Acidic pH as a determinant of TRI gene expression and trichothecene B biosynthesis in Fusarium graminearum

Food Additives and Contaminants - Part A

Volumn 27, Issue 5, 2010, Pages 710-717

  Merhej, J ^a   Boutigny, A L ^a   Pinson Gadais, L ^a   Richard Forget, F ^a   Barreau, C ^a  

^a CEMAGREF   (France)

Author keywords

Fusarium; pH; TRI gene; Trichoth c ne

Indexed keywords

PROTEIN TRI10; PROTEIN TRI101; PROTEIN TRI4; PROTEIN TRI5; PROTEIN TRI6; TERPENOID; TRANSCRIPTION FACTOR; TRICHOTHECENE B; UNCLASSIFIED DRUG;

ACIDIFICATION; ACIDITY; ARTICLE; CONTROLLED STUDY; FUNGAL GENE; FUNGAL GENETICS; FUNGAL GENOME; FUNGUS CULTURE; FUNGUS GROWTH; FUSARIUM CULMORUM; FUSARIUM GRAMINEARUM; GENE CLUSTER; GENE EXPRESSION; GENE INDUCTION; IN VITRO STUDY; MYCELIUM; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

ANIMALIA; FUSARIUM; FUSARIUM CULMORUM; GIBBERELLA ZEAE;

EID: 77952280813     PISSN: 19440049     EISSN: 14645122     Source Type: Journal    
DOI: 10.1080/19440040903514531     Document Type: Article

References (41)

1. Arst HN, Penalva MA. 2003. pH regulation in Aspergillus and parallels with higher eukaryotic regulatory systems. Trends Genet. 19(4):224-231.
2. Bennett JW, Klich M. 2003. Mycotoxins. Clin Microbiol Rev. 16(3):497-516.
3. Bhatnagar D, Yu J, Ehrlich KC. 2002. Toxins of filamentous fungi. Chem Immunol. 81:167-206.
4. Bily AC, Reid LM, Savard ME, Reddy R, Blackwell BA, Campbell CM, Krantis A, Durst T, Philogene BJR, Arnason JT, Regnault-Roger C. 2004. Analysis of Fusarium graminearum mycotoxins in different biological matrices by LC/MS. Mycopathology. 157:117-126.
5. Boutigny AL, Barreau C, Atanasova-Penichon V, Verdal-Bonnin MN, Pinson-Gadais L, Richard-Forget F. 2009. Ferulic acid, an efficient inhibitor of type B trichothecene biosynthesis and Tri gene expression in Fusarium liquid cultures. Mycol Res. 113:746-753.
6. Brown DW, Proctor RH, Dyer RB. 2003. Characterization of a Fusarium 2-gene cluster involved in trichothecene C-8 modification. J Agric Food Chem. 51:7936-7944.
7. Brown DW, Dyer RB, McCormick SP, Kendra DF, Plattner RD. 2004. Functional demarcation of the Fusarium core trichothecene gene cluster. Fungal Genet Biol. 4(4):454-462.
8. Cappellini RA, Peterson JL. 1965. CMC medium for stimulation of sporulation in Fusarium graminearum. Mycologia. 57:962-966.
9. Covarelli L, Turner A, Nicholson P. 2004. Repression of deoxynivalenol accumulation and expression of Tri genes in Fusarium culmorum by fungicides in vitro. Plant Pathol. 53:22-28.
10. Desjardins AE, Hohn TM, McCormick SP. 1993. Trichothecene biosynthesis in Fusarium species: chemistry, genetics, and significance. Microbiol Rev. 57(3):595-604.
11. Diez E, Alvaro J, Espeso EA, Rainbow L, Suarez T, Tilburn J, Arst Jr HN, Penalva MA. 2002. Activation of the Aspergillus PacC zinc finger transcription factor requires two proteolytic steps. EMBO J. 21(6):1350-1359.
12. Espeso EA, Penalva MA. 1996. Three binding sites for the Aspergillus nidulans PacC zinc-finger transcription factor are necessary and sufficient for regulation by ambient pH of the isopenicillin N synthase gene promoter. J Biol Chem. 271(46):28825-28830.
13. Flaherty J, Pirttila A, Bluhm B, Woloshuk C. 2003. PAC1, a pH-regulatory gene from Fusarium verticillioides. Appl Environ Microbiol. 69(9):5222-5227.
14. Gardiner DM, Osborne S, Kazan K, Manners JM. 2009. Low pH regulates the production of deoxynivalenol by Fusarium graminearum. Microbiology. 155(9):3149-3156.
15. Goswami RS, Kistler HC. 2004. Heading for disaster: Fusarium graminearum on cereal crops. Mol Plant Pathol. 5:515-525.
16. Hohn TM, Beremand PD. 1989. Isolation and nucleotide sequence of a sesquiterpene cyclase gene from the trichothecene-producing fungus Fusarium sporotrichioides. Gene. 79(1):131-138.
17. Hohn TM, McCormick SP, Desjardins AE. 1993. Evidence for a gene cluster involving trichothecene-pathway biosynthetic genes in Fusarium sporotrichioides. Curr Genet. 24(4):291-295.
18. Hohn TM, Desjardins AE, McCormick SP. 1995. The Tri4 gene of Fusarium sporotrichioides encodes a cytochrome P450 monooxygenase involved in trichothecene biosynthesis. Mol Gen Genet. 248(1):95-102.
19. Jernejc K, Legisa M. 2001. Activation of plasma membrane H+ -ATPase by ammonium ions in Aspergillus niger. Appl Microbiol Biotechnol. 57(3):368-373.
20. Jiao F, Kawakami A, Nakajima T. 2008. Effects of different carbon sources on trichothecene production and Tri gene expression by Fusarium graminearum in liquid culture. FEMS Microbiol Lett. 285(2):212-219.
21. Keller NP, Nesbitt C, Sarr B, Phillips TD, Burow GB. 1997. pH regulation of sterigmatocystin and aflatoxin biosynthesis in Aspergillus spp. Phytopathology. 87(6): 643-648.
22. Kimura M, Kaneko I, Komiyama M, Takatsuki A, Koshino H, Yoneyama K, Yamaguchi I. 1998. Trichothecene 3-O-acetyltransferase protects both the producing organism and transformed yeast from related mycotoxins. Cloning and characterization of Tri101. J Biol Chem. 273(3):1654-1661.
23. Kimura M, Tokai T, O'Donnell K, Ward TJ, Fujimura M, Hamamoto H, Shibata T, Yamaguchi I. 2003. The trichothecene biosynthesis gene cluster of Fusarium graminearum F15 contains a limited number of essential pathway genes and expressed non-essential genes. FEBS Lett. 539(1-3):105-110.
24. Kimura M, Tokai T, Takahashi-Ando N, Ohsato S, Fujimura M. 2007. Molecular and genetic studies of Fusarium trichothecene biosynthesis: pathways, genes, and evolution. Biosci Biotechnol Biochem. 71(9): 2105-2123.
25. Lee T, Han YK, Kim KH, Yun SH, Lee YW. 2002. Tri13 and Tri7 determine deoxynivalenol- and nivalenolproducing chemotypes of Gibberella zeae. Appl Environ Microbiol. 68(5):2148-2154.
26. McCormick SP, Harris LJ, Alexander NJ, Ouellet T, Saparno A, Allard S, Desjardins AE. 2004. Tri1 in Fusarium graminearum encodes a P450 oxygenase. Appl Environ Microbiol. 70. 4:2044-2051.
27. Miller JD, Greenhalgh R. 1985. Nutrients effects on biosynthesis of trichothecenes and other metabolites by Fusarium graminearum. Mycologia. 77:130-136.
28. Penalva MA, Tilburn J, Bignell E, Arst Jr HN. 2008. Ambient pH gene regulation in fungi: making connections. Trends Microbiol. 16(6):291-300.
29. Peplow AW, Tag AG, Garifullina GF, Beremand MN. 2003. Identification of new genes positively regulated by Tri10 and a regulatory network for trichothecene mycotoxin production. Appl Environ Microbiol. 69(5):2731-2736.
30. Pfaffl MW. 2001. A new mathematical model for relative quantification in Real-Time RT-PCR. Nucleic Acids Res. 29:2002-2007.
31. ®) for group-wise comparison and statistical analysis of relative expression results in Real-Time PCR. Nucleic Acids Res. 30:1-10.
32. Pinson-Gadais L, Richard-Forget F, Frasse P, Barreau C, Cahagnier B, Richard-Molard D, Bakan B. 2008. Magnesium represses trichothecene biosynthesis and modulates Tri5, Tri6, and Tri12 genes expression in Fusarium graminearum. Mycopathology. 165(1):51-59.
33. Ponts N, Pinson-Gadais L, Barreau C, Richard-Forget F, Ouellet T. 2007. Exogenous H(2)O(2) and catalase treatments interfere with Tri genes expression in liquid cultures of Fusarium graminearum. FEBS Lett. 581(3): 443-447.
34. Proctor RH, Hohn TM, McCormick SP, Desjardins AE. 1995. Tri6 encodes an unusual zinc finger protein involved in regulation of trichothecene biosynthesis in Fusarium sporotrichioides. Appl Environ Microbiol. 61(5): 1923-1930.
35. Schmidt-Heydt M, Magan N, Geisen R. 2008. Stress induction of mycotoxin biosynthesis genes by abiotic factors. FEMS Microbiol Lett. 284(2):142-149.
36. Seong KY, Pasquali M, Zhou X, Song J, Hilburn K, McCormick S, Dong Y, Xu JR, Kistler HC. 2009. Global gene regulation by Fusarium transcription factors Tri6 and Tri10 reveals adaptations for toxin biosynthesis. Mol Microbiol. 72(2):354-367.
37. Tag AG, Garifullina GF, Peplow AW, Ake Jr C, Phillips TD, Hohn TM, Beremand MN. 2001. A novel regulatory gene, Tri10, controls trichothecene toxin production and gene expression. Appl Environ Microbiol. 67(11):5294-5302.
38. Tilburn J, Sarkar S, Widdick DA, Espeso EA, Orejas M, Mungroo J, Penalva MA, Arst Jr HN. 1995. The Aspergillus PacC zinc finger transcription factor mediates regulation of both acid- and alkaline-expressed genes by ambient pH. EMBO J. 14(4):779-790.
39. Tokai T, Koshino H, Takahashi-Ando N. 2007. Fusarium Tri4 encodes a key multifunctional cytochrome P450 monooxygenase for four consecutive oxygenation steps in trichothecene biosynthesis. Biochem Biophys Res Commun. 353:412-417.
40. Vogel HJ. 1956. A convenient growth medium for Neurospora (Medium N). Microb Genet Bull. 13:42-43.
41. Xu XM, Berrie AM. 2005. Epidemiology of mycotoxigenic fungi associated with Fusarium ear blight and apple blue mould: a review. Food Addit Contam. 22(4):290-301.