메뉴 건너뛰기




Volumn 45, Issue 3, 2010, Pages 283-288

Advances in the study of the anti-tumor activity of small molecule vascular disrupting agents

Author keywords

Anti tumor activity; Tubulin binding agent; Vascular disrupting agent

Indexed keywords

5,6 DIMETHYLXANTHENONE 4 ACETIC ACID; CA 4P; COLCHICINE; COMBRETASTATIN A1 PHOSPHATE; COMBRETASTATIN A4 PHOSPHATE; N ACETYLCOLCHINOL PHOSPHATE; SERINE 2 METHOXY 5 [2 (3,4,5 TRIMETHOXYPHENYL)VINYL]ANILIDE; SOBLIDOTIN; UNCLASSIFIED DRUG; VASCULAR TARGETING AGENT; VINBLASTINE;

EID: 77952185880     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (3)

References (33)
  • 1
    • 0020081554 scopus 로고
    • Endothelial cell proliferation as a novel approach to targeting tumor therapy
    • Denekamp J. Endothelial cell proliferation as a novel approach to targeting tumor therapy [J]. Br J Cancer, 1982, 45: 136-139. (Pubitemid 12207761)
    • (1982) British Journal of Cancer , vol.45 , Issue.1 , pp. 136-139
    • Denekamp, J.1
  • 3
    • 12244292196 scopus 로고    scopus 로고
    • Differentiation and definition of vascular-targeted therapies
    • [J]
    • Siemann DW, Bibby MC, Dark GG, et al. Differentiation and definition of vascular-targeted therapies [J]. Clin Cancer Res, 2005, 11: 416-420.
    • (2005) Clin Cancer Res , vol.11 , pp. 416-420
    • Siemann, D.W.1    Bibby, M.C.2    Dark, G.G.3
  • 4
    • 0036891515 scopus 로고    scopus 로고
    • The development of combretastatin A4 phosphate as a vascular targeting agent
    • DOI 10.1016/S0360-3016(02)03924-X, PII S036030160203924X
    • Chaplin DJ, Hill SA. The development of combretastatin A4 phosphate as a vascular targeting agent [J]. Int J Radiat Oncol Biol Phys, 2002, 54: 1491-1496. (Pubitemid 35380054)
    • (2002) International Journal of Radiation Oncology Biology Physics , vol.54 , Issue.5 , pp. 1491-1496
    • Chaplin, D.J.1    Hill, S.A.2
  • 5
    • 20444403700 scopus 로고    scopus 로고
    • Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-41
    • [J]
    • Pettit GR, Rhodes MR, Herald DL, et al. Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-41 [J]. J Med Chem, 2005, 48: 4087-4099.
    • (2005) J Med Chem , vol.48 , pp. 4087-4099
    • Pettit, G.R.1    Rhodes, M.R.2    Herald, D.L.3
  • 6
    • 0842311621 scopus 로고    scopus 로고
    • Vascular Targeting Agents As Cancer Therapeutics
    • DOI 10.1158/1078-0432.CCR-0642-03
    • Thorpe PE. Vascular targeting agents as cancer therapeutics [J]. Clin Cancer Res, 2004, 10: 415-427. (Pubitemid 38173977)
    • (2004) Clinical Cancer Research , vol.10 , Issue.2 , pp. 415-427
    • Thorpe, P.E.1
  • 7
    • 0025717523 scopus 로고
    • Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti-cancer therapeutic agents
    • [J]
    • Kerbel RS. Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti-cancer therapeutic agents [J]. Bioassays, 1991, 13: 31-36.
    • (1991) Bioassays , vol.13 , pp. 31-36
    • Kerbel, R.S.1
  • 8
    • 33846809496 scopus 로고    scopus 로고
    • Synthesis and cytotoxic activities of 4,5-diarylisoxazoles
    • [J]
    • Sun CM, Lin LG, Yu HJ, et al. Synthesis and cytotoxic activities of 4,5-diarylisoxazoles [J]. Bioorg Med Chem Lett, 2007, 17: 1078-1081.
    • (2007) Bioorg Med Chem Lett , vol.17 , pp. 1078-1081
    • Sun, C.M.1    Lin, L.G.2    Yu, H.J.3
  • 9
    • 0027979227 scopus 로고
    • The influence of tumour temperature on ischemia-induced cell death: Potential implications for the evaluation of vascular mediated therapies
    • [J]
    • Chaplin DJ, Horsman MR. The influence of tumour temperature on ischemia-induced cell death: potential implications for the evaluation of vascular mediated therapies [J]. Radiother Oncol, 1994, 30: 59-65.
    • (1994) Radiother Oncol , vol.30 , pp. 59-65
    • Chaplin, D.J.1    Horsman, M.R.2
  • 11
    • 1842607060 scopus 로고    scopus 로고
    • Combretastatin A4 phosphate
    • [J]
    • West CM, Price P. Combretastatin A4 phosphate [J]. Anticancer Drugs, 2004, 15: 179-187.
    • (2004) Anticancer Drugs , vol.15 , pp. 179-187
    • West, C.M.1    Price, P.2
  • 12
    • 0038575250 scopus 로고    scopus 로고
    • Phase I/II Trials Committee of Cancer Research UK. Clinical aspects of a phase I trial of 5, 6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent
    • [J]
    • Jameson MB, Thompson PI, Baguley BC, et al. Phase I/II Trials Committee of Cancer Research UK. Clinical aspects of a phase I trial of 5, 6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent [J]. Br J Cancer, 2003, 88: 1844-1850.
    • (2003) Br J Cancer , vol.88 , pp. 1844-1850
    • Jameson, M.B.1    Thompson, P.I.2    Baguley, B.C.3
  • 13
    • 33644988592 scopus 로고    scopus 로고
    • Design, synthesis, and biological evaluation of combretastatin nitrogen-containing derivatives as inhibitors of tubulin assembly and vascular disrupting agents
    • [J]
    • Monk KA, Siles R, Hadimani MB, et al. Design, synthesis, and biological evaluation of combretastatin nitrogen-containing derivatives as inhibitors of tubulin assembly and vascular disrupting agents [J]. Bioorg Med Chem, 2006, 14: 3231-3244.
    • (2006) Bioorg Med Chem , vol.14 , pp. 3231-3244
    • Monk, K.A.1    Siles, R.2    Hadimani, M.B.3
  • 16
    • 0036891109 scopus 로고    scopus 로고
    • Antitumor efficacy of conventional anticancer drugs is enhanced by the vascular targeting agent ZD6126
    • [J]
    • Siemann DW, Rojiani AM. Antitumor efficacy of conventional anticancer drugs is enhanced by the vascular targeting agent ZD6126 [J]. Int J Radiat Oncol Biol Phys, 2002, 54: 1512-1517.
    • (2002) Int J Radiat Oncol Biol Phys , vol.54 , pp. 1512-1517
    • Siemann, D.W.1    Rojiani, A.M.2
  • 17
    • 20344394640 scopus 로고    scopus 로고
    • The vascular disrupting agent ZD6126 shows increased antitumor efficacy and enhanced radiation response in large, advanced tumors
    • [J]
    • Siemann DW, Rojiani AM. The vascular disrupting agent ZD6126 shows increased antitumor efficacy and enhanced radiation response in large, advanced tumors [J]. Int J Radiat Oncol Biol Phys, 2005, 62: 846-853.
    • (2005) Int J Radiat Oncol Biol Phys , vol.62 , pp. 846-853
    • Siemann, D.W.1    Rojiani, A.M.2
  • 18
    • 0142155561 scopus 로고    scopus 로고
    • Vascular targeting effects of ZD6126 in a C3H mouse mammary carcinoma and the enhancement of radiation response
    • DOI 10.1016/S0360-3016(03)00769-7
    • Horsman MR, Murata R. Vascular targeting effects of ZD6126 in a C3H mouse mammary carcinoma and the enhancement of radiation response [J]. Int J Radiat Oncol Biol Phys, 2003, 57: 1047-1055. (Pubitemid 37324123)
    • (2003) International Journal of Radiation Oncology Biology Physics , vol.57 , Issue.4 , pp. 1047-1055
    • Horsman, M.R.1    Murata, R.2
  • 20
    • 33846041131 scopus 로고    scopus 로고
    • A phase 2 study of TZT-1027, administered weekly to patients with advanced non-small cell lung cancer following treatment with platinum-based chemotherapy
    • DOI 10.1016/j.lungcan.2006.10.002, PII S0169500206005368
    • Riely GJ, Gadgeel S, Rothman I, et al. A phase 2 study of TZT-1027, administered weekly to patients with advanced nonsmall cell lung cancer following treatment with platinum-based chemotherapy [J]. Lung Cancer, 2007, 55: 181-185. (Pubitemid 46074222)
    • (2007) Lung Cancer , vol.55 , Issue.2 , pp. 181-185
    • Riely, G.J.1    Gadgeel, S.2    Rothman, I.3    Saidman, B.4    Sabbath, K.5    Feit, K.6    Kris, M.G.7    Rizvi, N.A.8
  • 21
    • 0029044610 scopus 로고
    • Antineoplastic agents 322. Synthesis of combretastatin A-4 prodrugs
    • [J]
    • Pettit GR, Temple C Jr, Narayanan VL, et al. Antineoplastic agents 322. Synthesis of combretastatin A-4 prodrugs [J]. Anticancer Drug Design, 1995, 10: 299-309.
    • (1995) Anticancer Drug Design , vol.10 , pp. 299-309
    • Pettit, G.R.1    Temple Jr., C.2    Narayanan, V.L.3
  • 23
    • 17544397865 scopus 로고    scopus 로고
    • Vascular targeting of solid tumours: A major 'inverse' volume-response relationship following combretastatin A-4 phosphate treatment of rat rhabdomyosarcomas
    • [J]
    • Landuyt W, Verdoes O, Darius DO, et al. Vascular targeting of solid tumours: a major 'inverse' volume-response relationship following combretastatin A-4 phosphate treatment of rat rhabdomyosarcomas [J]. Eur J Cancer, 2000, 36: 1833-1843.
    • (2000) Eur J Cancer , vol.36 , pp. 1833-1843
    • Landuyt, W.1    Verdoes, O.2    Darius, D.O.3
  • 24
    • 34247173906 scopus 로고    scopus 로고
    • Characterizing the tumor response to treatment with combretastatin A4 phosphate
    • [J]
    • Salmon BA, Siemann DW. Characterizing the tumor response to treatment with combretastatin A4 phosphate [J]. Int J Radiat Oncol Biol Phys, 2007, 68: 211-217.
    • (2007) Int J Radiat Oncol Biol Phys , vol.68 , pp. 211-217
    • Salmon, B.A.1    Siemann, D.W.2
  • 26
    • 27544511815 scopus 로고    scopus 로고
    • Antineoplastic strategy: Irreversible tumor blood flow stasis induced by the combretastatin A-4 derivative AVE8062 (AC7700)
    • DOI 10.1159/000088961
    • Hori K. Antineoplastic strategy: irreversible tumor blood flow stasis induced by the combretastatin A-4 derivative AVE-8062 (AC7700) [J]. Chemotherapy, 2005, 51: 357-360. (Pubitemid 41546713)
    • (2005) Chemotherapy , vol.51 , Issue.6 , pp. 357-360
    • Hori, K.1
  • 27
    • 0242329757 scopus 로고    scopus 로고
    • Microvascular mechanisms by which the combretastatin A-4 derivative AC7700 (AVE8062) induces tumour blood flow stasis
    • DOI 10.1038/sj.bjc.6601261
    • Hori K, Saito S. Microvascular mechanisms by which the combretastatin A-4 derivative AC7700 (AVE-8062) induces tumour blood flow stasis [J]. Br J Cancer, 2003, 89: 1334-1344. (Pubitemid 37363426)
    • (2003) British Journal of Cancer , vol.89 , Issue.7 , pp. 1334-1344
    • Hori, K.1    Saito, S.2
  • 28
    • 0142121501 scopus 로고    scopus 로고
    • Differential relationship between changes in tumour size and microcirculatory functions induced by therapy with an antivascular drug and with cytotoxic drugs: Implications for the evaluation of therapeutic efficacy of AC7700 (AVE-8062)
    • [J]
    • Hori K, Saito S, Sato Y, et al. Differential relationship between changes in tumour size and microcirculatory functions induced by therapy with an antivascular drug and with cytotoxic drugs: implications for the evaluation of therapeutic efficacy of AC7700 (AVE-8062) [J]. Eur J Cancer, 2003, 39: 1957-1966.
    • (2003) Eur J Cancer , vol.39 , pp. 1957-1966
    • Hori, K.1    Saito, S.2    Sato, Y.3
  • 29
    • 33746091695 scopus 로고    scopus 로고
    • Effect of the second-generation vascular disrupting agent OXi4503 on tumor vascularity
    • [J]
    • Salmon HW, Siemann DW. Effect of the second-generation vascular disrupting agent OXi4503 on tumor vascularity [J]. Clin Cancer Res, 2006, 12: 4090-4094.
    • (2006) Clin Cancer Res , vol.12 , pp. 4090-4094
    • Salmon, H.W.1    Siemann, D.W.2
  • 30
    • 0036324914 scopus 로고    scopus 로고
    • Preclinical evaluation of the antitumour activity of the novel vascular targeting agent Oxi 4503
    • [J]
    • Hill SA, Toze GM, Pettit GR, et al. Preclinical evaluation of the antitumour activity of the novel vascular targeting agent Oxi 4503 [J]. Anticancer Res, 2002, 22: 1453-1458.
    • (2002) Anticancer Res , vol.22 , pp. 1453-1458
    • Hill, S.A.1    Toze, G.M.2    Pettit, G.R.3
  • 32
    • 1642283508 scopus 로고    scopus 로고
    • Comparative preclinical pharmacokinetic and metabolic studies of the combretastatin prodrugs combretastatin A4 phosphate and A1 phosphate
    • [J]
    • Kirwan IG, Loadman PM, Swaine DJ, et al. Comparative preclinical pharmacokinetic and metabolic studies of the combretastatin prodrugs combretastatin A4 phosphate and A1 phosphate [J]. Clin Cancer Res, 2004, 10: 1446-1453.
    • (2004) Clin Cancer Res , vol.10 , pp. 1446-1453
    • Kirwan, I.G.1    Loadman, P.M.2    Swaine, D.J.3
  • 33
    • 38149097967 scopus 로고    scopus 로고
    • Oxidative metabolism of combretastatin A-1 produces quinone intermediates with the potential to bind to nucleophiles and to enhance oxidative stress via free radicals
    • [J]
    • Folkes LK, Christlieb M, Madej E, et al. Oxidative metabolism of combretastatin A-1 produces quinone intermediates with the potential to bind to nucleophiles and to enhance oxidative stress via free radicals [J]. Chem Res Toxicol, 2007, 20: 1885-1894.
    • (2007) Chem Res Toxicol , vol.20 , pp. 1885-1894
    • Folkes, L.K.1    Christlieb, M.2    Madej, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.