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Volumn 8, Issue 10, 2010, Pages 2397-2407

Synthesis and biological evaluation of 5-substituted O4- alkylpyrimidines as CDK2 inhibitors

(11) Marchetti, Francesco a Cano, Céline a Curtin, Nicola J b Golding, Bernard T c Griffin, Roger J a Haggerty, Karen a Newell, David R b Parsons, Rachel J a Payne, Sara L a Wang, Lan Z b Hardcastle, Ian R a

a NEWCASTLE UNIVERSITY (United Kingdom)

b NEWCASTLE UNIVERSITY (United Kingdom)

c NEWCASTLE UNIVERSITY (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYL SUBSTITUENT; AMINOPYRIMIDINES; BIOLOGICAL EVALUATION; CDK2 INHIBITOR; DIAMINOPYRIMIDINE; NITROSO; STRUCTURE ACTIVITY RELATIONSHIPS; TUMOUR CELLS;

HYDROCARBONS; NITROGEN COMPOUNDS; SYNTHESIS (CHEMICAL);

ALKYLATION;

CYCLIN DEPENDENT KINASE 2; OXYGEN; PROTEIN KINASE INHIBITOR; PYRIMIDINE DERIVATIVE;

ARTICLE; CHEMISTRY; DRUG ANTAGONISM; DRUG DEVELOPMENT; HUMAN; IC 50; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE 2; DRUG DISCOVERY; HUMANS; INHIBITORY CONCENTRATION 50; OXYGEN; PROTEIN KINASE INHIBITORS; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77952340084 PISSN: 14770520 EISSN: None Source Type: Journal
DOI: 10.1039/b925481a Document Type: Article

Times cited : (27)

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