Dose-response and relative biological effectiveness of fast neutrons: Induction of apoptosis and inhibition of neurogenesis in the hippocampus of adult mice

International Journal of Radiation Biology

Volumn 86, Issue 6, 2010, Pages 476-485

  Yang, Miyoung ^a   Kim, Joong Sun ^a   Song, Myoung Sub ^a   Kim, Jong Choon ^b   Shin, Taekyun ^c   Lee, Seung Sook ^d   Kim, Sung Ho ^a   Moon, Changjong ^a  

^a Department of Veterinary Anatomy ^*  (South Korea)

^b Chonnam National University   (South Korea)

^c Jeju National University   (South Korea)

^d Korea Institute of Radiation and Medical Science   (South Korea)

Author keywords

Apoptosis; Fast Neutron; Gamma ray; Hippocampus; Neurogenesis; Relative biological effectiveness (RBE)

Indexed keywords

COBALT 60; DOUBLECORTIN; KI 67 ANTIGEN;

ADULT ANIMAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DENTATE GYRUS; FAST NEUTRON RADIATION; GAMMA RADIATION; HIPPOCAMPUS; INSTITUTE FOR CANCER RESEARCH MOUSE; IONIZING RADIATION; LINEAR ENERGY TRANSFER; MALE; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION DOSE; RADIATION EXPOSURE; RELATIVE BIOLOGIC EFFECTIVENESS; WHOLE BODY RADIATION;

ANIMALS; APOPTOSIS; BIOLOGICAL MARKERS; CYCLOTRONS; DEOXYURACIL NUCLEOTIDES; DNA NUCLEOTIDYLEXOTRANSFERASE; DOSE-RESPONSE RELATIONSHIP, RADIATION; GAMMA RAYS; GENE EXPRESSION REGULATION; HIPPOCAMPUS; IN SITU NICK-END LABELING; KI-67 ANTIGEN; MALE; MICE; MICE, INBRED ICR; MICROTUBULE-ASSOCIATED PROTEINS; NEUROGENESIS; NEUROPEPTIDES; NEUTRONS; RELATIVE BIOLOGICAL EFFECTIVENESS; WHOLE-BODY IRRADIATION;

MUS;

EID: 77952534545     PISSN: 09553002     EISSN: 13623095     Source Type: Journal    
DOI: 10.3109/09553001003667990     Document Type: Article

References (32)

1. Andres-Mach M, Rola R, Fike JR. 2008. Radiation effects on neural precursor cells in the dentate gyrus. Cell and Tissue Research 331:251-262.
2. Bedford JS, Dewey WC. 2002. Radiation Research Society. 1952-2002. Historical and current highlights in radiation biology: has anything important been learned by irradiating cells? Radiation Research 158:251-291.
3. Bonicalzi ME, Haince JF, Droit A, Poirier GG. 2005. Regulation of poly (ADP-ribose) metabolism by poly (ADP-ribose) glycohydrolase: where and when? Cellular and Molecular Life Science 62:739-750.
4. Britten RA, Peters LJ, Murray D. 2001. Biological factors influencing the RBE of neutrons: Implications for their past, present and future use in radiotherapy. Radiation Research 156:125-135.
5. Christie D, Leiper AD, Chessells JM. 1995. Intellectual performance after presymptomatic cranial radiotherapy for leukemia: effects of age and sex. Archives of Disease in Childhood 73:136-140.
6. Conklin JJ, Walker RI. 1987. Military radiobiology. Orlando: Academic Press.
7. Fletcher JM, Copeland DR. 1988. Neurobehavioral effects of central nervous system prophylactic treatment of cancer in children. Journal of Clinical and Experimental Neuropsychology 10:495-537.
8. Hale AJ, Smith CA, Sutherland LC, Stoneman VE, Longthorne VL, Culhane AC, Williams GT. 1996. Apoptosis: Molecular regulation of cell death. European Journal of Biochemistry 236:1-26.
9. Hendry JH, Potten CS, Chadwick C. 1982. Cell death (apoptosis) in the mouse small intestine after low doses: effects of doserate, 14.7 MeV neutrons, and 600 MeV (maximum energy) neutrons. International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine 42:611-620.
10. Hendry JH, Potten CS, Merritt A. 1995. Apoptosis induced by high- and low-LET radiations. Radiation and Environmental Biophysics 34:59-62.
11. Ishida Y, Ohmachi Y, Nakata Y, Hiraoka T, Hamano T, Fushiki S, Ogiu T. 2006. Dose-response and large relative biological effectiveness of fast neutrons with regard to mouse fetal cerebral neuron apoptosis. Journal of Radiation Research 47:41-47.
12. Kim JS, Jung J, Lee HJ, Kim JC, Wang H, Kim SH, Shin T, Moon C. 2009. Differences in immunoreactivities of Ki-67 and doublecortin in the adult hippocampus in three strains of mice. Acta Histochemica 111:150-156.
13. Kim JS, Lee HJ, Kim JC, Kang SS, Bae CS, Shin T, Jin JK, Kim SH, Wang H, Moon C. 2008. Transient impairment of hippocampus-dependent learning and memory in relatively low-dose of acute radiation syndrome is associated with inhibition of hippocampal neurogenesis. Journal of Radiation Research 49:517-526.
14. Lee HJ, Kim JS, Moon C, Kim JC, Jo SK, Kim SH. 2008. Relative biological effectiveness of fast neutrons in a multiorgan assay for apoptosis in mouse. Environmental Toxicology 23:233-239.
15. Madsen TM, Kristjansen PEG, Bolwig TG, Wortwein G. 2003. Arrested neuronal proliferation and impaired hippocampal function following fractionated brain irradiation in the adult rat. Neuroscience 119:635-642.
16. Maity A, McKenna WG, Muschel RJ. 1994. The molecular basis for cell cycle delays following ionizing radiation: a review. Radiotherapy Oncology 31:1-13.
17. Mizumatsu S, Monje ML, Morhardt DR, Rola R, Palmer TD, Fike JR. 2003. Extreme sensitivity of adult neurogenesis to low doses of X-irradiation. Cancer Research 63:4021-4027.
18. Monje M. 2008. Cranial radiation therapy and damage to hippocampal neurogenesis. Developmental Disabilities Research Reviews 14:238-242.
19. Monje ML, Mizumatsu S, Fike JR, Palmer TD. 2002. Irradiation induces neural precursor-cell dysfunction. Nature Medicine 8:955-962.
20. Monje ML, Palmer T. 2003. Radiation injury and neurogenesis. Current Opinion Neurology 16:129-134.
21. Monje ML, Vogel H, Masek M, Ligon KL, Fisher PG, Palmer TD. 2007. Impaired human hippocampal neurogenesis after treatment for central nervous system malignancies. Annals of Neurology 62:515-520.
22. Nias AHW. 1998. An introduction to radiobiology, 2nd ed. Chichester: John Wiley and Sons.
23. Parent JM, Tada E, Fike JR, Lowenstein DH. 1999. Inhibition of dentate granule cell neurogenesis with brain irradiation does not prevent seizer-induced mossy fiber synaptic reorganization in the rat. Journal of Neuroscience 19:4508-4519.
24. Raber J, Rola R, LeFevour A, Morhardt D, Curley J, Mizumatsu S, Vandenberg SR, Fike JR. 2004. Radiationinduced cognitive impairments are associated with changes in indicators of hippocampal neurogenesis. Radiation Research 162:39-47.
25. Rola R, Otsuka S, Obenaus A, Nelson GA, Limoli CL, VandenBerg SR, Fike JR. 2004a. Indicators of hippocampal neurogenesis are altered by 56Fe-particle irradiation in a dosedependent manner. Radiation Research 162:442-446.
26. Rola R, Raber J, Rizk A, Otsuka S, VandenBerg SR, Morhardt DR, Fike JR. 2004b. Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice. Experimental Neurology 188:316-330. (Pubitemid 38891593)
27. Ryan LA, Wilkins RC, McFarlane NM, Sung MM, McNamee JP, Boreham DR. 2006. Relative biological effectiveness of 280 keV neutrons for apoptosis in human lymphocytes. Health Physics 91:68-75.
28. Snyder JS, Hong NS, McDonald RJ, Wojtowicz JM. 2005. A role for adult neurogenesis in spatial long-term memory. Neuroscience 130:843-852
29. Srinivasan M, Sudheer AR, Pillai KR, Kumar PR, Sudhakaran PR, Menon VP. 2006. Influence of ferulic acid on gammaradiation induced DNA damage, lipid peroxidation and antioxidant status in primary culture of isolated rat hepatocytes. Toxicology 228:249-258.
30. Tada E, Parent JM, Lownestein DH, Fike JR. 2000. X-irradiation causes a prolonged reduction in cell proliferation in the dentate gyrus of adult rats. Neuroscience 99:33-41.
31. Warenius HM, Down JD. 1995. RBE of fast neutrons for apoptosis in mouse thymocytes. International Journal of Radiation Biology 68:625-629.
32. Waselenko JK, MacVittie TJ, Blakely WF, Pesik N, Wiley AL, Dickerson WE, Tsu H, Confer DL, Coleman CN, Seed T, Lowry P, Armitage JO, Dainiak N. 2004. Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group. Annals of Internal Medicine 140:1037-1051.