haemagglutinin change receptor binding specificity. Nature 304 5921 (1983) 76-78
46. Vines A., Wells K., Matrosorich M., Castrucci M.R., Ito T., and Kawaoka Y. The role of influenza A virus hemagglutinin residues 226 and 228 in receptor specificity and host range restriction. J Virol 72 9 (1998) 7626-7631