Extended models of the ventilatory response to sustained isocapnic hypoxia in humans

Journal of Applied Physiology

Volumn 82, Issue 2, 1997, Pages 667-677

  Liang, Pei Ji ^a   Bascom, Daphne A ^a   Robbins, Peter A ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

hypoxic ventilatory decline; peripheral chemoreflex sensitivity; sustained isocapnic hypoxia

Indexed keywords

ARTICLE; CHEMORECEPTOR REFLEX; HUMAN; HYPOXIA; LUNG VENTILATION; MATHEMATICAL MODEL; PRIORITY JOURNAL;

EID: 0031053993     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1997.82.2.667     Document Type: Article

References (18)

1. Armitage, P., and G. Berry. Statistical Methods in Medical Research (2nd ed.). Oxford, UK: Blackwell Scientific, 1987.
2. Bascom, D. A., I. D. Clement, D. A. Cunningham, R. Painter, and P. A. Robbins. Changes in peripheral chemoreflex sensitivity during sustained, isocapnic hypoxia. Respir. Physiol. 82: 161-176, 1990.
3. 2 on ventilation during isocapnia in humans. Respir. Physiol. 88: 299-312, 1992.
4. 2 on central and peripheral chemoreceptive structures. In: Neurobiology of the Control of Breathing. New York: Raven, 1986, p. 9-17.
5. DeGoede, J., and A. Berkenbosch. Dynamic end-tidal forcing technique: modelling the ventilatory response to carbon dioxide. In: Modeling and Parameter Estimation in Respiratory Control. New York: Plenum, 1989, p. 59-69.
6. Easton, P. A., and N. R. Anthonisen. Carbon dioxide effects on the ventilatory response to sustained hypoxia. J. Appl. Physiol. 64: 1451-1456, 1988.
7. Easton, P. A., L. J. Slykerman, and N. R. Anthonisen. Ventilatory response to sustained hypoxia in normal adults. J. Appl. Physiol. 61: 906-911, 1986.
8. Easton, P. A., L. J. Slykerman, and N. R. Anthonisen. Recovery of the ventilatory response to hypoxia in normal adults. J. Appl. Physiol. 64: 521-528, 1988.
9. Khamnei, S., and P. A. Robbins. Hypoxic depression of ventilation in humans: alternative models for the chemoreflexes. Respir. Physiol. 81: 117-134, 1990.
10. 2 in humans. J. Appl. Physiol. 81: 2274-2286, 1996.
11. 2 in hypoxia and in high oxygen. Respir. Physiol. 20: 17-31, 1974.
12. Neubauer, J. A., J. E. Melton, and N. H. Edelman. Modulation of respiration during brain hypoxia. J. Appl. Physiol. 68: 441-451, 1990.
13. Painter, R., S. Khamnei, and P. Robbins. A mathematical model of the human ventilatory response to isocapnic hypoxia. J. Appl. Physiol. 74: 2007-2015, 1993.
14. Priban, I. P. An analysis of some short-term patterns of breathing in man at rest. J. Physiol. Lond. 166: 425-434, 1963.
15. 2: methods and implications. J. Appl. Physiol. 39: 377-385, 1975.
16. Van Beek, J. H. G. M., A. Berkenbosch, J. DeGoede, and C. N. Olievier. Effects of brain stem hypoxaemia on the regulation of breathing. Respir. Physiol. 57: 171-188, 1984.
17. Ward, D. S., A. Berkenbosch, J. DeGoede, and C. N. Olievier. Dynamics of the ventilatory response to central hypoxia in cats. J. Appl. Physiol. 68: 1107-1113, 1990.
18. Weil, J. V., and C. W. Zwillich. Assessment of ventilatory responses to hypoxia and hypercapnia in man. Chest. 70, Suppl.: 124-128, 1976.