Effects of antenatal dexamethasone treatment on glucocorticoid receptor and calcyon gene expression in the prefrontal cortex of neonatal and adult common marmoset monkeys

Behavioral and Brain Functions

Volumn 6, Issue , 2010, Pages

  Diaz Heijtz, Rochellys ^a,b,c   Fuchs, Eberhard ^d   Feldon, Joram ^e   Pryce, Christopher R ^e,f   Forssberg, Hans ^b,c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b Stockholm Brain Institute   (Sweden)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^d GERMAN PRIMATE CENTER   (Germany)

^e ETH ZURICH   (Switzerland)

^f UNIVERSITY HOSPITAL OF PSYCHIATRY   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CALCYON; DEXAMETHASONE; GLUCOCORTICOID RECEPTOR; MESSENGER RNA; MINERALOCORTICOID RECEPTOR; PROTEIN; UNCLASSIFIED DRUG; GLUCOCORTICOID; MEMBRANE PROTEIN;

ADOLESCENT; ADULTHOOD; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATTENTION DEFICIT DISORDER; CONTROLLED STUDY; DRUG EXPOSURE; FEMALE; GENE EXPRESSION; GESTATION PERIOD; MALE; MARMOSET; NERVE CELL DIFFERENTIATION; NEWBORN; NEWBORN PERIOD; NONHUMAN; NUCLEOTIDE SEQUENCE; PREFRONTAL CORTEX; PREGNANCY; PRENATAL CARE; PRIORITY JOURNAL; PROTEIN EXPRESSION; AGE; ANIMAL; BODY SIZE; BODY WEIGHT; DRUG EFFECT; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; PHYSIOLOGY; PRENATAL EXPOSURE;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; BODY SIZE; BODY WEIGHT; CALLITHRIX; DEXAMETHASONE; FEMALE; GLUCOCORTICOIDS; MALE; MEMBRANE PROTEINS; PREFRONTAL CORTEX; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RECEPTORS, GLUCOCORTICOID; RECEPTORS, MINERALOCORTICOID; RNA, MESSENGER;

EID: 77952264652     PISSN: 17449081     EISSN: None     Source Type: Journal    
DOI: 10.1186/1744-9081-6-18     Document Type: Article

References (40)

1. Talge NM, Neal C, Glover V. Antenatal maternal stress and long-term effects on child neurodevelopment: how and why?. J Child Psychol Psychiatry 2007, 48:245-261. 10.1111/j.1469-7610.2006.01714.x, 17355398.
2. Rodriguez A, Bohlin G. Are maternal smoking and stress during pregnancy related to ADHD symptoms in children?. J Child Psychol Psychiatry 2005, 46:246-254. 10.1111/j.1469-7610.2004.00359.x, 15755301.
3. Eventov-Friedman S, Shinwell ES. Current controversies in perinatal steroid therapy. Acta Paediatr 2008, 97:1492-1501. 10.1111/j.1651-2227.2008.00907.x, 18565151.
4. Seckl JR. Glucocorticoids, developmental 'programming' and the risk of affective dysfunction. Prog Brain Res 2008, 167:17-34. full_text, 18037004.
5. Trautman PD, Meyer-Bahlburg HF, Postelnek J, New MI. Effects of early prenatal dexamethasone on the cognitive and behavioral development of young children: results of a pilot study. Psychoneuroendocrinology 1995, 20:439-449. 10.1016/0306-4530(94)00070-0, 8532827.
6. Hauser J, Knapman A, Zurcher NR, Pilloud S, Maier C, Diaz Heijtz R, et al. Effects of prenatal dexamethasone treatment on physical growth, pituitary-adrenal hormones, and performance of motor, motivational, and cognitive tasks in juvenile and adolescent common marmoset monkeys. Endocrinology 2008, 149:6343-6355. 10.1210/en.2008-0615, 18755792.
7. Franke B, Neale BM, Faraone SV. Genome-wide association studies in ADHD. Hum Genet 2009, 126:13-50. 10.1007/s00439-009-0663-4, 19384554.
8. Meyer-Lindenberg A, Weinberger DR. Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nat Rev Neurosci 2006, 7:818-827. 10.1038/nrn1993, 16988657.
9. Fisher SE, Francks C, McCracken JT, McGough JJ, Marlow AJ, MacPhie IL, et al. A genomewide scan for loci involved in attention-deficit/hyperactivity disorder. Am J Hum Genet 2002, 70:1183-1196. 10.1086/340112, 447594, 11923911.
10. Laurin N, Misener VL, Crosbie J, Ickowicz A, Pathare T, Roberts W, et al. Association of the calcyon gene (DRD1IP) with attention deficit/hyperactivity disorder. Mol Psychiatry 2005, 10:1117-1125. 10.1038/sj.mp.4001737, 16172615.
11. Loos M, Pattij T, Janssen MC, Counotte DS, Schoffelmeer AN, Smit AB, et al. Dopamine Receptor D1/D5 Gene Expression in the Medial Prefrontal Cortex Predicts Impulsive Choice in Rats. Cereb Cortex 2009,
12. Heijtz RD, Alexeyenko A, Castellanos FX. Calcyon mRNA expression in the frontal-striatal circuitry and its relationship to vesicular processes and ADHD. Behav Brain Funct 2007, 3:33. 10.1186/1744-9081-3-33, 1949817, 17623072.
13. Trantham-Davidson H, Vazdarjanova A, Dai R, Terry A, Bergson C. Up-regulation of calcyon results in locomotor hyperactivity and reduced anxiety in mice. Behav Brain Res 2008, 189:244-249. 10.1016/j.bbr.2007.12.031, 2442570, 18295356.
14. Oakman SA, Meador-Woodruff JH. Calcyon transcript expression in macaque brain. J Comp Neurol 2004, 468:264-276. 10.1002/cne.10993, 14648684.
15. Zelenin S, Aperia A, Diaz Heijtz R. Calcyon in the rat brain: cloning of cDNA and expression of mRNA. J Comp Neurol 2002, 446:37-45. 10.1002/cne.10198, 11920718.
16. Makris N, Biederman J, Monuteaux MC, Seidman LJ. Towards conceptualizing a neural systems-based anatomy of attention-deficit/hyperactivity disorder. Dev Neurosci 2009, 31:36-49. 10.1159/000207492, 19372685.
17. Levitt P. Structural and functional maturation of the developing primate brain. J Pediatr 2003, 143:S35-S45. 10.1067/S0022-3476(03)00400-1, 14597912.
18. Newnham JP, Jobe AH. Should we be prescribing repeated courses of antenatal corticosteroids?. Semin Fetal Neonatal Med 2009, 14:157-163. 10.1016/j.siny.2008.11.005, 19103515.
19. Hauser J, Dettling-Artho A, Pilloud S, Maier C, Knapman A, Feldon J, et al. Effects of prenatal dexamethasone treatment on postnatal physical, endocrine, and social development in the common marmoset monkey. Endocrinology 2007, 148:1813-1822. 10.1210/en.2006-1306, 17218413.
20. Saltzman W, Prudom SL, Schultz-Darken NJ, Wittwer DJ, Abbott DH. Social suppression of cortisol in female marmoset monkeys: role of circulating ACTH levels and glucocorticoid negative feedback. Psychoneuroendocrinology 2004, 29:141-161. 10.1016/S0306-4530(02)00159-2, 14604597.
21. Welberg LA, Seckl JR, Holmes MC. Prenatal glucocorticoid programming of brain corticosteroid receptors and corticotrophin-releasing hormone: possible implications for behaviour. Neuroscience 2001, 104:71-79. 10.1016/S0306-4522(01)00065-3, 11311532.
22. de Vries A, Holmes MC, Heijnis A, Seier JV, Heerden J, Louw J, et al. Prenatal dexamethasone exposure induces changes in nonhuman primate offspring cardiometabolic and hypothalamic-pituitary-adrenal axis function. J Clin Invest 2007, 117:1058-1067. 10.1172/JCI30982, 1821070, 17380204.
23. Pryce CR, Feldon J, Fuchs E, Knuesel I, Oertle T, Sengstag C, et al. Postnatal ontogeny of hippocampal expression of the mineralocorticoid and glucocorticoid receptors in the common marmoset monkey. Eur J Neurosci 2005, 21:1521-1535. 10.1111/j.1460-9568.2005.04003.x, 15845080.
24. Roberts AC, Tomic DL, Parkinson CH, Roeling TA, Cutter DJ, Robbins TW, et al. Forebrain connectivity of the prefrontal cortex in the marmoset monkey (Callithrix jacchus): an anterograde and retrograde tract-tracing study. J Comp Neurol 2007, 502:86-112. 10.1002/cne.21300, 17335041.
25. Fride E, Weinstock M. Increased interhemispheric coupling of the dopamine systems induced by prenatal stress. Brain Res Bull 1987, 18:457-461. 10.1016/0361-9230(87)90020-7, 2438016.
26. Weinstock M. The long-term behavioural consequences of prenatal stress. Neurosci Biobehav Rev 2008, 32:1073-1086. 10.1016/j.neubiorev.2008.03.002, 18423592.
27. Berger MA, Barros VG, Sarchi MI, Tarazi FI, Antonelli MC. Long-term effects of prenatal stress on dopamine and glutamate receptors in adult rat brain. Neurochem Res 2002, 27:1525-1533. 10.1023/A:1021656607278, 12512957.
28. French NP, Hagan R, Evans SF, Mullan A, Newnham JP. Repeated antenatal corticosteroids: effects on cerebral palsy and childhood behavior. Am J Obstet Gynecol 2004, 190:588-595. 10.1016/j.ajog.2003.12.016, 15041985.
29. Wapner RJ, Sorokin Y, Mele L, Johnson F, Dudley DJ, Spong CY, et al. Long-term outcomes after repeat doses of antenatal corticosteroids. N Engl J Med 2007, 357:1190-1198. 10.1056/NEJMoa071453, 17881751.
30. Veldhuis HD, Van Koppen C, Van Ittersum M, De Kloet ER. Specificity of the adrenal steroid receptor system in rat hippocampus. Endocrinology 1982, 110:2044-2051. 10.1210/endo-110-6-2044, 7075547.
31. Noorlander CW, de Graan PN, Middeldorp J, Van Beers JJ, Visser GH. Ontogeny of hippocampal corticosteroid receptors: effects of antenatal glucocorticoids in human and mouse. J Comp Neurol 2006, 499:924-932. 10.1002/cne.21162, 17072842.
32. Patel PD, Katz M, Karssen AM, Lyons DM. Stress-induced changes in corticosteroid receptor expression in primate hippocampus and prefrontal cortex. Psychoneuroendocrinology 2008, 33:360-367. 10.1016/j.psyneuen.2007.12.003, 2386086, 18222612.
33. Sanchez MM, Young LJ, Plotsky PM, Insel TR. Distribution of corticosteroid receptors in the rhesus brain: relative absence of glucocorticoid receptors in the hippocampal formation. J Neurosci 2000, 20:4657-4668.
34. Xiao J, Dai R, Negyessy L, Bergson C. Calcyon, a novel partner of clathrin light chain, stimulates clathrin-mediated endocytosis. J Biol Chem 2006, 281:15182-15193. 10.1074/jbc.M600265200, 16595675.
35. Negyessy L, Bergson C, Garab S, Simon L, Goldman-Rakic PS. Ultrastructural localization of calcyon in the primate cortico-basal ganglia-thalamocortical loop. Neurosci Lett 2008, 440:59-62. 10.1016/j.neulet.2008.05.047, 18539394.
36. Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schutz G, Umesono K, et al. The nuclear receptor superfamily: the second decade. Cell 1995, 83:835-839. 10.1016/0092-8674(95)90199-X, 8521507.
37. Kassel O, Herrlich P. Crosstalk between the glucocorticoid receptor and other transcription factors: molecular aspects. Mol Cell Endocrinol 2007, 275:13-29. 10.1016/j.mce.2007.07.003, 17689856.
38. Mao X, Zhu X, Hurren R, Ezzat S, Schimmer AD. Dexamethasone increases ubiquitin transcription through an SP-1 dependent mechanism in multiple myeloma cells. Leuk Res 2008, 32:1480-1482. 10.1016/j.leukres.2007.11.031, 18177934.
39. Tauber SC, Schlumbohm C, Schilg L, Fuchs E, Nau R, Gerber J. Intrauterine exposure to dexamethasone impairs proliferation but not neuronal differentiation in the dentate gyrus of newborn common marmoset monkeys. Brain Pathol 2006, 16:209-217. 10.1111/j.1750-3639.2006.00021.x, 16911478.
40. Tauber SC, Bunkowski S, Schlumbohm C, Ruhlmann M, Fuchs E, Nau R, et al. No long-term effect two years after intrauterine exposure to dexamethasone on dentate gyrus volume, neuronal proliferation and differentiation in common marmoset monkeys. Brain Pathol 2008, 18:497-503.