-
1
-
-
0035868913
-
Twenty-two years of phase III trials for patients with advanced non-small-cell lung cancer: sobering results
-
Breathnach O.S., Freidlin B., Conley B., Green M.R., Johnson D.H., Gandara D.R., et al. Twenty-two years of phase III trials for patients with advanced non-small-cell lung cancer: sobering results. J Clin Oncol 2001, 19:1734-1742.
-
(2001)
J Clin Oncol
, vol.19
, pp. 1734-1742
-
-
Breathnach, O.S.1
Freidlin, B.2
Conley, B.3
Green, M.R.4
Johnson, D.H.5
Gandara, D.R.6
-
2
-
-
0034069620
-
Prospective randomized trial of docetaxel versus best supportive care in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy
-
Shepherd F.A., Dancey J., Ramlau R., Mattson K., Gralla R., O'Rourke M., et al. Prospective randomized trial of docetaxel versus best supportive care in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy. J Clin Oncol 2000, 18:2095-2103.
-
(2000)
J Clin Oncol
, vol.18
, pp. 2095-2103
-
-
Shepherd, F.A.1
Dancey, J.2
Ramlau, R.3
Mattson, K.4
Gralla, R.5
O'Rourke, M.6
-
3
-
-
2442661845
-
Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy
-
Hanna N., Shepherd F.A., Fossella F.V., Pereira J.R., De Marinis F., von Pawel J., et al. Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy. J Clin Oncol 2004, 22:1589-1597.
-
(2004)
J Clin Oncol
, vol.22
, pp. 1589-1597
-
-
Hanna, N.1
Shepherd, F.A.2
Fossella, F.V.3
Pereira, J.R.4
De Marinis, F.5
von Pawel, J.6
-
4
-
-
22044445517
-
Erlotinib in previously treated non-small-cell lung cancer
-
Shepherd F.A., Rodrigues Pereira J., Ciuleanu T., Tan E.H., Hirsh V., Thongprasert S., et al. Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med 2005, 353:123-132.
-
(2005)
N Engl J Med
, vol.353
, pp. 123-132
-
-
Shepherd, F.A.1
Rodrigues Pereira, J.2
Ciuleanu, T.3
Tan, E.H.4
Hirsh, V.5
Thongprasert, S.6
-
5
-
-
0034861227
-
Pemetrexed disodium: a novel antifolate clinically active against multiple solid tumors
-
Hanauske A.R., Chen V., Paoletti P., Niyikiza C. Pemetrexed disodium: a novel antifolate clinically active against multiple solid tumors. Oncologist 2001, 6:363-373.
-
(2001)
Oncologist
, vol.6
, pp. 363-373
-
-
Hanauske, A.R.1
Chen, V.2
Paoletti, P.3
Niyikiza, C.4
-
6
-
-
64049115311
-
The differential efficacy of pemetrexed according to NSCLC histology: a review of two phase III studies
-
Scagliotti G., Hanna N., Fossella F., Sugarman K., Blatter J., Peterson P., et al. The differential efficacy of pemetrexed according to NSCLC histology: a review of two phase III studies. Oncologist 2009, 14:253-263.
-
(2009)
Oncologist
, vol.14
, pp. 253-263
-
-
Scagliotti, G.1
Hanna, N.2
Fossella, F.3
Sugarman, K.4
Blatter, J.5
Peterson, P.6
-
7
-
-
22044453790
-
Erlotinib in lung cancer-molecular and clinical predictors of outcome
-
Tsao M.S., Sakurada A., Cutz J.C., Zhu C.Q., Kamel-Reid S., Squire J., et al. Erlotinib in lung cancer-molecular and clinical predictors of outcome. N Engl J Med 2005, 353:133-144.
-
(2005)
N Engl J Med
, vol.353
, pp. 133-144
-
-
Tsao, M.S.1
Sakurada, A.2
Cutz, J.C.3
Zhu, C.Q.4
Kamel-Reid, S.5
Squire, J.6
-
8
-
-
0034594628
-
New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada
-
Therasse P., Arbuck S.G., Eisenhauer E.A., Wanders J., Kaplan R.S., Rubinstein L., et al. New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 2000, 92:205-216.
-
(2000)
J Natl Cancer Inst
, vol.92
, pp. 205-216
-
-
Therasse, P.1
Arbuck, S.G.2
Eisenhauer, E.A.3
Wanders, J.4
Kaplan, R.S.5
Rubinstein, L.6
-
9
-
-
10744228140
-
CTCAE v3.0: development of a comprehensive grading system for the adverse effects of cancer treatment
-
Trotti A., Colevas A.D., Setser A., Rusch V., Jaques D., Budach V., et al. CTCAE v3.0: development of a comprehensive grading system for the adverse effects of cancer treatment. Semin Radiat Oncol 2003, 13:176-181.
-
(2003)
Semin Radiat Oncol
, vol.13
, pp. 176-181
-
-
Trotti, A.1
Colevas, A.D.2
Setser, A.3
Rusch, V.4
Jaques, D.5
Budach, V.6
-
10
-
-
33645277368
-
Raltitrexed-eloxatin salvage chemotherapy in gemcitabine-resistant metastatic pancreatic cancer
-
Reni M., Pasetto L., Aprile G., Cordio S., Bonetto E., Dell'Oro S., et al. Raltitrexed-eloxatin salvage chemotherapy in gemcitabine-resistant metastatic pancreatic cancer. Br J Cancer 2006, 94:785-791.
-
(2006)
Br J Cancer
, vol.94
, pp. 785-791
-
-
Reni, M.1
Pasetto, L.2
Aprile, G.3
Cordio, S.4
Bonetto, E.5
Dell'Oro, S.6
-
11
-
-
33847641797
-
The impact of induction chemotherapy on the outcome of second-line therapy with pemetrexed or docetaxel in patients with advanced non-small-cell lung cancer
-
Weiss G.J., Rosell R., Fossella F., Perry M., Stahel R., Barata F., et al. The impact of induction chemotherapy on the outcome of second-line therapy with pemetrexed or docetaxel in patients with advanced non-small-cell lung cancer. Ann Oncol 2007, 18:453-460.
-
(2007)
Ann Oncol
, vol.18
, pp. 453-460
-
-
Weiss, G.J.1
Rosell, R.2
Fossella, F.3
Perry, M.4
Stahel, R.5
Barata, F.6
-
12
-
-
33947375647
-
Molecular basis of antifolate resistance
-
Assaraf Y.G. Molecular basis of antifolate resistance. Cancer Metastasis Rev 2007, 26:153-181.
-
(2007)
Cancer Metastasis Rev
, vol.26
, pp. 153-181
-
-
Assaraf, Y.G.1
-
13
-
-
0035878867
-
Pharmacogenomic dissection of resistance to thymidylate synthase inhibitors
-
Wang W., Marsh S., Cassidy J., McLeod H.L. Pharmacogenomic dissection of resistance to thymidylate synthase inhibitors. Cancer Res 2001, 61:5505-5510.
-
(2001)
Cancer Res
, vol.61
, pp. 5505-5510
-
-
Wang, W.1
Marsh, S.2
Cassidy, J.3
McLeod, H.L.4
-
14
-
-
0041695633
-
Induction of resistance to the multitargeted antifolate pemetrexed (ALIMTA) in WiDr human colon cancer cells is associated with thymidylate synthase overexpression
-
Sigmond J., Backus H.H., Wouters D., Temmink O.H., Jansen G., Peters G.J. Induction of resistance to the multitargeted antifolate pemetrexed (ALIMTA) in WiDr human colon cancer cells is associated with thymidylate synthase overexpression. Biochem Pharmacol 2003, 66:431-438.
-
(2003)
Biochem Pharmacol
, vol.66
, pp. 431-438
-
-
Sigmond, J.1
Backus, H.H.2
Wouters, D.3
Temmink, O.H.4
Jansen, G.5
Peters, G.J.6
-
15
-
-
0041825123
-
Thymidylate synthase inhibitors as anticancer agents: from bench to bedside
-
Chu E., Callender M.A., Farrell M.P., Schmitz J.C. Thymidylate synthase inhibitors as anticancer agents: from bench to bedside. Cancer Chemother Pharmacol 2003, 52(Suppl. 1):S80-S89.
-
(2003)
Cancer Chemother Pharmacol
, vol.52
, Issue.SUPPL. 1
-
-
Chu, E.1
Callender, M.A.2
Farrell, M.P.3
Schmitz, J.C.4
-
16
-
-
32944482800
-
A phase II trial of pemetrexed in advanced breast cancer: clinical response and association with molecular target expression
-
Gomez H.L., Santillana S.L., Vallejos C.S., Velarde R., Sanchez J., Wang X., et al. A phase II trial of pemetrexed in advanced breast cancer: clinical response and association with molecular target expression. Clin Cancer Res 2006, 12:832-838.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 832-838
-
-
Gomez, H.L.1
Santillana, S.L.2
Vallejos, C.S.3
Velarde, R.4
Sanchez, J.5
Wang, X.6
-
17
-
-
33748306343
-
The determinants of sensitivity and acquired resistance to gemcitabine differ in non-small cell lung cancer: a role of ABCC5 in gemcitabine sensitivity
-
Oguri T., Achiwa H., Sato S., Bessho Y., Takano Y., Miyazaki M., et al. The determinants of sensitivity and acquired resistance to gemcitabine differ in non-small cell lung cancer: a role of ABCC5 in gemcitabine sensitivity. Mol Cancer Ther 2006, 5:1800-1806.
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 1800-1806
-
-
Oguri, T.1
Achiwa, H.2
Sato, S.3
Bessho, Y.4
Takano, Y.5
Miyazaki, M.6
-
18
-
-
0002831066
-
Pretreatment deoxycytidine kinase levels predict in vivo gemcitabine sensitivity
-
Kroep J.R., Loves W.J., van der Wilt C.L., Alvarez E., Talianidis I., Boven E., et al. Pretreatment deoxycytidine kinase levels predict in vivo gemcitabine sensitivity. Mol Cancer Ther 2002, 1:371-376.
-
(2002)
Mol Cancer Ther
, vol.1
, pp. 371-376
-
-
Kroep, J.R.1
Loves, W.J.2
van der Wilt, C.L.3
Alvarez, E.4
Talianidis, I.5
Boven, E.6
-
19
-
-
0033800910
-
Cross-resistance in the 2′,2′-difluorodeoxycytidine (gemcitabine)-resistant human ovarian cancer cell line AG6000 to standard and investigational drugs
-
Bergman A.M., Giaccone G., van Moorsel C.J., Mauritz R., Noordhuis P., Pinedo H.M., et al. Cross-resistance in the 2′,2′-difluorodeoxycytidine (gemcitabine)-resistant human ovarian cancer cell line AG6000 to standard and investigational drugs. Eur J Cancer 2000, 36:1974-1983.
-
(2000)
Eur J Cancer
, vol.36
, pp. 1974-1983
-
-
Bergman, A.M.1
Giaccone, G.2
van Moorsel, C.J.3
Mauritz, R.4
Noordhuis, P.5
Pinedo, H.M.6
-
20
-
-
20144382254
-
The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates
-
Wielinga P., Hooijberg J.H., Gunnarsdottir S., Kathmann I., Reid G., Zelcer N., et al. The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates. Cancer Res 2005, 65:4425-4430.
-
(2005)
Cancer Res
, vol.65
, pp. 4425-4430
-
-
Wielinga, P.1
Hooijberg, J.H.2
Gunnarsdottir, S.3
Kathmann, I.4
Reid, G.5
Zelcer, N.6
-
21
-
-
20044383925
-
The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites
-
Pratt S., Shepard R.L., Kandasamy R.A., Johnston P.A., Perry W., Dantzig A.H. The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites. Mol Cancer Ther 2005, 4:855-863.
-
(2005)
Mol Cancer Ther
, vol.4
, pp. 855-863
-
-
Pratt, S.1
Shepard, R.L.2
Kandasamy, R.A.3
Johnston, P.A.4
Perry, W.5
Dantzig, A.H.6
-
22
-
-
27144524050
-
In vivo induction of resistance to gemcitabine results in increased expression of ribonucleotide reductase subunit M1 as the major determinant
-
Bergman A.M., Eijk P.P., Ruiz van Haperen V.W., Smid K., Veerman G., Hubeek I., et al. In vivo induction of resistance to gemcitabine results in increased expression of ribonucleotide reductase subunit M1 as the major determinant. Cancer Res 2005, 65:9510-9516.
-
(2005)
Cancer Res
, vol.65
, pp. 9510-9516
-
-
Bergman, A.M.1
Eijk, P.P.2
Ruiz van Haperen, V.W.3
Smid, K.4
Veerman, G.5
Hubeek, I.6
-
23
-
-
2542530631
-
An increase in the expression of ribonucleotide reductase large subunit 1 is associated with gemcitabine resistance in non-small cell lung cancer cell lines
-
Davidson J.D., Ma L., Flagella M., Geeganage S., Gelbert L.M., Slapak C.A. An increase in the expression of ribonucleotide reductase large subunit 1 is associated with gemcitabine resistance in non-small cell lung cancer cell lines. Cancer Res 2004, 64:3761-3766.
-
(2004)
Cancer Res
, vol.64
, pp. 3761-3766
-
-
Davidson, J.D.1
Ma, L.2
Flagella, M.3
Geeganage, S.4
Gelbert, L.M.5
Slapak, C.A.6
-
24
-
-
0033198464
-
Overexpression of ribonucleotide reductase as a mechanism of resistance to 2,2-difluorodeoxycytidine in the human KB cancer cell line
-
Goan Y.G., Zhou B., Hu E., Mi S., Yen Y. Overexpression of ribonucleotide reductase as a mechanism of resistance to 2,2-difluorodeoxycytidine in the human KB cancer cell line. Cancer Res 1999, 59:4204-4207.
-
(1999)
Cancer Res
, vol.59
, pp. 4204-4207
-
-
Goan, Y.G.1
Zhou, B.2
Hu, E.3
Mi, S.4
Yen, Y.5
-
25
-
-
70349092474
-
Maintenance pemetrexed (Pem) plus best supportive care (BSC) versus placebo (Plac) plus BSC: a randomized phase III study in advanced non-small cell lung cancer (NSCLC)
-
CRA8000-
-
Belani C.P., Brodowicz T., Ciuleanu T., Kim J.H., Krzakowski M., Laack E., et al. Maintenance pemetrexed (Pem) plus best supportive care (BSC) versus placebo (Plac) plus BSC: a randomized phase III study in advanced non-small cell lung cancer (NSCLC). J Clin Oncol (Meeting Abstracts) 2009, 27. CRA8000-
-
(2009)
J Clin Oncol (Meeting Abstracts)
, vol.27
-
-
Belani, C.P.1
Brodowicz, T.2
Ciuleanu, T.3
Kim, J.H.4
Krzakowski, M.5
Laack, E.6
-
26
-
-
49049089802
-
Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer
-
Scagliotti G.V., Parikh P., von Pawel J., Biesma B., Vansteenkiste J., Manegold C., et al. Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer. J Clin Oncol 2008, 26:3543-3551.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3543-3551
-
-
Scagliotti, G.V.1
Parikh, P.2
von Pawel, J.3
Biesma, B.4
Vansteenkiste, J.5
Manegold, C.6
-
27
-
-
33749587054
-
Squamous cell carcinoma of the lung compared with other histotypes shows higher messenger RNA and protein levels for thymidylate synthase
-
Ceppi P., Volante M., Saviozzi S., Rapa I., Novello S., Cambieri A., et al. Squamous cell carcinoma of the lung compared with other histotypes shows higher messenger RNA and protein levels for thymidylate synthase. Cancer 2006, 107:1589-1596.
-
(2006)
Cancer
, vol.107
, pp. 1589-1596
-
-
Ceppi, P.1
Volante, M.2
Saviozzi, S.3
Rapa, I.4
Novello, S.5
Cambieri, A.6
-
28
-
-
70350275038
-
Baseline thymidylate synthase expression according to histological subtypes of non-small cell lung cancer
-
7521
-
Scagliotti G., Monica V., Ceppi P., Righi L., Cambieri A., Volante M., et al. Baseline thymidylate synthase expression according to histological subtypes of non-small cell lung cancer. J Clin Oncol (Meeting Abstracts) 2009, 27. 7521
-
(2009)
J Clin Oncol (Meeting Abstracts)
, vol.27
-
-
Scagliotti, G.1
Monica, V.2
Ceppi, P.3
Righi, L.4
Cambieri, A.5
Volante, M.6
-
29
-
-
67650281462
-
Phase III study by the Norwegian Lung Cancer Study Group: pemetrexed plus carboplatin compared with gemcitabine plus carboplatin as first-line chemotherapy in advanced non-small-cell lung cancer
-
JCO.2008.20.9114
-
Gronberg B.H., Bremnes R.M., Flotten O., Amundsen T., Brunsvig P.F., Hjelde H.H., et al. Phase III study by the Norwegian Lung Cancer Study Group: pemetrexed plus carboplatin compared with gemcitabine plus carboplatin as first-line chemotherapy in advanced non-small-cell lung cancer. J Clin Oncol 2009, JCO.2008.20.9114.
-
(2009)
J Clin Oncol
-
-
Gronberg, B.H.1
Bremnes, R.M.2
Flotten, O.3
Amundsen, T.4
Brunsvig, P.F.5
Hjelde, H.H.6
-
30
-
-
58149380051
-
Efficacy and toxicity of pemetrexed as a third-line treatment for non-small cell lung cancer
-
Sun J.M., Lee K.W., Kim J.H., Kim Y.J., Yoon H.I., Lee J.H., et al. Efficacy and toxicity of pemetrexed as a third-line treatment for non-small cell lung cancer. Jpn J Clin Oncol 2009, 39:27-32.
-
(2009)
Jpn J Clin Oncol
, vol.39
, pp. 27-32
-
-
Sun, J.M.1
Lee, K.W.2
Kim, J.H.3
Kim, Y.J.4
Yoon, H.I.5
Lee, J.H.6
|