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Volumn 352, Issue 7, 2010, Pages 1135-1138

Morpholinium trifluoroacetate-catalyzed aldol condensation of acetone with both aromatic and aliphatic aldehydes

Author keywords

Aldehydes; Aldol condensation; Amine salts; Enones; Organocatalysis

Indexed keywords


EID: 77952181442     PISSN: 16154150     EISSN: 16154169     Source Type: Journal    
DOI: 10.1002/adsc.200900902     Document Type: Article
Times cited : (63)

References (43)
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    • and references cited therein
    • Other methods for synthesizing enones: a) metathesis: B. H. Lipshutz, S. Ghorai, W.W.Y. Leong, J. Org. Chem. 2009, 74, 2854-2857, and references cited therein;
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    • Performing the reaction under reflux conditions did not diminish the selectivity and the yield, but led to slightly longer reaction times
    • Performing the reaction under reflux conditions did not diminish the selectivity and the yield, but led to slightly longer reaction times.
  • 34
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    • Lower catalyst loadings have been tried but lower selectivities and longer reaction times were obtained
    • Lower catalyst loadings have been tried but lower selectivities and longer reaction times were obtained.
  • 35
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    • We were also able to upscale this reaction to > 1.5 mol
    • We were also able to upscale this reaction to > 1.5 mol.


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