The common FTO genetic polymorphism rs9939609 is associated with increased BMI in type 1 diabetes but not with diabetic nephropathy

Biomarker Insights

Volumn 2010, Issue 5, 2010, Pages 29-32

  Gu, Harvest F ^a   Alvarsson, Alexandra ^a   Brismar, Kerstin ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Diabetic nephropathy; Fat mass and obesity associated; Genetic association; Single nucleotide polymorphism

Indexed keywords

CREATININE; CYSTATIN; FAT MASS AND OBESITY ASSOCIATED PROTEIN; GENE PRODUCT; UNCLASSIFIED DRUG;

ARTICLE; BODY MASS; CONTROLLED STUDY; CREATININE URINE LEVEL; DIABETIC NEPHROPATHY; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HOMOZYGOSITY; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; OBESITY; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 77952306484     PISSN: None     EISSN: 11772719     Source Type: Journal    
DOI: 10.4137/bmi.s4599     Document Type: Article

References (12)

1. Eknoyan G. Obesity, diabetes, and chronic kidney disease. Curr Diab Rep. 2007;7:449-53.
2. Knight SF, Imig JD. Obesity, insulin resistance, and renal function. Microcirculation. 2007;14:349-62.
3. Groop PH, Forsblom C, Thomas MC. Mechanisms of disease: Pathwayselective insulin resistance and microvascular complications of diabetes. Nat Clin Pract Endocrinol Metab. 2005;1:100-10.
4. Navaneethan SD, Yehnert H, Moustarah F, Schreiber MJ, Schauer PR, Beddhu S. Weight loss interventions in chronic kidney disease: a systematic review and meta-analysis. Clin J Am Soc Nephrol. 2009;4(10):1565-74.
5. Frayling TM, Timpson NJ, Weedon MN, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science. 2007;316:889-94.
6. Hinney A, Nguyen TT, Scherag A, et al. Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants. PLoS One. 2007;2:e1361.
7. Scott LJ, Mohlke KL, Bonnycastle LL, et al. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science. 2007;316:1341-5.
8. Dina C, Meyre D, Gallina S, et al. Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet. 2007;39:724-6.
9. Mueller PW, Rogus JJ, Cleary PA, et al. Genetics of Kidneys in Diabetes (GoKinD) study: a genetics collection available for identifying genetic susceptibility factors for DN in T1D. J Am Soc Nephrol. 2006;17:1782-90.
10. Zhang D, Freedman BI, Flekac M, et al. Evaluation of genetic association and expression reduction of TRPC1 in the development of diabetic nephropathy. Am J Nephrol. 2009;29:244-51.
11. Mäkinen VP, Forsblom C, Thorn LM, et al. FinnDiane Study Group. Metabolic phenotypes, vascular complications, and premature deaths in a population of 4,197 patients with type 1 diabetes. Diabetes. 2008;57:2480-7.
12. Field SF, Howson JM, Walker NM, Dunger DB, Todd JA. Analysis of the obesity gene FTO in 14,803 type 1 diabetes cases and controls. Diabetologia. 2007;50:2218-20.