Progressive multifocal leucoencephalopathy in an immunocompetent patient with favourable outcome. A case report

BMC Neurology

Volumn 10, Issue , 2010, Pages

  Naess, Halvor ^a   Glad, Solveig ^a   Storstein, Anette ^a   Rinaldo, Christine H ^b   Mørk, Sverre J ^a   Myhr, Kjell Morten ^a   Hirsch, Hans ^c  

^a HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY HOSPITAL OF NORTH NORWAY   (Norway)

^c UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; CD4 ANTIGEN; CD56 ANTIGEN; CD8 ANTIGEN; CEFTRIAXONE; CIDOFOVIR; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4; DNA; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; METHYLPREDNISOLONE;

ADULT; ANTIBODY TITER; APHASIA; ARTICLE; BRAIN BIOPSY; BRAIN DAMAGE; CASE REPORT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CEREBROSPINAL FLUID ANALYSIS; CONVALESCENCE; DETERIORATION; DISEASE COURSE; DNA EXTRACTION; EARLY INTERVENTION; ENZYME IMMUNOASSAY; FOLLOW UP; HEMIANOPIA; HUMAN; IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME; IMMUNOCOMPETENCE; JC VIRUS; LIMB WEAKNESS; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTCOME ASSESSMENT; PLASMAPHERESIS; POLYMERASE CHAIN REACTION; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; RELAPSE; SEQUENCE ANALYSIS; TREATMENT OUTCOME; METHODOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADULT; HUMANS; IMMUNOCOMPETENCE; LEUKOENCEPHALOPATHY, PROGRESSIVE MULTIFOCAL; MAGNETIC RESONANCE IMAGING; MALE;

EID: 77952286293     PISSN: None     EISSN: 14712377     Source Type: Journal    
DOI: 10.1186/1471-2377-10-32     Document Type: Article

References (20)

1. Khanna N, Elzi L, Mueller NJ, Garzoni C, Cavassini M, Fux CA, Vernazza P, Bernasconi E, Battegay M, Hirsch HH. Incidence and outcome of progressive multifocal leukoencephalopathy over 20 years of the Swiss HIV Cohort Study. Clin Infect Dis 2009, 48(10):1459-1466. 10.1086/598335, 19348592.
2. Kappos L, Bates D, Hartung HP, Havrdova E, Miller D, Polman CH, Ravnborg M, Hauser SL, Rudick RA, Weiner HL, et al. Natalizumab treatment for multiple sclerosis: recommendations for patient selection and monitoring. Lancet Neurol 2007, 6(5):431-441. 10.1016/S1474-4422(07)70078-9, 17434098.
3. Carson KR, Evens AM, Richey EA, Habermann TM, Focosi D, Seymour JF, Laubach J, Bawn SD, Gordon LI, Winter JN, et al. Progressive multifocal leukoencephalopathy after rituximab therapy in HIV-negative patients: a report of 57 cases from the Research on Adverse Drug Events and Reports project. Blood 2009, 113(20):4834-4840. 10.1182/blood-2008-10-186999, 2686134, 19264918.
4. Carson KR, Focosi D, Major EO, Petrini M, Richey EA, West DP, Bennett CL. Monoclonal antibody-associated progressive multifocal leucoencephalopathy in patients treated with rituximab, natalizumab, and efalizumab: a Review from the Research on Adverse Drug Events and Reports (RADAR) Project. Lancet Oncol 2009, 10(8):816-824. 10.1016/S1470-2045(09)70161-5, 19647202.
5. Berger JR, Major EO. Progressive multifocal leukoencephalopathy. Semin Neurol 1999, 19(2):193-200. 10.1055/s-2008-1040837, 10718540.
6. De Luca A, Giancola ML, Ammassari A, Grisetti S, Cingolani A, Paglia MG, Govoni A, Murri R, Testa L, Monforte AD, et al. Cidofovir added to HAART improves virological and clinical outcome in AIDS-associated progressive multifocal leukoencephalopathy. Aids 2000, 14(14):F117-121. 10.1097/00002030-200009290-00001, 11061646.
7. Viallard JF, Lazaro E, Ellie E, Eimer S, Camou F, Caubet O, Lafon ME, Fleury H, Pellegrin JL. Improvement of progressive multifocal leukoencephalopathy after cidofovir therapy in a patient with a destructive polyarthritis. Infection 2007, 35(1):33-36. 10.1007/s15010-006-5103-y, 17297588.
8. Viallard JF, Lazaro E, Lafon ME, Pellegrin JL. Successful cidofovir therapy of progressive multifocal leukoencephalopathy preceding angioimmunoblastic T-cell lymphoma. Leuk Lymphoma 2005, 46(11):1659-1662. 10.1080/10428190500177995, 16334909.
9. Roberts MT, Carmichael A, Lever AM. Prolonged survival in AIDS-related progressive multifocal leucoencephalopathy following anti-retroviral therapy and cidofovir. Int J Antimicrob Agents 2003, 21(4):347-349. 10.1016/S0924-8579(02)00393-X, 12672581.
10. Marra CM, Rajicic N, Barker DE, Cohen BA, Clifford D, Donovan Post MJ, Ruiz A, Bowen BC, Huang ML, Queen-Baker J, et al. A pilot study of cidofovir for progressive multifocal leukoencephalopathy in AIDS. Aids 2002, 16(13):1791-1797. 10.1097/00002030-200209060-00012, 12218391.
11. Tan K, Roda R, Ostrow L, McArthur J, Nath A. PML-IRIS in patients with HIV infection: clinical manifestations and treatment with steroids. Neurology 2009, 72(17):1458-1464. 10.1212/01.wnl.0000343510.08643.74, 2677476, 19129505.
12. Linda H, von Heijne A, Major EO, Ryschkewitsch C, Berg J, Olsson T, Martin C. Progressive multifocal leukoencephalopathy after natalizumab monotherapy. N Engl J Med 2009, 361(11):1081-1087. 10.1056/NEJMoa0810316, 19741229.
13. Drachenberg CB, Papadimitriou JC, Mann D, Hirsch HH, Wali R, Ramos E. Negative impact of human leukocyte antigen matching in the outcome of polyomavirus nephropathy. Transplantation 2005, 80(2):276-278. 10.1097/01.TP.0000165096.01034.15, 16041275.
14. Egli A, Infanti L, Dumoulin A, Buser A, Samaridis J, Stebler C, Gosert R, Hirsch HH. Prevalence of polyomavirus BK and JC infection and replication in 400 healthy blood donors. J Infect Dis 2009, 199(6):837-846. 10.1086/597126, 19434930.
15. Price RW, Nielsen S, Horten B, Rubino M, Padgett B, Walker D. Progressive multifocal leukoencephalopathy: a burnt-out case. Ann Neurol 1983, 13(5):485-490. 10.1002/ana.410130503, 6307116.
16. Cinque P, Bossolasco S, Brambilla AM, Boschini A, Mussini C, Pierotti C, Campi A, Casari S, Bertelli D, Mena M, et al. The effect of highly active antiretroviral therapy-induced immune reconstitution on development and outcome of progressive multifocal leukoencephalopathy: study of 43 cases with review of the literature. J Neurovirol 2003, 9(Suppl 1):73-80.
17. Meintjes G, Lynen L. Prevention and treatment of the immune reconstitution inflammatory syndrome. Curr Opin HIV AIDS 2008, 3(4):468-476. 10.1097/COH.0b013e3282fe6e84, 19373007.
18. Langer-Gould A, Atlas SW, Green AJ, Bollen AW, Pelletier D. Progressive multifocal leukoencephalopathy in a patient treated with natalizumab. N Engl J Med 2005, 353(4):375-381. 10.1056/NEJMoa051847, 15947078.
19. Cardenas RL, Cheng KH, Sack K. The effects of cidofovir on progressive multifocal leukoencephalopathy: an MRI case study. Neuroradiology 2001, 43(5):379-382. 10.1007/s002340000495, 11396742.
20. Berenguer J, Miralles P, Arrizabalaga J, Ribera E, Dronda F, Baraia-Etxaburu J, Domingo P, Marquez M, Rodriguez-Arrondo FJ, Laguna F, et al. Clinical course and prognostic factors of progressive multifocal leukoencephalopathy in patients treated with highly active antiretroviral therapy. Clin Infect Dis 2003, 36(8):1047-1052. 10.1086/374048, 12684918.