Phenyl-α-tert-butyl-nitrone and Benzonidazole Treatment Controlled the Mitochondrial Oxidative Stress and Evolution of Cardiomyopathy in Chronic Chagasic Rats

Journal of the American College of Cardiology

Volumn 55, Issue 22, 2010, Pages 2499-2508

  Wen, Jian Jun ^a   Gupta, Shivali ^a   Guan, Zhangjun ^b   Dhiman, Monisha ^a   Condon, David ^a   Lui, Charles ^b   Garg, Nisha Jain ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

antioxidant; benzonidazole; Chagas disease; mitochondrial oxidative stress; Trypanosoma cruzi

Indexed keywords

4 HYDROXYNONENAL; ADENOSINE TRIPHOSPHATE; ALPHA ACTIN; ANTIOXIDANT; ANTIPARASITIC AGENT; ATRIAL NATRIURETIC FACTOR; BENZNIDAZOLE; BRAIN NATRIURETIC PEPTIDE; CARBONYL DERIVATIVE; COLLAGEN; CYTOKINE; MALONALDEHYDE; MYELOPEROXIDASE; NICOTINAMIDE ADENINE DINUCLEOTIDE; PHENYL ALPHA TERT BUTYL NITRONE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREATHING; CHAGAS DISEASE; CONTROLLED STUDY; DRUG MECHANISM; ENERGY; ENZYME ACTIVITY; GENE EXPRESSION; HEART FAILURE; HEART HEMODYNAMICS; HEART INJURY; HEART LEFT VENTRICLE; INFLAMMATION; INFLAMMATORY INFILTRATE; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; RESPIRATORY CHAIN; SPRAGUE DAWLEY RAT; TRYPANOSOMA CRUZI;

ANALYSIS OF VARIANCE; ANIMALS; CHAGAS CARDIOMYOPATHY; CHAGAS DISEASE; CHRONIC DISEASE; CYCLIC N-OXIDES; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; HEART FUNCTION TESTS; HEMODYNAMICS; LIPID PEROXIDATION; MITOCHONDRIA, HEART; NITROIMIDAZOLES; OXIDATIVE STRESS; PROBABILITY; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; STATISTICS, NONPARAMETRIC; TRYPANOSOMA CRUZI;

EID: 77952518968     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacc.2010.02.030     Document Type: Article

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