Capsule depolymerase overexpression reduces Bacillus anthracis virulence

Microbiology

Volumn 156, Issue 5, 2010, Pages 1459-1467

  Scorpio, Angelo ^a,b   Chabot, Donald J ^a   Day, William A ^a,c   Hoover, Timothy A ^a   Friedlander, Arthur M ^a  

^a UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

^b BATTELLE MEMORIAL INSTITUTE   (United States)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CAPSULE DEPOLYMERASE; ELONGATION FACTOR TU; GAMMA GLUTAMYLTRANSFERASE; HEAT SHOCK PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BACILLUS ANTHRACIS; BACTERIAL STRAIN; BINDING SITE; BIOSYNTHESIS; CODON; GENE OVEREXPRESSION; GENE SEQUENCE; GUINEA PIG; IMMUNOBLOTTING; MICROCAPSULE; NEUTROPHIL; NONHUMAN; PHAGOCYTE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RIBOSOME; VIRULENCE; WILD TYPE;

ANIMALS; BACILLUS ANTHRACIS; BACTERIAL CAPSULES; CHAPERONIN 60; CLONING, MOLECULAR; EVOLUTION, MOLECULAR; GLYCOSIDE HYDROLASES; GUINEA PIGS; MACROPHAGES; OPERON; PHENOTYPE; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; VIRULENCE;

BACILLUS ANTHRACIS; CAVIA;

EID: 77952358138     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/mic.0.035857-0     Document Type: Article

References (21)

1. Candela, T. & Fouet, A. (2005). Bacillus anthracis CapD, belonging to the gamma-glutamyltranspeptidase family, is required for the covalent anchoring of capsule to peptidoglycan. Mol Microbiol 57, 717-726. (Pubitemid 41025954)
2. Candela, T., Mock, M. & Fouet, A. (2005). CapE, a 47-amino-acid peptide, is necessary for Bacillus anthracis polyglutamate capsule synthesis. J Bacteriol 187, 7765-7772. (Pubitemid 41594652)
3. Chabot, D. J., Scorpio, A., Tobery, S. A., Little, S. F., Norris, S. L. & Friedlander, A. M. (2004). Anthrax capsule vaccine protects against experimental infection. Vaccine 23, 43-47. (Pubitemid 39446358)
4. Day, W. A., Rasmussen, S. L., Carpenter, B. M., Peterson, S. N. & Friedlander, A. M. (2007). Microarray analysis of transposon insertion mutations in Bacillus anthracis: global identification of genes required for sporulation and germination. J Bacteriol 189, 3296-3301.
5. Gesteland, R. F. & Atkins, J. F. (1996). Recoding: dynamic reprogramming of translation. Annu Rev Biochem 65, 741-768.
6. Green, B. D., Battisti, L., Koehler, T. M., Thorne, C. B. & Ivins, B. E. (1985). Demonstration of a capsule plasmid in Bacillus anthracis. Infect Immun 49, 291-297. (Pubitemid 15004855)
7. Kimura, K., Tran, L. S., Uchida, I. & Itoh, Y. (2004). Characterization of Bacillus subtilis gamma-glutamyltransferase and its involvement in the degradation of capsule poly-gamma-glutamate. Microbiology 150, 4115-4123. (Pubitemid 40045340)
8. Makino, S., Watarai, M., Cheun, H. I., Shirahata, T. & Uchida, I. (2002). Effect of the lower molecular capsule released from the cell surface of Bacillus anthracis on the pathogenesis of anthrax. J Infect Dis 186, 227-233. (Pubitemid 34765511)
9. Menard, R., Sansonetti, P. J. & Parsot, C. (1993). Nonpolar mutagenesis of the ipa genes defines IpaB, IpaC, and IpaD as effectors of Shigella flexneri entry into epithelial cells. J Bacteriol 175, 5899-5906. (Pubitemid 23277438)
10. Mendelson, I., Tobery, S., Scorpio, A., Bozue, J., Shafferman, A. & Friedlander, A. M. (2004). The NheA component of the nonhemolytic enterotoxin of Bacillus cereus is produced by Bacillus anthracis but is not required for virulence. Microb Pathog 37, 149-154. (Pubitemid 39209304)
11. Mock, M. & Fouet, A. (2001). Anthrax. Annu Rev Microbiol 55, 647-671.
12. Oppenheim, D. S. & Yanofsky, C. (1980). Translational coupling during expression of the tryptophan operon of Escherichia coli. Genetics 95, 785-795. (Pubitemid 11128549)
13. Ozbudak, E. M., Thattai, M., Kurtser, I., Grossman, A. D. & Van, O. A. (2002). Regulation of noise in the expression of a single gene. Nat Genet 31, 69-73.
14. Rex, G., Surin, B., Besse, G., Schneppe, B. & McCarthy, J. E. (1994). The mechanism of translational coupling in Escherichia coli. Higher order structure in the atpHA mRNA acts as a conformational switch regulating the access of de novo initiating ribosomes. J Biol Chem 269, 18118-18127. (Pubitemid 24982653)
15. Richter, S., Anderson, V. J., Garufi, G., Lu, L., Budzik, J. M., Joachimiak, A., He, C., Schneewind, O. & Missiakas, D. (2009). Capsule anchoring in Bacillus anthracis occurs by a transpeptidation reaction that is inhibited by capsidin. Mol Microbiol 71, 404-420.
16. Scorpio, A., Wei, J., Ghassemian, M., Su, J., Chen, W., Blank, T. E., Richardson, T. H., Bozue, J. A., Hoover, T. A. & other authors (2005). The proteome of Bacillus anthracis isolated from infected animals. In Bacillus anthracis, B. cereus, and B. thuringiensis International Conference, p. 20. Santa Fe, New Mexico, USA.
17. Scorpio, A., Chabot, D. J., Day, W. A., O'Brien, D. K., Vietri, N. J., Itoh, Y., Mohamadzadeh, M. & Friedlander, A. M. (2007). Poly-gamma-glutamate capsule-degrading enzyme treatment enhances phagocytosis and killing of encapsulated Bacillus anthracis. Antimicrob Agents Chemother 51, 215-222. (Pubitemid 46047709)
18. Scorpio, A., Tobery, S. A., Ribot, W. J. & Friedlander, A. M. (2008). Treatment of experimental anthrax with recombinant capsule depolymerase. Antimicrob Agents Chemother 52, 1014-1020. (Pubitemid 351358382)
19. Shcherbakov, D. V. & Garber, M. B. (2000). Overlapping genes in bacterial and bacteriophage genomes. Mol Biol (Mosk) 34, 572-583.
20. Su, J., Yang, J., Zhao, D., Kawula, T. H., Banas, J. A. & Zhang, J. R. (2007). Genome-wide identification of Francisella tularensis virulence determinants. Infect Immun 75, 3089-3101. (Pubitemid 46870195)
21. Uchida, I., Makino, S., Sasakawa, C., Yoshikawa, M., Sugimoto, C. & Terakado, N. (1993). Identification of a novel gene, dep, associated with depolymerization of the capsular polymer in Bacillus anthracis. Mol Microbiol 9, 487-496. (Pubitemid 23248761)