5-HT1A receptor binding in euthymic bipolar patients using positron emission tomography with [carbonyl-11C]WAY-100635

Journal of Affective Disorders

Volumn 123, Issue 1-3, 2010, Pages 77-80

  Sargent, Peter A ^a,b   Rabiner, Eugenii A ^c   Bhagwagar, Zubin ^d   Clark, Luke ^e   Cowen, Philip ^a   Goodwin, Guy M ^a   Grasby, Paul M ^f  

^a WARNEFORD HOSPITAL   (United Kingdom)

^b OXFORD HEALTH NHS FOUNDATION TRUST   (United Kingdom)

^c HAMMERSMITH HOSPITAL   (United Kingdom)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UK   (United Kingdom)

^f IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

Bipolar; Imaging; Serotonin

Indexed keywords

CARBAMAZEPINE; CARBON 11; FLUOXETINE; LITHIUM CARBONATE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; PAROXETINE; SEROTONIN 1A RECEPTOR; VALPROIC ACID;

ADULT; ARTICLE; BIPOLAR DEPRESSION; BIPOLAR DISORDER; BRAIN REGION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HAMILTON SCALE; HUMAN; MAJOR DEPRESSION; MALE; POSITRON EMISSION TOMOGRAPHY; POSTSYNAPTIC MEMBRANE; PRIORITY JOURNAL; RECEPTOR BINDING; STRUCTURED CLINICAL INTERVIEW FOR DSM DISORDERS; TREATMENT OUTCOME;

ADULT; AGE FACTORS; BRAIN; CARBON RADIOISOTOPES; FEMALE; HUMANS; MALE; MIDDLE AGED; PIPERAZINES; POSITRON-EMISSION TOMOGRAPHY; PYRIDINES; RECEPTOR, SEROTONIN, 5-HT1A; REFERENCE VALUES; SEROTONIN ANTAGONISTS;

EID: 77952240976     PISSN: 01650327     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jad.2009.07.015     Document Type: Article

References (28)

1. Benkelfat C., Seletti B., Palmour R.M., Hillel J., Ellenbogen M., and Young S.N. Tryptophan depletion in stable lithium-treated patients with bipolar disorder in remission. Arch. Gen. Psychiatry 52 (1995) 154-156
2. Bhagwagar Z., Rabiner E.A., Sargent P.A., Grasby P.M., and Cowen P.J. Persistent reduction in brain serotonin1A receptor binding in recovered depressed men measured by positron emission tomography with [11C]WAY-100635. Mol. Psychiatry 9 (2004) 386-392
3. Blier P., and de Montigny C. Short-term lithium administration enhances serotonergic neurotransmission: electrophysiological evidence in the rat CNS. Eur. J. Pharmacol. 113 (1985) 69-77
4. Carli M., Afkhami-Dastjerdian D.S., and Reader T.A. Effects of a chronic lithium treatment on cortical serotonin uptake sites and 5-HT 1A receptors. Neurochem. Res. 22 (1997) 427-435
5. Drevets W.C., Frank E., Price J.C., Kupfer D.J., Holt D., Greer P.J., Huang Y., Gautier C., and Mathis C. PET imaging of serotonin 1A receptor binding in depression. Biol. Psychiatry 46 (1999) 1375-1387
6. Drevets W.C., Thase M.E., Moses-Kolko E.L., Price J., Frank E., Kupfer D.J., and Mathis C. Serotonin-1A receptor imaging in recurrent depression: replication and literature review. Nucl. Med. Biol. 34 (2007) 865-877
7. Elphick M., Yang J.D., and Cowen P.J. Effects of carbamazapine on dopamine- and serotonin-mediated neuroendocrine responses. Arch. Gen. Psychiatry 47 (1990) 135-139
8. 3H]hydroxytryptamine from rat brain cortical, hippocampal and hypothalamic slices. J. Neurochem. 50 (1988) 195-201
9. Glue P.W., Cowen P.J., Nutt D.J., Kolakowska T., and Grahame-Smith D.G. The effect of lithium on 5-HT-mediated neuroendocrine responses and platelet 5-HT receptors. Psychopharmacology 90 (1986) 398-402
10. 11C]WAY-100635 for PET. Neuroimage 8 (1998) 426-440
11. 11C]WAY-100635. Int. J. Neuropsychopharmacol. 11 (2008) 465-476
12. Hotta I., Yamawaki S., and Segawa T. Long-term lithium treatment causes serotonin receptor down-regulation via serotonergic presynapses in rat brain. Neuropsychobiology 16 (1986) 19-26
13. IA receptors in rat brain, assessed using in vivo microdialysis and PET after fenfluramine. Synapse 41 (2001) 150-159
14. Johnson L., El-Khoury A., Aberg-Wistedt A., Stain-Malmgren R., and Mathe A.A. Tryptophan depletion in lithium-stabilized patients with affective disorder. Int. J. Neuropsychopharmacol. 4 (2001) 329-336
15. Maes M., Calabrese J., Jayathilake K., and Meltzer H.Y. Effects of subchronic treatment with valproate on L-5-HTP-induced cortisol responses in mania: evidence for increased central serotonergic neurotransmission. Psychiatry Res. 71 (1997) 67-76
16. 11C carboxylation of an immobilized Gringard reagent. J Label Compounds Radio-pharm. 38 (1996) 941-953
17. McCance S.L., Cohen P.R., and Cowen P.J. Lithium increases 5-HT-mediated prolactin release. Psychopharmacology 99 (1989) 276-281
18. Meltzer H.Y., Lowry M., Robertson A., Goodnick P., and Perline R. Effect of 5-hydroxytryptophan on serum cortisol levels in major affective disorders. III. Effect of antidepressant and lithium carbonate. Arch. Gen. Psychiatry 41 (1984) 391-397
19. Mizuta T., and Segawa T. Chronic effects of imipramine and lithium on 5-HT receptor subtypes in rat frontal cortex, hippocampus and choroid plexus: quantitative receptor autoradiographic analysis. Jpn. J. Pharmacol. 50 (1989) 315-326
20. Muhlbauer H.D., and Muller-Oerlinghausen B. Fenfluramine stimulation of serum cortisol in patients with major affective disorder and healthy controls: further evidence for a central serotonergic action of lithium in man. J. Neural. Transm. 61 (1985) 81-94
21. Odagaki Y., Koyama T., Matsubara S., Matsubara R., and Yamashita I. Effects of chronic lithium treatment on serotonin binding sites in rat brain. J. Psychiatr. Res. 24 (1990) 271-277
22. Parsey R.V., Oquendo M.A., Ogden R.T., Olvet D.M., Simpson N., Huang Y.Y., Van Heertum R.L., Arango V., and Mann J.J. Altered serotonin 1A binding in major depression: a [carbonyl-C-11]WAY100635 positron emission tomography study. Biol Psychiatry 59 (2006) 106-113
23. Price L.H., Charney D.S., Delgado P.L., and Heninger G.R. Lithium treatment and serotonergic function: neuroendocrine responses and behavioural responses to intravenous L-tryptophan in affective disorder patients. Arch. Gen. Psychiatry 46 (1989) 13-19
24. 1A receptors in normal male volunteers; normative data and relationship to methodological, demographic, physiological and behavioral variables. Neuroimage 15 (2002) 620-632
25. 11C]WAY-100635: effects of depression and antidepressant treatment. Arch. Gen. Psychiatry 57 (2000) 174-180
26. Subhash M.N., Vinod K.Y., and Srinivas B.N. Differential effect of lithium on 5-HT1 receptor-linked system in regions of rat brain. Neurochem. Int. 35 (1999) 337-343
27. Treiser S.L., Cascio C.S., O Donohue T.L., Thoa N.B., Jacobowitz D.M., and Kellar K.J. Lithium increases serotonin release and decreases serotonin receptors in the hippocampus. Science 213 (1981) 1529-1531
28. Uchitomi Y., and Yamawaki S. Chronic lithium treatment enhances the postsynaptic 5-HT1A receptor-mediated 5-HT behavioral syndrome induced by 8-OH-DPAT in rats via catecholaminergic systems. Psychopharmacology 112 (1993) 74-79