Editorial: Steatosis and fibrosis in paediatric liver transplant: Insidious graft's enemies - A call for clinical studies and research

Pediatric Transplantation

Volumn 14, Issue 4, 2010, Pages 441-444

  Nobili, Valerio ^a   Candusso, Manila ^a   Torre, Giuliano ^a   De Ville De Goyet, Jean ^a  

^a BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CLINICAL EFFECTIVENESS; CLINICAL RESEARCH; CLINICAL STUDY; DIABETES MELLITUS; DIAGNOSTIC ACCURACY; ECHOGRAPHY; EDITORIAL; ELASTOGRAPHY; FATTY LIVER; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; HEREDITY; HYPERLIPIDEMIA; HYPERTENSION; INCIDENCE; LIVER BIOPSY; LIVER FIBROSIS; LIVER TRANSPLANTATION; METABOLIC DISORDER; NONALCOHOLIC FATTY LIVER; OBESITY; PATHOPHYSIOLOGY; PATIENT MONITORING; PEDIATRICS; SENSITIVITY AND SPECIFICITY; SURGICAL RISK; WEIGHT; AGE; BIOPSY; CHILD; DISEASE PREDISPOSITION; FIBROSIS; GRAFT REJECTION; HUMAN; IMMUNOLOGY; LIFE EXPECTANCY; NUTRITIONAL STATUS; PATHOLOGY; POSTOPERATIVE COMPLICATION; RISK FACTOR; TIME;

IMMUNOSUPPRESSIVE AGENT;

AGE FACTORS; BIOPSY; CHILD; DISEASE SUSCEPTIBILITY; ELASTICITY IMAGING TECHNIQUES; FATTY LIVER; FIBROSIS; GRAFT REJECTION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LIFE EXPECTANCY; LIVER TRANSPLANTATION; NUTRITIONAL STATUS; POSTOPERATIVE COMPLICATIONS; RISK FACTORS; TIME FACTORS;

EID: 77952261521     PISSN: 13973142     EISSN: 13993046     Source Type: Journal    
DOI: 10.1111/j.1399-3046.2010.01324.x     Document Type: Editorial

References (22)

1. Soltys KA, Mazariegos GV, Squires RH, Sindhi RK, Anand R. Late graft loss or death in pediatric liver transplantation: An analysis of the SPLIT database. Am J Transplant 2007 : 7 : 2165 2171.
2. Ryckman FC, Bucuvalas JC, Nathan J, Alonso M, Tiao G, Balistreri WF. Outcomes following liver transplantation. Semin Pediatr Surg 2008 : 17 : 123 130.
3. Feng S. Long-term management of immunosuppression after pediatric liver transplantation: Is minimization or withdrawal desirable or possible or both? Curr Opin Organ Transplant 2008 : 13 : 506 512.
4. Veldt BJ, Poterucha JJ, Watt KD, et al. Insulin resistance, serum adipokines and risk of fibrosis progression in patients transplanted for hepatitis C. Am J Transplant 2009 : 9 : 1406 1413.
5. Toniutto P, Fabris C, Avellini C, et al. Excess body weight, liver steatosis, and early fibrosis progression due to hepatitis C recurrence after liver transplantation. World J Gastroenterol 2005 : 11 : 5944 5950.
6. Ekong UD, Melin-Aldana H, Seshadri R, et al. Graft histology characteristics in long-term survivors of pediatric liver transplantation. Liver Transpl 2008 : 14 : 1582 1587.
7. Burke A, Lucey MR. Non-alcoholic fatty liver disease, non-alcoholic steatohepatitis and orthotopic liver transplantation. Am J Transplant 2004 : 4 : 686 693.
8. Dumortier J, Giostra E, Belbouab S, et al. Non-alcoholic fatty liver disease in liver transplant recipients: Another story of "seed and soil." Am J Gastroenterol 2010 : 105 : 613 620.
9. Pagadala M, Dasarathy S, Eghtesad B, Mccullough AJ. Posttransplant metabolic syndrome: An epidemic waiting to happen. Liver Transpl 2009 : 15 : 1662 1670.
10. Mcalister VC, Haddad E, Renouf E, Malthaner RA, Kjaer MS, Gluud LL. Cyclosporin versus tacrolimus as primary immunosuppressant after liver transplantation: A meta-analysis. Am J Transplant 2006 : 6 : 1578 1585.
11. Tümgör G, Ankan C, Nart D, Kihiç M, Aydob̀du S. Fatty liver due to high levels of serum tacrolimus after liver transplantation. Turk J Pediatr 2007 : 49 : 223 225.
12. Wilfred De Alwis NM, Day CP. Genes and nonalcoholic fatty liver disease. Curr Diab Rep 2008 : 8 : 156 163.
13. Noujaim HM, De Ville De Goyet J, Montero EF, et al. Expanding postmortem donor pool using steatotic liver grafts: A new look. Transplantation 2009 : 87 : 919 925.
14. Botha JF, Thompson E, Gilroy R, et al. Mild donor liver steatosis has no impact on hepatitis C virus fibrosis progression following liver transplantation. Liver Int 2007 : 27 : 758 763.
15. Saadeh S, Younossi ZM, Remer EM, et al. The utility of radiological imaging in non-alcoholic fatty liver disease. Gastroenterology 2002 : 123 : 745 750.
16. Lim LG, Cheng CL, Wee A, et al. Prevalence and clinical associations of posttransplant fatty liver disease. Liver Int 2007 : 27 : 76 80.
17. Scheenstra R, Peeters PM, Verkade HJ, Gouw AS. Graft fibrosis after pediatric liver transplantation: Ten years of follow-up. Hepatology 2009 : 49 : 880 886.
18. Taylor RM, Franck LS, Gibson F, Donaldson N, Dhawan A. Study of the factors affecting health-related quality of life in adolescents after liver transplant. Am J Transplant 2009 : 9 : 1179 1188.
19. Ganschow R, Broering DC, Nolkemper D, et al. Th2 cytokine profile in infants predisposes to improved graft acceptance after liver transplantation. Transplantation 2001 : 72 : 929 934.
20. Magee JC. Graft fibrosis in stable pediatric liver transplant recipients: what does it mean? Hepatology 2009 : 49 : 726 728.
21. Nobili V, Parkes J, Bottazzo G, et al. Performance of ELF serum markers in predicting fibrosis stage in pediatric non-alcoholic fatty liver disease. Gastroenterology 2009 : 136 : 160 167.
22. Nobili V, Vizzutti F, Arena U, et al. Accuracy and reproducibility of transient elastography for the diagnosis of fibrosis in pediatric nonalcoholic steatohepatitis. Hepatology 2008 : 48 : 442 448.