Prodrugs to enhance central nervous system effects of the TRH-like peptide pGlu-Glu-Pro-NH2

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 6, 2003, Pages 1011-1014

  Prokai Tatrai, Katalin ^a   Nguyen, Vien ^b   Zharikova, Alevtina D ^b   Braddy, April C ^b   Stevens Jr , Stanley M ^b   Prokai, Laszlo ^b,c  

^a Department of Clinical and Health Psychology   (United States)

^b Department of Pharmaceutical Sciences and Experimental Therapeutics   (United States)

^c UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 GLUTAMYLGLUTAMYLPROLINAMIDE; ALCOHOL; DICYCLOHEXYLCARBODIIMIDE; PRODRUG; PROTIRELIN; TRIPEPTIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ARTIFICIAL MEMBRANE; BINDING AFFINITY; BLOOD BRAIN BARRIER; BRAIN REGION; BRAIN TISSUE; CENTRAL NERVOUS SYSTEM FUNCTION; CEREBROSPINAL FLUID; CHROMATOGRAPHY; CONTROLLED STUDY; DRUG CLEARANCE; DRUG SYNTHESIS; DRUG UPTAKE; LIPID MEMBRANE; MEMBRANE BINDING; NONHUMAN; RAT;

ANIMALIA;

EID: 0037463764     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(03)00081-7     Document Type: Article

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25. i is the dose (μmol/kg body weight), and h is the Hill coefficient. Five different doses per compound were used, and non-linear fitting yielded h=1.