-
1
-
-
33644510421
-
Genetic and epigenetic analysis of von Hippel-Lindau (VHL) gene alterations and relationship with clinical variables in sporadic renal cancer
-
Banks RE, Tirukonda P, Taylor C et al. Genetic and epigenetic analysis of von Hippel-Lindau (VHL) gene alterations and relationship with clinical variables in sporadic renal cancer. Cancer Res 2006; 66: 2000-2011.
-
(2006)
Cancer Res
, vol.66
, pp. 2000-2011
-
-
Banks, R.E.1
Tirukonda, P.2
Taylor, C.3
-
2
-
-
0029785321
-
Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein
-
Iliopoulos O, Levy AP, Jiang C et al. Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein. Proc Natl Acad Sci U S A 1996; 93: 10595-10599.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 10595-10599
-
-
Iliopoulos, O.1
Levy, A.P.2
Jiang, C.3
-
3
-
-
0042343801
-
A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer [see comment]
-
Maxwell PH, Wiesener MS, Chang GW et al. A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer [see comment]. N Engl J Med 2003; 349: 427-434.
-
(2003)
N Engl J Med
, vol.349
, pp. 427-434
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
-
5
-
-
2442621619
-
Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
-
Ferrara N, Hillan KJ, Gerber HP, Novotny W. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat Rev Drug Discov 2004; 3: 391-400.
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 391-400
-
-
Ferrara, N.1
Hillan, K.J.2
Gerber, H.P.3
Novotny, W.4
-
6
-
-
0042343801
-
A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
-
Yang JC, Haworth L, Sherry RM et al. A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med 2003; 349: 427-434.
-
(2003)
N Engl J Med
, vol.349
, pp. 427-434
-
-
Yang, J.C.1
Haworth, L.2
Sherry, R.M.3
-
7
-
-
37349080670
-
Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial
-
Escudier B, Pluzanska A, Koralewski P et al. Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial. Lancet 2007; 370: 2103-2111.
-
(2007)
Lancet
, vol.370
, pp. 2103-2111
-
-
Escudier, B.1
Pluzanska, A.2
Koralewski, P.3
-
8
-
-
0034896362
-
Inhibition of growth factor production and angiogenesis in human cancer cells by ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor
-
Ciardiello F, Caputo R, Bianco R et al. Inhibition of growth factor production and angiogenesis in human cancer cells by ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor. Clin Cancer Res 2001; 7: 1459-1465.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1459-1465
-
-
Ciardiello, F.1
Caputo, R.2
Bianco, R.3
-
9
-
-
0036651519
-
EGFR antisense treatment of human HNSCC cell lines down-regulates VEGF expression and endothelial cell migration
-
Riedel F, Gotte K, Li M et al. EGFR antisense treatment of human HNSCC cell lines down-regulates VEGF expression and endothelial cell migration. Int J Oncol 2002; 21: 11-16.
-
(2002)
Int J Oncol
, vol.21
, pp. 11-16
-
-
Riedel, F.1
Gotte, K.2
Li, M.3
-
10
-
-
35648938219
-
Randomized phase II study of erlotinib combined with bevacizumab compared with bevacizumab alone in metastatic renal cell cancer [see comment]
-
Bukowski RM, Kabbinavar FF, Figlin RA et al. Randomized phase II study of erlotinib combined with bevacizumab compared with bevacizumab alone in metastatic renal cell cancer [see comment]. J Clin Oncol 2007; 25: 4536-4541.
-
(2007)
J Clin Oncol
, vol.25
, pp. 4536-4541
-
-
Bukowski, R.M.1
Kabbinavar, F.F.2
Figlin, R.A.3
-
11
-
-
30944452354
-
Treatment of metastatic renal cell carcinoma with a combination of bevacizumab and erlotinib
-
Hainsworth JD, Sosman JA, Spigel DR et al. Treatment of metastatic renal cell carcinoma with a combination of bevacizumab and erlotinib. J Clin Oncol 2005; 23: 7889-7896.
-
(2005)
J Clin Oncol
, vol.23
, pp. 7889-7896
-
-
Hainsworth, J.D.1
Sosman, J.A.2
Spigel, D.R.3
-
12
-
-
70249115638
-
Phase II presurgical feasibility study of bevacizumab in untreated patients with metastatic renal cell carcinoma
-
Jonasch E, Wood CG, Matin SF et al. Phase II presurgical feasibility study of bevacizumab in untreated patients with metastatic renal cell carcinoma. J Clin Oncol 2009; 27: 4076-4081.
-
(2009)
J Clin Oncol
, vol.27
, pp. 4076-4081
-
-
Jonasch, E.1
Wood, C.G.2
Matin, S.F.3
-
13
-
-
17444411872
-
Oncocytic renal neoplasms: diagnostic considerations
-
vi
-
Abrahams NA, Tamboli P. Oncocytic renal neoplasms: diagnostic considerations. Clin Lab Med 2005; 25: 317-339, vi.
-
(2005)
Clin Lab Med
, vol.25
, pp. 317-339
-
-
Abrahams, N.A.1
Tamboli, P.2
-
14
-
-
34548141874
-
Non-parametric quantification of protein lysate arrays
-
Hu J, He X, Baggerly KA et al. Non-parametric quantification of protein lysate arrays. Bioinformatics 2007; 23: 1986-1994.
-
(2007)
Bioinformatics
, vol.23
, pp. 1986-1994
-
-
Hu, J.1
He, X.2
Baggerly, K.A.3
-
15
-
-
33750456480
-
Reverse phase protein array: validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoietic stem cells
-
Tibes R, Qiu Y, Lu Y et al. Reverse phase protein array: validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoietic stem cells. Mol Cancer Ther 2006; 5: 2512-2521.
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 2512-2521
-
-
Tibes, R.1
Qiu, Y.2
Lu, Y.3
-
18
-
-
44249091849
-
Automating dChip: toward reproducible sharing of microarray data analysis
-
Li C. Automating dChip: toward reproducible sharing of microarray data analysis. BMC Bioinformatics 2008; 9: 231.
-
(2008)
BMC Bioinformatics
, vol.9
, pp. 231
-
-
Li, C.1
-
20
-
-
0035829361
-
Controlling the false discovery rate in behavior genetics research
-
Benjamini Y, Drai D, Elmer G et al. Controlling the false discovery rate in behavior genetics research. Behav Brain Res 2001; 125: 279-284.
-
(2001)
Behav Brain Res
, vol.125
, pp. 279-284
-
-
Benjamini, Y.1
Drai, D.2
Elmer, G.3
-
21
-
-
0037655970
-
Unmasking the S-phase-promoting potential of cyclin B1
-
Moore JD, Kirk JA, Hunt T. Unmasking the S-phase-promoting potential of cyclin B1. Science 2003; 300: 987-990.
-
(2003)
Science
, vol.300
, pp. 987-990
-
-
Moore, J.D.1
Kirk, J.A.2
Hunt, T.3
-
22
-
-
33745899320
-
Alteration of subcellular and cellular expression patterns of cyclin B1 in renal cell carcinoma is significantly related to clinical progression and survival of patients
-
Ikuerowo SO, Kuczyk MA, Mengel M et al. Alteration of subcellular and cellular expression patterns of cyclin B1 in renal cell carcinoma is significantly related to clinical progression and survival of patients. Int J Cancer 2006; 119: 867-874.
-
(2006)
Int J Cancer
, vol.119
, pp. 867-874
-
-
Ikuerowo, S.O.1
Kuczyk, M.A.2
Mengel, M.3
-
23
-
-
0024565997
-
Cdc2 protein kinase is complexed with both cyclin A and B: evidence for proteolytic inactivation of MPF
-
Draetta G, Luca F, Westendorf J et al. Cdc2 protein kinase is complexed with both cyclin A and B: evidence for proteolytic inactivation of MPF. Cell 1989; 56: 829-838.
-
(1989)
Cell
, vol.56
, pp. 829-838
-
-
Draetta, G.1
Luca, F.2
Westendorf, J.3
-
24
-
-
1542618348
-
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
-
Shaw RJ, Kosmatka M, Bardeesy N et al. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci U S A 2004; 101: 3329-3335.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 3329-3335
-
-
Shaw, R.J.1
Kosmatka, M.2
Bardeesy, N.3
-
25
-
-
0037025356
-
AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling
-
Bolster DR, Crozier SJ, Kimball SR, Jefferson LS. AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling. J Biol Chem 2002; 277: 23977-23980.
-
(2002)
J Biol Chem
, vol.277
, pp. 23977-23980
-
-
Bolster, D.R.1
Crozier, S.J.2
Kimball, S.R.3
Jefferson, L.S.4
-
26
-
-
0345167800
-
TSC2 mediates cellular energy response to control cell growth and survival
-
Inoki K, Zhu T, Guan KL. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003; 115: 577-590.
-
(2003)
Cell
, vol.115
, pp. 577-590
-
-
Inoki, K.1
Zhu, T.2
Guan, K.L.3
-
27
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005; 307: 1098-1101.
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
28
-
-
0033551070
-
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
-
Cantley LC, Neel BG. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci U S A 1999; 96: 4240-4245.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 4240-4245
-
-
Cantley, L.C.1
Neel, B.G.2
-
29
-
-
34547105803
-
Energy depletion inhibits phosphatidylinositol 3-kinase/Akt signaling and induces apoptosis via AMP-activated protein kinase-dependent phosphorylation of IRS-1 at Ser-794
-
Tzatsos A, Tsichlis PN. Energy depletion inhibits phosphatidylinositol 3-kinase/Akt signaling and induces apoptosis via AMP-activated protein kinase-dependent phosphorylation of IRS-1 at Ser-794. J Biol Chem 2007; 282: 18069-18082.
-
(2007)
J Biol Chem
, vol.282
, pp. 18069-18082
-
-
Tzatsos, A.1
Tsichlis, P.N.2
-
30
-
-
65949116390
-
Adiponectin-activated AMPK stimulates dephosphorylation of AKT through protein phosphatase 2A activation
-
Kim KY, Baek A, Hwang JE et al. Adiponectin-activated AMPK stimulates dephosphorylation of AKT through protein phosphatase 2A activation. Cancer Res 2009; 69: 4018-4026.
-
(2009)
Cancer Res
, vol.69
, pp. 4018-4026
-
-
Kim, K.Y.1
Baek, A.2
Hwang, J.E.3
-
31
-
-
33750293584
-
Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling
-
Baba M, Hong SB, Sharma N et al. Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling. Proc Natl Acad Sci U S A 2006; 103: 15552-15557.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 15552-15557
-
-
Baba, M.1
Hong, S.B.2
Sharma, N.3
-
32
-
-
0037304479
-
Elevated Akt activation and its impact on clinicopathological features of renal cell carcinoma
-
Horiguchi A, Oya M, Uchida A et al. Elevated Akt activation and its impact on clinicopathological features of renal cell carcinoma. J Urol 2003; 169: 710-713.
-
(2003)
J Urol
, vol.169
, pp. 710-713
-
-
Horiguchi, A.1
Oya, M.2
Uchida, A.3
-
33
-
-
77953672577
-
Upfront, randomized, phase 2 trial of sorafenib versus sorafenib and low-dose interferon alfa in patients with advanced renal cell carcinoma: clinical and biomarker analysis
-
Oct 27 [Epub ahead of print]
-
Jonasch E, Corn P, Pagliaro LC et al. Upfront, randomized, phase 2 trial of sorafenib versus sorafenib and low-dose interferon alfa in patients with advanced renal cell carcinoma: clinical and biomarker analysis. Cancer 2009 Oct 27. [Epub ahead of print].
-
(2009)
Cancer
-
-
Jonasch, E.1
Corn, P.2
Pagliaro, L.C.3
-
34
-
-
33845309430
-
Activation of the mTOR signaling pathway in renal clear cell carcinoma
-
Robb VA, Karbowniczek M, Klein-Szanto AJ, Henske EP. Activation of the mTOR signaling pathway in renal clear cell carcinoma. J Urol 2007; 177: 346-352.
-
(2007)
J Urol
, vol.177
, pp. 346-352
-
-
Robb, V.A.1
Karbowniczek, M.2
Klein-Szanto, A.J.3
Henske, E.P.4
-
35
-
-
0036568448
-
Loss of tumor suppressor protein PTEN during renal carcinogenesis
-
Brenner W, Farber G, Herget T et al. Loss of tumor suppressor protein PTEN during renal carcinogenesis. Int J Cancer 2002; 99: 53-57.
-
(2002)
Int J Cancer
, vol.99
, pp. 53-57
-
-
Brenner, W.1
Farber, G.2
Herget, T.3
-
36
-
-
30044432434
-
Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer
-
Thomas GV, Tran C, Mellinghoff IK et al. Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer. Nat Med 2006; 12: 122-127.
-
(2006)
Nat Med
, vol.12
, pp. 122-127
-
-
Thomas, G.V.1
Tran, C.2
Mellinghoff, I.K.3
-
37
-
-
58049216350
-
Differential dependence of hypoxia-inducible factors 1 alpha and 2 alpha on mTORC1 and mTORC2
-
Toschi A, Lee E, Gadir N et al. Differential dependence of hypoxia-inducible factors 1 alpha and 2 alpha on mTORC1 and mTORC2. J Biol Chem 2008; 283: 34495-34499.
-
(2008)
J Biol Chem
, vol.283
, pp. 34495-34499
-
-
Toschi, A.1
Lee, E.2
Gadir, N.3
-
38
-
-
56849096837
-
HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma
-
Gordan JD, Lal P, Dondeti VR et al. HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma. Cancer Cell 2008; 14: 435-446.
-
(2008)
Cancer Cell
, vol.14
, pp. 435-446
-
-
Gordan, J.D.1
Lal, P.2
Dondeti, V.R.3
-
39
-
-
1542398693
-
Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma
-
Atkins MB, Hidalgo M, Stadler WM et al. Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma. J Clin Oncol 2004; 22: 909-918.
-
(2004)
J Clin Oncol
, vol.22
, pp. 909-918
-
-
Atkins, M.B.1
Hidalgo, M.2
Stadler, W.M.3
-
40
-
-
2942735384
-
Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer
-
Raymond E, Alexandre J, Faivre S et al. Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer. J Clin Oncol 2004; 22: 2336-2347.
-
(2004)
J Clin Oncol
, vol.22
, pp. 2336-2347
-
-
Raymond, E.1
Alexandre, J.2
Faivre, S.3
|