[Glu2]TRH dose-dependently attenuates TRH-evoked analeptic effect in mice

Brain Research Bulletin

Volumn 82, Issue 1-2, 2010, Pages 83-86

  Nguyen, Vien ^a   Zharikova, Alevtina D ^b   Prokai Tatrai, Katalin ^a   Prokai, Laszlo ^a  

^a UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

Acetylcholine; Analeptic effect; Endogenous analogue; Thyrotropin releasing hormone

Indexed keywords

ACETYLCHOLINE; BARBITURIC ACID DERIVATIVE; GLUTAMIC ACID; PEPTIDE; PROTIRELIN; PROTIRELIN DERIVATIVE; PROTIRELIN[2 GLUTAMIC ACID]; RECEPTOR; UNCLASSIFIED DRUG; CENTRAL STIMULANT AGENT; DRUG DERIVATIVE; HYPNOTIC SEDATIVE AGENT; PENTOBARBITAL;

ACETYLCHOLINE RELEASE; ANIMAL EXPERIMENT; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG STRUCTURE; HIPPOCAMPUS; HORMONE ACTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SLEEP TIME; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; SLEEP;

ANIMALS; CENTRAL NERVOUS SYSTEM STIMULANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HYPNOTICS AND SEDATIVES; MICE; MOLECULAR STRUCTURE; PENTOBARBITAL; SLEEP; THYROTROPIN-RELEASING HORMONE;

EID: 77952302074     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2010.02.007     Document Type: Article

References (30)

1. Box G.E., Hunter W.G., Hunter J.S. Statistics for Experimenters: Design, Innovation, and Discovery 2005, Wiley, pp. 173-174. 2nd edition.
2. i) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. Biochem. Pharmacol. 1973, 22:3099-3108.
3. Cockle S.M., Aitken M.A., Beg F., Smyth D.G. A novel peptide, pyroglutamylglutamylproline amide, in the rabbit prostate complex, structurally related to thyrotrophin-releasing hormone. J. Biol. Chem. 1989, 264:7788-7791.
4. Colsona A.O., Gershengorn M.C. Thyrotropin-releasing hormone analogs. Mini Rev. Med. Chem. 2006, 6:221-226.
5. Cott J., Engel J. Antagonism of the analeptic activity of thyrotropin-releasing hormone (TRH) by agents which enhance GABA transmission. Psychopharmacology. 1976, 55:145-149.
6. Del Rio-Garcia J., Smyth D.G. Distribution of pyroglutamylpeptide amides related to thyrotropin-releasing hormone in the central nervous system and periphery of the rat. J. Endocrinol. 1990, 127:445-450.
7. Giovannini M.G., Casamenti F., Nistri A., Paoli F., Pepeu G. Effect of thyrotropin releasing hormone (TRH) on acetylcholine release from different brain areas investigated by microdialysis. Br. J. Pharmacol. 1991, 102:363-368.
8. Harvey S., Trudeau V.L., Ashworth R.J., Cockle S.M. pGlutamylglutamylprolineamide modulation of growth hormone secretion in domestic fowl: antagonism of thyrotrophin-releasing hormone action?. J. Endocrinol. 1993, 138:137-147.
9. Hinkle P.M., Pekary A.E., Senanayaki S., Sattin A. Role of TRH receptors as possible mediators of analeptic actions of TRH-like peptides. Brain Res. 2002, 935:59-64.
10. Horita A. An update on the CNS actions of TRH and its analogs. Life Sci. 1998, 62:1443-1448.
11. Kelly J.A., Slator G.R., Tipton K.F., Williams C.H., Bauer K. Kinetic investigation of the specificity of porcine brain thyrotropin-releasing hormone-degrading ectoenzyme for thyrotropin-releasing hormone-like peptides. J. Biol. Chem. 2000, 275:16746-16751.
12. Klootwijk W., de Boer R.D.H., Sleddens-Linkels E., Cockle S.M., de Herder W.W., Bauer K., Visser T.J., de Greef W.J. Urinary excretion of the TRH-like peptide pyroglutamyl-glutamyl-prolineamide in rats. J. Endocrinol. 1997, 153:411-421.
13. Klootwijk W., de Herder W.W., Kwekkeboom D.J., Lamberts S.W., Krenning E.P., Visser T.J., de Greef W.J. High serum levels of the thyrotropin-releasing hormone-like peptide pyroglutamyl-glutamyl-prolineamide in patients with carcinoid tumors. J. Clin. Endocrinol. Metab. 1997, 82:3068-3073.
14. Lloyd R.L., Pekary A.E., Sattin E., Amundson T. Antidepressant effects of thyrotropin-releasing hormone analogues using a rodent model of depression. Pharmacol. Biochem. Behav. 2001, 70:15-22.
15. Monga V., Meena C.L., Kaur N., Jain R. Chemistry and biology of thyrotropin-releasing hormone (TRH) and its analogs. Curr. Med. Chem. 2008, 15:2718-2733.
16. Mushiroi T., Shibahara R., Tamura M., Shimizu T., Itoh Y., Ukai Y., Yoshikuni Y., Kimura K. Montirelin hydrate (NS-3), a TRH analog, improved the disturbance of consciousness caused by head concussion and pentobarbital in mice. Folia Pharmacol. Jpn. 1996, 107:237-245.
17. 2]TRH) in the brain: an in vivo microdialysis study. Neurosci. Lett. 2007, 415:64-67.
18. Prange J., Breese G.R., Cott J.M., Martin B.R., Cooper B.R., Wilson C.I., Plotnikoff N.P. Thyrotropin releasing hormone: antagonism of pentobarbital in rodents. Life Sci. 1974, 14:447-455.
19. Prokai L. Central nervous system effects of thyrotropin-releasing hormone and its analogues: opportunities and perspectives for drug discovery and development. Progress in Drug Research 2002, vol. 59:133-169. Birkhäuser, Basel, Switzerland.
20. Prokai L., Prokai-Tatrai K., Zharikova A.D., Nguyen V., Perjési P., Stevens S.M. Centrally acting and metabolically stable thyrotropin-releasing hormone analogues by replacement of histidine with substituted pyridinium. J. Med. Chem. 2004, 47:6025-6033.
21. 2]TRH and its chemical brain-targeting system. Brain Res. 2002, 952:268-274.
22. 2. Bioorg. Med. Chem. Lett. 2003, 13:1011-1014.
23. Prokai-Tatrai K., Perjesi P., Zharikova A.D., Li X., Prokai L. Design, synthesis and biological evaluation of novel, centrally-acting thyrotropin-releasing hormone analogues. Bioorg. Med. Chem. Lett. 2002, 12:2171-2174.
24. Prokai-Tatrai K., Prokai L. Prodrugs of thyrotropin-releasing hormone and related peptides as central nervous system agents. Molecules 2008, 14:633-654.
25. 2 and its prodrugs as central nervous system agents. Med. Chem. 2005, 2:141-152.
26. Roussel J.P., Astier H., Tapia-Arancibia L. Benzodiazepines inhibit thyrotropin (TSH)-releasing hormone-induced TSH and growth hormone release from perifused rat pituitaries. Endocrinology 1986, 119:2519-2526.
27. Scalabrino G.A., Hogan N., O'Boyle K.M., Slator G.R., Gregg D.J., Fitchett C.M., Draper S.M., Bennett G.W., Hinkle P.M., Bauer K., Williams C.H., Tipton K.F., Kelly J.A. Discovery of a dual action first-in-class peptide that mimics and enhances CNS-mediated actions of thyrotropin-releasing hormone. Neuropharmacology 2007, 52:1472-1481.
28. Schmidt D.E. Effects of thyrotropine releasing hormone (TRH) on pentobarbital-induced decrease in cholinergic neuronal activity. Commun. Psychopharmacol. 1977, 1:469-473.
29. Teixido M., Prokai-Tatrai K., Wang X., Nguyen V., Prokai L. Exploratory neuropharmacological evaluation of a bridged thyrotropin-releasing hormone analogue. Brain Res. Bull. 2007, 73:103-107.
30. Yarbrough G.G. TRH potentiates excitatory actions of acetylcholine on cerebral cortical neurons. Nature 1976, 263:523-552.