Coupled regulation of interleukin-12 receptor beta-1 of CD8+ central memory and CCR7-negative memory T cells in an early alloimmunity in liver transplant recipients

Clinical and Experimental Immunology

Volumn 160, Issue 3, 2010, Pages 420-430

  Egawa, H ^a   Ozawa, K ^b   Takada, Y ^a   Teramukai, S ^c   Mori, A ^a   Ogawa, K ^a   Kaido, T ^a   Fujimoto, Y ^a   Kawaguchi, Y ^a   Hatano, E ^a   Sato, H ^e   Ono, M ^b   Takai, K ^d   Tanaka, K ^f   Uemoto, S ^a  

^a KYOTO UNIVERSITY   (Japan)

^b Hepatic Disease Research Institute   (Japan)

^c KYOTO UNIVERSITY HOSPITAL   (Japan)

^d SRL INC   (Japan)

^e SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^f INSTITUTE OF BIOMEDICAL RESEARCH AND INNOVATION   (Japan)

Author keywords

CD8 T cells; Cytokine interleukin chemokine; Cytotoxicity; Liver transplantation; Memory cells

Indexed keywords

ALLOANTIGEN; CHEMOKINE RECEPTOR CCR7; CORTICOSTEROID; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; INTERLEUKIN 12 RECEPTOR BETA1; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PROSTAGLANDIN E1; RITUXIMAB; TACROLIMUS;

ACUTE GRAFT REJECTION; ADULT; ALLOIMMUNITY; ARTICLE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOTOXICITY; DISEASE SEVERITY; EFFECTOR CELL; FEMALE; GRAFT RECIPIENT; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOREGULATION; LIVER DISEASE; LIVER GRAFT; LIVER GRAFT REJECTION; MAJOR CLINICAL STUDY; MALE; MEMORY T LYMPHOCYTE; MULTIPLE ORGAN FAILURE; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; RETRANSPLANTATION; SEPSIS;

ADULT; CD8-POSITIVE T-LYMPHOCYTES; DOWN-REGULATION; FEMALE; GRAFT REJECTION; HUMANS; IMMUNOLOGIC MEMORY; INFECTION; INTERFERON-GAMMA; ISOANTIGENS; LIVER TRANSPLANTATION; LIVING DONORS; MALE; MIDDLE AGED; MULTIPLE ORGAN FAILURE; PERFORIN; RECEPTORS, CCR7; RECEPTORS, INTERLEUKIN-12; RETROSPECTIVE STUDIES; SEPSIS; TIME FACTORS; TRANSPLANTATION, HOMOLOGOUS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77952204230     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2010.04117.x     Document Type: Article

References (27)

1. Kobayashi H, Koga S, Novick AC, Toma H, Fairchild RL. T-cell mediated induction of allogeneic endothelial cell chemokine expression. Transplantation 2003 75 : 529 536. (Pubitemid 36241151)
2. Sallusto F, Lenig D, Förster R, Lipp M, Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999 401 : 708 712. (Pubitemid 129515761)
3. Sallusto F, Geginat J, Lanzavecchia A. Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu Rev Immunol 2004 22 : 745 763. (Pubitemid 38680440)
4. Adams AB, Williams MA, Jones TR et al. Heterologous immunity provides a potent barrier to transplantation tolerance. J Clin Invest 2003 111 : 1887 1895.
5. Oberbarnscheidt MH, Ng YH, Chalasani G. The roles of CD8 central and effector memory T-cell subsets in allograft rejection. Am J Transplant 2008 8 : 1809 1818.
6. Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 2003 3 : 133 146. (Pubitemid 37328691)
7. Gish RG, Krams SM, Martinez OM. Interleukin-12: a possible cytotoxic T-lymphocyte differentiation factor in allograft recipients. Transplant Proc 1995 27 : 459 460.
8. Piccotti JR, Li K, Chan SY, Eichwald EJ, Bishop DK. Interleukin-12 (IL-12)-driven alloimmune responses in vitro and in vivo: requirement for beta1 subunit of the IL-12 receptor. Transplantation 1999 67 : 1453 1460. (Pubitemid 29282989)
9. Egawa H, Uemoto S, Takada Y et al. Initial steroid bolus injection promotes vigorous CD8+ alloreactive responses toward early graft acceptance immediately after liver transplantation in humans. Liver Transpl 2007 13 : 1262 1271. (Pubitemid 47457053)
10. Tanaka K, Ozawa K, Teramukai S et al. Classification of human liver transplant recipients by their preoperative CD8+ T cell subpopulation and its relation to outcome. Liver Transpl 2006 12 : 792 800.
11. Uemoto S, Ozawa K, Egawa H et al. Serial assessment of immune status by circulating CD8+ effector T cell frequencies for posttransplant infectious complications. Clin Dev Immunol 2008 2008 : 718386. (Pubitemid 351845460)
12. Adams AB, Pearson TC, Larsen CP. Heterologous immunity: an overlooked barrier to tolerance. Immunol Rev 2003 196 : 147 160.
13. Welsh RM, Selin LK. No one is naive: the significance of heterologous T-cell immunity. Nat Rev Immunol 2002 2 : 417 426.
14. Tanaka K, Inomata Y, Kaihara S. Living-donor liver transplantation. Surgical techniques and innovation.
15. Kozaki K, Egawa H, Kasahara M et al. Therapeutic strategy and the role of apheresis therapy for ABO incompatible living donor liver transplantation. Ther Apher Dial 2005 9 : 285 291. (Pubitemid 41800795)
16. Banff Working Group, Demetris AJ, Adeyi O, Bellamy CO et al. Liver biopsy interpretation for causes of late liver allograft dysfunction. Hepatology 2006 44 : 489 501.
17. Uemoto S, Tanaka K, Fujita S et al. Infectious complications in living related liver transplantation. J Pediatr Surg 1994 29 : 514 517. (Pubitemid 24132656)
18. Bone RC. Let's agree on terminology: definitions of sepsis. Crit Care Med 1991 19 : 973 976.
19. Waldrop SL, Pitcher CJ, Peterson DM, Maino VC, Picker LJ. Determination of antigen-specific memory/effector CD4+ T cell frequencies by flow cytometry: evidence for a novel, antigen-specific homeostatic mechanism in HIV-associated immunodeficiency. J Clin Invest 1997 99 : 1739 1750.
20. Everitt BS, Landau S, Leese M. Hierarchical clustering. In : Everitt BS, Landau S, Leese M, eds. Cluster analysis, 4th edn.
21. Yu AS, Ahmed A, Keeffe EB. Liver transplantation: evolving patient selection criteria. Can J Gastroenterol 2001 15 : 729 738. (Pubitemid 34048410)
22. Debes GF, Arnold CN, Young AJ et al. Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues. Nat Immunol 2005 6 : 889 894.
23. Bromley SK, Thomas SY, Luster AD. Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics. Nat Immunol 2005 6 : 895 901. (Pubitemid 43090444)
24. Arnold CN, Butcher EC, Campbell DJ. Antigen-specific lymphocyte sequestration in lymphoid organs: lack of essential roles for alphaL and alpha4 integrin-dependent adhesion or Galphai protein-coupled receptor signaling. J Immunol 2004 173 : 866 873.
25. Denton MD, Magee CC, Sayegh MH. Immunosuppressive strategies in transplantation. Lancet 1999 353 : 1083 1091.
26. Valujskikh A. The challenge of inhibiting alloreactive T-cell memory. Am J Transplant 2006 6 : 647 651. (Pubitemid 43345000)
27. Fearon DT, Carr JM, Telaranta A, Carrasco MJ, Thaventhiran JE. The rationale for the IL-2-independent generation of the self-renewing central memory CD8+ T cells. Immunol Rev 2006 211 : 104 118. (Pubitemid 43882965)