Abrogation of microcystin cytotoxicity by MAP kinase inhibitors and N-acetyl cysteine is confounded by OATPIB1 uptake activity inhibition

Toxicon

Volumn 55, Issue 4, 2010, Pages 827-837

  Daily, Abigail ^a   Monks, Noel R ^a   Leggas, Markos ^b   Moscow, Jeffrey A ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b University of Kentucky   (United States)

Author keywords

DIOA; HSP27; KCC transporters; Microcystin LR; OATP1B1

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 ETHYL 2 (4 METHOXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACETYLCYSTEINE; ALKANOIC ACID; DIHYDROINDENYL OXYALKANOIC ACID; HEAT SHOCK PROTEIN 27; MICROCYSTIN; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 1B1; POTASSIUM CHLORIDE COTRANSPORTER; UNCLASSIFIED DRUG; MITOGEN ACTIVATED PROTEIN KINASE; ORGANIC ANION TRANSPORTER; PROTEIN KINASE INHIBITOR; SLCO1B1 PROTEIN, HUMAN;

ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; GENETIC TRANSFECTION; GROWTH INHIBITION; HELA CELL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VITRO STUDY; INHIBITION KINETICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; DRUG ANTAGONISM; METABOLISM; WESTERN BLOTTING;

ACETYLCYSTEINE; BLOTTING, WESTERN; HELA CELLS; HUMANS; MICROCYSTINS; MITOGEN-ACTIVATED PROTEIN KINASES; ORGANIC ANION TRANSPORTERS; PROTEIN KINASE INHIBITORS;

EID: 77952498953     PISSN: 00410101     EISSN: 18793150     Source Type: Journal    
DOI: 10.1016/j.toxicon.2009.11.019     Document Type: Article

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