Molecular analysis of multicatalytic monoclonal antibodies

Molecular Immunology

Volumn 47, Issue 9, 2010, Pages 1747-1756

  Zein, Haggag S ^a,c   Teixeira da Silva, Jaime A ^b   Miyatake, Kazutaka ^c  

^a CAIRO UNIVERSITY   (Egypt)

^b KAGAWA UNIVERSITY   (Japan)

^c Osaka Prefecture University   (Japan)

Author keywords

Affinity; Catalytic antibody genes; Coat protein; Cucumber mosaic virus; DNase; ELISA; Monoclonal antibodies; Protease; RNase

Indexed keywords

AUTOANTIBODY; DNA ANTIBODY; DOUBLE STRANDED DNA; EPITOPE; MONOCLONAL ANTIBODY; PROTEINASE; RIBONUCLEASE; SINGLE STRANDED DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN ANTIBODY REACTION; ARTICLE; AUTOIMMUNITY; CATALYSIS; CONTROLLED STUDY; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVITY; ENZYME SPECIFICITY; GENE EXPRESSION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, CATALYTIC; ANTIBODIES, MONOCLONAL; ANTIBODIES, VIRAL; BIOCATALYSIS; BLOTTING, WESTERN; CAPSID PROTEINS; CUCUMOVIRUS; DEOXYRIBONUCLEASES; DNA; DNA, SINGLE-STRANDED; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HYDROLYSIS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; PEPTIDE HYDROLASES; PEPTIDES; SEQUENCE HOMOLOGY, AMINO ACID;

CUCUMBER MOSAIC VIRUS;

EID: 77952321581     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2010.02.024     Document Type: Article

References (57)

1. Andrievskaya O.A., Buneva V.N., Baranovskii A.G., Gal'vita A.V., Benzo E.S., Naumov V.A., Nevinsky G.A. Catalytic diversity of polyclonal RNA-hydrolyzing IgG antibodies from the sera of patients with systemic lupus erythematosus. Immunol. Lett. 2002, 81:191-198.
2. Avalle B., Debat H., Friboulet A., Thomas D. Catalytic mechanism of an abzyme displaying a β-lactamase-like activity. Appl. Biochem. Biotechnol. 2000, 83:163-169.
3. Baranovskii A.G., Ershova N.A., Buneva V.N., Kanyshkova T.G., Mogelnitskii A.S., Doronin B.M., Boiko A.N., Gusev E.I., Favorova O.O., Nevinsky G.A. Catalytic heterogeneity of polyclonal DNA-hydrolyzing antibodies from the sera of patients with multiple sclerosis. Immunol. Lett. 2001, 76:163-167.
4. Durova O.M., Vorobiev I.I., Smirnov I.V., Reshetnyak A.V., Telegin G.B., Shamborant O.G., Orlova N.A., Genkin D.D., Bacon A., Ponomarenko N.A., Friboulet A., Gabibov A.G. Strategies for induction of catalytic antibodies toward HIV-1 glycoprotein gp120 in autoimmune prone mice. Mol. Immunol. 2009, 47:87-95.
5. Erhan S., Greller L.D. Do immunoglobulins have proteolytic activity?. Nature 1974, 251:353-355.
6. Fujii I., Fukuyama S., Iwabuchi Y., Tanimura R. Evolving catalytic antibodies in a phage-displayed combinatorial library. Nat. Biotechnol. 1998, 16:463-467.
7. Fujii I., Tanaka F., Miyashita H., Tanimura R., Kinoshita K. Correlation between antigen-combining-site structures and functions within a panel of catalytic antibodies generated against a single transition state analog. J. Am. Chem. Soc. 1995, 117:6199-6209.
8. Gabibov A.G., Friboulet A., Thomas D., Demin A.V., Ponomarenko N.A., Vorobiev I.I., Pillet D., Paon M., Alexandrova E.A., Telegin G.B., Reshetnyak A.V., Grigorieva O.V., Gnuchev N.V., Malishkin K.A., Genkin D.D. Antibody proteases: induction of catalytic response. Biochemistry (Moscow) 2002, 67:1168-1179.
9. Gololobov G.V., Rumbley C.A., Rumbley J.N., Schourov D.V., Makarevich O.I., Gabibov A.G., Voss E.W., Rodkey L.S. DNA hydrolysis by monoclonal anti-ssDNA autoantibody BV 04-01: origins of catalytic activity. Mol. Immunol. 1997, 34:1083-1093.
10. Harlow E., Lane D. Antibodies. A Laboratory Manual 1988, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
11. Hifumi E., Mitsuda Y., Ohara K., Uda T. Targeted destruction of the HIV-1 coat protein gp41 by a catalytic antibody light chain. J. Immunol. Methods 2002, 269:283-298.
12. Huse W.D., Sastry L., Iverson S.A., Kang A.S., Alting-Mees M., Burton D.R., Benkovic S.J., Lerner R.A. Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda. Science 1989, 246:1273-1278.
13. Iverson B.L., Lerner R.A. Sequence-specific peptide cleavage catalyzed by an antibody. Science 1989, 243:1184-1188.
14. Izadyar L., Friboulet A., Remy M.H., Roseto A., Thomas D. Monoclonal anti-idiotypic antibodies as functional internal images of enzyme active sites. Production of a catalytic antibody with a cholinesterase activity. Proc. Natl. Acad. Sci. U.S.A. 1993, 90:8876-8880.
15. Jang Y.J., Stollar B.D. Anti-DNA antibodies: aspects of structure and pathogenicity. Cell. Mol. Life Sci. 2003, 60:309-320.
16. Kabat E.A., Wu T.T., Perry H.M., Gottesman K.S., Foeller C. Sequences of Proteins of Immunological Interest 1991, Public Health Service, National Institutes of Health, Publication No. 91-3242, Washington, DC. 5th ed.
17. Kim D.S., Lee S.H., Kim J.S., Lee S.C., Kwon M.H., Kim Y.S. Generation of humanized anti-DNA hydrolyzing catalytic antibodies by complementarity determining region grafting Biochem. Biophys. Res. Commun. 2009, 379(2):314-318.
18. Kim Y.R., Kim J.S., Lee S.H., Lee W.R., Sohn J.N., Chung Y.C., Shim H.K., Lee S.C., Kwon M.H., Kim Y.S. Heavy and light chain variable single domains of an anti-DNA binding antibody hydrolyze both double- and single-stranded DNAs without sequence specificity. J. Biol. Chem. 2006, 281:15287-15295.
19. Kolesnikov A.V., Kozyr A.V., Alexandrova E.S., Koralewski F., Demin A.V., Titov M.I., Avalle B., Tramontano A., Paul S., Thomas D., Gabibov A.G., Friboulet A. Enzyme mimicry by the antiidiotypic antibody approach. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:13526-13531.
20. Krasnorutskii M.A., Buneva V.N., Nevinsky G.A. Antibodies against DNA hydrolyze DNA and RNA. J. Mol. Recognit. 2008, 21:338-347.
21. Lacroix-Desmazes S., Bayry J., Kaveri S.V., Hayon-Sonsino D., Thorenoor N., Charpentier J., Luyt C.E., Mira J.P., Nagaraja V., Kazatchkine M.D., Dhainaut J.F., Mallet V.O. High levels of catalytic antibodies correlate with favorable outcome in sepsis. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:4109-4113.
22. Lacroix-Desmazes S., Moreau A., Sooryanarayana Bonnemain C., Stieltjes N., Pashov A., Sultan Y., Hoebeke J., Kazatchkine M.D., Kaveri S.V. Catalytic activity of antibodies against factor VIII in patients with hemophila A. Nat. Med. 1999, 5:1044-1047.
23. Lefranc M.P., Lefranc G. The Immunoglobulin Facts Book 2001, Academic Press, London.
24. Liu E., Prasad L., Delbaere L.T., Waygood E.B., Lee J.S. Conversion of an antibody into an enzyme which cleaves the protein HPr. Mol. Immunol. 1998, 35(16):1069-1077.
25. Liu S., He X., Park G., Josefsson C., Perry K.L. A Conserved capsid protein surface domain of Cucumber mosaic virus is essential for efficient aphid vector transmission. J. Virol. 2002, 76:9756-9762.
26. Ma L., Hsieh-Wilson L.C., Schultz P.G. Antibody catalysis of peptidyl-prolyl cis-trans isomerization in the folding of RNase T1. Proc. Natl. Acad. Sci. U.S.A. 1998, 95(13):7251-7256.
27. Marion T.N., Krishnan M.R., Desai D.D., Jou N.T., Tillman D.M. Monoclonal Anti-DNA Antibodies: structure, specificity, and biology. Methods 1997, 11:3-11.
28. Martin A.C.R. Structure, Function and Genetics 1996, 25:130-133.
29. Matsuura K., Yamamoto K., Sinohara H. Amidase activity of human Bence Jones proteins. Biochem. Biophys. Res. Commun. 1994, 204:57-62.
30. Mitsuda Y., Hifumi E., Tsuruhata K., Fujinami H., Yamamoto N., Uda T. Catalytic antibody light chain capable of cleaving a chemokine receptor CCR-5 peptide with a high reaction rate constant. Biotechnol. Bioeng. 2004, 86:217-225.
31. Miyashita H., Hara T., Tanimura R., Fukuyama S., Cagnon C., Kohara A., Fujii I. Site-directed mutagenesis of active site contact residues in a hydrolytic abzyme: evidence for an essential histidine involved in transition state stabilization. J. Mol. Biol. 1997, 267:1247-1257.
32. Miyashita H., Hara T., Tanimura R., Tanaka F., Kikuchi M., Fujii I. A common ancestry for multiple catalytic antibodies generated against a single transition-state analog. Proc. Natl. Acad. Sci. U.S.A. 1994, 91:6045-6049.
33. Muesing M.A., Smith D.H., Cabradilla C.D., Benton C.V., Lasky L.A., Capon D.J. Nucleic acid structure and expression of the human AIDS/lymphadenopathy retrovirus. Nature 1985, 313(6002):450-458.
34. Nardi M., Tomlinson S., Greco M.A., Karpatkin S. Complement-independent, peroxide-induced antibody lysis of platelets in HIV-1-related immune thrombocytopenia. Cell 2001, 106:551.
35. Nevinsky G.A., Buneva V.N. Human catalytic RNA- and DNA-hydrolyzing antibodies. J. Immunol. Methods 2002, 269:235-249.
36. Nevinsky G.A., Buneva V.N. Natural Catalytic Antibodies-Abzymes 2005, John Wiley & Sons, Weinheim, Germany.
37. Nguyen H.T.T., Jang Y.J., Jeong S., Yu J. DNA-specific autoantibody cleaves DNA by hydrolysis of phosphodiester and glycosidic bond. Biochem. Biophys. Res. Commun. 2003, 311:767-773.
38. Nissen P., Kjeldgaard M., Nyborg J. Macromolecular mimicry. EMBO J. 2000, 19:489-495.
39. Paul S., Karle S., Planque S., Taguchi H., Nishiyama Y., Handy B., Salas M., Edmundson A., Hanson A. Naturally occurring proteolytic antibodies: selective immunoglobulin M-catalyzed hydrolysis of HIV gp120. J. Biol. Chem. 2004, 279:39611-39619.
40. Paul S., Mei S., Mody B., Eklund S.H., Beach C.M., Massey R.J., Hamel F. Cleavage of vasoactive intestinal peptide at multiple sites by autoantibodies. J. Biol. Chem. 1991, 266:16128-16134.
41. Paul S., Volle D.J., Beach C.M., Johnson D.R., Powell M.J., Massey R.J. Catalytic hydrolysis of vasoactive intestinal peptide by human autoantibody. Science 1989, 244:1158-1162.
42. Planque S., Bangale Y., Song X.T., Karle S., Taguchi H., Poindexter B., Bick R., Edmundson A., Nishiyama Y., Paul S. Ontogeny of proteolytic immunity: IgM serine proteases. J. Biol. Chem. 2004, 279(14):14024-14032.
43. Ponomarenko N.A., Durova O.M., Vorobiev I.I., Aleksandrova E.S., Telegin G.B., Chamborant O.G., Sidorik L.L., Suchkov S.V., Alekberova Z.S., Gnuchev N.V., Gabibov A.G. Antibody proteases: induction of catalytic response. J. Immunol. Methods 2002, 269:197-211.
44. Ponomarenko N.A., Durova O.M., Vorobiev I.I., Belogurov A.A., Kurkova I.N., Petrenko A.G., Telegin G.B., Suchkov S.V., Kiselev S.L., Lagarkova M.A., Govorun V.M., Serebryakova M.V., Avalle B., Tornatore P., Karavanov A., Morse H.C., Thomas D., Friboulet A., Gabibov A.G. Autoantibodies to myelin basic protein catalyze site- specific degradation of their antigen. Proc. Natl. Acad. Sci. U.S.A. 2006, 103(2):281-286.
45. Ponomarenko N.A., Pillet D., Paon M., Vorobiev I.I., Smirnov I.V., Adenier H., Avalle B., Kolesnikov A.V., Kozyr A.V., Thomas D., Gabibov A.G., Friboulet A. Anti-idiotypic antibody mimics proteolytic function of parent antigen. Biochemistry 2007, 46(50):14598-14609.
46. Reichard U., Buttner S., Eiffert H., Staib F., Ruchel R. Purification and characterisation of an extracellular serine proteinase from Aspergillus fumigatus and its detection in tissue. J. Med. Microbiol. 1990, 33:243-251.
47. Romesberg F.E., Spiller B., Schultz P.G., Stevens R.C. Immunological origins of binding and catalysis in a Diels-Alderase antibody. Science 1998, 279:1929-1933.
48. Shuster A.M., Gololobov G.V., Kvashuk O.A., Bogomolova A.E., Smirnov I.V., Gabibov A.G. DNA hydrolyzing autoantibodies. Science 1992, 256:665-667.
49. Smithrud D.B., Benkovic P.A., Benkovic S.J., Roberts V., Liu J., Neagu I., Iwama S., Phillips B.W., Smith A.B., Hirschmann R. Cyclic peptide formation catalyzed by an antibody ligase. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:1953-1958.
50. Takahashi N., Kakinuma H., Liu L., Nishi Y., Fujii I. In vitro abzyme evolution to optimize antibody recognition for catalysis. Nat. Biotechnol. 2001, 19(6):563-567.
51. Tawfik D.S., Chap R., Green B.S., Sela M., Eshhar Z. Unexpected high occurrence of catalytic antibodies in MRL/lpr and SJL mice immunized with a transition-state analog: is there a linkage to autoimmunity?. Proc. Natl. Acad. Sci. U.S.A. 1995, 92:2145-2149.
52. Thiagarajan P., Paul S. Prothrombin cleaving antibody light chains. Chem. Immunol. 2000, 77:115-129.
53. Uda T., Hifumi E., Kobayashi T., Shimizu K., Sata T., Ogino K. An approach for an immunoaffinity AIDS sensor using the conservative region of the HIV envelope protein (gp41) and its monoclonal antibody. Biosens. Bioelectron. 1995, 10(5):477-483.
54. Uda T., Hifumi E., Ohara K., Yan Z. Catalytic activity of antibody light chain to gp41: a consideration of refolding in relation to activation mechanism. Chem. Immunol. 2000, 77:18-32.
55. Vlassov A., Florentz C., Helm M., Naumov V., Buneva V., Nevinsky G., Giege R. Characterization and selectivity of catalytic antibodies from human serum with RNase activity. Nucleic Acids Res. 1998, 26:5243-5250.
56. Wootla B., Nicoletti A., Patey N., Dimitrov J.D., Legendre C., Christophe O.D., Friboulet A.S., Kaveri V., Lacroix-Desmazes S., Thaunat O. Factor VIII hydrolysis mediated by anti-factor VIII autoantibodies in acquired hemophilia. J. Immunol. 2008, 180:8455-8460.
57. Zein H.S., Teixeira da Silva J.A., Miyatake K. Monoclonal antibodies specific to Cucumber mosaic virus coat protein possess DNA-hydrolyzing activity. Mol. Immunol. 2009, 46:1527-1533.