Chronic mountain sickness and the heart

Progress in Cardiovascular Diseases

Volumn 52, Issue 6, 2010, Pages 540-549

  León Velarde, Fabiola ^a   Villafuerte, Francisco C ^a   Richalet, Jean Paul ^b  

^a UNIVERSIDAD PERUANA CAYETANO HEREDIA   (Peru)

^b UNIVERSITÉ PARIS 13   (France)

Author keywords

Chronic mountain sickness; Heart; High altitude; High altitude pulmonary hypertension; Monge's disease

Indexed keywords

ACETAZOLAMIDE; PLACEBO;

ALTITUDE; ALTITUDE DISEASE; ARTICLE; BLOOD PRESSURE; BLOOD VOLUME; CLINICAL FEATURE; CLINICAL TRIAL; DRUG MECHANISM; ERYTHROCYTOSIS; HEART FUNCTION; HEART OUTPUT; HEART RIGHT VENTRICLE HYPERTROPHY; HEMATOCRIT; HUMAN; HYPOXEMIA; LUNG VASCULAR RESISTANCE; NONHUMAN; ORTHOSTATIC STRESS; PATHOPHYSIOLOGY; PULMONARY HYPERTENSION; VASCULAR RESISTANCE; VASOCONSTRICTION;

ALTITUDE; ALTITUDE SICKNESS; ANOXIA; BLOOD PRESSURE; CARDIAC OUTPUT; CARDIOVASCULAR SYSTEM; CHEMORECEPTOR CELLS; CHRONIC DISEASE; CLINICAL TRIALS AS TOPIC; HEMATOCRIT; HUMANS; HYPERTENSION, PULMONARY; HYPERTROPHY, RIGHT VENTRICULAR; POLYCYTHEMIA; PULMONARY ARTERY; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RESPIRATORY SYSTEM; VASCULAR RESISTANCE;

EID: 77952171943     PISSN: 00330620     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pcad.2010.02.012     Document Type: Article

References (76)

1. Peñaloza D., Sime F., Banchero N., et al. Pulmonary hypertension in healthy men born and living at high altitudes. Am J Cardiol 1963, 11:150-157.
2. Hurtado A. Animals in high altitudes: resident man. Handbook of physiology. adaptation to the environment 1964, 843-860. American Physiological Society, Washington, DC. D. Dill, E. Adolph, C. Wilber (Eds.).
3. Monge-M C., Monge-C C. High altitude diseases: mechanism and management 1966, Charles C. Thomas, Springfield (Ill).
4. Antezana G., Barragán L., Coudert J., et al. The pulmonary circulation of high altitude natives. High altitude physiology and medicine 1982, 142-149. Springer-Verlag, New York. W. Brendel, R. Zink (Eds.).
5. Monge C. Chronic mountain sickness. Physiol Rev 1943, 23:166.
6. Monge-M C., Encinas E., Heraud C., et al. La Enfermedad de los Andes (Síndromes Eritrémicos) 1928, Lima, Imprenta Americana.
7. Monge-M C. Sobre un caso de Enfermedad de Váquez 1925, Academia Nacional de Medicina, Lima, Peru.
8. Hurtado A. Chronic mountain sickness. JAMA 1942, 120:1278-1282.
9. Penaloza D., Sime F. Chronic cor pulmonale due to loss of altitude acclimatization (chronic mountain sickness). Am J Med 1971, 50:728-743.
10. Peñaloza D., Sime F., Ruiz L. Cor pulmonale in chronic mountain sickness: present concept of Monge's disease. High altitude physiology: cardiac and respiratory aspects 1971, 41-60. Churchill Livingstone, Edinburgh. R. Porter, J. Knight (Eds.).
11. Beall C.M., Decker M.J., Brittenham G.M., et al. An Ethiopian pattern of human adaptation to high-altitude hypoxia. Proc Natl Acad Sci U S A 2002, 99:17215-17218.
12. Winslow R.M., Monge-C C. Hypoxia, polycythemia, and chronic mountain sickness 1987, Johns Hopkins University Press, Baltimore (Md).
13. Arregui A., Cabrera J., Leon-Velarde F., et al. High prevalence of migraine in a high-altitude population. Neurology 1991, 41:1668-1669.
14. Sorensen S.C., Lassen N.A., Severinghaus J.W., et al. Cerebral glucose metabolism and cerebral blood flow in high-altitude residents. J Appl Physiol 1974, 37:305-310.
15. Massik J., Tang Y.L., Hudak M.L., et al. Effect of hematocrit on cerebral blood flow with induced polycythemia. J Appl Physiol 1987, 62:1090-1096.
16. Monge-M C. La enfermedad de los Andes. An Fac Med 1928, 1-309.
17. Leon-Velarde F., Maggiorini M., Reeves J.T., et al. Consensus statement on chronic and subacute high altitude diseases. High Alt Med Biol 2005, 6:147-157.
18. Leon-Velarde F., Mejia O. Gene expression in chronic high altitude diseases. High Alt Med Biol 2008, 9:130-139.
19. Monge-C C., León-Velarde F., Arregui A. Chronic mountain sickness. High altitude. an exploration of human adaptation 2001, 815-838. Marcel Dekker, Inc, New York. C. Lenfant (Ed.).
20. Kryger M., McCullough R., Doekel R., et al. Excessive polycythemia of high altitude: role of ventilatory drive and lung disease. Am Rev Respir Dis 1978, 118:659-666.
21. Severinghaus J.W., Bainton C.R., Carcelen A. Respiratory insensitivity to hypoxia in chronically hypoxic man. Respir Physiol 1966, 1:308-334.
22. Vargas E., Spielvogel H. Chronic mountain sickness, optimal hemoglobin, and heart disease. High Alt Med Biol 2006, 7:138-149.
23. Liang P.J., Bascom D.A., Robbins P.A. Extended models of the ventilatory response to sustained isocapnic hypoxia in humans. J Appl Physiol 1997, 82:667-677.
24. Leon-Velarde F., Gamboa A., Rivera-Ch M., et al. Selected contribution: peripheral chemoreflex function in high-altitude natives and patients with chronic mountain sickness. J Appl Physiol 2003, 94:1269-1278. discussion 1253-1264.
25. Milledge J.S., Lahiri S. Respiratory control in lowlanders and Sherpa highlanders at altitude. Respir Physiol 1967, 2:310-322.
26. 2 in high-altitude natives and patients with chronic mountain sickness. J Appl Physiol 2003, 94:1279-1287.
27. 2 and in arterial pH. Handbook of physiology-the respiratory system 1986, 475-528. American Physiological Society, Bethesda (Md). J.G. Cherniack (Ed.).
28. Fatemian M., Robbins P.A. Selected contribution: chemoreflex responses to CO2 before and after an 8-h exposure to hypoxia in humans. J Appl Physiol 2001, 90:1607-1614. discussion 1606.
29. Robbins P.A. The ventilatory response of the human respiratory system to sine waves of alveolar carbon dioxide and hypoxia. J Physiology 1984, 350:461-474.
30. Milledge J.S., Sorensen S.C. Cerebral arteriovenous oxygen difference in man native to high altitude. J Appl Physiol 1972, 32:687-689.
31. Leon-Velarde F., Richalet J.P. Respiratory control in residents at high altitude: physiology and pathophysiology. High Alt Med Biol 2006, 7:125-137.
32. Villafuerte F.C., Cardenas R., Monge C.C. Optimal hemoglobin concentration and high altitude: a theoretical approach for Andean men at rest. J Appl Physiol May 2004, 96:1581-1588.
33. Reeves J.T., Leon-Velarde F. Chronic mountain sickness: recent studies of the relationship between hemoglobin concentration and oxygen transport. High Alt Med Biol 2004, 5:147-155.
34. Winslow R.M., Monge C.C., Brown E.G., et al. Effects of hemodilution on O2 transport in high-altitude polycythemia. J Appl Physiol 1985, 59:1495-1502.
35. Cruz J., Diaz C., Marticorena E., et al. Phlebotomy improves pulmonary gas exchange in chronic mountain polycythemia. Respiration 1979, 38:305-313.
36. Manier G., Guenard H., Castaing Y., et al. Pulmonary gas exchange in Andean natives with excessive polycythemia-effect of hemodilution. J Appl Physiol 1988, 65:2107-2117.
37. Ergueta J., Spielvogel H., Cudkowicz L. Cardio-respiratory studies in chronic mountain sickness (Monge's syndrome). Respiration 1971, 28:485-517.
38. Rotta A., Canepa A., Hurtado A., et al. Pulmonary circulation at sea level and at high altitude. J Appl Physiol 1956, 11:143-149.
39. Richalet J.P., Rivera-Ch M., Maignan M., et al. Acetazolamide for Monge's disease: efficiency and tolerance of 6-month treatment. Am J Respir Crit Care Med 2008, 177:1370-1376.
40. Richardson T.Q., Guyton A.C. Effects of polycythemia and anemia on cardiac output and other circulatory factors. Am J Physiol 1959, 197:1167-1170.
41. Guyton A.C., Richardson T.Q. Effect of hematocrit on venous return. Circ Res 1961, 9:157-164.
42. Claydon V.E., Norcliffe L.J., Moore J.P., et al. Orthostatic tolerance and blood volumes in Andean high altitude dwellers. Exp Physiol 2004, 89:565-571.
43. Richalet J.P., Rivera M., Bouchet P., et al. Acetazolamide: a treatment for chronic mountain sickness. Am J Respir Crit Care Med 2005, 172:1427-1433.
44. Saldana M., Arias-Stella J. Studies on the structure of the pulmonary trunk. III. The thickness of the media of the pulmonary trunk and ascending aorta in high altitude natives. Circulation 1963, 27:1101-1104.
45. Saldana M., Arias-Stella J. Studies on the structure of the pulmonary trunk. II. The evolution of the elastic configuration of the pulmonary trunk in people native to high altitudes. Circulation 1963, 27:1094-1100.
46. Saldana M., Arias-Stella J. Studies on the structure of the pulmonary trunk. I. Normal changes in the elastic configuration of the human pulmonary trunk at different ages. Circulation 1963, 27:1086-1093.
47. Wagner K.F., Katschinski D.M., Hasegawa J., et al. Chronic inborn erythrocytosis leads to cardiac dysfunction and premature death in mice overexpressing erythropoietin. Blood 2001, 97:536-542.
48. Ruschitzka F.T., Wenger R.H., Stallmach T., et al. Nitric oxide prevents cardiovascular disease and determines survival in polyglobulic mice overexpressing erythropoietin. Proc Natl Acad Sci U S A 2000, 97:11609-11613.
49. Brown C.M., Hainsworth R. Assessment of capillary fluid shifts during orthostatic stress in normal subjects and subjects with orthostatic intolerance. Clin Auton Res 1999, 9:69-73.
50. Bush V.E., Wight V.L., Brown C.M., et al. Vascular responses to orthostatic stress in patients with postural tachycardia syndrome (POTS), in patients with low orthostatic tolerance, and in asymptomatic controls. Clin Auton Res 2000, 10:279-284.
51. Cooper V.L., Hainsworth R. Effects of head-up tilting on baroreceptor control in subjects with different tolerances to orthostatic stress. Clin Sci (Lond) 2002, 103:221-226.
52. Appenzeller O., Thomas P.K., Ponsford S., et al. Acral paresthesias in the Andes and neurology at sea level. Neurology 2002, 59:1532-1535.
53. Kwaan H.C., Wang J. Hyperviscosity in polycythemia vera and other red cell abnormalities. Semin Thromb Hemost 2003, 29:451-458.
54. Claydon V.E., Norcliffe L.J., Moore J.P., et al. Cardiovascular responses to orthostatic stress in healthy altitude dwellers, and altitude residents with chronic mountain sickness. Exp Physiol 2005, 90:103-110.
55. Norcliffe L.J., Rivera-Ch M., Claydon V.E., et al. Cerebrovascular responses to hypoxia and hypocapnia in high-altitude dwellers. J Physiol 2005, 566(Pt 1):287-294.
56. Moore J.P., Claydon V.E., Norcliffe L.J., et al. Carotid baroreflex regulation of vascular resistance in high-altitude Andean natives with and without chronic mountain sickness. Exp Physiol 2006, 91:907-913.
57. Antezana A.M., Richalet J.P., Noriega I., et al. Hormonal changes in normal and polycythemic high-altitude natives. J Appl Physiol 1995, 79:795-800.
58. Gamboa A., Gamboa J.L., Holmes C., et al. Plasma catecholamines and blood volume in native Andeans during hypoxia and normoxia. Clin Auton Res 2006, 16:40-45.
59. Penaloza D., Arias-Stella J. The heart and pulmonary circulation at high altitudes: healthy highlanders and chronic mountain sickness. Circulation 2007, 115:1132-1146.
60. Pei S.X., Chen X.J., Si Ren B.Z., et al. Chronic mountain sickness in Tibet. Q J Med 1989, 71:555-574.
61. Wu T.Y., Li W., Li Y., et al. Epidemiology of chronic mountain sickness: ten years' study in Qinghai-Tibet. Progress in Mountain Medicine and High Altitude Physiology. Matsumoto: Press Committee of the 3rd World Congress on Mountain Medicine and High Altitude Physiology 1998, 120-125. H. Ohno, T. Kobayashi, S. Masuyama, M. Nakashima (Eds.).
62. Sime F., Penaloza D., Ruiz L. Bradycardia, increased cardiac output, and reversal of pulmonary hypertension in altitude natives living at sea level. Br Heart J 1971, 33:647-657.
63. Allemann Y., Sartori C., Lepori M., et al. Echocardiographic and invasive measurements of pulmonary artery pressure correlate closely at high altitude. Am J Physiol 2000, 279:H2013-H2016.
64. Kojonazarov B.K., Imanov B.Z., Amatov T.A., et al. Noninvasive and invasive evaluation of pulmonary arterial pressure in highlanders. Eur Respir J 2007, 29:352-356.
65. Naeije R., Torbicki A. More on the noninvasive diagnosis of pulmonary hypertension: Doppler echocardiography revisited. Eur Respir J 1995, 8:1445-1449.
66. Tei C., Dujardin K.S., Hodge D.O., et al. Doppler echocardiographic index for assessment of global right ventricular function. J Am Soc Echocardiogr 1996, 9:838-847.
67. Harjai K.J., Scott L., Vivekananthan K., et al. The Tei index: a new prognostic index for patients with symptomatic heart failure. J Am Soc Echocardiogr 2002, 15:864-868.
68. Maignan M., Rivera-Ch M., Privat C., et al. Pulmonary pressure and cardiac function in chronic mountain sickness patients. Chest 2009, 135:499-504.
69. Cruz-Jibaja J., Banchero N., Sime F., et al. Correlation between pulmonary artery pressure and level of altitude. Dis Chest 1964, 46:446-451.
70. Wu T. Chronic mountain sickness in Qinghai-Tibet, China. Life on the Qinghai-Tibetan Plateau 2007, 118-133. Pekín University Medical Press, Beijing. R. Ge, P. Hackett (Eds.).
71. Arias-Stella J., Saldana M. The terminal portion of the pulmonary arterial tree in people native to high altitudes. Circulation 1963, 28:915-925.
72. Maggiorini M., Leon-Velarde F. High-altitude pulmonary hypertension: a pathophysiological entity to different diseases. Eur Respir J 2003, 22:1019-1025.
73. Smith T., Balanos G., Croft Q., et al. The increase in pulmonary arterial pressure caused by hypoxia depends on iron status. J Physiol 2008, 586:5999-6005.
74. Smith T., Talbot N., Privat C., et al. Effects of iron supplementation and depletion on hypoxic pulmonary hypertension: two randomized controlled trials. JAMA 2009, 302:1444-1450.
75. Rivera-Ch M., Leon-Velarde F., Huicho L. Treatment of chronic mountain sickness: critical reappraisal of an old problem. Respir Physiol Neurobiol 2007, 158:251-265.
76. Rivera-Ch M., Huicho L., Bouchet P., et al. Effect of acetazolamide on ventilatory response in subjects with chronic mountain sickness. Respir Physiol Neurobiol 2008, 162:184-189.