Biodistribution and radiation dosimetry of [11C]choline: A comparison between rat and human data

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 37, Issue 5, 2010, Pages 874-883

  Tolvanen, Tuula ^a   Yli Kerttula, Timo ^a   Ujula, Tiina ^a   Autio, Anu ^a   Lehikoinen, Pertti ^a   Minn, Heikki ^a   Roivainen, Anne ^a,b  

^a TURKU UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

Author keywords

11C Choline; Positron emission tomography; Radiation dosimetry; Whole body distribution

Indexed keywords

CHOLINE C 11;

ABDOMEN; ADRENAL GLAND; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DOSIMETRY; DRUG ABSORPTION; DRUG DISTRIBUTION; DRUG EXCRETION; EX VIVO STUDY; FEASIBILITY STUDY; HUMAN; HUMAN TISSUE; IN VIVO STUDY; KIDNEY PARENCHYMA; LIVER; LUNG PARENCHYMA; NONHUMAN; PANCREAS; POSITRON EMISSION TOMOGRAPHY; RADIATION DOSE DISTRIBUTION; RADIOACTIVITY; RAT; RHEUMATOID ARTHRITIS; SYNOVITIS; THORAX; URINE LEVEL;

ADULT; ANIMALS; CHOLINE; FEMALE; HUMANS; MALE; MIDDLE AGED; POSITRON-EMISSION TOMOGRAPHY; RADIATION DOSAGE; RADIOMETRY; RADIOPHARMACEUTICALS; RATS;

EID: 77952089733     PISSN: 16197070     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00259-009-1346-z     Document Type: Article

References (48)

1. SH Zeisel 1996 Choline. A nutrient that is involved in the regulation of cell proliferation, cell death, and cell transformation Adv Exp Med Biol 399 131 141 1:CAS:528:DyaK2sXotl2lsg%3D%3D 8937553
2. A Ramírez de Molina A Rodríguez-González R Gutiérrez L Martínez-Piñeiro J Sánchez F Bonilla, et al. 2000 Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers Biochem Biophys Res Commun 296 580 583 10.1016/S0006-291X(02)00920-8
3. EM Cornford LD Braun WH Oldendorf 1978 Carrier mediated blood-brain barrier transport of choline and certain choline analogs J Neurochem 30 299 308 10.1111/j.1471-4159.1978.tb06530.x 1:CAS:528:DyaE1cXkt1WjsL0%3D 624938
4. R Katz-Brull H Degani 1996 Kinetics of choline transport and phosphorylation in human breast cancer cells; NMR application of the zero trans method Anticancer Res 16 1375 1380 1:CAS:528:DyaK28XkslWjt7o%3D 8694504 (Pubitemid 26257805)
5. M Utriainen M Komu V Vuorinen P Lehikoinen P Sonninen T Kurki, et al. 2003 Evaluation of brain tumor metabolism with [11C]choline PET and 1H-MRS J Neurooncol 62 329 338 10.1023/A:1023342516925 1:STN:280:DC%2BD3s3ltlahsg%3D%3D 12777086 (Pubitemid 36591970)
6. O Kobori Y Kirihara N Kosaka T Hara 1999 Positron emission tomography of esophageal carcinoma using (11)C-choline and (18)F-fluorodeoxyglucose: a novel method of preoperative lymph node staging Cancer 86 1638 1648 10.1002/(SICI)1097-0142(19991101)86:9<1638::AID-CNCR4>3.0.CO;2-U 1:STN:280:DC%2BD3c%2Fhs1aqsg%3D%3D 10547535 (Pubitemid 29513031)
7. E Sutinen M Nurmi A Roivainen M Varpula T Tolvanen P Lehikoinen, et al. 2004 Kinetics of [(11)C]choline uptake in prostate cancer: a PET study Eur J Nucl Med Mol Imaging 31 317 324 10.1007/s00259-003-1377-9 1:CAS:528: DC%2BD2cXhtlygtLw%3D 14628097 (Pubitemid 38314074)
8. IJ de Jong J Pruim PH Elsinga MM Jongen HJ Mensink W Vaalburg 2002 Visualisation of bladder cancer using (11)C-choline PET: first clinical experience Eur J Nucl Med Mol Imaging 29 1283 1288 10.1007/s00259-002-0881-7 12271408 (Pubitemid 44392207)
9. A Roivainen R Parkkola T Yli-Kerttula P Lehikoinen T Viljanen T Möttönen, et al. 2003 Use of positron emission tomography with methyl-11C-choline and 2-18F-fluoro-2-deoxy-D-glucose in comparison with magnetic resonance imaging for the assessment of inflammatory proliferation of synovium Arthritis Rheum 48 3077 3084 10.1002/art.11282 1:CAS:528: DC%2BD3sXpvVygtL4%3D 14613269 (Pubitemid 37409318)
10. A Roivainen T Yli-Kerttula 2006 Whole-body distribution of (11)C-choline and uptake in knee synovitis Eur J Nucl Med Mol Imaging 33 1372 1373 10.1007/s00259-006-0184-5 16865392 (Pubitemid 44630796)
11. T Hara 2002 C-11 Choline and 2-deoxy-2[F-18]fluoro-D-glucose in tumor imaging with positron emission tomography Mol Imaging Biol 4 267 273 10.1016/S1536-1632(02)00015-X 14537115 (Pubitemid 35214587)
12. A Roivainen S Forsback T Grönroos P Lehikoinen M Kähkönen E Sutinen, et al. 2000 Blood metabolism of [methyl-11C]choline; implications for in vivo imaging with positron emission tomography Eur J Nucl Med 27 25 32 10.1007/PL00006658 1:CAS:528:DyaK1MXnvFektro%3D 10654143 (Pubitemid 30097256)
13. PK Lehikoinen JR Bergman UM Hällsten EPJ Kokkomäki OI Eskola OH Solin 1999 A simple synthesis of [methyl-11C]choline J Labelled Comp Radiopharm 42 S480 S482
14. RW Howell BW Wessels R Lovinger 1999 The MIRD perspective 1999 J Nucl Med 40 3S 10S 1:STN:280:DyaK1M7jtFOrsw%3D%3D 9935082
15. MG Stabin R Sparks E Crowe 2005 OLINDA/EXM: the second-generation personal computer software for internal dose assessment in nuclear medicine J Nucl Med 46 1023 1027 15937315 (Pubitemid 43733519)
16. Snyder WS, Cook MJ, Nasset ES, Karhausen LR, Howells GP, Tipton IH. Report of the Task Group on Reference Man. Oxford, UK: Pergamon Press; 1974. p. 325-7.
17. International Commission on Radiological Protection 1979 ICRP Publication 30. Limits for intakes of radionuclides by workers - dosimetric model for bone Ann ICRP 2 35 46 10.1016/0146-6453(79)90070-8
18. RP Friedland CA Mathis TF Budinger BR Moyer M Rosen 1983 Labeled choline and phosphorylcholine: body distribution and brain autoradiography: concise communication J Nucl Med 24 812 815 1:CAS:528:DyaL3sXlslajt74%3D 6604143
19. DR Haubrich PFL Wang PW Wedeking 1975 Distribution and metabolism of intravenously administered choline[methyl-3-H] and synthesis in vivo of acetylcholine in various tissues of guinea pigs J Pharmacol Exp Ther 193 246 255 1:CAS:528:DyaE2MXhsFakurk%3D 1133767
20. TR DeGrado RE Reiman DT Price S Wang RE Coleman 2002 Pharmacokinetics and radiation dosimetry of 18F-fluorocholine J Nucl Med 43 92 96 1:CAS:528:DC%2BD38XksVynu7c%3D 11801711
21. International Commission on Radiological Protection 2008 ICRP Publication 106. Radiation doses to patients from radiopharmaceuticals - a third amendment to ICRP Publication 53 Ann ICRP 38 1 198
22. CM Laymon NS Mason WG Frankle JP Carney BJ Lopresti MY Litschge, et al. 2009 Human biodistribution and dosimetry of the D2/3 agonist 11C-N-propylnorapomorphine (11C-NPA) determined from PET J Nucl Med 50 814 817 10.2967/jnumed.108.058131 1:CAS:528:DC%2BD1MXmtV2hsrg%3D 19372487
23. V Treyer J Streffer SM Ametamey A Bettio P Bläuenstein M Schmidt, et al. 2008 Radiation dosimetry and biodistribution of 11C-ABP688 measured in healthy volunteers Eur J Nucl Med Mol Imaging 35 766 770 10.1007/s00259-007- 0638-4 1:CAS:528:DC%2BD1cXjsVClu7c%3D 18071702
24. JR Virta T Tolvanen K Någren A Brück A Roivainen JO Rinne 2008 1-11C-methyl-4-piperidinyl-N-butyrate radiation dosimetry in humans by dynamic organ-specific evaluation J Nucl Med 49 347 353 10.2967/jnumed.107.047233 18287260 (Pubitemid 351355198)
25. MM Graham LM Peterson M Muzi BB Graham AM Spence JM Link, et al. 1998 1-[Carbon-11]-glucose radiation dosimetry and distribution in human imaging studies J Nucl Med 39 1805 1810 1:CAS:528:DyaK1cXmvFGhu7s%3D 9776292 (Pubitemid 28473535)
26. S Thees B Neumaier G Glatting S Deisenhofer CA von Arnim SN Reske, et al. 2007 Radiation dosimetry and biodistribution of the beta-amyloid plaque imaging tracer 11C-BTA-1 in humans Nuklearmedizin 46 175 180 1:STN:280: DC%2BD2snltlygtw%3D%3D 17938750 (Pubitemid 47612281)
27. NM Scheinin TK Tolvanen IA Wilson EM Arponen KÅ Någren JO Rinne 2007 Biodistribution and radiation dosimetry of the amyloid imaging agent 11C-PIB in humans J Nucl Med 48 128 133 1:CAS:528:DC%2BD2sXhvFKmtrw%3D 17204709
28. GJ O'Keefe TH Saunder S Ng U Ackerman HJ Tochon-Danguy JG Chan, et al. 2009 Radiation dosimetry of beta-amyloid tracers 11C-PiB and 18F-BAY94-9172 J Nucl Med 50 309 315 10.2967/jnumed.108.055756 19164222
29. N Liu M Li X Li X Meng G Yang S Zhao, et al. 2009 PET-based biodistribution and radiation dosimetry of epidermal growth factor receptor-selective tracer 11C-PD153035 in humans J Nucl Med 50 303 308 10.2967/jnumed.108.056556 19164239
30. P Santens F De Vos H Thierens D Decoo G Slegers RA Dierckx, et al. 1998 Biodistribution and dosimetry of carbon-11-methoxyprogabidic acid, a possible ligand for GABA-receptors in the brain J Nucl Med 39 307 310 1:CAS:528:DyaK1cXhsVKisLo%3D 9476942 (Pubitemid 28114524)
31. MA Seltzer SA Jahan R Sparks DB Stout N Satyamurthy M Dahlbom, et al. 2004 Radiation dose estimates in humans for C-11-acetate whole-body PET J Nucl Med 45 1233 1236 1:CAS:528:DC%2BD2cXnsFygsbo%3D 15235071 (Pubitemid 47611670)
32. HM Deloar T Fujiwara T Nakamura M Itoh D Imai M Miyake, et al. 1998 Estimation of internal absorbed dose of L-[methyl-C-11]methionine using whole-body positron emission tomography Eur J Nucl Med 15 629 633 10.1007/s002590050265 (Pubitemid 28297838)
33. VL Cropley M Fujita JL Musachio J Hong S Ghose J Sangare, et al. 2006 Whole-body biodistribution and estimation of radiation-absorbed doses of the dopamine D-1 receptor radioligand C-11-NNC 112 in humans J Nucl Med 47 100 104 1:CAS:528:DC%2BD28XhsFeis7Y%3D 16391193 (Pubitemid 46768518)
34. MJ Ribeiro M Ricard MA Lièvre S Bourgeois P Emond P Gervais, et al. 2007 Whole-body distribution and radiation dosimetry of the dopamine transporter radioligand [(11)C]PE2I in healthy volunteers Nucl Med Biol 34 465 470 10.1016/j.nucmedbio.2007.02.005 1:CAS:528:DC%2BD2sXlt1ahs7k%3D 17499737 (Pubitemid 46722682)
35. M Slifstein DR Hwang D Martinez J Ekelund Y Huang E Hackett, et al. 2006 Biodistribution and radiation dosimetry of the dopamine D-2 ligand C-11-raclopride determined from human whole-body PET J Nucl Med 47 313 319 1:CAS:528:DC%2BD28XhslantrY%3D 16455638 (Pubitemid 46780897)
36. MJ Ribeiro M Ricard S Bourgeois MA Lièvre M Bottlaender P Gervais, et al. 2005 Biodistribution and radiation dosimetry of [C-11]raclopride in healthy volunteers Eur J Nucl Med Mol Imaging 32 952 958 10.1007/s00259-005- 1783-2 15841376 (Pubitemid 41205667)
37. AK Brown M Fujita Y Fujimura JS Liow M Stabin YH Ryu, et al. 2007 Radiation dosimetry and biodistribution in monkey and man of 11C-PBR28: a PET radioligand to image inflammation J Nucl Med 48 2072 2079 10.2967/jnumed.107. 044842 1:CAS:528:DC%2BD1cXnvFSlsA%3D%3D 18006619 (Pubitemid 350232319)
38. K Marthi SB Hansen S Jakobsen D Bender SB Smith DF Smith 2003 Biodistribution and radiation dosimetry of [N-rnethyl-C-11]mirtazapine, an antidepressant affecting adrenoceptors Appl Radiat Isot 59 175 179 10.1016/S0969-8043(03)00156-8 1:CAS:528:DC%2BD3sXms1aisbs%3D 12941508 (Pubitemid 36993613)
39. JQ Lu M Ichise JS Liow S Ghose D Vines RB Innis 2004 Biodistribution and radiation dosimetry of the serotonin transporter ligand C-11-DASB determined from human whole-body PET J Nucl Med 45 1555 1559 1:CAS:528:DC%2BD2cXosVWisL8%3D 15347724 (Pubitemid 47618510)
40. N Seneca SS Zoghbi JS Liow W Kreisl P Herscovitch K Jenko, et al. 2009 Human brain imaging and radiation dosimetry of 11C-N-desmethyl-loperamide, a PET radiotracer to measure the function of P-glycoprotein J Nucl Med 50 807 813 10.2967/jnumed.108.058453 1:CAS:528:DC%2BD1MXmtV2hsrs%3D 19372478
41. RV Parsey MJ Belanger GM Sullivan NR Simpson MG Stabin R Van Heertum, et al. 2005 Biodistribution and radiation dosimetry of C-11-WAY100635 in humans J Nucl Med 46 614 619 1:CAS:528:DC%2BD2MXjvVyqtL0%3D 15809484 (Pubitemid 41716406)
42. International Commission on Radiological Protection 1998 ICRP Publication 80. Recalculated dose data for 19 frequently used radiopharmaceuticals from ICRP Publication 53 Ann ICRP 28 47 83 10.1016/S0146-6453(99)00009-3 (Pubitemid 129710673)
43. RV Parsey LO Sokol MJ Bélanger JS Kumar NR Simpson T Wang, et al. 2005 Amyloid plaque imaging agent [C-11]-6-OH-BTA-1: biodistribution and radiation dosimetry in baboon Nucl Med Commun 26 875 880 10.1097/00006231- 200510000-00005 1:CAS:528:DC%2BD2MXhtVShsLjF 16160646 (Pubitemid 41426549)
44. J Harvey G Firnau ES Garnett 1985 Estimation of the radiation dose in man due to 6-[18F]fluoro-L-dopa J Nucl Med 26 931 935 1:CAS:528:DyaL28Xhs1Cgtr8%3D 3928836 (Pubitemid 16001497)
45. WD Brown TR Oakes OT DeJesus MD Taylor AD Roberts RJ Nickles, et al. 1998 Fluorine-18-fluoro-L-DOPA dosimetry with carbidopa pretreatment J Nucl Med 39 1884 1891 1:CAS:528:DyaK1cXnsFWjsLc%3D 9829576
46. G Tang M Wang X Tang L Luo M Gan 2003 Pharmacokinetics and radiation dosimetry estimation of O-(2-[18F]fluoroethyl)-L-tyrosine as oncologic PET tracer Appl Radiat Isotopes 58 219 225 10.1016/S0969-8043(02)00311-1 1:CAS:528:DC%2BD3sXotlGqug%3D%3D (Pubitemid 36172512)
47. D Pauleit F Floeth H Herzog K Hamacher L Tellmann HW Müller, et al. 2003 Whole-body distribution and dosimetry of O-(2-[18F]fluoroethyl)-L-tyrosine Eur J Nucl Med Mol Imaging 30 519 524 1:CAS:528:DC%2BD3sXislyqtr4%3D 12589478
48. RW Leggett 2001 Reliability of the ICRP's dose coefficients for members of the public. 1. Sources of uncertainty in the biokinetic models Radiat Prot Dosimetry 95 199 213 1:STN:280:DC%2BD3MrmtVahtw%3D%3D 11605794