Long-term dietary supplementation with a yang-invigorating chinese herbal formula increases lifespan and mitigates age-associated declines in mitochondrial antioxidant status and functional ability of various tissues in male and female C57BL/6J mice

Rejuvenation Research

Volumn 13, Issue 2-3, 2010, Pages 168-171

  Ko, Kam Ming ^a   Chiu, Po Yee ^a   Leung, Hoi Yan ^a   Siu, Ada Hoi Ling ^a   Chen, Na ^a   Leong, Eriol Pou Kwan ^a   Poon, Michel K T ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIOXIDANT; CHINESE DRUG; GLUTATHIONE; GLUTATHIONE SYNTHASE; UNCLASSIFIED DRUG; VIGCONIC 28;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHINESE HERB; CHINESE MEDICINE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG FORMULATION; DRUG SYNTHESIS; FEMALE; LIFE EXTENSION; MALE; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SURVIVAL RATE;

AGING; ANIMAL FEED; ANIMALS; ANTIOXIDANTS; DIETARY SUPPLEMENTS; DRUG EVALUATION, PRECLINICAL; DRUGS, CHINESE HERBAL; FEMALE; LONGEVITY; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIA; SURVIVAL ANALYSIS; TIME FACTORS; YANG DEFICIENCY; YIN-YANG;

ANIMALIA; MUS;

EID: 77952358377     PISSN: 15491684     EISSN: None     Source Type: Journal    
DOI: 10.1089/rej.2009.0893     Document Type: Article

References (14)

1. Chan DC. Mitochondria: Dynamic organelles in diseases, aging, and development. Cell 2006;125:1241-1252.
2. Harman D. The biologic clock: the mitochondria? J Am Geriatr Soc 1972;20:145-147.
3. Linnane AW, Marzuki S, Ozawa T, Tanaka M. Mitochon-drial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet 1989;1:642-645.
4. Leung HY, Chiu PY, Poon MKT, Ko KM. Ayang-invigorating Chinese herbal formula enhances mitochondrial functional ability and antioxidant capacity in various tissues of male and female rats. Rejuven Res 2005;8:238-247.
5. Chiu PY, Leung HY, Siu AHL, N. Chen N, Poon MKT, Ko KM. Long-term treatment with a Yang-invigorating Chinese herbal formula produces generalized tissue protection against oxidative damage in rats. Rejuven Res 2008;11: 43-62.
6. Mak DHF, Chiu PY, Poon MK, Ng TT, Chung YK, Lam BY, Du Y, Ko KM. A yang-promoting Chinese herbal suppository preparation enhances the antioxidant status of red cells in male human subjects. Phytother Res 2004;18: 525-530.
7. Griffith OW. Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal Biochem 1980;106:207-212.
8. Sadrzadeh SM, Nanji AA, Meydani M. Effect of chronic ethanol feeding on plasma and liver alpha-and gamma-tocopherol levels in normal and vitamin E-deficient rats. Relationship to lipid peroxidation. Biochem Pharmacol 1994;47:2005-2010.
9. McCord JM, Fridovich I. Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J Biol Chem 1969;244:6049-6055.
10. Bezlepkin VG, Sirota NP, Gaziev AI. The prolongation of survival in mice by dietary antioxidants depends on their age by the start of feeding this diet. Mech Age Dev 1996;92:227-234.
11. Lipman RD, Bronson RT, Wu D, Smith DE, Prior G, Cao G, Han SN, Martin KR, Meydani SN, Meydani M. Disease incidence and longevity are unaltered by dietary antioxidant supplementation initiated during middle age in C57BL=6 mice. Mech Age Dev 1998;103:269-284.
12. nd, Wolf N, Remmen H, Richardson A. Reduction in glutathione peroxidase 4 increases life span through increased sensitivity to apoptosis. J Gerontol A Biol Sci Med Sci 2007;62:932-942.
13. Meng Q, Wong YT, Chen J, Ruan R. Age-related changes in mitochondrial function and antioxidative enzyme activity in Fischer 344 rats. Mech Age Dev 2007;128:286-292.
14. Preston CC, Oberlin AS, Holmuhamedov EL, Gupta A, Sagar S, Syed RH, Siddiqui SA, Raghavakaimal S, Terzic A, Jahangir A. Aging-induced alterations in gene transcripts and functional activity of mitochondrial oxidative phos-phorylation complexes in the heart. Mech Age Dev 2008;129: 304-312.