Pharmacokinetics and protein binding of intravenous ibuprofen in the premature newborn infant

Acta Paediatrica, International Journal of Paediatrics

Volumn 86, Issue 3, 1997, Pages 289-293

  Aranda, J V ^a,b   Varvarigou, A ^a,b   Beharry, K ^c   Bansal, R ^a,b   Bardin, C ^a,b   Modanlou, H ^c   Papageorgiou, A ^a,b   Chemtob, S ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c LONG BEACH MEMORIAL MEDICAL CENTER   (United States)

Author keywords

cyclooxygenase blocker; ibuprofen; intraventricular hemorrhage; newborn; pharmacokinetics

Indexed keywords

IBUPROFEN;

ARTICLE; BRAIN HEMORRHAGE; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG ELIMINATION; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; NEWBORN; NORMAL HUMAN; PATENT DUCTUS ARTERIOSUS; PHARMACOKINETICS; PREMATURE LABOR; PRIORITY JOURNAL; PROTEIN BINDING;

EID: 0030896562     PISSN: 08035253     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1651-2227.1997.tb08892.x     Document Type: Article

References (23)

1. Mitchell JA, Akarasereenont P, Thiemermann C, Flower RJ, Vane JR. Selectivity of non-steroidal anti-inflammatory drugs as inhibitors of constitutive and inducible cyclo-oxygenase. Proc Natl Acad Sci USA 1993; 90: 11693-7
2. Chemtob S, Beharry K, Rex J, Varma DR, Aranda JV. Changes in cerebrovascular prostaglandins and thromboxane as a function of systemic blood pressure: cerebral blood flow autoregulation of the newborn. Circ Res 1990; 67: 674-82
3. Chemtob S, Beharry K, Rex J, Varma DR, Aranda JV. Prostanoids determine the range of cerebral blood flow autoregulation of the newborn piglet. Stroke 1990; 21: 777-84
4. Chemtob S, Beharry K, Barna T, Varma DR, Aranda JV. Differences in the effects in the newborn piglet of various non-steroidal anti-inflammatory drugs on cerebral blood flow but not on cerebrovascular prostaglandins. Pediatr Res 1991; 30: 106-11
5. Varvarigou N, Beharry K, Bardin C, Chemtob S, Papageorgiou A, Aranda JV. Closure of patent ductus arteriosus by intravenous ibuprofen in premature newborns. Pediatr Res 1994; 35, 259A
6. Kaufman RE, Nelson MV. Effect of age on ibuprofen pharmacokinetics and antipyretic response. J Pediatr 1992; 121: 969-73
7. Kelley MT, Walson PD, Edge JH, Cox S, Mortensen ME. Pharmacokinetics and pharmacodynamics of ibuprofen isomers and acetominophen in febrile children. Clin Pharmacol Ther 1992; 52: 181-9
8. Konstan MW, Hoppel CL, Chai BL, Davis PB. Ibuprofen in children with cystic fibrosis: pharmacokinetics and adverse effects. J Pediatr 1991; 118: 956-64
9. Albert KS, Gernaat CM. Pharmacokinetics of ibuprofen. Am J Med 1984; 77: 40-6
10. Albert KS, Gillespie WR, Wagner JG, Pau A, Lockwood GF. Effect of age on the clinical pharmacokinetics of ibuprofen. Am J Med 1984; 77: 47-50
11. Martin W, Koselowske G, Toberich H, Kerkmann Th, Mangold B, Augustin J. Pharmacokinetics and absolute bioavailability of ibuprofen after oral administration of ibuprofen lysine in man. Biopharm Drug Disp 1990; 11: 265-78
12. Wagner JG Albert KS, Szpnunar GJ, et al. Pharmacokinetics of ibuprofen in man. IV. Absorption and disposition. J Pharmacokinet Biopharm 1984; 12: 381-99
13. Lockwood GF, Albert KS, Gillespie WR. Pharmacokinetics of ibuprofen in man. I. Free and total area/dose relationships. Clin Pharmacol Ther 1983; 34: 97-103
14. Janssen GME, Venema JF. Ibuprofen plasma concentrations in man. J Int Res 1985; 13: 68-73
15. Gallo JM, Gall EP, Gillespie WR, Albert KS, Perrier D. Ibuprofen kinetics in plasma and synovial fluid of arthritic patients. J Clin Pharmacol 1986; 26: 65-70
16. Nahata MC, Durrell DE, Powell DA, Gupta N. Pharmacokinetics of ibuprofen in febrile children. European J Clin Pharmacol 1991; 40: 427-8
17. Brown RD, Wilson JT, Kearns GL, Eichler VF, Johnson VA, Bertrand KM. Single dose pharmacokinetics of ibuprofen and acetominophen in febrile children. J Clin Pharmacol 1992; 32: 231-41
18. Aravind MK, Miceli JN, Kauffman RE. Determination of ibuprofen by high-performance liquid chromatography. J Chromatograph 1984; 308: 350-3
19. Varvarigou A, Chemtob S, Bardin C, Beharry K, Papageorgiou A, Aranda JV. Early ibuprofen administration to prevent patent ductus arteriosus in premature newborn infants. JAMA 1996; 275: 539-44
20. Rickard EC, Strohl MM, Nielsen RG. Correlation of electrophoretic mobilities from capillary electrophoresis with physicochemical properties of proteins and peptides. Analyt Biochem 1991; 197: 197-207
21. Chu Y, Avila LZ, Biebuyek HA, Whitesides GM. Use of affinity capillary electrophoresis to measure binding constants of ligands to proteins. J Med Chem 1992; 35: 2915-7
22. Hut AJ, Cadwell J. The metabolic chiral inversion of 2-aryl propionic acids - a novel route with pharmacological consequences. J Pharm Pharmacol 1983; 35: 693-704
23. Lee EJD, Williams K, Day R, Gram G, and Champion D. Stereo-selective disposition of ibuprofen enantiomers in man. Br J Clin Pharmacol 1985; 19: 663-8