Functional Evidence for Oxygen-Sensitive Voltage-Gated Potassium Channels in Human Placental Vasculature

Placenta

Volumn 31, Issue 6, 2010, Pages 553-555

  Kiernan, M F ^a   Barrie, A ^a   Szkolar, J ^a   Mills, T A ^a   Wareing, M ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Human; Placenta vasculature; Potassium channel

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; AGITOXIN 2; CORREOLIDE; MARGATOXIN; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL KV1.2; POTASSIUM CHANNEL KV1.5; POTASSIUM CHANNEL KV2.1; STROMATOXIN 1; THROMBOXANE A2 RECEPTOR STIMULATING AGENT; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

ARTERY CONSTRICTION; ARTICLE; BLOOD VESSEL TONE; CHORION; CONCENTRATION RESPONSE; FEMALE; HUMAN; HUMAN TISSUE; MYOGRAPHY; PLACENTA CIRCULATION; PRIORITY JOURNAL; VENOCONSTRICTION;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ANALYSIS OF VARIANCE; ARTERIES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; PLACENTA; PREGNANCY; SCORPION VENOMS; SHAKER SUPERFAMILY OF POTASSIUM CHANNELS; TRITERPENES; VASOCONSTRICTION; VEINS;

EID: 77952547605     PISSN: 01434004     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.placenta.2010.03.009     Document Type: Article

References (19)

1. Hampl V., Bibova J., Stranak Z., Wu X., Michelakis E.D., Hashimoto K., et al. Hypoxic fetoplacental vasoconstriction in humans is mediated by potassium channel inhibition. Am J Physiol Heart Circ Physiol (2002) H2440-H2449
2. Sand A., Andersson E., and Fried G. Nitric oxide donors mediate vasodilation in human placental arteries partly through a direct effect on potassium channels. Placenta (2006) 181-190
3. Wareing M., Bai X., Seghier F., Turner C.M., Greenwood S.L., Baker P.N., et al. Expression and function of potassium channels in the human placental vasculature. Am J Physiol Regul Integr Comp Physiol (2006) R437-R446
4. Michelakis E.D., Thebaud B., Weir E.K., and Archer S.L. Hypoxic pulmonary vasoconstriction: redox regulation of O2-sensitive K+ channels by a mitochondrial O2-sensor in resistance artery smooth muscle cells. J Mol Cell Cardiol (2004) 1119-1136
5. Archer S., and Michelakis E. The mechanism(s) of hypoxic pulmonary vasoconstriction: potassium channels, redox O(2) sensors, and controversies. News Physiol Sci (2002) 131-137
6. Myatt L. Control of vascular resistance in the human placenta. Placenta (1992) 329-341
7. Poston L., McCarthy A.L., and Ritter J.M. Control of vascular resistance in the maternal and feto-placental arterial beds. Pharmacol Ther (1995) 215-239
8. Wareing M., Greenwood S.L., Fyfe G.K., Baker P.N., and Taggart M.J. Glibenclamide inhibits agonist-induced vasoconstriction of placental chorionic plate arteries. Placenta (2006) 660-668
9. Corcoran J., Lacey H., Baker P.N., and Wareing M. Altered potassium channel expression in the human placental vasculature of pregnancies complicated by fetal growth restriction. Hypertens Pregnancy (2008) 1-12
10. Gutman G.A., Chandy K.G., Grissmer S., Lazdunski M., McKinnon D., Pardo L.A., et al. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacol Rev (2005) 473-508
11. Koo G.C., Blake J.T., Shah K., Staruch M.J., Dumont F., Wunderler D., et al. Correolide and derivatives are novel immunosuppressants blocking the lymphocyte Kv1.3 potassium channels. Cell Immunol (1999) 99-107
12. Karczewski J., Kiss L., Kane S.A., Koblan K.S., Lynch R.J., and Spencer R.H. High-throughput analysis of drug binding interactions for the human cardiac channel, Kv1.5. Biochem Pharmacol (2009) 177-185
13. + channels in resistance pulmonary arteries explains regional heterogeneity in hypoxic pulmonary vasoconstriction: ionic diversity in smooth muscle cells. Circ Res (2004) 308-318
14. Wareing M., Crocker I.P., Warren A.Y., Taggart M.J., and Baker P.N. Characterization of small arteries isolated from the human placental chorionic plate. Placenta (2002) 400-409
15. Wareing M., Greenwood S.L., and Baker P.N. Reactivity of human placental chorionic plate vessels is modified by level of oxygenation: differences between arteries and veins. Placenta (2006) 42-48
16. Hulme J.T., Coppock E.A., Felipe A., Martens J.R., and Tamkun M.M. Oxygen sensitivity of cloned voltage-gated K(+) channels expressed in the pulmonary vasculature. Circ Res (1999) 489-497
17. Moreno L., Frazziano G., Cogolludo A., Cobeno L., Tamargo J., and Perez-Vizcaino F. Role of protein kinase Czeta and its adaptor protein p62 in voltage-gated potassium channel modulation in pulmonary arteries. Mol Pharmacol (2007) 1301-1309
18. Wareing M., Baker P.N., and Taggart M.J. Effects of hypoxia on human placental veins investigated under physiological conditions with pressure, intraluminal flow and oxygenation. Reprod Sci (2007) [181A]
19. 2-sensitive potassium channel Kv1.5 reduces pulmonary hypertension and restores hypoxic pulmonary vasoconstriction in chronically hypoxic rats. Circulation (2003) 2037-2044