Microhaemodynamics within the blade tip clearance of a centrifugal turbodynamic blood pump

Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine

Volumn 222, Issue 4, 2008, Pages 573-581

  Antaki, J F ^a   Diao, C G ^a   Shu, F J ^a   Wu, J C ^b   Zhao, R ^a   Kameneva, M V ^c  

^a CARNEGIE MELLON UNIVERSITY   (United States)

^b LaunchPoint Technologies LLC   (United States)

^c University of Pittsburgh   (United States)

Author keywords

Blood damage; Cellular dynamics; Haemolysis; Hydrodynamics; Left ventricular assist device; Microscopic flow visualization; Shear stress

Indexed keywords

CELLS; CENTRIFUGAL PUMPS; COMPUTER NETWORKS; CONCENTRATION (PROCESS); CONTINUUM MECHANICS; CYTOLOGY; GALLIUM ALLOYS; HYDRAULIC MACHINERY; MERCURY (METAL); PUMPS; REAL TIME SYSTEMS; VISUALIZATION; CCD CAMERAS; CHARGE COUPLED DEVICES; HYDRODYNAMICS; LEFT VENTRICULAR ASSIST DEVICES; MOBILE SECURITY; SHEAR FLOW; SHEAR STRESS;

BLOOD DAMAGE; CELLULAR DYNAMICS; HAEMOLYSIS; HYDRODYNAMICS; LEFT VENTRICULAR ASSIST DEVICE; MICROSCOPIC FLOW VISUALIZATION; SHEAR STRESS;

BLOOD;

ARTICLE; CENTRIFUGATION; COMPUTER AIDED DESIGN; EQUIPMENT; EQUIPMENT DESIGN; HEART ASSIST DEVICE; HEMODYNAMICS; HUMAN; INSTRUMENTATION; METHODOLOGY; MICROFLUIDICS;

CENTRIFUGATION; COMPUTER-AIDED DESIGN; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; HEART-ASSIST DEVICES; HEMODYNAMICS; HUMANS; MICROFLUIDICS;

BLADE TIP CLEARANCE; BLOOD DAMAGE; CELLULAR DYNAMICS; FLUORESCENT PARTICLE; HAEMOLYSIS; MICROSCOPIC VISUALIZATION; OPTICAL VISUALIZATION; QUANTITATIVE DESIGN;

EID: 48449103802     PISSN: 09544119     EISSN: None     Source Type: Journal    
DOI: 10.1243/09544119JEIM352     Document Type: Article

References (22)

1. Baldwin, J. T., Borovetz, H. S., Duncan, B. W., Gartner, M. J., Jarvik, R. K., Weiss, W. J., and Hoke, T. R. The National Heart, Lung, and Blood Institute Pediatric Circulatory Support Program. Circulation, 2006, 113(1), 147-155.
2. Antaki, J. F., Butler, K. C., Kormos, R. L., Kawai, A., Konishi, H., Kerrigan, J. P., Borovetz, H. S., Maher, T. R., Kameneva, M. V., and Griffith, B. P. In vivo evaluation of the Nimbus axial flow ventricular assist system: criteria and methods. ASAIO J., 1993, 39(3), M237-M241.
3. Wu, Z. J., Antaki, J. F., Burgreen, G. W., Butler, K. C., Thomas, D. C., and Griffith, B. P. Fluid dynamic characterization of operating conditions for continuous flow blood pumps. ASAIO J., 1999, 45(5), 442-449.
4. James, N. L., Wilkinson, C. M., Lingard, N. L., Van der Meer, A. L., and Woodard, J. C. Evaluation of hemolysis in the VentrAssist implantable rotary blood pump. Artif. Organs., 2003, 27(1), 108-113.
5. Westaby, S., Banning, A. P., Jarvik, R., Frazier, O. H., Pigott, D. W., Jin, X. Y., Catarino, P. A., Saito, S., Robson, D., Freeland, A., Myers, T. S., and Poole-Wilson, P. A. First permanent implant of the Jarvik 2000 heart. Lancet., 2000, 356(9233), 900-903.
6. Kilic, A., Nolan, T. D. C., Li, T., Yankey, G. K., Prastein, D. J., Cheng, G., Jarvik, R. K., Wu, Z. J., and Griffith, B. P. Early in vivo experience with the pediatric Jarvik 2000 heart. ASAIO J., 2007, 53(3), 374-378.
7. Wilhelm, M. J., Hammel, D., Schmid, C., Rhode, A., Kaan, T., Rothenburger, M., Stypmann, J., Schäfers, M., Schmidt, C., Baba, H. A., and Scheid, H. H. Long-term support of 9 patients with the DeBakey VAD for more than 200 days. J. Thoracic Cardiovascular Surg., 2005, 130(4), 1122-1129.
8. Schima, H., Müller, M. R., Papantonis, D., Schlusche, C., Huber, I., Schmidt, C., Trubel, W., Thoma, H., Losert, U., and Wolner, E. Minimization of hemolysis in centrifugal blood pumps: influence of different geometries. Int. J Artif. Organs, 1993, 16(7), 521-529.
9. Wernicke, J. T., Meier, D., Mizuguchi, K., Damm, G., Aber, G., Benkowski, R., Nosé, Y., Noon, G. P., and DeBakey, M. E. A fluid dynamic analysis using flow visualization of the Baylor /NASA implantable axial flow blood pump for design improvement. Artif. Organs, 1995, 19(2), 161-177.
10. Yamane, T., Asztalos, B., Nishida, M., Masuzawa, T., Takiura, K., Taenaka, Y., Konishi, Y., Miyazoe, Y., and Ito, K. Flow visualization as a complementary tool to hemolysis testing in the development of centrifugal blood pumps. Artif. Organs, 1998, 22(5), 375-380.
11. Masuzawa, T., Tsukiya, T., Endo, S., Tatsumi, E., Taenaka, Y., Takano, H., Yamane, T., Nishida, M., Asztalos, B., Miyazoe, Y., Ito, K., Sawairi, T., and Konishi, Y. Development of design methods for a centrifugal blood pump with a fluid dynamic approach: results in hemolysis tests. Artif. Organs, 1999, 23(8), 757-761.
12. Yasuda, T., Shimokasa, K., Funakubo, A., Higami, T., Kawamura, T., and Fukui, Y. An investigation of blood flow behavior and hemolysis in artificial organs. ASAIO J., 2000, 46(5), 527-531.
13. Nishida, M., Asztalos, B., Yamane, T., Masuzawa, T., Tsukiya, T., Endo, S., Taenaka, Y., Miyazoe, Y., Ito, K., and Konishi, Y. Flow visualization study to improve hemocompatibility of a centrifugal blood pump. Artif. Organs, 1999, 23(8), 697-703.
14. Day, S. W., McDaniel, J. C., Wood, H. G., Allaire, P. E., Landrot, N., and Curtas, A. Particle image velocimetry measurements of blood velocity in a continuous flow ventricular assist device. ASAIO J., 2001, 47(4), 406-411.
15. Anderson, J. B., Wood, H. G., Allaire, P. E., Bearnson, G., and Khanwilkar, P. Computational flow study of the continuous flow ventricular assist device, prototype number 3 blood pump. Artif. Organs, 2000, 24(5), 377-385.
16. Song, X., Wood, H. G., and Olsen, D. Computational fluid dynamics (CFD) study of the 4th generation prototype of a continuous flow ventricular assist device (VAD). J. Biomech Engng, 2004, 126(2), 180-187.
17. Bludszuweit, C. Three-dimensional numerical prediction of stress loading of blood particles in a centrifugal pump. Artif. Organs, 1995, 19(7), 590-596.
18. Bludszuweit, C. Model for a general mechanical blood damage prediction. Artif. Organs, 1995, 19(7), 583-589.
19. Throckmorton, A. L., Lim, D. S., McGulloch, M. A., Jiang, W., Song, X., Allaire, P. E., Wood, H. G., and Olsen, D. B. Computational design and experimental performance testing of an axial-flow pediatric: ventricular assist device. ASAIO J., 2005, 51(5), 629-635.
20. Zhao, R., Antaki, J. F., Naik, T., Bachman, T. N., Kameneva, M. V., and Wu, Z. J. Microscopic investigation of erythrocyte deformation dynamics. Biorheology, 2006, 43(6), 747-765.
21. Wu, J., Antaki, J. F., Wagner, W. R., Snyder, T. A., Paden, B. E., and Borovetz, H. S. Elimination of adverse leakage flow in a miniature pediatric centrifugal blood pump by computational fluid dynamics-based design optimization. ASAIO J., 2005, 51(5), 636-643.
22. Giersiepen, M., Wurzinger, L. J., Opitz, R., and Reul, H. Estimation of shear stress-related blood damage in heart valve prostheses - in vitro comparison of 25 aortic valves. Int. J. Artif. Organs, 1990, 13(5), 300-306.