Neuropharmacodynamic evaluation of the centrally active thyrotropin-releasing hormone analogue [Leu2]TRH and its chemical brain-targeting system

Brain Research

Volumn 952, Issue 2, 2002, Pages 268-274

  Prokai, Laszlo ^a   Zharikova, Alevtina D ^a  

^a UNIVERSITY OF FLORIDA HEALTH   (United States)

Author keywords

Acetylcholine; Brain delivery; In vivo microdialysis; TRH analogue

Indexed keywords

ACETYLCHOLINE; PEPTIDE; PROTIRELIN; PROTIRELIN DERIVATIVE;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN PERFUSION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG EFFICACY; HIPPOCAMPUS; IN VIVO STUDY; MALE; MICRODIALYSIS; NEUROPHARMACOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT;

ACETYLCHOLINE; ANIMALS; BRAIN; DRUG DELIVERY SYSTEMS; DRUG EVALUATION, PRECLINICAL; HIPPOCAMPUS; MALE; MICRODIALYSIS; PYRROLIDONECARBOXYLIC ACID; RATS; RATS, SPRAGUE-DAWLEY; THYROTROPIN-RELEASING HORMONE;

EID: 0037131089     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(02)03251-1     Document Type: Article

References (38)

1. Bassiri R.M., Utiger R.D. Metabolism and excretion of exogenous thyrotropin-releasing hormone in humans. J. Clin. Invest. 52:1973;1616-1619.
2. Bodor N., Prokai L., Wu W.-M., Farag H., Jonalagadda S., Kawamura M., Simpkins J.W. A strategy for delivering peptides into the central nervous system by sequential metabolism. Science. 257:1992;1698-1700.
3. Breese G., Cott J., Cooper B., Prange A., Lippton M., Plotnikoff N. Effects of thyrotropin-releasing hormone (TRH) on the actions of phenobarbital and other centrally acting drugs. J. Pharmacol. Exp. Ther. 193:1975;11-22.
4. Elmquist W.F., Sawchuk R.J. Application of microdialysis in pharmacokinetic studies. Pharm. Res. 14:1997;267-288.
5. Flohé L., Bauer K., Friedrichs E., Günzler W.A., Hennies H.H., Herring S., Lagler F., Ötting F., Schwertner E. Biological effects of degradation-stabilized TRH analogues. Griffiths E., Bennett G.W., Thyrotropin-Releasing Hormone. 1983;327-340 Raven Press, New York.
6. Giacobini E. Cholinergic receptors in human brain - effects of aging and Alzheimer-disease. J. Neurosci. Res. 27:1990;548-560.
7. Giovannini M.G., Casamenti F., Nistria A., Paoli F., Pepeu G. Effect of thyrotropin releasing hormone (TRH) on acetylcholine release from different brain areas investigated by microdialysis. Br. J. Pharmacol. 102:1991;363-368.
8. Hedner J., Hedner T., Wessberg P., Lundberg D., Jonason J. Effects of TRH and TRH analogues on the central regulation of breathing in the rat. Acta Physiol. Scand. 117:1983;427-437.
9. Horita A. An update on the CNS actions of TRH and its analogs. Life Sci. 62:1998;1443-1448.
10. Horita A., Carino M.A., Lai H. Pharmacology of thyrotropin releasing hormone. Annu. Rev. Pharmacol. Toxicol. 26:1986;311-332.
11. Horita A., Carino M., Lai H. Analeptic activity produced by TRH microinjection into basal forebrain area in the rat. Fed. Proc. 45:1986;795.
12. Horita A., Carino M., Smith J. Effects of TRH on the central nervous system of the rabbit. Pharmacol. Biochem. Behav. 5:1976;111-116.
13. Hutson P.H., Semark J.E., Middlemiss D.N. The TRH analogue MK-771 increases acetylcholine release in hippocampus but not striatum of the conscious rat. Neurosci. Lett. 116:1990;149-155.
14. Kalivas P., Horita A. Thyrotropin-releasing hormone: neurogenesis of action in the pentobarbital narcotized rat. J. Pharmacol. Exp. Ther. 212:1980;203-210.
15. Kelly J.A., Slator G.R., Tipton K.F., Williams C.H., Bauer K. Kinetic investigation of the specificity of porcine brain thyrotropin-releasing hormone-degrading ectoenzyme for thyrotropin-releasing hormone-like peptides. J. Biol. Chem. 275:2000;16746-16751.
16. Kraemer G., Mueller R., Breese G., Prange A. Jr., Lewis J., Morrison H., McKinnee W. Jr. Thyrotropin releasing hormone: antagonism of phenobarbital narcosis in the monkey. Pharmacol. Biochem. Behav. 4:1976;709-712.
17. Lampe T., Norris J., Risse S., Owens-Williams E., Keenan T. Therapeutic potential of thyrotropin-releasing hormone and lecithin co-administration in Alzheimer's disease. Iqbal K., McLachlan D.R.C., Winbald B., Wishniewski C.H.M., Alzheimer's Disease: Basic Mechanisms, Diagnosis and Therapeutic Strategies. 1991;643-648 Wiley, New York.
18. Mellow A.M., Aronson S.M., Giordani B., Berent S. A peptide enhancement strategy in Alzheimer's disease: pilot study with TRH-physostigmine infusions. Biol. Psychiatry. 34:1993;271-273.
19. Mellow A.M., Sunderland T., Cohen R., Lawlor B., Hill J., Newhouse P., Cohen M., Murphy D. Acute effects of high-dose thyrotropin-releasing hormone infusion in Alzheimer's disease. Psychopharmacology. 98:1989;403-407.
20. Metcalf G. Regulatory peptides as a source of new drugs - the clinical prospects for analogues of TRH which are resistant to metabolic degradation. Brain Res. Rev. 4:1982;389-408.
21. Meisenberg G., Simmons W. Peptides and the blood-brain-barrier. Life Sci. 32:1983;2611-2623.
22. Miyamota M., Nagai Y., Norumi S., Saji Y., Nagawa Y. TRH and its novel analog (DN-1417): antipentobarbital action and involvement of cholinergic mechanism. Pharmacol. Biochem. Behav. 17:1982;797-806.
23. Narumi S., Nagai Y., Miyamoto M., Nagawa Y. Thyrotropin-releasing hormone (TRH) and its analog (DN-1417): interaction with pentobarbital in choline uptake and acetylcholine synthesis of rat brain slices. Life Sci. 32:1983;1637-1645.
24. Nutt R.F., Holly F.W., Homnick C., Hirschman R., Veber D.F. Synthesis of thyrotropin-releasing hormone analogues with selective central nervous system effects. J. Med. Chem. 24:1981;692-698.
25. Oka M., Oichi Y., Furukawa K., Ito T., Miura Y., Karasawa T., Kadokawa T. L-6-Ketopiperidine-2-carbonyl-L-leucyl-L-proline amide as a novel thyrotropin releasing hormone analog with improving effects on impaired central nervous system functions. Arzneim.-Forsch. Drug Res. 39:1989;297-303.
26. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates. 2nd Edition:1986;Academic Press, San Diego, CA.
27. Peabody C., Deblois T., Tinkelberg J. Thyrotropin-releasing hormone (TRH) and Alzheimer's disease. Am. J. Psychiatry. 143:1986;262-263.
28. Prokai L. Peptide drug delivery into the central nervous system. Jucker E.M., Progress in Drug Research. Vol. 51:1998;95-131 Birkhäuser, Basel.
29. Prokai L., Ouyang X., Wu W.-M., Bodor N. Chemical delivery system to transport a pyroglutamylpeptide amide to the central nervous system. J. Am. Chem. Soc. 116:1994;2643-2644.
30. Prokai L., Ouyang X., Prokai-Tatrai K., Simpkins J.W., Bodor N. Synthesis and behavioral evaluation of a chemical brain-targeting system for a thyrotropin-releasing hormone analog. Eur. J. Med. Chem. 33:1998;879-886.
31. Prokai L., Prokai-Tatrai K., Bodor N. Targeting drugs to the brain by redox chemical delivery systems. Med. Res. Rev. 20:2000;367-416.
32. Prokai L., Prokai-Tatrai K., Ouyang X., Wu W.-M., Kim H.-S., Zharikova A., Bodor N. Metabolism-based brain-targeting system for a thyrotropin-releasing hormone analogue. J. Med. Chem. 42:1999;4563-4571.
33. Schröder H., Giacobini E., Struble R., Zilles K., Maelicke A. Nicotinic cholinoceptive neurons of the frontal-cortex are reduced in Alzheimer's disease. Neurobiol. Aging. 12:1991;259-262.
34. Sirén A.-L., Lake C.R., Feuerstein G. Hemodynamic and neural mechanisms of action of thyrotropin-releasing hormone in the rat. Circ. Res. 62:1988;139-154.
35. Sunderland T., Mellow A., Gross M., Cohen R., Tariot P., Newhouse P., Murphy D. Thyrotropin-releasing hormone and dementia. Am. J. Psychiatry. 143:1986;1381.
36. Szirtes T., Kisfaludy L., Palosi E., Szporny L. Synthesis of thyrotropin-releasing hormone analogues. I. Complete dissociation of central nervous system effects from thyrotropin-releasing activity. J. Med. Chem. 27:1984;741-745.
37. Toide K., Shinoda M., Takase M., Iwata K., Yoshida H. Effects of a novel thyrotropin-releasing-hormone analog, JTP-2942, on extracellular acetylcholine and choline levels in the rat frontal-cortex and hippocampus. Eur. J. Pharmacol. 233:1993;21-28.
38. Vonhof S., Feuerstein G.Z., Cohen L.A., Labroo V.M. Norvaline2-TRH: binding to TRH receptors in rat brain homogenates. Eur. J. Pharmacol. 180:1990;1-12.