Prolonged survival in AIDS-related progressive multifocal leucoencephalopathy following anti-retroviral therapy and cidofovir

International Journal of Antimicrobial Agents

Volumn 21, Issue 4, 2003, Pages 347-349

  Roberts, M T M ^a   Carmichael, A ^a   Lever, A M L ^a  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

Cidofovir; HAART; PML

Indexed keywords

ANTIRETROVIRUS AGENT; CIDOFOVIR; LAMIVUDINE; NEVIRAPINE; PROBENECID; STAVUDINE; VIRUS ANTIBODY;

ADULT; AIDS RELATED COMPLEX; ANTIBODY DETECTION; ARTICLE; CASE REPORT; CEREBELLAR ATAXIA; CLINICAL FEATURE; FOLLOW UP; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; INDEPENDENCE; JC VIRUS; MALE; MEDICAL EXAMINATION; MOTOR COORDINATION; NEPHROTOXICITY; PRIORITY JOURNAL; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; SURVIVAL; TREATMENT OUTCOME;

EID: 0037383015     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0924-8579(02)00393-X     Document Type: Article

References (13)

1. Fong I.W., Toma E. The natural history of progressive multifocal leucoencephalopathy in patients with AIDS. Clin. Infect. Dis. 20:1995;1305-1310.
2. De Clercq E. Therapeutic potential of cidofovir for the treatment of DNA virus infections. Verh. K. Acad. Geneeskd. Belg. 58:1996;19-47.
3. Britton CB, Romagnoli M, Sisti M et al. Progressive multifocal leucoencephalopathy: disease progression, stabilisation and response to intrathecal Ara-C in 26 patients [abstract Th 1512]. In: Program and abstracts of the 8th international conference on AIDS (Amsterdam). Amsterdam: CONGREX Holland BV, 1992.
4. Happe S., Lunenborg N., Rickert C.H., et al. Progressive multifocal leucoencephalopathy in AIDS. Overview and retrospective analysis of 17 patients. Nervenarzt. 71:2000;96-104.
5. Taoufik Y., Delfraissy J.F., Gasnault J. Highly active antiretroviral therapy does not improve survival of patients with high JC virus load in the cerebrospinal fluid at progressive multifocal leucoencephalopathy diagnosis. AIDS. 14:(14):2000;758-780.
6. Sasnault J., Taoufik Y., Goujard C., et al. Prolonged survival without neurological improvement in patients with AIDS-related progressive multifocal leucoencephalopathy on potent combined antiretroviral therapy. J. Neurovirol. 5:1999;421-429.
7. Moreno S., Miralles P., Diaz D., et al. Cytarabine therapy for progressive multifocal leucoencephalopathy in patients with AIDS. Clin. Infect. Dis. 23:1996;1066-1068.
8. Cundy K.C. Clinical pharmacokinetics of the antiviral nucleotide analogues cidofovir and adofovir. Clin. Pharmacokinet. 36:1999;127-143.
9. De Luca A., Giancola M.L., Ammassari A., et al. Cidofovir added to HAART improves virological and clinical outcome in AIDS-associated progressive multifocal leucoencephalopathy. AIDS. 29:(14):2000;F117-121.
10. Gasnault J, Taoufik Y, Abbed K et al. Experience of cidofovir in HIV-associated progressive multifocal leucoencephalopathy: clinical and virological monitoring. Sixth Conference on Retroviruses and Opportunistic Infections. Chicago, February 1999 [abstract 417].
11. Happe S., Besselmann M., Matheja P., et al. Cidofovir (vistide) in therapy of progressive multifocal leucoencephalopathy in AIDS. Review of the literature and report of 2 cases. Nervenarzt. 70:1999;935-943.
12. De Luca A., Fantoni M., Tartaglione T., Antmoni A. Response to cidofovir after failure of antiretroviral therapy alone in AIDS-associated progressive multifocal leucoencephalopathy. Neurology. 10:(52):1999;891-892.
13. Houston S., Roberts N., Mashinter L. Failure of cidofovir therapy in progressive multifocal leucoencephalopathy unrelated to human immunodeficiency virus. Clin. Infect. Dis. 32:2001;150-152.