메뉴 건너뛰기




Volumn 518, Issue 13, 2010, Pages 2554-2569

Expression of BK-type calcium-activated potassium channel splice variants during chick cochlear development

Author keywords

Alternative exon; Basilar papilla; BKCa; Hair cell; Maxi K

Indexed keywords

CALCIUM ION; ISOPROTEIN; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNIT; AVIAN PROTEIN; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL;

EID: 77952186494     PISSN: 00219967     EISSN: 10969861     Source Type: Journal    
DOI: 10.1002/cne.22352     Document Type: Article
Times cited : (10)

References (60)
  • 1
    • 0028918074 scopus 로고
    • The calcium-activated potassium channels of turtle hair cells
    • Art JJ, Wu YC, Fettiplace R. 1995. The calcium-activated potassium channels of turtle hair cells. J Gen Physiol 105: 49-72.
    • (1995) J Gen Physiol , vol.105 , pp. 49-72
    • Art, J.J.1    Wu, Y.C.2    Fettiplace, R.3
  • 3
    • 33947520423 scopus 로고    scopus 로고
    • Thyroid hormone deficiency affects postnatal spiking activity and expression of Ca2+ and K+ channels in rodent inner hair cells
    • DOI 10.1523/JNEUROSCI.3965-06.2007
    • Brandt N, Kuhn S, Munkner S, Braig C, Winter H, Blin N, Vonthein R, Knipper M, Engel J. 2007. Thyroid hormone deficiency affects postnatal spiking activity and expression of Ca2+ and K+ channels in rodent inner hair cells. J Neurosci 27:3174-3186. (Pubitemid 46474116)
    • (2007) Journal of Neuroscience , vol.27 , Issue.12 , pp. 3174-3186
    • Brandt, N.1    Kuhn, S.2    Munkner, S.3    Braig, C.4    Winter, H.5    Blin, N.6    Vonthein, R.7    Knipper, M.8    Engel, J.9
  • 5
    • 25844456659 scopus 로고    scopus 로고
    • Functionally diverse complement of large conductance calcium- And voltage-activated potassium channel (BK) α-subunits generated from a single site of splicing
    • DOI 10.1074/jbc.M505383200
    • Chen L, Tian L, MacDonald SH, McClafferty H, Hammond MS, Huibant JM, Ruth P, Knaus HG, Shipston MJ. 2005. Functionally diverse complement of large conductance calciumand voltage-activated potassium channel (BK) alpha-subunits generated from a single site of splicing. J Biol Chem 280:33599-33609. (Pubitemid 41397161)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.39 , pp. 33599-33609
    • Chen, L.1    Tian, L.2    MacDonald, S.H.-F.3    McClafferty, H.4    Hammond, M.S.L.5    Huibant, J.-M.6    Ruth, P.7    Knaus, H.-G.8    Shipston, M.J.9
  • 6
    • 20444382084 scopus 로고    scopus 로고
    • Tamoxifen alters gating of the BK alpha subunit and mediates enhanced interactions with the avian beta subunit
    • Duncan RK. 2005. Tamoxifen alters gating of the BK alpha subunit and mediates enhanced interactions with the avian beta subunit. Biochem Pharmacol 70:47-58.
    • (2005) Biochem Pharmacol , vol.70 , pp. 47-58
    • Duncan, R.K.1
  • 7
    • 0037338180 scopus 로고    scopus 로고
    • Variation in large-conductance, calcium-activated potassium channels from hair cells along the chicken basilar papilla
    • Duncan RK, Fuchs PA. 2003. Variation in large-conductance, calcium-activated potassium channels from hair cells along the chicken basilar papilla. J Physiol 547(Pt 2):357-371.
    • (2003) J Physiol , vol.547 , Issue.PT 2 , pp. 357-371
    • Duncan, R.K.1    Fuchs, P.A.2
  • 10
    • 67349260120 scopus 로고    scopus 로고
    • Convergent evolution of alternative splices at domain boundaries of the BK channel
    • Fodor AA, Aldrich RW. 2009. Convergent evolution of alternative splices at domain boundaries of the BK channel. Annu Rev Physiol 71:19-36.
    • (2009) Annu Rev Physiol , vol.71 , pp. 19-36
    • Fodor, A.A.1    Aldrich, R.W.2
  • 11
    • 0025104476 scopus 로고
    • The acquisition during development of Ca-activated potassium currents by cochlear hair cells of the chick
    • Fuchs PA, Sokolowski BH. 1990. The acquisition during development of Ca-activated potassium currents by cochlear hair cells of the chick. Proc Biol Sci 241:122-126.
    • (1990) Proc Biol Sci , vol.241 , pp. 122-126
    • Fuchs, P.A.1    Sokolowski, B.H.2
  • 12
    • 0034133041 scopus 로고    scopus 로고
    • Functional characteristics of two BK(Ca) channel variants differentially expressed in rat brain tissues
    • DOI 10.1046/j.1432-1327.2000.01076.x
    • Ha TS, Jeong SY, Cho SW, Jeon H, Roh GS, Choi WS, Park CS. 2000. Functional characteristics of two BKCa channel variants differentially expressed in rat brain tissues. Eur J Biochem 267:910-918. (Pubitemid 30082406)
    • (2000) European Journal of Biochemistry , vol.267 , Issue.3 , pp. 910-918
    • Ha, T.S.1    Jeong, S.Y.2    Cho, S.-W.3    Jeon, H.-K.4    Roh, G.S.5    Choi, W.S.6    Park, C.-S.7
  • 13
    • 12344333247 scopus 로고    scopus 로고
    • Localization and developmental expression of BK channels in mammalian cochlear hair cells
    • DOI 10.1016/j.neuroscience.2004.09.038, PII S0306452204008310
    • Hafidi A, Beurg M, Dulon D. 2005. Localization and developmental expression of BK channels in mammalian cochlear hair cells. Neuroscience 130:475-484. (Pubitemid 40125486)
    • (2005) Neuroscience , vol.130 , Issue.2 , pp. 475-484
    • Hafidi, A.1    Beurg, M.2    Dulon, D.3
  • 14
    • 84924926133 scopus 로고
    • A series of normal stages in the development of the chick embryo
    • Hamburger V, Hamilton HL. 1951. A series of normal stages in the development of the chick embryo. J Morphol 88: 49-92.
    • (1951) J Morphol , vol.88 , pp. 49-92
    • Hamburger, V.1    Hamilton, H.L.2
  • 18
    • 0032557165 scopus 로고    scopus 로고
    • Identification of Ca2+-activated K+ channel splice variants and their distribution in the turtle cochlea
    • DOI 10.1098/rspb.1998.0348
    • Jones EM, Laus C, Fettiplace R. 1998. Identification of Ca(2+)-activated K+ channel splice variants and their distribution in the turtle cochlea. Proc Biol Sci 265:685-692. (Pubitemid 28200763)
    • (1998) Proceedings of the Royal Society B: Biological Sciences , vol.265 , Issue.1397 , pp. 685-692
    • Jones, E.M.C.1    Laus, C.2    Fettiplace, R.3
  • 19
    • 0032969425 scopus 로고    scopus 로고
    • The functional role of alternative splicing of Ca2+-activated K+ channels in auditory hair cells
    • DOI 10.1111/j.1749-6632.1999.tb11299.x
    • Jones EM, Gray-Keller M, Art JJ, Fettiplace R. 1999. The functional role of alternative splicing of Ca(2+)-aetivated K-f channels in auditory hair cells. Ann N Y Acad Sci 868: 379-385. (Pubitemid 29281138)
    • (1999) Annals of the New York Academy of Sciences , vol.868 , pp. 379-385
    • Jones, E.M.C.1    Gray-Keller, M.2    Art, J.J.3    Fettiplace, R.4
  • 20
  • 21
    • 68549107901 scopus 로고    scopus 로고
    • A protein interaction network for the large conductance Ca2+-activated K+ channel in the mouse cochlea
    • Kathiresan T, Harvey M, Orchard S, Sakai Y, Sokolowski B. 2009. A protein interaction network for the large conductance Ca2+-activated K+ channel in the mouse cochlea. Mol Cell Proteomics 8:1972-1987.
    • (2009) Mol Cell Proteomics , vol.8 , pp. 1972-1987
    • Kathiresan, T.1    Harvey, M.2    Orchard, S.3    Sakai, Y.4    Sokolowski, B.5
  • 22
    • 34249044569 scopus 로고    scopus 로고
    • Alternatively spliced C-terminal domains regulate the surface expression of large conductance calcium-activated potassium channels
    • DOI 10.1016/j.neuroscience.2007.03.038, PII S0306452207003375
    • Kim EY, Ridgway LD, Zou S, Chiu YH, Dryer SE. 2007. Alternatively spliced C-terminal domains regulate the surface expression of large conductance calcium-activated potassium channels. Neuroscience 146:1652-1661. (Pubitemid 46783216)
    • (2007) Neuroscience , vol.146 , Issue.4 , pp. 1652-1661
    • Kim, E.Y.1    Ridgway, L.D.2    Zou, S.3    Chiu, Y.-H.4    Dryer, S.E.5
  • 23
    • 49949096488 scopus 로고    scopus 로고
    • Nephrin binds to the COOH terminus of a large-conductance Ca2+-activated K+ channel isoform and regulates its expression on the cell surface
    • Kim EY, Choi KJ, Dryer SE. 2008. Nephrin binds to the COOH terminus of a large-conductance Ca2+-activated K+ channel isoform and regulates its expression on the cell surface. Am J Physiol Renal Physiol 295:F235-246.
    • (2008) Am J Physiol Renal Physiol , vol.295
    • Kim, E.Y.1    Choi, K.J.2    Dryer, S.E.3
  • 25
    • 0027997416 scopus 로고
    • Functional differences among alternatively spliced variants of Slowpoke, a Drosophila calcium-activated potassium channel
    • Lagrutta A, Shen KZ, North RA, Adelman JP. 1994. Functional differences among alternatively spliced variants of Slowpoke, a Drosophila calcium-activated potassium channel. J Biol Chem 269:20347-20351. (Pubitemid 24260433)
    • (1994) Journal of Biological Chemistry , vol.269 , Issue.32 , pp. 20347-20351
    • Lagrutta, A.1    Shen, K.-Z.2    North, R.A.3    Adelman, J.P.4
  • 26
    • 0037420960 scopus 로고    scopus 로고
    • Expression of Ca2+-activated BK channel mRNA and its splice variants in the rat cochlea
    • DOI 10.1002/cne.10471
    • Langer P, Grunder S, Rusch A. 2003. Expression of Ca2+-activated BK Channel mRNA and its splice variants in the rat cochlea. J Comp Neurol 455:198-209. (Pubitemid 35424257)
    • (2003) Journal of Comparative Neurology , vol.455 , Issue.2 , pp. 198-209
    • Langer, P.1    Grunder, S.2    Rusch, A.3
  • 29
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method
    • DOI 10.1006/meth.2001.1262
    • Livak KJ, Schmittgen TD. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25:402-408. (Pubitemid 34164012)
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 31
    • 33847164462 scopus 로고    scopus 로고
    • Differential trafficking of carboxyl isoforms of Ca2+-gated (Slo1) potassium channels
    • DOI 10.1016/j.febslet.2007.01.077, PII S0014579307001378
    • Ma D, Nakata T, Zhang G, Hoshi T, Li M, Shikano S. 2007. Differential trafficking of carboxyl isoforms of Ca2+-gated (SIo1) potassium channels. FEBS Lett 581:1000-1008. (Pubitemid 46282735)
    • (2007) FEBS Letters , vol.581 , Issue.5 , pp. 1000-1008
    • Ma, D.1    Nakata, T.2    Zhang, G.3    Hoshi, T.4    Li, M.5    Shikano, S.6
  • 32
    • 33748527537 scopus 로고    scopus 로고
    • Increased large conductance calcium-activated potassium (BK) channel expression accompanied by STREX variant downregulation in the developing mouse CNS
    • MacDonald SH, Ruth P, Knaus HG, Shipston MJ. 2006. Increased large conductance calcium-activated potassium (BK) channel expression accompanied by STREX variant downregulation in the developing mouse CNS. BMC Dev Biol 6:37.
    • (2006) BMC Dev Biol , vol.6 , pp. 37
    • MacDonald, S.H.1    Ruth, P.2    Knaus, H.G.3    Shipston, M.J.4
  • 33
    • 0037731494 scopus 로고    scopus 로고
    • Development of changes in the expression of potassium currents of embryonic, neonatal and mature mouse inner hair cells
    • DOI 10.1113/jphysiol.2002.034801
    • Marcotti W, Johnson SL, Holley MC, Kros CJ. 2003. Developmental changes in the expression of potassium currents of embryonic, neonatal and mature mouse inner hair cells. J Physiol 548(R 2):383-400. (Pubitemid 36527462)
    • (2003) Journal of Physiology , vol.548 , Issue.2 , pp. 383-400
    • Marcotti, W.1    Johnson, S.L.2    Holley, M.C.3    Kros, C.J.4
  • 34
    • 55949134720 scopus 로고    scopus 로고
    • The role of temporal fine structure processing in pitch perception, masking, and speech perception for normal-hearing and hearing-impaired people
    • Moore BC. 2008. The role of temporal fine structure processing in pitch perception, masking, and speech perception for normal-hearing and hearing-impaired people. J Assoc Res Otolaryngol 9:399-406.
    • (2008) J Assoc Res Otolaryngol , vol.9 , pp. 399-406
    • Moore, B.C.1
  • 35
    • 33748886717 scopus 로고    scopus 로고
    • Mechanisms underlying the temporal precision of sound coding at the inner hair cell ribbon synapse
    • DOI 10.1113/jphysiol.2006.114835
    • Moser T, Neef A, Khimich D. 2006. Mechanisms underlying the temporal precision of sound coding at the inner hair cell ribbon synapse. J Physiol 576(Pt 1):55-62. (Pubitemid 44426220)
    • (2006) Journal of Physiology , vol.576 , Issue.1 , pp. 55-62
    • Moser, T.1    Neef, A.2    Khimich, D.3
  • 36
    • 0030612952 scopus 로고    scopus 로고
    • Differential distribution of Ca2+activated K+ channel splice variants among hair cells along the tonotopic axis of the chick cochlea
    • Navaratnam DS, Bell TJ, Tu TD, Cohen EL, Oberholtzer JC. 1997. Differential distribution of Ca2+activated K+ channel splice variants among hair cells along the tonotopic axis of the chick cochlea. Neuron 19:1077-1085.
    • (1997) Neuron , vol.19 , pp. 1077-1085
    • Navaratnam, D.S.1    Bell, T.J.2    Tu, T.D.3    Cohen, E.L.4    Oberholtzer, J.C.5
  • 38
    • 56749098074 scopus 로고    scopus 로고
    • Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing
    • Pan Q, Shai O, Lee LJ, Frey BJ, Blencowe BJ. 2008. Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing. Nat Genet 40: 1413-1415.
    • (2008) Nat Genet , vol.40 , pp. 1413-1415
    • Pan, Q.1    Shai, O.2    Lee, L.J.3    Frey, B.J.4    Blencowe, B.J.5
  • 41
    • 7444259580 scopus 로고    scopus 로고
    • Extrasynaptic localization of inactivating calcium-activated potassium channels in mouse inner hair cells
    • DOI 10.1523/JNEUROSCI.3162-04.2004
    • Pyott SJ, Glowatzki E, Trimmer JS, Aldrich RW. 2004. Extrasynaptic localization of inactivating calcium-activated potassium channels in mouse inner hair cells. J Neurosci 24: 9469-9474. (Pubitemid 39441500)
    • (2004) Journal of Neuroscience , vol.24 , Issue.43 , pp. 9469-9474
    • Pyott, S.J.1    Glowatzki, E.2    Trimmer, J.S.3    Aldrich, R.W.4
  • 42
    • 0033534539 scopus 로고    scopus 로고
    • A molecular mechanism for electrical tuning of cochlear hair cells
    • Ramanathan K, Michael TH, Jiang GJ, Hiel H, Fuchs PA. 1999. A molecular mechanism for electrical tuning of cochlear hair cells. Science 283:215-217. (Pubitemid 129504599)
    • (1999) Science , vol.283 , Issue.5399 , pp. 215-217
    • Ramanathan, K.1    Michael, T.H.2    Jiang, G.-J.3    Hiel, H.4    Fuchs, P.A.5
  • 43
    • 0034161491 scopus 로고    scopus 로고
    • β subunits modulate alternatively spliced, large conductance, calcium- Activated potassium channels of avian hair cells
    • Ramanathan K, Michael TH, Fuchs PA. 2000. beta subunits modulate alternatively spliced, large conductance, calciumactivated potassium channels of avian hair cells. J Neurosci 20:1675-1684. (Pubitemid 30220365)
    • (2000) Journal of Neuroscience , vol.20 , Issue.5 , pp. 1675-1684
    • Ramanathan, K.1    Michael, T.H.2    Fuchs, P.A.3
  • 44
    • 0025514341 scopus 로고
    • Colocalization of ion channels involved in frequency selectivity and synaptic transmission at presynaptic active zones of hair cells
    • Roberts WM, Jacobs RA, Hudspeth AJ. 1990. Colocalization of ion channels involved in frequency selectivity and synaptic transmission at presynaptic active zones of hair cells. J Neurosci 10:3664-3684.
    • (1990) J Neurosci , vol.10 , pp. 3664-3684
    • Roberts, W.M.1    Jacobs, R.A.2    Hudspeth, A.J.3
  • 45
    • 0030612948 scopus 로고    scopus 로고
    • Distribution of Ca2+-activated K+ channel isoforms along the tonotopic gradient of the chicken's cochlea
    • Rosenblatt KP, Sun ZP, Heller S, Hudspeth AJ. 1997. Distribution of Ca2+-activated K+ channel isoforms along the tonotopic gradient of the chicken's cochlea. Neuron 19:1061-1075. (Pubitemid 27512366)
    • (1997) Neuron , vol.19 , Issue.5 , pp. 1061-1075
    • Rosenblatt, K.P.1    Sun, Z.-P.2    Heller, S.3    Hudspeth, A.J.4
  • 47
    • 0015692185 scopus 로고
    • The development of auditory evoked responses in the cochlea and cochlear nuclei of the chick
    • Saunders JC, Coles RB, Gates GR. 1973. The development of auditory evoked responses in the cochlea and cochlear nuclei of the chick. Brain Res 63:59-74.
    • (1973) Brain Res , vol.63 , pp. 59-74
    • Saunders, J.C.1    Coles, R.B.2    Gates, G.R.3
  • 48
    • 0030852701 scopus 로고    scopus 로고
    • A novel calcium-sensing domain in the BK channel
    • Schreiber M, Salkoff L. 1997. A novel calcium-sensing domain in the BK channel. Biophys J 73:1355-1363.
    • (1997) Biophys J , vol.73 , pp. 1355-1363
    • Schreiber, M.1    Salkoff, L.2
  • 50
    • 55749103554 scopus 로고    scopus 로고
    • A mutually exclusive alternative exon of slo1 codes for a neuronal BK channel with altered function
    • (Austin)
    • Soom M, Gessner G, Heuer H, Hoshi T, Heinemann SH. 2008. A mutually exclusive alternative exon of slo1 codes for a neuronal BK channel with altered function. Channels (Austin) 2:278-282.
    • (2008) Channels , vol.2 , pp. 278-282
    • Soom, M.1    Gessner, G.2    Heuer, H.3    Hoshi, T.4    Heinemann, S.H.5
  • 52
    • 0035890140 scopus 로고    scopus 로고
    • Alternative splicing determines sensitivity of murine calcium-activated potassium channels to glucocorticoids
    • DOI 10.1111/j.1469-7793.2001.0057k.x
    • Tian L, Hammond MS, Florence H, Antoni FA, Shipston MJ. 2001b. Alternative splicing determines sensitivity of murine calcium-activated potassium channels to glucocorticoids. J Physiol 537(Pt 1):57-68. (Pubitemid 33076954)
    • (2001) Journal of Physiology , vol.537 , Issue.1 , pp. 57-68
    • Tian, L.1    Hammond, M.S.L.2    Florance, H.3    Antoni, F.A.4    Shipston, M.J.5
  • 53
    • 0028579516 scopus 로고
    • Cloning, expression, and distribution of functionally distinct Ca(2+)-activated K+ channel isoforms from human brain
    • Tseng-Crank J, Foster CD, Krause JD, Mertz R, Godinot N, DiChiara TJ, Reinhart PH. 1994. Cloning, expression, and distribution of functionally distinct Ca(2+)-activated K+ channel isoforms from human brain. Neuron 13:1315-1330.
    • (1994) Neuron , vol.13 , pp. 1315-1330
    • Tseng-Crank, J.1    Foster, C.D.2    Krause, J.D.3    Mertz, R.4    Godinot, N.5    Dichiara, T.J.6    Reinhart, P.H.7
  • 54
    • 24944534978 scopus 로고    scopus 로고
    • Real-time PCR for mRNA quantitation
    • Wong ML, Medrano JF. 2005. Real-time PCR for mRNA quantitation. Biotechniques 39:75-85.
    • (2005) Biotechniques , vol.39 , pp. 75-85
    • Wong, M.L.1    Medrano, J.F.2
  • 55
    • 0037158754 scopus 로고    scopus 로고
    • Multiple regulatory sites in large-conductance calcium-activated potassium channels
    • DOI 10.1038/nature00956
    • Xia XM, Zeng X, Lingle CJ. 2002. Multiple regulatory sites in large-conductance calcium-activated potassium channels. Nature 418:880-884. (Pubitemid 34966307)
    • (2002) Nature , vol.418 , Issue.6900 , pp. 880-884
    • Xia, X.-M.1    Zeng, X.2    Lingle, C.J.3
  • 56
    • 0032540395 scopus 로고    scopus 로고
    • Control of alternative splicing of potassium channels by stress hormones
    • DOI 10.1126/science.280.5362.443
    • Xie J, McCobb DP. 1998. Control of alternative splicing of potassium channels by stress hormones. Science 280: 443-446. (Pubitemid 28208168)
    • (1998) Science , vol.280 , Issue.5362 , pp. 443-446
    • Xie, J.1    McCobb, D.P.2
  • 57
    • 33646912980 scopus 로고    scopus 로고
    • Tissue-specific alternative splicing of BK channel transcripts in Drosophila
    • DOI 10.1111/j.1601-183X.2005.00164.x
    • Yu JY, Upadhyaya AB, Atkinson NS. 2006. Tissue-specific alternative splicing of BK channel transcripts in Drosophila. Genes Brain Behav 5:329-339. (Pubitemid 43794815)
    • (2006) Genes, Brain and Behavior , vol.5 , Issue.4 , pp. 329-339
    • Yu, J.Y.1    Upadhyaya, A.B.2    Atkinson, N.S.3
  • 58
    • 0035844185 scopus 로고    scopus 로고
    • A novel maxik splice variant exhibits dominant-negative properties for surface expression
    • DOI 10.1074/jbc.M008852200
    • Zarei MM, Zhu N, Alioua A, Eghbali M, Stefani E, Toro L. 2001. A novel Maxi-K splice variant exhibits dominant-negative properties for surface expression. J Biol Chem 276: 16232-16239. (Pubitemid 37391665)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.19 , pp. 16232-16239
    • Zarei, M.M.1    Zhu, N.2    Alioua, A.3    Eghbali, M.4    Stefani, E.5    Toro, L.6
  • 60
    • 0033103174 scopus 로고    scopus 로고
    • A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane K(ATP) channels
    • Zerangue N, Schwappach B, Jan YN, Jan LY. 1999. A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane K(ATP) channels. Neuron 22:537-548. (Pubitemid 29159852)
    • (1999) Neuron , vol.22 , Issue.3 , pp. 537-548
    • Zerangue, N.1    Schwappach, B.2    Yuh, N.J.3    Lily, Y.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.