GD2 expression is closely associated with neuronal differentiation of human umbilical cord blood-derived mesenchymal stem cells

Cellular and Molecular Life Sciences

Volumn 67, Issue 11, 2010, Pages 1845-1858

  Jin, Hye Jin ^a,b   Nam, Hae Yun ^b   Bae, Yun Kyong ^a   Kim, Soo Yeon ^c   Im, I Rang ^b   Oh, Wonil ^a   Yang, Yoon Sun ^a   Choi, Soo Jin ^a,b   Kim, Seong Who ^b  

^a MEDIPOST Co Ltd   (South Korea)

^b University of Ulsan College of Medicine   (South Korea)

^c Mercersburg Academy   (United States)

Author keywords

Basic helix loop helix; Ganglioside GD2; Mesenchymal stem cells; Multi lineage differentiation; Neuronal differentiation; Umbilical cord blood

Indexed keywords

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; GANGLIOSIDE GD2; (N ACETYLNEURAMINYL) GALACTOSYLGLUCOSYLCERAMIDE N ACETYLGALACTOSAMINYLTRANSFERASE; (N-ACETYLNEURAMINYL)-GALACTOSYLGLUCOSYLCERAMIDE N-ACETYLGALACTOSAMINYLTRANSFERASE; GANGLIOSIDE; GANGLIOSIDE, GD2; N ACETYLGALACTOSAMINYLTRANSFERASE; PRIMER DNA; SMALL INTERFERING RNA;

ARTICLE; CELL FRACTIONATION; CELL LINEAGE; CELL POPULATION; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; MESODERM; NERVE CELL DIFFERENTIATION; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; UMBILICAL CORD BLOOD; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SEPARATION; CLONOGENIC ASSAY; CORD BLOOD STEM CELL TRANSPLANTATION; CYTOLOGY; DRUG ANTAGONISM; FETUS BLOOD; GENETICS; MESENCHYMAL STEM CELL; METABOLISM; NERVE CELL; NERVOUS SYSTEM DEVELOPMENT; NEWBORN;

BASE SEQUENCE; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SEPARATION; CELLS, CULTURED; COLONY-FORMING UNITS ASSAY; CORD BLOOD STEM CELL TRANSPLANTATION; DNA PRIMERS; FETAL BLOOD; GANGLIOSIDES; HUMANS; INFANT, NEWBORN; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; N-ACETYLGALACTOSAMINYLTRANSFERASES; NEUROGENESIS; NEURONS; RNA, SMALL INTERFERING;

EID: 77952574517     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-010-0292-z     Document Type: Article

References (45)

1. Y Jiang BN Jahagirdar RL Reinhardt RE Schwartz CD Keene XR Ortiz-Gonzalez M Reyes T Lenvik T Lund M Blackstad J Du S Aldrich A Lisberg WC Low DA Largaespada CM Verfaillie 2002 Pluripotency of mesenchymal stem cells derived from adult marrow Nature 418 41 49 10.1038/nature00870 1:CAS:528: DC%2BD38XltVantrs%3D 12077603 (Pubitemid 34742565)
2. OK Lee TK Kuo WM Chen KD Lee SL Hsieh TH Chen 2004 Isolation of multipotent mesenchymal stem cells from umbilical cord blood Blood 103 1669 1675 10.1182/blood-2003-05-1670 1:CAS:528:DC%2BD2cXhvVOhsL4%3D 14576065 (Pubitemid 38268958)
3. AI Caplan JE Dennis 2006 Mesenchymal stem cells as trophic mediators J Cell Biochem 98 1076 1084 10.1002/jcb.20886 1:CAS:528:DC%2BD28XnsVyjtL0%3D 16619257 (Pubitemid 44128350)
4. M Gnecchi H He N Noiseux OD Liang L Zhang F Morello H Mu LG Melo RE Pratt JS Ingwall VJ Dzau 2006 Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement Faseb J 20 661 669 10.1096/fj.05-5211com 1:CAS:528: DC%2BD28XjtlensLc%3D 16581974 (Pubitemid 44933310)
5. B Parekkadan D van Poll Z Megeed N Kobayashi AW Tilles F Berthiaume ML Yarmush 2007 Immunomodulation of activated hepatic stellate cells by mesenchymal stem cells Biochem Biophys Res Commun 363 247 252 10.1016/j.bbrc.2007.05.150 1:CAS:528:DC%2BD2sXhtFWgsrjJ 17869217 (Pubitemid 47484321)
6. S Kern H Eichler J Stoeve H Kluter K Bieback 2006 Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue Stem Cells 24 1294 1301 10.1634/stemcells.2005-0342 1:CAS:528: DC%2BD28XhtFGhu7fJ 16410387 (Pubitemid 44464698)
7. Y Fukuchi H Nakajima D Sugiyama I Hirose T Kitamura K Tsuji 2004 Human placenta-derived cells have mesenchymal stem/progenitor cell potential Stem Cells 22 649 658 10.1634/stemcells.22-5-649 1:CAS:528:DC%2BD2cXnvFOltbY%3D 15342929
8. S Gronthos M Mankani J Brahim PG Robey S Shi 2000 Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo Proc Natl Acad Sci USA 97 13625 13630 10.1073/pnas.240309797 1:CAS:528:DC%2BD3cXoslygurY%3D 11087820
9. A Flynn F Barry T O'Brien 2007 UC blood-derived mesenchymal stromal cells: an overview Cytotherapy 9 717 726 10.1080/14653240701584578 1:CAS:528:DC%2BD2sXhtl2is7jK 17917891 (Pubitemid 350226750)
10. DS Kim JH Kim JK Lee SJ Choi JS Kim SS Jeun W Oh YS Yang JW Chang 2009 Overexpression of CXC chemokine receptors is required for the superior glioma-tracking property of umbilical cord blood-derived mesenchymal stem cells Stem Cells Dev 18 511 519 10.1089/scd.2008.0050 1:CAS:528:DC%2BD1MXkvVGgtrs%3D 18624673
11. SW Kim H Han GT Chae SH Lee S Bo JH Yoon YS Lee KS Lee HK Park KS Kang 2006 Successful stem cell therapy using umbilical cord blood-derived multipotent stem cells for Buerger's disease and ischemic limb disease animal model Stem Cells 24 1620 1626 10.1634/stemcells.2005-0365 16497946 (Pubitemid 44464680)
12. SP Bruder N Jaiswal SE Haynesworth 1997 Growth kinetics, self-renewal, and the osteogenic potential of purified human mesenchymal stem cells during extensive subcultivation and following cryopreservation J Cell Biochem 64 278 294 10.1002/(SICI)1097-4644(199702)64:2<278::AID-JCB11>3.0.CO;2-F 1:CAS:528:DyaK2sXpt1Kqsg%3D%3D 9027588 (Pubitemid 27065442)
13. ME Owen J Cave CJ Joyner 1987 Clonal analysis in vitro of osteogenic differentiation of marrow CFU-F J Cell Sci 87 Pt 5 731 738 3499442
14. EJ Gang D Bosnakovski CA Figueiredo JW Visser RC Perlingeiro 2007 SSEA-4 identifies mesenchymal stem cells from bone marrow Blood 109 1743 1751 10.1182/blood-2005-11-010504 1:CAS:528:DC%2BD2sXjt1Cgtrc%3D 17062733 (Pubitemid 46239610)
15. C Martinez TJ Hofmann R Marino M Dominici EM Horwitz 2007 Human bone marrow mesenchymal stromal cells express the neural ganglioside GD2: a novel surface marker for the identification of MSCs Blood 109 4245 4248 10.1182/blood-2006-08-039347 1:CAS:528:DC%2BD2sXls1amsro%3D 17264296 (Pubitemid 46743389)
16. D Baksh R Yao RS Tuan 2007 Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow Stem Cells 25 1384 1392 10.1634/stemcells.2006-0709 1:CAS:528:DC%2BD2sXntlWrsbc%3D 17332507 (Pubitemid 47106005)
17. HJ Buhring VL Battula S Treml B Schewe L Kanz W Vogel 2007 Novel markers for the prospective isolation of human MSC Ann N Y Acad Sci 1106 262 271 10.1196/annals.1392.000 17395729 (Pubitemid 47443036)
18. S Bae CW Park HK Son HK Ju D Paik CJ Jeon GY Koh J Kim H Kim 2008 Fibroblast activation protein alpha identifies mesenchymal stromal cells from human bone marrow Br J Haematol 142 827 830 10.1111/j.1365-2141.2008.07241.x 1:CAS:528:DC%2BD1cXhtFWntrvK 18510677
19. S Hakomori 1990 Bifunctional role of glycosphingolipids. Modulators for transmembrane signaling and mediators for cellular interactions J Biol Chem 265 18713 18716 1:CAS:528:DyaK3cXmtVylu7s%3D 2229037
20. CG Giraudo VM Rosales Fritz HJ Maccioni 1999 GA2/GM2/GD2 synthase localizes to the trans-golgi network of CHO-K1 cells Biochem J 342 Pt 3 633 640 10.1042/0264-6021:3420633 1:CAS:528:DyaK1MXmsVygs70%3D 10477274 (Pubitemid 29452648)
21. RK Yu LJ Macala T Taki HM Weinfield FS Yu 1988 Developmental changes in ganglioside composition and synthesis in embryonic rat brain J Neurochem 50 1825 1829 10.1111/j.1471-4159.1988.tb02484.x 1:CAS:528:DyaL1cXktVCnsr4%3D 3131485
22. RK Yu 1994 Development regulation of ganglioside metabolism Prog Brain Res 101 31 44 10.1016/S0079-6123(08)61938-X 1:CAS:528:DyaK2cXktVGls7o%3D 8029460
23. JK Lee MK Lee HJ Jin DS Kim YS Yang W Oh SE Yang TS Park SY Lee BS Kim SS Jeun 2007 Efficient intracytoplasmic labeling of human umbilical cord blood mesenchymal stromal cells with ferumoxides Cell Transplant 16 849 857 18088004
24. HJ Jin SK Park W Oh YS Yang SW Kim SJ Choi 2009 Down-regulation of CD105 is associated with multi-lineage differentiation in human umbilical cord blood-derived mesenchymal stem cells Biochem Biophys Res Commun 381 676 681 10.1016/j.bbrc.2009.02.118 1:CAS:528:DC%2BD1MXjvVOqs7s%3D 19250924
25. KJ Livak TD Schmittgen 2001 Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method Methods 25 402 408 10.1006/meth.2001.1262 1:CAS:528:DC%2BD38XhtFelt7s%3D 11846609 (Pubitemid 34164012)
26. M Dominici K Le Blanc I Mueller I Slaper-Cortenbach F Marini D Krause R Deans A Keating D Prockop E Horwitz 2006 Minimal criteria for defining multipotent mesenchymal stromal cells, The International Society for Cellular Therapy position statement Cytotherapy 8 315 317 10.1080/14653240600855905 1:STN:280:DC%2BD28vpvFSjsA%3D%3D 16923606 (Pubitemid 44269669)
27. PH Lopez RL Schnaar 2009 Gangliosides in cell recognition and membrane protein regulation Curr Opin Struct Biol 19 549 557 10.1016/j.sbi.2009.06.001 1:CAS:528:DC%2BD1MXht1ylsL3N 19608407
28. S Yoshida S Fukumoto H Kawaguchi S Sato R Ueda K Furukawa 2001 Ganglioside G(D2) in small cell lung cancer cell lines: enhancement of cell proliferation and mediation of apoptosis Cancer Res 61 4244 4252 1:CAS:528:DC%2BD3MXktVWqtLk%3D 11358851
29. N Bertrand DS Castro F Guillemot 2002 Proneural genes and the specification of neural cell types Nat Rev Neurosci 3 517 530 10.1038/nrn874 1:CAS:528:DC%2BD38XkvFKksb8%3D 12094208 (Pubitemid 135706662)
30. K Oishi K Watatani Y Itoh H Okano F Guillemot K Nakajima Y Gotoh 2009 Selective induction of neocortical GABAergic neurons by the PDK1-Akt pathway through activation of Mash1 Proc Natl Acad Sci USA 106 13064 13069 10.1073/pnas.0808400106 1:CAS:528:DC%2BD1MXhtVKru7%2FF 19549840
31. Z Zhao M Zhao G Xiao RT Franceschi 2005 Gene transfer of the Runx2 transcription factor enhances osteogenic activity of bone marrow stromal cells in vitro and in vivo Mol Ther 12 247 253 10.1016/j.ymthe.2005.03.009 1:CAS:528:DC%2BD2MXmvVWmt7w%3D 16043096 (Pubitemid 41025094)
32. BC Heng T Cao EH Lee 2004 Directing stem cell differentiation into the chondrogenic lineage in vitro Stem Cells 22 1152 1167 10.1634/stemcells.2004- 0062 15579636 (Pubitemid 39636395)
33. J Xu W Liao D Gu L Liang M Liu W Du P Liu L Zhang S Lu C Dong B Zhou Z Han 2009 Neural ganglioside GD2 identifies a subpopulation of mesenchymal stem cells in umbilical cord Cell Physiol Biochem 23 415 424 10.1159/000218188 1:CAS:528:DC%2BD1MXmtFektro%3D 19471109
34. CK Rebelatto AM Aguiar MP Moretao AC Senegaglia P Hansen F Barchiki J Oliveira J Martins C Kuligovski F Mansur A Christofis VF Amaral PS Brofman S Goldenberg LS Nakao A Correa 2008 Dissimilar differentiation of mesenchymal stem cells from bone marrow, umbilical cord blood, and adipose tissue Exp Biol Med (Maywood) 233 901 913 10.3181/0712-RM-356 1:CAS:528:DC%2BD1cXotVygsro%3D
35. M Secco YB Moreira E Zucconi NM Vieira T Jazedje AR Muotri OK Okamoto S Verjovski-Almeida M Zatz 2009 Gene expression profile of mesenchymal stem cells from paired umbilical cord units: cord is different from blood Stem Cell Rev Rep 5 387 401 10.1007/s12015-009-9098-5 1:CAS:528:DC%2BC3cXjtlaltg%3D%3D
36. RA Panepucci JL Siufi WA Silva Jr R Proto-Siquiera L Neder M Orellana V Rocha DT Covas MA Zago 2004 Comparison of gene expression of umbilical cord vein and bone marrow-derived mesenchymal stem cells Stem Cells 22 1263 1278 10.1634/stemcells.2004-0024 1:CAS:528:DC%2BD2MXks1ehtg%3D%3D 15579645 (Pubitemid 39646504)
37. M Secco E Zucconi NM Vieira LL Fogaca A Cerqueira MD Carvalho T Jazedje OK Okamoto AR Muotri M Zatz 2008 Multipotent stem cells from umbilical cord: cord is richer than blood! Stem Cells 26 146 150 10.1634/stemcells.2007-0381 1:CAS:528:DC%2BD1cXhvVCktLg%3D 17932423
38. K Takamiya A Yamamoto K Furukawa S Yamashiro M Shin M Okada S Fukumoto M Haraguchi N Takeda K Fujimura M Sakae M Kishikawa H Shiku K Furukawa S Aizawa 1996 Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system Proc Natl Acad Sci USA 93 10662 10667 10.1073/pnas.93.20.10662 1:CAS:528:DyaK28XmtVOlt78%3D 8855236 (Pubitemid 26333045)
39. NR Blondheim YS Levy T Ben-Zur A Burshtein T Cherlow I Kan R Barzilai M Bahat-Stromza Y Barhum S Bulvik E Melamed D Offen 2006 Human mesenchymal stem cells express neural genes, suggesting a neural predisposition Stem Cells Dev 15 141 164 10.1089/scd.2006.15.141 1:CAS:528:DC%2BD28XjvFyqur8%3D 16646662 (Pubitemid 43726495)
40. J Deng BE Petersen DA Steindler ML Jorgensen ED Laywell 2006 Mesenchymal stem cells spontaneously express neural proteins in culture and are neurogenic after transplantation Stem Cells 24 1054 1064 10.1634/stemcells.2005-0370 1:CAS:528:DC%2BD28XhtFKiu7jK 16322639 (Pubitemid 44464738)
41. DH Lee DB Koo K Ko K Ko SM Kim JU Jung JS Ryu JW Jin HJ Yang SI Do KY Jung YK Choo 2007 Effects of daunorubicin on ganglioside expression and neuronal differentiation of mouse embryonic stem cells Biochem Biophys Res Commun 362 313 318 10.1016/j.bbrc.2007.07.142 1:CAS:528:DC%2BD2sXpvFKnurs%3D 17707770 (Pubitemid 47332410)
42. K Furukawa K Takamiya K Furukawa 2002 Beta1, 4-N- acetylgalactosaminyltransferase-GM2/GD2 synthase: a key enzyme to control the synthesis of brain-enriched complex gangliosides Biochim Biophys Acta 1573 356 362 1:CAS:528:DC%2BD38Xotl2gtLc%3D 12417418
43. SE Ross ME Greenberg CD Stiles 2003 Basic helix-loop-helix factors in cortical development Neuron 39 13 25 10.1016/S0896-6273(03)00365-9 1:CAS:528:DC%2BD3sXlsV2ku70%3D 12848929 (Pubitemid 36830945)
44. SH Yi AY Jo CH Park HC Koh RH Park H Suh-Kim I Shin YS Lee J Kim SH Lee 2008 Mash1 and neurogenin 2 enhance survival and differentiation of neural precursor cells after transplantation to rat brains via distinct modes of action Mol Ther 16 1873 1882 10.1038/mt.2008.189 1:CAS:528:DC%2BD1cXht12ls7jM 18781144
45. SS Kim SW Yoo TS Park SC Ahn HS Jeong JW Kim DY Chang KG Cho SU Kim Y Huh JE Lee SY Lee YD Lee H Suh-Kim 2008 Neural induction with neurogenin1 increases the therapeutic effects of mesenchymal stem cells in the ischemic brain Stem Cells 26 2217 2228 10.1634/stemcells.2008-0108 18617687