Serum cytokine and periodontal profiles in relation to disease activity of rheumatoid arthritis in Japanese adults

Journal of Periodontology

Volumn 81, Issue 5, 2010, Pages 650-657

  Kobayashi, Tetsuo ^a,b   Murasawa, Akira ^c   Komatsu, Yasutaka ^b   Yokoyama, Tomoko ^b   Ishida, Kohei ^b   Abe, Asami ^c   Yamamoto, Kouji ^b   Yoshie, Hiromasa ^b  

^a NIIGATA UNIVERSITY MEDICAL AND DENTAL HOSPITAL   (Japan)

^b NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^c Niigata Rheumatic Center   (Japan)

Author keywords

Arthritis; C reactive protein; Cytokines; Periodontitis; Rheumatoid; Serum

Indexed keywords

ANTIRHEUMATIC AGENT; C REACTIVE PROTEIN; CYTOKINE; INTERLEUKIN 12; INTERLEUKIN 12P40; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 6; NONSTEROID ANTIINFLAMMATORY AGENT; RHEUMATOID FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; BLOOD; CASE CONTROL STUDY; CLASSIFICATION; COMPARATIVE STUDY; DISEASE PREDISPOSITION; FEMALE; GINGIVA BLEEDING; HOSPITALIZATION; HUMAN; MALE; MIDDLE AGED; PERIODONTAL DISEASE; PERIODONTAL POCKET; PERIODONTITIS; RHEUMATOID ARTHRITIS; RHEUMATOID NODULE; TIME; TOOTH PLAQUE;

ADULT; AGED; AGED, 80 AND OVER; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; C-REACTIVE PROTEIN; CASE-CONTROL STUDIES; CYTOKINES; DENTAL PLAQUE; DISEASE SUSCEPTIBILITY; FEMALE; GINGIVAL HEMORRHAGE; HUMANS; INTERLEUKIN-12; INTERLEUKIN-12 SUBUNIT P40; INTERLEUKIN-18; INTERLEUKIN-1BETA; INTERLEUKIN-6; MALE; MIDDLE AGED; PERIODONTAL ATTACHMENT LOSS; PERIODONTAL POCKET; PERIODONTITIS; RHEUMATOID FACTOR; RHEUMATOID NODULE; SEVERITY OF ILLNESS INDEX; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77952082682     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2010.090688     Document Type: Article

References (36)

1. Greenwald RA, Kirkwood K. Adult periodontitis as a model for rheumatoid arthritis (with emphasis on treatment strategies). J Rheumatol 1999;26:1650-1653.
2. Mercado FB, Marshall RI, Bartold PM. Inter-relationships between rheumatoid arthritis and periodontal disease. A review. J Clin Periodontol 2003;30:761-772.
3. de Pablo P, Chapple IL, Buckley CD, Dietrich T. Periodontitis in systemic rheumatic diseases. Nat Rev Rheumatol 2009;5:218-224.
4. Kässer UR, Gleissner C, Dehne F, Michel A,Willershausen- Zönnchen B, Bolten WW. Risk for periodontal disease in patients with longstanding rheumatoid arthritis. Arthritis Rheum 1997;40:2248-2251.
5. Mercado F, Marshall RI, Klestov AC, Bartold PM. Is there a relationship between rheumatoid arthritis and periodontal disease? J Clin Periodontol 2000;27:267-272.
6. Mercado FB, Marshall RI, Klestov AC, Bartold PM. Relationship between rheumatoid arthritis and periodontitis. J Periodontol 2001;72:779-787.
7. Pischon N, Pischon T, Kröger J, et al. Association among rheumatoid arthritis, oral hygiene, and periodontitis. J Periodontol 2008;79:979-986.
8. Ribeiro J, Leão A, Novaes AB. Periodontal infection as a possible severity factor for rheumatoid arthritis. J Clin Periodontol 2005;32:412-416.
9. Al-Katma MK, Bissada NF, Bordeaux JM, Sue J, Askari AD. Control of periodontal infection reduces the severity of active rheumatoid arthritis. J Clin Rheumatol 2007;13:134-137.
10. Ortiz P, Bissada NF, Palomo L, et al. Periodontal therapy reduces the severity of active rheumatoid arthritis in patients treated with or without tumor necrosis factor inhibitors. J Periodontol 2009;80:535-540.
11. Feldmann M, Brennan FM, Maini RN. Role of cytokines in rheumatoid arthritis. Annu Rev Immunol 1996;14: 397-440.
12. Kjeldsen M, Holmstrup P, Bendtzen K. Marginal periodontitis and cytokines: A review of the literature. J Periodontol 1993;64:1013-1022.
13. Bartold PM, Marshall RI, Haynes DR. Periodontitis and rheumatoid arthritis: A review. J Periodontol 2005;76: 2066-2074.
14. Havemose-Poulsen A, Sørensen LK, Stoltze K, Bendtzen K, Holmstrup P. Cytokine profiles in peripheral blood and whole blood cell cultures of patients associated with aggressive periodontitis, juvenile idiopathic arthritis, and rheumatoid arthritis. J Periodontol 2005;76:2276-2285.
15. Pers JO, Saraux A, Pierre R, Youinou P. Anti-TNF-α immunotherapy is associated with increased gingival inflammation without clinical attachment loss in subjects with rheumatoid arthritis. J Periodontol 2008;79: 1645-1651.
16. Miranda LA, Fischer RG, Sztajnbok FR, et al. Increased interleukin-18 in patients with juvenile idiopathic arthritis and early attachment loss. J Periodontol 2005;76:75-82.
17. Orozco A, Gemmell E, Bickel M, Seymour GJ. Interleukin-1β, interleukin-12 and interleukin-18 levels in gingival fluid and serum of patients with gingivitis and periodontitis. Oral Microbiol Immunol 2006;21: 256-260.
18. Nakanishi K, Yoshimoto T, Tsutsui H, Okamura H. Interleukin-18 regulates both Th1 and Th2 responses. Annu Rev Immunol 2001;19:423-474.
19. Gately MK, Renzetti LM, Magram J, et al. The interleukin-12/interleukin- 12-receptor system: Role in normal and pathologic immune responses. Annu Rev Immunol 1998;16:495-521.
20. Kobayashi T, Ito S, Kuroda T, et al. The interleukin-1 and Fcγ receptor gene polymorphisms in Japanese patients with rheumatoid arthritis and periodontitis. J Periodontol 2007;78:2311-2318.
21. Kobayashi T, Murasawa A, Ito S, et al. Cytokine gene polymorphisms associated with rheumatoid arthritis and periodontitis in Japanese adults. J Periodontol 2009;80:792-799.
22. Havemose-Poulsen A, Sørensen LK, Bendtzen K, Holmstrup P. Polymorphisms within the IL-1 gene cluster: Effects on cytokine profiles in peripheral blood and whole blood cell cultures of patients with aggressive periodontitis, juvenile idiopathic arthritis, and rheumatoid arthritis. J Periodontol 2007;78:475-492.
23. Arnett FC, Edworthy SM, Bloch DA, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-324.
24. Department of Rheumatology University Medical Center Nijmegen-The Netherlands. DAS-score.nl:home of the DAS. Available at: http://www.reuma- nijmegen.nl/www.das-score.nl/index.html. Accessed December 2, 2009.
25. Matsui T, Kuga Y, Kaneko A, et al. Disease activity score 28 (DAS28) using C-reactive protein underestimates disease activity and overestimates EULAR response criteria compared with DAS28 using erythrocyte sedimentation rate in a large observational cohort of rheumatoid arthritis patients in Japan. Ann Rheum Dis 2007;66:1221-1226.
26. Petrovic-Rackov L, Pejnovic N. Clinical significance of IL-18, IL-15, IL-12 and TNF-α measurement in rheumatoid arthritis. Clin Rheumatol 2006;25:448-452.
27. Rioja I, Hughes FJ, Sharp CH, et al. Potential novel biomarkers of disease activity in rheumatoid arthritis patients: CXCL13, CCL23, transforming growth factor α, tumor necrosis factor receptor superfamily member 9, and macrophage colony-stimulating factor. Arthritis Rheum 2008;58:2257-2267.
28. D'Aiuto F, Parkar M, Andreou G, et al. Periodontitis and systemic inflammation: Control of the local infection is associated with a reduction in serum inflammatory markers. J Dent Res 2004;83:156-160.
29. Nilsson M, Kopp S. Gingivitis and periodontitis are related to repeated high levels of circulating tumor necrosis factor-alpha in patients with rheumatoid arthritis. J Periodontol 2008;79:1689-1696.
30. Ide M, McPartlin D, Coward PY, Crook M, Lumb P, Wilson RF. Effect of treatment of chronic periodontitis on levels of serum markers of acute-phase inflammatory and vascular responses. J Clin Periodontol 2003; 30:334-340.
31. Yamazaki K, Honda T, Oda T, et al. Effect of periodontal treatment on the C-reactive protein and proinflammatory cytokine levels in Japanese periodontitis patients. J Periodontal Res 2005;40: 53-58.
32. Been V, Engel D. The effects of immunosuppressive drugs on periodontal inflammation in human renal allograft patients. J Periodontol 1982;53:245-248.
33. Howell TH. Blocking periodontal disease progression with anti-inflammatory agents. J Periodontol 1993;64: 828-833.
34. Miranda LA, Islabão AG, Fischer RG, Figueredo CM, Oppermann RV, Gustafsson A. Decreased interleukin-1β and elastase in the gingival crevicular fluid of individuals undergoing anti-inflammatory treatment for rheumatoid arthritis. J Periodontol 2007;78:1612-1619.
35. Sørensen LK, Havemose-Poulsen A, Bendtzen K, Holmstrup P. Aggressive periodontitis and chronic arthritis: Blood mononuclear cell gene expression and plasma protein levels of cytokines and cytokine inhibitors. J Periodontol 2009;80:282-289.
36. Orozco A, Gemmell E, Bickel M, Seymour GJ. Interleukin 18 and periodontal disease. J Dent Res 2007; 86:586-593.