Computational fluid dynamics analysis of blade tip clearances on hemodynamic performance and blood damage in a centrifugal ventricular assist device

Artificial Organs

Volumn 34, Issue 5, 2010, Pages 402-411

  Wu, Jingchun ^a   Paden, Bradley E ^b   Borovetz, Harvey S ^c   Antaki, James F ^d  

^a Safety Analysis and Forensic Engineering (SAFE)   (United States)

^b University of California   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

^d CARNEGIE MELLON UNIVERSITY   (United States)

Author keywords

Blade tip clearance; Computational fluid dynamics; Hemolysis; Left ventricular assist device; Optimization; Shear stress history

Indexed keywords

BLOOD; COMPUTATIONAL FLUID DYNAMICS; FIBER OPTIC SENSORS; FLOW PATTERNS; LEAKAGE (FLUID); LEFT VENTRICULAR ASSIST DEVICES; PUMPS; SHEAR FLOW; VORTEX FLOW;

BLADE-TIP CLEARANCES; BLOOD DAMAGE; FLUID DYNAMIC ANALYSIS; FLUID-DYNAMIC ANALYSIS; HAEMODYNAMICS; HAEMOLYSIS; OPTIMISATIONS; SHEAR STRESS HISTORY; STRESS HISTORY; VENTRICULAR ASSIST DEVICE;

SHEAR STRESS;

ARTICLE; BLADE TIP CLEARANCE; COMPUTATIONAL FLUID DYNAMICS; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; EQUIPMENT DESIGN; HEART ASSIST DEVICE; HEART HEMODYNAMICS; HEMOLYSIS; HYDRODYNAMICS; PHYSICAL PARAMETERS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SIMULATION; BIOLOGICAL MODEL; CHILD; COMPUTER SIMULATION; HEMODYNAMICS; HUMAN; MECHANICAL STRESS;

CHILD; COMPUTER SIMULATION; EQUIPMENT DESIGN; HEART-ASSIST DEVICES; HEMODYNAMICS; HEMOLYSIS; HUMANS; MODELS, BIOLOGICAL; STRESS, MECHANICAL;

EID: 77952203682     PISSN: 0160564X     EISSN: 15251594     Source Type: Journal    
DOI: 10.1111/j.1525-1594.2009.00875.x     Document Type: Article

References (27)

1. Goto A. Study of internal flows in a mixed-flow pump impeller at various tip clearances using three-dimensional viscous flow computations. ASME J Turbomach 1992 114 : 373 382.
2. Engeda A, Rautenberg M. Comparison of the relative effect of tip clearance on centrifugal impellers. ASME J Turbomach 1987 109 : 545 549.
3. Hirsch C, Kang S, Pointel GA. Numerically supported investigation of the 3-d flow in centrifugal impellers, Part II: secondary flow structure. ASME Paper 1996 96-GT-152.
4. Antaki JF, Ghattas O, Burgreen GW, He B. Computational flow optimization of rotary blood pump components. Artif Organs 1995 19 : 608 615.
5. Wu J, Antaki JF, Wagner W, Snyder T, Paden B, Borovetz H. Elimination of adverse leakage flow in a miniature pediatric centrifugal blood pump by computational fluid dynamics-based design optimization. ASAIO J 2005 51 : 636 643.
6. Antaki JF, Diao CG, Shu FJ, Wu JC, Zhao R, Kameneva MV. Microhaemodynamics within the blade tip clearance of a centrifugal turbodynamic blood pump. JEIM 2008 222 : 573 581.
7. Ichikawa S, Nosé Y. Centrifugal blood pumps for various clinical needs. Artif Organs 2002 26 : 916 918.
8. Bearnson G, Jacobs G, Kirk J, Khanwilkar P, Nelson K, Long J. HeartQuest ventricular assist device magnetically levitated centrifugal blood pump. Artif Organs 2006 30 : 339 346.
9. Chan WK, Wong YW, Ding Y, Chua LP, Yu SCM. Numerical investigation of the effect of blade geometry on blood trauma in a centrifugal blood pump. Artif Organs 2002 26 : 785 793.
10. Wu J, Shimmei K, Tani K, Niikura K, Sato J. CFD-based design optimization for hydro turbines. ASME J Fluids Eng 2007 129 : 159 168.
11. Rogers DF. An Introduction to NURBS: With Historical Perspective.
12. Japikse D, Marscher W, Furst R. Centrifugal Pump Design and Performance. Concepts ETI, Inc., 1997.
13. Stepanoff AJ. Centrifugal and Axial Flow Pumps: Theory, Design and Application.
14. CFX ANSYS, User's Guide, 2006.
15. Mitoh A, Yano T, Sekine K, et al. Computational fluid dynamics analysis of an intra-cardiac axial flow pump. Artif Organs 2003 27 : 34 40.
16. Wu J, Antaki JF, Snyder TA, Wagner WR, Borovetz HS, Paden BE. Design optimization of blood shearing instrument by computational fluid dynamics. Artif Organs 2005 29 : 482 489.
17. Giersiepen M, Wurzinger LJ, Optiz R, Reul H. Estimation of shear stress-related blood damage in heart valve prostheses - in vitro comparison of 25 aortic valves. Int J Artif Organs 1990 13 : 300 306.
18. Heuser G, Optiz RA. Couette viscometer for short time shearing of blood. Biorheology 1980 17 : 17 24.
19. Yeleswarapu K, Antaki JF, Kameneva M, Rajagopal K. A mathematical model for shear-induced hemolysis. Artif Organs 1995 19 : 576 582.
20. Yokobori T. An Interdisciplinary Approach to Fracture and Strength of Solids.
21. Bludszuweit C. Model for a general mechanical blood damage prediction. Artif Organs 1995 19 : 583 589.
22. Dey D, Camci C. Development of tip clearance flow downstream of a rotor blade with coolant injection from a tip trench. Proceedings of the 8th International Symposium on Transport Phenomena and Dynamics of Rotating Machinery, March 2000 572 579.
23. Anderson J, Wood H, Allaire P, Bearnson G, Khanwilkar P. Computational flow study of the continuous flow ventricular assist device, prototype number 3 blood pump. Artif Organs 2000 24 : 377 385. (Pubitemid 30353915)
24. Song X, Wood H, Olson D. Computational fluid dynamics (CFD) study of the 4th generation prototype of a continuous flow ventricular assist device (VAD). ASME J Biomech Eng 2004 126 : 180 187. (Pubitemid 38621130)
25. Kataoka H, Takatani S. Measurement and simulation of hemolysis in a hydrodynamic bearing of a centrifugal blood pump. ASAIO 2006 52 : 7A.
26. James NL, Wilkinson C, Lingard N, Meer AL, Woodard J. Evaluation of hemolysis in the VentrAssist implantable rotary blood pump. Artif Organs 2003 27 : 108 113. (Pubitemid 36114852)
27. Fåhraeus R. Suspension stability of the blood. Physiol Rev 1929 9 : 241 274.