Endocannabinoid system regulates migration of endometrial stromal cells via cannabinoid receptor 1 through the activation of PI3K and ERK1/2 pathways

Fertility and Sterility

Volumn 93, Issue 8, 2010, Pages 2588-2593

  Gentilini, Davide ^a   Besana, Alessandra ^a   Vigano, Paola ^b,c   Dalino, Paolo ^a,d   Vignali, Michele ^e,f   Melandri, Michela ^f   Busacca, Mauro ^e,f   Di Blasio, Anna Maria ^a  

^a ISTITUTO AUXOLOGICO ITALIANO   (Italy)

^b Center for Research in Obstetrics and Gynecology CROG   (Italy)

^c SANT ANNA HOSPITAL   (Italy)

^d OSPEDALE NIGUARDA CA GRANDA   (Italy)

^e UNIVERSITY OF MILAN   (Italy)

^f Melloni Hospital   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; ACTIN; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; ENDOCANNABINOID; F ACTIN; METHANANDAMIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; POTASSIUM CHANNEL; PROTEIN KINASE B;

ARTICLE; CELL MIGRATION; CELL STRUCTURE; CHEMOKINESIS; CHEMOTAXIS; CYTOSKELETON; DOSE RESPONSE; ENDOMETRIUM CELL; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; LAPAROSCOPY; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STRESS FIBER; STROMA CELL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADULT; ARACHIDONIC ACIDS; CELL MOVEMENT; ENDOCANNABINOIDS; ENDOMETRIUM; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; HUMANS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, CANNABINOID, CB1; STROMAL CELLS;

EID: 77952108753     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2010.02.006     Document Type: Article

References (30)

1. Fowler C.J., Holt S., Nilsson O., Jonsson K.O., Tiger G., and Jacobsson S.O. The endocannabinoid signaling system: pharmacological and therapeutic aspects. Pharmacol Biochem Behav 81 (2005) 248-262
2. Lutz B. Molecular biology of cannabinoid receptors. Prostaglandins Leukot Essent Fatty Acids 66 (2002) 123-142
3. Das S.K., Paria B.C., Chakraborty I., and Dey S.K. Cannabinoid ligand-receptor signaling in the mouse uterus. Proc Natl Acad Sci U S A 92 (1995) 4332-4336
4. Schmid P.C., Paria B.C., Krebsbach R.J., Schmid H.H., and Dey S.K. Changes in anandamide levels in mouse uterus are associated with uterine receptivity for embryo implantation. Proc Natl Acad Sci U S A 94 (1997) 4188-4192
5. Tranguch S., Daikoku T., Guo Y., Wang H., and Dey S.K. Molecular complexity in establishing uterine receptivity and implantation. Cell Mol Life Sci 62 (2005) 1964-1973
6. Battista N., Pasquariello N., Di Tommaso M., and Maccarrone M. Interplay between endocannabinoids, steroids and cytokines in the control of human reproduction. J Neuroendocrinol 20 (2008) 82-89
7. Wang H., Dey S.K., and Maccarrone M. Jekyll and Hyde: two faces of cannabinoid signaling in male and female fertility. Endocr Rev 27 (2006) 427-448
8. Mitchell M.D., Sato T.A., Wang A., Keelan J.A., Ponnampalam A.P., and Glass M. Cannabinoids stimulate prostaglandin production by human gestational tissues through a tissue- and CNR1-receptor-specific mechanism. Am J Physiol Endocrinol Metab 294 (2008) 352-356
9. Kessler C.A., Moghadam K.K., Schroeder J.K., Buckley A.R., Brar A.K., and Handwerger S. Cannabinoid receptor I activation markedly inhibits human decidualization. Mol Cell Endocrinol 14 229 (2005) 65-74
10. Salamonsen L.A. Tissue injury and repair in the female human reproductive tract. Reproduction 125 (2003) 301-311
11. Grewal S. Implantation of the human embryo requires RAC1-dependent endometrial stromal cell migration. Proc Natl Acad Sci U S A 42 (2008) 16189-16194
12. Viganò P., Gaffuri B., Somigliana E., Busacca M., Di Blasio A.M., and Vignali M. Expression of intercellular adhesion molecule (ICAM)-1 mRNA and protein is enhanced in endometriosis versus endometrial stromal cells in culture. Mol Hum Reprod 4 (1998) 1150-1156
13. Viganò P., Somigliana E., Gaffuri B., Santorsola R., Busacca M., and Vignali M. Endometrial release of soluble intercellular adhesion molecule 1 and endometriosis: relationship to the extent of the disease. Obstet Gynecol 95 (2000) 115-118
14. Gentilini D., Busacca M., Di Francesco S., Vignali M., Viganò P., and Di Blasio A.M. PI3K/Akt and ERK1/2 signalling pathways are involved in endometrial cell migration induced by 17beta-estradiol and growth factors. Mol Hum Reprod 13 (2007) 317-322
15. Gentilini D., Vigano P., Somigliana E., Vicentini L.M., Vignali M., Busacca M., et al. Endometrial stromal cells from women with endometriosis reveal a peculiar migratory behaviour in response to ovarian steroids. Fertil Steril 93 (2010) 706-715
16. Simoncini T., Scorticati C., Mannella P., Fadiel A., Giretti M.S., and Fu X.D. Estrogen receptor alpha interacts with Galpha13 to drive actin remodeling and endothelial cell migration via the RhoA/Rho kinase/moesin pathway. Mol Endocrinol (2006) 1756-1771
17. Guzeloglu-Kayisli O., Kayisli U.A., Luleci G., and Arici A. In vivo and in vitro regulation of Akt activation in human endometrial cells is estrogen dependent. Biol Reprod 71 (2004) 714-721
18. Lazzarin N., Valensise H., Bari M., Ubaldi F., Battista N., Finazzi-Agrò A., et al. Fluctuations of fatty acid amide hydrolase and anandamide levels during the human ovulatory cycle. Gynecol Endocrinol 18 (2004) 212-218
19. Guzmán M., Sánchez C., and Galve-Roperh I. Control of the cell survival/death decision by cannabinoids. J Mol Med 78 (2001) 613-625
20. Sánchez M.G., Ruiz-Llorente L., Sánchez A.M., and Díaz-Laviada I. Activation of phosphoinositide 3-kinase/PKB pathway by CNR1 and CNR2 cannabinoid receptors expressed in prostate PC-3 cells. Involvement in Raf-1 stimulation and NGF induction. Cell Signal 15 (2003) 851-859
21. Demuth D.G., and Molleman A. Cannabinoid signalling. Life Sci 78 (2006) 549-563
22. Anand-Apte B., and Zetter B. Signaling mechanisms in growth factor-stimulated cell motility. Stem Cells 15 (1997) 259-267
23. Schwab A., Hanley P., Fabian, and Stock C. Potassium channels keep mobile cells on the go. Physiol 23 (2008) 212-220
24. Friedl P., and Wolf K. Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer 3 (2003) 362-374
25. Kassis J., Lauffenburger D.A., Turner T., and Wells A. Tumor invasion as dysregulated cell motility. Semin Cancer Biol 11 (2001) 105-117
26. Alessandro R., and Kohn E.C. Signal transduction targets in invasion. Clin Exp Metastasis 19 (2002) 265-273
27. Friedl P., and Wolf K. Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer 3 (2003) 362-374
28. Mareel M., and Leroy A. Clinical, cellular, and molecular aspects of cancer invasion. Physiol Rev 83 (2003) 337-376
29. Hotulainen P., and Lappalainen P. Stress fibers are generated by two distinct actin assembly mechanisms in motile cells. J Cell Biol 173 (2006) 383-394
30. Marczylo TH, Lam PMW, Konje JC. Quantitation of the endocannabinoid anandamide in human peritoneal fluid and correlation with incidences of endometriosis [abstract]. Program of the 56th Annual Meeting of the Society for Gynecological Investigation, Glasgow, U.K., 2009.