Cardiovascular receptor binding affinity of aqueous extracts from Allium species

International Journal of Food Sciences and Nutrition

Volumn 61, Issue 4, 2010, Pages 433-439

  Nencini, Cristina ^a   Franchi, Gian Gabriele ^a   Micheli, Lucia ^a  

^a UNIVERSITY OF SIENA   (Italy)

Author keywords

Adrenergic receptors; Allium wild type species; Binding assay; Dopaminergic receptors; Garlic

Indexed keywords

ADRENERGIC RECEPTOR; ANTIHYPERTENSIVE AGENT; DOPAMINE RECEPTOR; PLANT EXTRACT;

ARTICLE; BINDING COMPETITION; CARDIOVASCULAR FUNCTION; CHEMISTRY; CLASSIFICATION; DRUG EFFECT; FEEDBACK SYSTEM; GARLIC; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; PHYLOGENY; PLANT LEAF; PLANT ROOT; PROTEIN BINDING; RADIOASSAY; SPECIES DIFFERENCE;

ALLIUM; ANTIHYPERTENSIVE AGENTS; BINDING, COMPETITIVE; CARDIOVASCULAR PHYSIOLOGICAL PHENOMENA; FEEDBACK, PHYSIOLOGICAL; PHYLOGENY; PLANT EXTRACTS; PLANT LEAVES; PLANT ROOTS; PROTEIN BINDING; RADIOLIGAND ASSAY; RECEPTORS, ADRENERGIC; RECEPTORS, DOPAMINE; SPECIES SPECIFICITY;

ALLIUM; ALLIUM NEAPOLITANUM; ALLIUM ROSEUM; ALLIUM SATIVUM; ALLIUM SUBHIRSUTUM;

EID: 77952564258     PISSN: 09637486     EISSN: 14653478     Source Type: Journal    
DOI: 10.3109/09637481003591608     Document Type: Article

References (27)

1. Amagase H. 2006. Clarifying the real bioactive constituents of garlic. J Nutr 136 (3 Suppl): 716S-725S.
2. Baluchnejad Mojarad T, Hosseini M, Roghani M, Homayounfar H, Kamalinejad M. 2003. Subchronic administration of aqueous garlic extract attenuates alpha adrenergic agonist induced contraction of isolated aorta in rat. Yakhteh Med J 4: 187-194.
3. Banerjee SK, Maulik SK. 2002. Effect of garlic on cardiovascular disorders: A review. Nutr J 1: 4-14.
4. 3H]-SCH 23390, a selective D1 receptor antagonist ligand, in rat striatum. Life Sci 35: 1885-1893.
5. 3H]-Spiroperidol labels dopamine receptors in pituitary and brain. Eur J Pharmacol 46: 377-381.
6. Dhawan V, Jain S. 2004. Effect of garlic supplementation on oxidised low density lipoproteins and lipid peroxidation in patients of essential hypertension. Mol Cell Biochem 266: 109-15.
7. Dhawan V, Jain S. 2005. Garlic supplementation prevents oxidative DNA damage in essential hypertension. Mol Cell Biochem 275: 85-94.
8. Gardner CD, Messina M, Lawson LD, Farquhar JW. 2003. Soy, garlic, and ginkgo biloba: Their potential role in cardiovascular disease prevention and treatment. Curr Atheroscler Rep 5: 468-475.
9. Greengrass P, Bremner R. 1979. Binding characteristics of [3H]-prazosin to rat brain alpha-adrenergic receptors. Eur J Pharmacol 55: 323-326.
10. Guarrera PM. 2006. Usi e tradizioni della flora italiana-Medicina popolare ed etnobotanica. I ed. Roma: Aracne Editrice S.r.l. pp 51-52.
11. Han J, Lawson L, Han G, Han P. 1995. A spectrophotometric method for quantitative determination of allicin and total garlic thiosulfinates. Anal Biochem. 225 (1): 157-160.
12. Jindal DP, Babita S, Mohane SC, Bruni G, Massarelli P. 2005. Synthesis of 4-(1-oxo-isoindoline) and 4-(5, 6-dimethoxy-1-oxo-isoindoline)-substituted phenoxypropanol amines and their β1-, β2-adrenergic receptor binding studies. Bioorg Chem 33: 310-324.
13. Khanum F, Anilakumar KR, Viswanathan KR. 2004. Anticarcinogenic properties of garlic: A review. Crit Rev Food Sci Nutr 44: 479-488.
14. Minneman KP, Hegstrand LR, Molinoff PB. 1979. The pharmacological specificity of beta-1 and beta-2 adrenergic receptors in rat heart and lung in vitro. Mol Pharmacol 16: 21-33.
15. 2 receptors. Mol Pharmacol 17: 1-7.
16. Mohamadi A, Jarrell ST, Shi SJ, Andrawis NS, Myers A, Clouatre D, Preuss MQ. 2000. Effects of wild versus cultivated garlic on blood pressure and other parameters in hypertensive rats. Heart Dis 2: 3-9.
17. Nencini C, Cavallo F, Bruni G, Capasso A, De Feo V, De Martino L, Giorgi G, Micheli L. 2006. Affinity of Iresine herbstii and Brugmansia arborea extracts on different cerebral receptors. J Ethnopharmacol 105: 352-357.
18. Nencini C, Cavallo F, Capasso A, Franchi GG, Giorgi G, Micheli L. 2007. Evaluation of antioxidative properties of spontaneous Allium species from Italy. Phytother Res 21: 874-878.
19. Ozturk Y, Aydin S, Kosar M, Baser KH. 1994. Endothelium-dependent and independent effects of garlic on rat aorta. J Ethnopharmacol 44: 109-116.
20. Perry BD, U'Prichard DC. 1981. [3H]-rauwolscine (alpha-yohimbine): A specific antagonist radioligand for brain alpha2-adrenergic receptors. Eur J Pharmacol 76: 461-464.
21. Preuss HG, Clouatre D, Mohamadi A, Jarrell ST. 2001. Wild garlic has a greater effect than regular garlic on blood pressure and blood chemistries of rats. Int Urol Nephrol 32: 525-530.
22. Ried K, Frank OR, Stocks NP, Fakler P, Sullivan T. 2008. Effect of garlic on blood pressure: A systematic review and meta-analysis. BMC Cardiovasc Disord 8:13.
23. Sharifi AM, Darabi R, Akbarloo N. 2003. Investigation of antihypertensive mechanism of garlic in 2K1C hypertensive rat. J Ethnopharmacol 86: 219-224.
24. Tattelman E. 2005. Health effects of garlic. Am Fam Phys 72: 103-106.
25. Turner B, Molgaard C, Marckmann P. 2004. Effect of garlic (Allium sativum) powder tablets on serum lipids, blood pressure and arterial stiffness in normo-lipidaemic volunteers: A randomised, double-blind, placebo-controlled trial. Br J Nutr 92: 701-706.
26. Uncini Manganelli RE, Chericoni S, Baragatti B. 2000. Ethnopharmacobotany in Tuscany: Plants used as antihypertensives. Fitoterapia 71: S95-S100.
27. WHO. 1999. Bulbus Allii Sativi. In: WHO monographs on selected medicinal plants. Vol 1. Geneva: WHO. pp 16-32.