Respiratory, autonomic, and experiential responses to repeated inhalations of 20% CO2 enriched air in panic disorder, social phobia, and healthy controls

Biological Psychology

Volumn 84, Issue 1, 2010, Pages 104-111

  Blechert, Jens ^a   Wilhelm, Frank H ^b   Meuret, Alicia E ^c   Wilhelm, Eva M ^b   Roth, Walton T ^d,e  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF BASEL   (Switzerland)

^c SOUTHERN METHODIST UNIVERSITY   (United States)

^d STANFORD UNIVERSITY   (United States)

^e VA PALO ALTO HEALTH CARE SYSTEM   (United States)

Author keywords

Anxiety disorder; Biological challenge; Carbon dioxide; Habituation; Psychophysiology; Sensitization

Indexed keywords

ADULT; ANXIETY; ARTICLE; AUTONOMIC NERVOUS SYSTEM; AWARENESS; BREATHING; BREATHING RATE; CARBON DIOXIDE BREATHING; CLINICAL ARTICLE; COGNITION; CONTROLLED STUDY; DYSPNEA; FEMALE; FLOW RATE; HABITUATION; HUMAN; MALE; PANIC; PRIORITY JOURNAL; PSYCHOPHYSIOLOGY; QUESTIONNAIRE; SENSITIVITY ANALYSIS; SENSITIZATION; SOCIAL PHOBIA; TIDAL VOLUME;

ADMINISTRATION, INHALATION; ADULT; ANALYSIS OF VARIANCE; ANXIETY; AUTONOMIC NERVOUS SYSTEM; CARBON DIOXIDE; DYSPNEA; ELECTROCARDIOGRAPHY; FEMALE; HUMANS; MALE; MIDDLE AGED; PANIC DISORDER; PHOBIC DISORDERS; RESPIRATION; TIDAL VOLUME;

EID: 77952287787     PISSN: 03010511     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsycho.2010.01.002     Document Type: Article

References (58)

1. Acheson D.T., Forsyth J.P., Prenoveau J.M., Bouton M.E. Interoceptive fear conditioning as a learning model of panic disorder: an experimental evaluation using 20% CO(2)-enriched air in a non-clinical sample. Behaviour Research and Therapy 2007, 45(10):2280-2294.
2. American Psychiatric Association (APA) Diagnostic and Statistical Manual of Mental Disorders 1994, American Psychiatric Association, Washington, DC. Fourth edition.
3. Barlow D.H., Brown T.A., Craske M.G. Definitions of panic attacks and panic disorder in the DSM-IV: implications for research. Journal of Abnormal Psychology 1994, 103(3):553-564.
4. Beck A.T., Ward C.H., Mendelson M., Mock J.E., Erbaugh J.K. An inventory for measuring depression. Archives of General Psychiatry 1961, 4:561-571.
5. Beck J.G., Shipherd J.C. Repeated exposure to interoceptive cues: does habituation of fear occur in panic disorder patients? A preliminary report. Behaviour Research and Therapy 1997, 35(6):551-557.
6. 2 inhalation in individuals with high anxiety sensitivity. Behaviour Research and Therapy 1999, 37(11):1073-1089.
7. Beck J.G., Shipherd J.C., Zebb B.J. How does interoceptive exposure for panic disorder work? An uncontrolled case study. Journal of Anxiety Disorders 1997, 11(5):541-556.
8. 2. Journal of Behavior Therapy and Experimental Psychiatry 2001, 32(1):1-16.
9. 2-induced panic attacks: a twin study. American Journal of Psychiatry 1998, 155(9):1184-1188.
10. Berntson G.G., Cacioppo J.T., Quigley K.S. Cardiac psychophysiology and autonomic space in humans: empirical perspectives and conceptual implications. Psychological Bulletin 1993, 114(2):296-322.
11. Bertani A., Perna G., Arancio C., Caldirola D., Bellodi L. Pharmacologic effect of imipramine, paroxetine, and sertraline on 35% carbon dioxide hypersensitivity in panic patients: a double-blind, random, placebo-controlled study. Journal of Clinical Psychopharmacology 1997, 17(2):97-101.
12. Blechert J., Michael T., Grossman P., Lajtman M., Wilhelm F.H. Autonomic and respiratory characteristics of posttraumatic stress disorder and panic disorder. Psychosomatic Medicine 2007, 69(9):935-943.
13. Bouton M.E., Mineka S., Barlow D.H. A modern learning theory perspective on the etiology of panic disorder. Psychological Review 2001, 108:4-32.
14. Brown T.A., Barlow D.H. Dimensional versus categorical classification of mental disorders in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders and beyond: comment on the special section. Journal of Abnormal Psychology 2005, 114(4):551-556.
15. Brown T.A., Barlow D.H. A proposal for a dimensional classification system based on the shared features of the DSM-IV anxiety and mood disorders: implications for assessment and treatment. Psychological Assessment 2009, 21(3):256-271.
16. 2 challenge test in patients with social phobia. Psychiatry Research 1997, 71(1):41-48.
17. Coryell W., Dindo L., Fyer A., Pine D.S. Onset of spontaneous panic attacks: a prospective study of risk factors. Psychosomatic Medicine 2006, 68(5):754-757.
18. Coryell W., Fyer A., Pine D., Martinez J., Arndt S. Aberrant respiratory sensitivity to CO(2) as a trait of familial panic disorder. Biological Psychiatry 2001, 49(7):582-587.
19. Deacon B.J., Abramowitz J.S., Woods C.M., Tolin D.F. The Anxiety Sensitivity Index - Revised: psychometric properties and factor structure in two nonclinical samples. Behaviour Research and Therapy 2003, 41(12):1427-1449.
20. 2 paradigm. Biological Psychology 2008, 78(1):87-92.
21. First M.B., Spitzer R.L., Gibbon M., Williams J.B.W. Structured Clinical Interview for DSM-IV Axis I Disorders 1995, American Psychiatric Press, Washington, DC.
22. Forsyth J.P., Eifert G.H. Response intensity in content-specific fear conditioning comparing 20% versus 13% CO-sub-2-enriched air as unconditioned stimuli. Journal of Abnormal Psychology 1998, 107(2):291-304.
23. Friedman B.H., Thayer J.F. Autonomic balance revisited: panic anxiety and heart rate variability. Journal of Psychosomatic Research 1998, 44(1):133-151.
24. Gorman J.M., Papp L.A., Martinez J., Goetz R.R., Hollander E., Liebowitz M.R., et al. High-dose carbon dioxide challenge test in anxiety disorder patients. Biological Psychiatry 1990, 28:743-757.
25. Griez E., Deloof C., Pols H., Zandbergen J., Lousberg H. Specific sensitivity of patients with panic attacks to carbon dioxide inhalation. Psychiatry Research 1990, 31(2):193-199.
26. Grossman P., Taylor E.W. Toward understanding respiratory sinus arrhythmia: relations to cardiac vagal tone, evolution and biobehavioral functions. Biological Psychology 2007, 74(2):263-285.
27. Haslan N. Categorical versus dimensional models of mental disorder-the taxonomic evidence. Australian and New Zealand Journal of Psychiatry 2003, 37(696-704):696.
28. Hayano J., Taylor J.A., Mukai S., Okada A., Watanabe Y., Takata K., et al. Assessment of frequency shifts in R-R interval variability and respiration with complex demodulation. Journal of Applied Physiology 1994, 77(6):2879-2888.
29. Kent J.M., Papp L.A., Martinez J.M., Browne S.T., Coplan J.D., Klein D.F., et al. Specificity of panic response to CO(2) inhalation in panic disorder: a comparison with major depression and premenstrual dysphoric disorder. American Journal of Psychiatry 2001, 158(1):58-67.
30. Klein D.F. False suffocation alarms, spontaneous panics, and related conditions. An integrative hypothesis. Archives of General Psychiatry 1993, 50(4):306-317.
31. Mackinnon D.F., Craighead B., Lorenz L. Carbon dioxide induces erratic respiratory responses in bipolar disorder. Journal of Affective Disorders 2008.
32. 2 as a therapeutic approach for panic disorder. Journal of Psychiatric Research 2008, 42(7):560-568.
33. Meuret A.E., Wilhelm F.H., Roth W.T. Respiratory feedback for treating panic disorder. Journal of Clinical Psychology 2004, 60(2):197-207.
34. Michael T., Blechert J., Vriends N., Margraf J., Wilhelm F.H. Fear conditioning in panic disorder: enhanced resistance to extinction. Journal of Abnormal Psychology 2007, 116(3):612-617.
35. Papp L.A., Klein D.F., Martinez J., Schneier F., Cole R., Liebowitz M.R., et al. Diagnostic and substance specificity of carbon-dioxide-induced panic. American Journal of Psychiatry 1993, 150(2):250-257.
36. Papp L.A., Martinez J.M., Klein D.F., Coplan J.D., Norman R.G., Cole R., et al. Respiratory psychophysiology of panic disorder: three respiratory challenges in 98 subjects. American Journal of Psychiatry 1997, 154(11):1557-1565.
37. Pelosi P., Croci M., Ravagnan I., Tredici S., Pedoto A., Lissoni A., et al. The effects of body mass on lung volumes, respiratory mechanics, and gas exchange during general anesthesia. Anesthesia and Analgesia 1998, 87(3):654-660.
38. Perna G., Bussi R., Allevi L., Bellodi L. Sensitivity to 35% carbon dioxide in patients with generalized anxiety disorder. Journal of Clinical Psychiatry 1999, 60(6):379-384.
39. Perna G., Gabriele A., Caldirola D., Bellodi L. Hypersensitivity to inhalation of carbon dioxide and panic attacks. Psychiatry Research 1995, 57(3):267-273.
40. 2 reactivity in patients with panic disorder. Journal of Psychosomatic Research 2003, 54(6):573-577.
41. Peterson R.A., Heilbronner R.L. The Anxiety Sensitivity Index: construct validity and factor analytic structure. Journal of Anxiety Disorders 1987, 1(2):117-121.
42. Rapee R.M. Psychological factors influencing the affective response to biological challenge in panic disorder. Journal of Anxiety Disorders 1995, 9(1):59-74.
43. Rassovsky Y., Kushner M.G. Carbon dioxide in the study of panic disorder: issues of definition, methodology, and outcome. Journal of Anxiety Disorders 2003, 17(1):1-32.
44. Reiss S., Peterson R.A., Gursky D.M., McNally R.J. Anxiety sensitivity, anxiety frequency, and the prediction of fearfulness. Behaviour Research and Therapy 1986, 24:1-8.
45. Ritz T. Studying noninvasive indices of vagal control: the need for respiratory control and the problem of target specificity. Biological Psychology 2009, 80(2):158-168.
46. Ritz T., Dahme B. Implementation and interpretation of respiratory sinus arrhythmia measures in psychosomatic medicine: practice against better evidence?. Psychosomatic Medicine 2006, 68(4):617-627.
47. Roth W.T., Wilhelm F.H., Trabert W. Voluntary breath holding in panic and generalized anxiety disorders. Psychosomatic Medicine 1998, 60(6):671-679.
48. Spielberger C.D., Gorsuch R.L., Luchene R.E. State-Trait Anxiety Inventory 1970, Consulting Psychology Press, Palo Alto.
49. Taylor S., Cox B.J. An expanded Anxiety Sensitivity Index: evidence for a hierarchic structure in a clinical sample. Journal of Anxiety Disorders 1998, 12(5):463-483.
50. Taylor S., Zvolensky M.J., Cox B.J., Deacon B., Heimberg R.G., Ledley D.R., et al. Robust dimensions of anxiety sensitivity: development and initial validation of the Anxiety Sensitivity Index-3. Psychological Assessment 2007, 19(2):176-188.
51. 2-enriched air inhalation. Behaviour Research and Therapy 1995, 33(5):517-527.
52. van den Bergh O., Stegen K., van de Woestijne K.P. Learning to have psychosomatic complaints: conditioning of respiratory behavior and somatic complaints in psychosomatic patients. Psychosomatic Medicine 1997, 59(1):13-23.
53. van den Bergh O., Stegen K., Van Diest I., Raes C., Stulens P., Eelen P., et al. Acquisition and extinction of somatic symptoms in response to odours: a Pavlovian paradigm relevant to multiple chemical sensitivity. Occupational and Environmental Medicine 1999, 56(5):295-301.
54. 2 exposure. American Journal of Psychiatry 1987, 144(6):788-791.
55. Van Diest I., De Peuter S., Piedfort K., Bresseleers J., Devriese S., Van de Woestijne K.P., et al. Acquired lightheadedness in response to odors after hyperventilation. Psychosomatic Medicine 2006, 68(2):340-347.
56. Wilhelm F.H., Gerlach A.L., Roth W.T. Slow recovery from voluntary hyperventilation in panic disorder. Psychosomatic Medicine 2001, 63(4):638-649.
57. Wilhelm F.H., Grossman P., Roth W.T. Assessment of heart rate variability during alterations in stress: complex demodulation vs. spectral analysis. Biomedical Sciences Instrumentation 2005, 41:346-351.
58. Wilhelm F.H., Trabert W., Roth W.T. Physiological instability in panic disorder and generalized anxiety disorder. Biological Psychiatry 2001, 49(7):596-605.