The dose-response relation between serum homocysteine and cardiovascular disease: Implications for treatment and screening

European Journal of Cardiovascular Prevention and Rehabilitation

Volumn 11, Issue 3, 2004, Pages 250-253

  Wald, David S ^a   Law, Malcolm ^a   Morris, Joan K ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Dose response relationship; Homocysteine; Ischaemic heart disease; Screening

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); HOMOCYSTEINE;

ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEATH; DEEP VEIN THROMBOSIS; GENETIC POLYMORPHISM; HUMAN; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK REDUCTION; SCREENING TEST;

EID: 3042728564     PISSN: 17418267     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.hjr.0000129742.15346.ab     Document Type: Article

References (31)

1. Wald DS, Law M, Morris J. Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. BMJ 2002; 325:1202-1206.
2. The Homocysteine Studies Collaboration. Homocysteine and risk of ischaemic heart disease and stroke. JAMA 2002; 288:2015-2022.
3. Klerk M, Verhoef P, Clarke R, Blom H, Kok FJ, Schoutten EG. MTHFR 677C to T Polymorphism and risk of coronary heart disease. JAMA 288: 2023-2031.
4. Homocysteine Lowering Trialists Collaboration. Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. BMJ 1998; 316:894-898.
5. Wald DS, Bishop L, Wald NJ, Law MR, Hennessy E, McPartlin J, et al. Randomised trial of folic acid supplementation on serum homocysteine levels. Arch Int Med 2001; 161:695-700.
6. Rosenberg IH. Is it time to standardize and to measure blood homocysteine levels in patients with heart disease? Am J Med 2002; 112:582-583.
7. Mann J, Green T. Hyperhomocysteinaemia: time to screen and treat? N Z Med J 2002; 115:1163.
8. Haynes WG. Homocysteine and atherosclerosis: potential mechanisms and clinical implications. Proc R Coll Physicians Edinb 2000; 30:114-122.
9. Christiansen DC. Homocysteine testing and cardiovascular disease risk. Br J Cardiol 1999; 6:693-696.
10. Ridker PM, Stampfer MJ, Rifai N. Novel risk factors for systemic atherosclerosis. JAMA 2001; 285:2481-2485.
11. Pocket guide to prevention of coronary heart disease. International Task Force for Prevention of Coronary Heart Disease. 2002; www.chd-taskforce.com
12. Law MR, Wald NJ. Risk factor thresholds: their existence under scrutiny. BMJ 2002; 324:1570-1576.
13. PROGRESS Collaborative Group. Randomised trial of a perindopril-based blood pressure lowering regimen among 6105 individuals with previous stroke or transient ischaemic attack. Lancet 2001; 358:1033-1041.
14. Heart Protection Study Collaborative Group. MRC/BHF Heart protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet 2002; 360:7-22.
15. Ridker PM, Manson JE, Buring JE, Shih J, Matias M, Hennekens CH. Homocysteine and risk of cardiovascular disease among postmenopausal women. JAMA 1999; 281:1817-1821.
16. Wald NJ, Watt HC, Law MR, Weir DG, Mcpartlin J, Scott JM. Homocysteine and ischaemic heart disease: results of a prospective study with implications regarding prevention. Arch Int Med 1998; 158-862-867.
17. Israelsson B, Bratttstrom LE, Hultberg BL. Homocysteine and myocardial infarction. Atherosclerosis 1988; 71:227-233.
18. Genest JJ Jr, McNamara JR, Salem DN, Wilson PWF, Schaefer EJ, Malinow MR. Plasma homocysteine levels in men with premature coronary artery disease. J Am Coll Cardiol 1990; 16:1114-1119.
19. Pancharuniti N, Lewis CA, Sauberlich HE, Perkins LL, Go RC, Alvarez JO, et al. Plasma homocysteine, folate, vitamin B12 concentrations and risk for early onset coronary artery disease. Am J Clin Nutr 1994; 59:940-948.
20. Verhoef P, Stampfer MJ, Buring JE, Gazrano JM, Allen RH, Stabler SP, et al. Homocysteine metabolism and risk of myocardial infarction: relation with vitamins B6, B12 and folate. Am J Epidemiol 1996; 143:845-859.
21. Malinow MR, Ducimetiere P, Luc G, Evans AE, Arveiler D, Cambien F, et al. Plasma homocysteine levels and graded risk for myocardial infarction: findings in two populations at contrasting risk for coronary disease. Atherosclerosis 1996; 126:27-34.
22. Joubran R, Asmi M, Busjahn A, Vergopoulos A, Luft FC, Jouma M. Homocysteine levels and coronary heart disease in Syria. J Cardiovasc Risk 1998; 5:257-261.
23. 677T of 5, 10-methylenetetrahydrofolate reductase and total plasma homocysteine are not associated with greater than normal risk of a first myocardial infarction in northern Sweden. Coron Artery Dis 2001; 12:85-90.
24. den Heijer M, Koster T, Blom HJ, Bos GMJ, Briet E, Reitsma PH, et al. Hyperhomocysteinemia as a risk factor for venous thrombosis. N Engl J Med 1996; 334:759-762.
25. Simioni P, Prandoni P, Burlina A, Tormene D, Sardella Ferrari V, et al. Hyperhomocysteimia and deep-vein thrombosis. Thromb Haemost 1996; 76:883-886.
26. Legnani C, Gualtiero P, Grauso F, Sassi S, Grossi G, Piazzi S, et al. Hyperhomocyst(e)inemia and a common methylenetetrahydrofolate reductase mutation (Ala223Val MTHFR) in patients with inherited thrombophilia coagulation defects. Arterioscler Thromb Vasc Biol 1997; 17:2924-2929.
27. Quéré I, Chassé JF, Dupuy E, Bellet E, Molho-Sabatier P, Tobelem G, et al. Homocysteine, 5-10-methylenetetrahydrofolate reductase et thrombose veineuse profonde. Enquete aupres de 120 patients en medecine interne. Rev Med Interne 1998; 19:29-33.
28. Langman LJ, Ray JG, Evrovski Yeo E, Cole DE. Hyperhomocysteinemia and the increased risk of venous thromboembolism. Arch Intern Med 2000; 160:961-964.
29. Ubbink JB, Vermaak WJH, Bennett JM, Becker PJ, van Staden DA, Bissbort S. The prevalence of homocysteinaemia and hypercholesterolaemia in angiographically defined coronary heart disease. Klinische Wochenschrift 1991; 69:527-534.
30. Brattstrom L, Wilcken DE. Homocysteine and cardiovascular disease: cause or effect? Am J Clin Nutr 2000; 72:315-323.
31. Ubbink JB, Delport R, Vermaak WJH. Plasma homocysteine concentrations in a population with a low coronary heart disease prevalence. J Nutr 1996; 126:1254S-1257S.