Moderate caloric restriction during gestation results in lower arcuate nucleus NPY- and αMSH-neurons and impairs hypothalamic response to fed/fasting conditions in weaned rats

Diabetes, Obesity and Metabolism

Volumn 12, Issue 5, 2010, Pages 403-413

  Garcia A P ^a   Palou, M ^a   Priego, T ^a   Sanchez J ^a   Palou, A ^a   Pico C ^a  

^a UNIVERSITAT DE LES ILLES BALEARS   (Spain)

Author keywords

Developmental programming; Energy balance; Hypothalamus; Insulin and leptin resistance; Obesity

Indexed keywords

ALPHA INTERMEDIN; GHRELIN; INSULIN RECEPTOR; LEPTIN; LEPTIN RECEPTOR; NEUROPEPTIDE Y; PROOPIOMELANOCORTIN; SUPPRESSOR OF CYTOKINE SIGNALING 3;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; BODY WEIGHT; CALORIC RESTRICTION; CONTROLLED STUDY; DIET RESTRICTION; DISEASE PREDISPOSITION; ENERGY BALANCE; ENERGY EXPENDITURE; FEMALE; FOOD INTAKE; GENE EXPRESSION; HYPOTHALAMUS FUNCTION; INSULIN RESISTANCE; MALE; MATERNAL NUTRITION; NONHUMAN; PREGNANCY; RAT;

EID: 77952085931     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/j.1463-1326.2009.01174.x     Document Type: Article

References (46)

1. Bellisari A. Evolutionary origins of obesity. Obes Rev 2008, 9:165-180.
2. Godfrey KM, Barker DJ. Fetal programming and adult health. Public Health Nutr 2001, 4:611-624.
3. Breier BH. Fetal programming of appetite and obesity. Mol Cell Endocrinol 2001, 185:73-79.
4. Gluckman PD, Hanson MA. Living with the past: evolution, development, and patterns of disease. Science 2004, 305:1733-1736.
5. Jones AP, Friedman MI. Obesity and adipocyte abnormalities in offspring of rats undernourished during pregnancy. Science 1982, 215:1518-1519.
6. Thompson NM, Norman AM, Donkin SS. Prenatal and postnatal pathways to obesity: different underlying mechanisms, different metabolic outcomes. Endocrinology 2007, 148:2345-2354.
7. Schwartz MW, Woods SC, Porte D, Seeley RJ, Baskin DG. Central nervous system control of food intake. Nature 2000, 404:661-671.
8. Plagemann A, Harder T, Rake A. Hypothalamic nuclei are malformed in weanling offspring of low protein malnourished rat dams. J Nutr 2000, 130:2582-2589.
9. Chang GQ. Maternal high-fat diet and fetal programming: increased proliferation of hypothalamic peptide-producing neurons that increase risk for overeating and obesity. J Neurosci 2008, 28:12107-12119.
10. Delahaye F, Breton C, Risold PY. Maternal perinatal undernutrition drastically reduces postnatal leptin surge and affects the development of arcuate nucleus proopiomelanocortin neurons in neonatal male rat pups. Endocrinology 2008, 149:470-475.
11. Ikenasio-Thorpe BA, Breier BH, Vickers MH, Fraser M. Prenatal influences on susceptibility to diet-induced obesity are mediated by altered neuroendocrine gene expression. J Endocrinol 2007, 193:31-37.
12. Coll AP, Farooqi IS, O'Rahilly S. The hormonal control of food intake. Cell 2007, 129:251-262.
13. Schwartz MW, Woods SC, Porte D, Seeley RJ, Baskin DG. Central nervous system control of food intake. Nature 2000, 404:661-671.
14. Palou A, Serra F, Bonet ML, Pico C. Obesity: molecular bases of a multifactorial problem. Eur J Nutr 2000, 39:127-144.
15. Nakazato M, Murakami N, Date Y. A role for ghrelin in the central regulation of feeding. Nature 2001, 409:194-198.
16. Zhang Y, Scarpace PJ. The role of leptin in leptin resistance and obesity. Physiol Behav 2006, 88:249-256.
17. Palou A, Pico C. Leptin intake during lactation prevents obesity and affects food intake and food preferences in later life. Appetite 2009, 52:249-252.
18. Sanchez J, Priego T, Palou M. Oral supplementation with physiological doses of leptin during lactation in rats improves insulin sensitivity and affects food 7 preferences later in life. Endocrinology 2008, 149:733-740.
19. Pico C, Oliver P, Sanchez J. The intake of physiological doses of leptin during lactation in rats prevents obesity in later life. Int J Obes (Lond) 2007, 31:1199-1209.
20. Krechowec SO, Vickers M, Gertler A, Breier BH. Prenatal influences on leptin sensitivity and susceptibility to diet-induced obesity. J Endocrinol 2006, 189:355-363.
21. Mullis PE, Tonella P. Regulation of fetal growth: consequences and impact of being born small. Best Pract Res Clin Endocrinol Metab 2008, 22:173-190.
22. Ravelli GP, Stein ZA, Susser MW. Obesity in young men after famine exposure in utero and early infancy. N Engl J Med 1976, 295:349-353.
23. Jones AP, Simson EL, Friedman MI. Gestational undernutrition and the development of obesity in rats. J Nutr 1984, 114:1484-1492.
24. Cinti S. The adipose organ. Prostaglandins Leukot Essent Fatty Acids 2005, 73:9-15.
25. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001, 25:402-408.
26. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates 1998, 27-33. 4th edn, San Diego, CA, Academic Press
27. Hsu SM, Raine L, Fanger H. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 1981, 29:577-580.
28. Elmquist JK. Hypothalamic pathways underlying the endocrine, autonomic, and behavioral effects of leptin. Int J Obes 2001, 25:S78-S82.
29. Niswender KD, Baskin DG, Schwartz MW. Insulin and its evolving partnership with leptin in the hypothalamic control of energy homeostasis. Trends Endocrinol Metab 2004, 15:362-369.
30. Horvath TL. The hardship of obesity: a soft-wired hypothalamus. Nat Neurosci 2005, 8:561-565.
31. Ahima RS, Bjorbaek C, Osei S, Flier JS. Regulation of neuronal and glial proteins by leptin: implications for brain development. Endocrinology 1999, 140:2755-2762.
32. Bouret SG, Draper SJ, Simerly RB. Trophic action of leptin on hypothalamic neurons that regulate feeding. Science 2004, 304:108-110.
33. Vickers MH, Gluckman PD, Coveny AH. Neonatal leptin treatment reverses developmental programming. Endocrinology 2005, 146:4211-4216.
34. Bodosi B, Gardi J, Hajdu I. Rhythms of ghrelin, leptin, and sleep in rats: effects of the normal diurnal cycle, restricted feeding, and sleep deprivation. Am J Physiol Regul Integr Comp Physiol 2004, 287:R1071-R1079.
35. Sanchez J, Oliver P, Pico C, Palou A. Diurnal rhythms of leptin and ghrelin in the systemic circulation and in the gastric mucosa are related to food intake in rats. Pflugers Arch 2004, 448:500-506.
36. Morrison CD, Morton GJ, Niswender KD, Gelling RW, Schwartz MW. Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that 16 requires phosphatidylinositol 3-OH-kinase signaling. Am J Physiol Endocrinol Metab 2005, 289:E1051-E1057.
37. Baskin DG, Hahn TM, Schwartz MW. Leptin sensitive neurons in the 19 hypothalamus. Horm Metab Res 1999, 31:345-350.
38. Munzberg H, Myers MG. Molecular and anatomical determinants of central leptin resistance. Nat Neurosci 2005, 8:566-570.
39. Ueki K, Kondo T, Kahn CR. Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Mol Cell Biol 2004, 24:5434-5446.
40. Senn JJ, Klover PJ, Nowak IA. Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes. J Biol Chem 2003, 278:13740-13746.
41. Ahren B, Sauerberg P, Thomsen C. Increased insulin secretion and normalization of glucose tolerance by cholinergic agonism in high fat-fed mice. Am J Physiol 1999, 277:E93-E102.
42. Levin BE, Dunn-Meynell AA. Reduced central leptin sensitivity in rats with diet-induced obesity. Am J Physiol Regul Integr Comp Physiol 2002, 283:R941-R948.
43. Fam BC, Morris MJ, Hansen MJ. Modulation of central leptin sensitivity and energy balance in a rat model of diet-induced obesity. Diabetes Obes Metab 2007, 9:840-852.
44. Anguita RM, Sigulem DM, Sawaya AL. Intrauterine food restriction is associated with obesity in young rats. J Nutr 1993, 123:1421-1428.
45. Bellinger L, Sculley DV, Langley-Evans SC. Exposure to undernutrition in fetal life determines fat distribution, locomotor activity and food intake in ageing rats. Int J Obes (Lond) 2006, 30:729-738.
46. Kemnitz JW, Goy RW, Keesey RE. Effects of gonadectomy on hypothalamic obesity in male and female rats. Int J Obes 1977, 1:259-270.