Magnesium metabolism in internal and intensive care medicine;Der magnesiumhaushalt in der inneren und intensivmedizin

Nieren- und Hochdruckkrankheiten

Volumn 39, Issue 5, 2010, Pages 182-194

  Kisters, K ^a,g   Cziborra, M ^a   Funke, C ^a   Kozianka, J ^a   Nguyen, M Q ^b   Tokmak, F ^b   Kramer B ^b   Gremmler, B ^c   Hausberg, M ^d   Micke, O ^e,g   Buntzel J ^f,g   Mucke R ^g   Liebscher, D H ^h  

^a ST ANNA HOSPITAL   (Germany)

^b RUHR UNIVERSITY BOCHUM   (Germany)

^c Marien Hospital Bottrop gGmbH   (Germany)

^d STÄDTISCHES KLINIKUM KARLSRUHE   (Germany)

^e FRANZISKUS HOSPITAL   (Germany)

^f Südharz Hospital   (Germany)

^g AKTE   (Germany)

^h SHO Mineralimbalancen EV   (Germany)

Author keywords

Hypertension; Intensive care medicine; Mg++

Indexed keywords

MAGNESIUM;

ALLERGIC REACTION; CRITICALLY ILL PATIENT; HEART ARRHYTHMIA; HUMAN; HYPERTENSION; INTENSIVE CARE; MAGNESIUM DEFICIENCY; MAGNESIUM METABOLISM; MUSCLE CRAMP; PREECLAMPSIA; REVIEW;

EID: 77952031708     PISSN: 03005224     EISSN: None     Source Type: Journal    
DOI: 10.5414/nhp39182     Document Type: Review

References (132)

1. Altura BM, Altura BT. Cardiovascular risk factors and magnesium: relation-ships to atherosclerosis, ischemic heart disease and hypertension. Magnesium and Trace Elements. 1991; 10: 182-192.
2. Altura BM, Altura BT. Interactions of Mg and K on blood vessels - aspects in view of hypertension. Review of present status and new findings. Magnesium. 1984; 3: 175-194.
3. Anderson D, Westmoreland D, Porta S. Effects of maximal and submaximal exercise on plasma electrolyte shifts. Trace Elem Electrolytes. 2008; 24: 117.
4. Anke M, Schneider HJ. Changes in the magnesium content of hair, urine and blood plasma following oral magnesium administration in humans and the importance of these findings regarding to the therapy of oxalate urolithiasis. Urol Nephrol. 1968; 61: 361-365.
5. Anke M, Gumz W, Gagern WV. Influence of endogenous factors on the ash, calcium, magnesium, potassium, sodium, phosphorus, zinc, iron, copper and magnesese contents in the bristles of pigs. Influence of time of cutting on the mineral composition of the hair (boar bristles). Arch Tierernahr. 1975; 25: 59-68.
6. Anke M, Schneider HJ. Significance of magnesium in the clinical diagnostics of uremia. Acta Biol Med Ger. 1970; 25: 502-508.
7. Büntzel J, Kisters K, Micke O, Mücke R. Zytoprotektion, Spurenelemente und Elektrolyte in der Tumortherapie. München - Orlando: Dustri; 2004.
8. Cernak I, Savic V, Kotur J et al. Alteration in magnesium and oxidative status during chronic emotional stress. Magnesium Research. 2000; 13: 29-36.
9. Classen HG, Marquardt P, Spath M. Hypermagnesemia following exposure to acute stress. Pharmacology. 1971; 5: 287-294.
10. Classen HG. Stress and magnesium. Artery. 1981; 9: 182-189.
11. Classen HG. Systemic stress, magnesium status and cardiovascular damage. Magnesium. 1986; 5: 105-110.
12. Classen HG, Nowitzki S. Die klinische Bedeutung von Magnesium. Fortschr Med. 1990; 10: 198-200.
13. Dralle D. Magnesium and epilepsy (a short review of the literature). Trace Elem Electrolytes. 2008; 24: 118.
14. Dyckner T, Wester PO. Effect of magnesium on blood pressure. Br Med J (Clinical Research Edition). 1983; 286: 1847-1849.
15. von Ehrlich B. Magnesium - physiological insulin- sensitizer in metabolic syndrome, diabetes and arterial hypertension. Trace Elem Electrolytes. 2008; 25: 232.
16. von Ehrlich B, Barbagallo M, Classen HG, Guerrero- Romero F, Kisters K, Rodriguez-Moran M, Vormann J, Weigert A, Vierling W. Leitlinie Magnesium und Diabetes. Nieren- und Hochdruckkrkh. 2010; 38: 633-635.
17. Galland L. Magnesium, stress and neuropsychiatric disorders. Magnesium and Trace Elements. 1991; 10: 287-301.
18. Gasser S, Scherr E, Gasser R. An ion-selective microelektrode study in the effect of acidification on free intracellular magnesium in cardiac guinea pig papillary muscle. Trace Elem Electrolyt. 2008; 25: 14-20. (Pubitemid 351155187)
19. Gasser S, Ablasser K, Roessl U, Dellacher A, von Lewinski D, Mangge H, Mächler H, Trantina A, Tscheliessnigg KH, Udermann H, Porta S, Friehs I, Scherer E, Gasser R. A microarray study on the effect of extracellular magnesium deprivation upon expression profiles of molecular pathways and biological processes in isolated human atrial myocardium. Trace Elem Electrolytes. 2009; 26: 1-14.
20. Golf SW. Biochemistry of magnesium in man. In: Golf SW, Dralle D, Vecchiet L(Hrsg). Magnesium 1993. London: John Libbey Ltd; 1993, 31-41.
21. Golf S. Magnesium and physical exercise. Trace Elem Electrolytes. 2008; 24: 118.
22. Gremmler B, Kisters K, Kunert M, Hausberg M, Jegodka R, Ulrich L. Observation of NT-pro-BNP, cardiac output and magnesium in a case of hypertension induced severe heart failure under a combined ACE-inhibitor and candesartan therapy - a case report. Trace Elem Electrolytes. 2008; 25: 235.
23. Gröber U. Antihypertensives and magnesium - update 2007. Trace Elem Electrolytes. 2009; 26: 15-16.
24. Grubert C, Haas M, Behrens C, Spätling L, Fallenstein F, Classen HG. Klinische und tierexperimentelle Studien zur oralen Magnesiumtherapie. Mag-Bull. 1997; 4: 99-105. (Pubitemid 127793955)
25. Gunther T. Biochemistry and pathobiochemistry of magnesium. Artery. 1981; 9: 167-181.
26. Hausberg M, Hillebrand U, Kisters K. Addressing the relationship between sympathetic activity and inflammation. J Hypertens. 2008; 12: 2276-2278.
27. Heidinger DD, Porta S, Porta G, Kunz M. Changes in stress compatibility of amateur runners after chronic supplementation of magnesium and potassium. Trace Elem Electrolytes. 2008; 24: 119.
28. Holtmeier HJ. Das Magnesiummangelsyndrom beim Menschen. In: Holtmeier HJ (Hrsg). Magnesium und Calcium. Stuttgart: Wissenschaftliche Verlagsgesellschaft mbH; 1995, 3-25.
29. Hunger R. Magnesium and the membrane potential. Trace Elem Electrolytes. 2008; 25: 234.
30. Iseri LT, French JH. Magnesium natures physiologic calcium blocker. American Heart Journal. 1984; 108 (Editorial): 188-193.
31. Itoh K, Kawasaka T, Nakamura M. The effects of high oral magnesium supplementation on blood pressure, serum lipids and related variables in apparently healthy japanese subjects. The British Journal of Nutrition. 1997; 78: 737-750. (Pubitemid 27483017)
32. ++ concentration in preeclampsia. J Hypertens. 1990; 8: 303-306.
33. Kisters K, Spieker C, Tepel M, Zidek W. New data about effects of oral physiological magnesium supplementation on several cardiovascular risk factors (lipids and blood pressure). Magnes Res. 1993; 4: 355-360.
34. ++ concentrations in a subgroup of hypertensives- cell models for the pathogenesis of primary hypertension. J Hum Hypertens. 1997; 11: 367-372.
35. Kisters K, Schodjaian K, Nguyen SA, Köneke J, Westermann G, Spieker C, Barenbrock M. Plasma and intracellular magnesium status in patients with alcoholic steatosis or cirrhosis of liver with and without essential hypertension. Trace Elem Electrolytes. 1997; 4: 153-166.
36. ++ Konzentration. Schweiz Med Wochen Schr. 1998; 119: 1837-1839.
37. ++ concentrations in a subgroup of hypertensives. Membrane model for the pathogenesis of primary hypertension. Am J Hypertens. 1998; 11: 1390-1393.
38. + exchange in vascular smooth muscle cells from SHR. Clin Sci. 1998; 95: 583-587.
39. Kisters K. Störungen des Magnesiumhaushaltes. Internist. 1998; 39: 815-819.
40. ++ concentrations in normal pregnancy and in pre-eclampsia. Gynecol Obstet. 1998; 46: 158-163.
41. ++ contents in smooth muscle cells in spontaneously hypertensive rats. Am J Hypertens. 1999; 12: 648-652.
42. Kisters K, Barenbrock M, Louwen F, Hausberg M, Rahn KH, Kosch M. Membrane, intracellular and plasma magnesium and calcium concentrations in preeclampsia. Am J Hypertens. 2000; 13: 765-769. (Pubitemid 30604114)
43. Kisters K, Krefting ER, Hausberg M, Kohnert K, Honig A, Bettin D. Importance of decreased intracellular phosphate and magnesium concentrations and reduced ATPase activities in SHR. Magnes Res. 2000; 13: 183-188.
44. Kisters K, Schodjaian K, Tokmak F, Kosch M, Rahn KH. Effect of ethanol on blood pressure - role of magnesium. Am J Hypertens. 2000; 13: 455-456. (Pubitemid 30312670)
45. Kisters K, Schäfer R, Kosch M. Importance of an intact magnesium balance. Urologe A. 2000; 29: 64-70.
46. Kisters K, Hausberg M, Kosch M. Effect of oral magnesium supplementation on blood pressure, platelet aggregation and calcium handling in deoxycorticosterone acetate-induced hypertension in rats. J Hypertens. 2001; 1: 161-162. (Pubitemid 32099290)
47. Kisters K, Wessels F, Tokmak F, Küper H, Haus - berg M, Krefting ER. Increased arterial smooth muscle cell calcium and decreased magnesium concentrations in spontaneously hypertensive rats (SHR) and in human hypertension. Trace Elem Electrolytes. 2003; 21: 201.
48. Kisters K, Wessels F, Tokmak F, Krefting ER, Gremmler B, Kosch M, Hausberg M. Early-onset increased calcium and decreased magnesium concentrations and an increased calcium/magnesium ratio in SHR versus WKY. Magnes Res. 2004; 17: 264-269.
49. Kisters K, Wessels F, Küper H, Tokmak F, Krefting ER, Gremmler B, Kosch M, Barenbrock M, Hausberg M. Increased calcium and decreased magnesium concentrations and an increased calcium/ magnesium ratio in spontaneously hypertensive rats versus Wistar-Kyoto rats: relation to arteriosclerosis. Am J Hypertens. 2004; 17: 59-62.
50. Kisters K, Tokmak F, Gremmler B, Kosch M, Hausberg M. Increased calcium/magnesium ratio in young and old SHR - pathogenetic factor in the development of hypertension and vascular fibrosis. Am J Hypertens. 2005; 18: 1136.
51. Kisters K, Gremmler B, Hausberg M. Magnesium and arterial stiffness. Hypertension. 2005; 47:e3.
52. Kisters K, Hoffmann O, Hausberg M, Funke C, Kozianka J, Gremmler B. Magnesium und Pulsdruck bei Hypertonie. Nieren- und Hochdruckkrkh. 2005; 10: 455-457.
53. Kisters K, Gremmler B, Hausberg M. Pulse pressure, plasma magnesium status, and antihypertensive therapy. Am J Hypertens. 2005; 18: 1136.
54. Kisters K, Hoffmann O, Gremmler B, Hausberg M. Plasma magnesium deficiency is correlated to pulse pressure values in essential hypertension - influence of a metabolic syndrome. Am J Hypertens. 2005; 18: 215A.
55. Kisters K, Al-Tayar H, Hausberg M. Magnesium-mangel und Intima-Media-Dicke bei Hypertonie. DMW. 2005; 130: S148.
56. Kisters K, Wessels F, Krefting ER, Gremmler B, Nguyen MQ, Kozianka J, Hausberg M. Early onset of a decreased intracellular magnesium and phosphate concentrations in smooth muscle cells of SHR. Magnes Res. 2005; 18: 207-213. (Pubitemid 43287474)
57. Kisters K, Gremmler B, Hausberg M. Preventing pregnancy-induced hypertension: the role of calcium und magnesium. J Hypertens. 2006; 24: 2010.
58. Kisters K, Gremmler B, Kozianka J, Hausberg M. Magnesium deficiency and diabetes mellitus. Clinical Nephrology. 2006; 65: 77-78.
59. Kisters K, Liebscher H, Cziborra M, Al-Tayar H, Gremmler B, Tokmak F, Funke C, Hausberg M. Hypertonia: intima-media thickness and magnesium. Trace Elem Electrolytes. 2007; 24: 251.
60. Kisters K, Cziborra M, Funke C, Liebscher A, Liebscher DA. The clinical importance of a magnesium deficiency. Trace Elem Electrolytes. 2007; 24: 254.
61. Kisters K, Gremmler B, Tokmak F, Cziborra M, Funke C, Hausberg M. Decreased mineral metabolism parameters (magnesium and phosphate) and elevated pulse pressure in hypertension. Clin Nephrol. 2007; 68: 130-131. (Pubitemid 47243961)
62. ++ transporters in hypertension. J Hypertens. 2008; 12: 2450-2451.
63. Kisters K, Hausberg M, Gremmler B, Liebscher U, Tokmak F, Nguyen MQ, Liebscher H. Klinische Symptome bei Magnesiummangel-Patienten. Nieren- und Hochdruckkrkh. 2008; 37: 597-601.
64. Kisters K, Al-Tayar H, Liebscher H, Cziborra M, Wessels F, Büntzel J, Nguyen MQ, Micke O, Tokmak F, Gremmler B, Hausberg M. Hypertension, magnesium deficiency and an increased carotid intima media thickness. Trace Elem Electrolytes. 2008; 25: 41-44.
65. Kisters K. Diabetes, heart disease and magnesium. Trace Elem Electrolytes. 2009; 26: 143-144.
66. ++ ratio.Trace Elem Electrolytes. 2009; 26: 167-170.
67. Kisters K, Gremmler B, Nguyen MQ, Tokmak F. Stable plasma magnesium and potassium status in essential hypertensive patients with normal renal function under therapy with the renin inhibitor aliskiren. Trace Elem Electrolytes. (2010; in press).
68. Kosch M, Hausberg M, Louwen F, Barenbrock M, Rahn KH, Kisters K. Alterations of plasma calcium and intracellular and membrane calcium in erythrocytes of patients with pre-eclampsia. J Hum Hypertens. 2000; 14: 333-336. (Pubitemid 30311516)
69. Kosch M, Hausberg M, Westermann G, Köneke J, Meatzkies F, Rahn KH, Kisters K. Alterations in calcium and magnesium content of red cell membranes in patients with primary hypertension. Am J Hypertens. 2001; 14: 1787-1792.
70. Kriska AM, Hanle AJ, Harris SB et al. Physical activity, physical fitness, and insulin and glucose concentrations in isolated native Canadian population experiencing rapid lifestyle change. Diabetes Care. 2001; 24: 1787-1792.
71. Kun M, Grieshofer P, Inzinger M, Sejak S, Porta G, Porta S. Correlation between magnesium and stress parameters before and after rehabilitation. Trace Elem Electrolytes. 2008; 24: 120.
72. Langley WF, Mann D. Central nervous system magnesium deficiency. Arch Int Med. 1991; 151: 593-596.
73. Laires MJ, Monteiro C. Exercise, magnesium and immune function. Magnesium Research. 2008; 21: 92-96.
74. Lajer H, Daugaard G. Cisplatin and hypomagnesemia. Cancer Treatment Reviews. 1999; 25: 47-58.
75. Laukkanen JA, Lakka TA, Rauramaa R . Cardiovascular fitness as predictor of mortality in men. Arch Int Med. 2001; 161: 825-831.
76. Laurent S, Katsahian S, Fassot C, Tropeano AI, Gautier I, Laloux B, Boutouyrie P. Aortic stiffness is an independent predictor of fatal stroke in essential hypertension. Stroke. 2003; 34: 1203-1206.
77. Laurent S, Boutouyrie P, Lacolley P. Structural and genetic bases of arterial stiffness. Hypertension. 2005; 45: 1050-1055. (Pubitemid 40770302)
78. Leary WP. Interactions between magnesium and drugs in the treatment of hypertension. Magnesium Bulletin. 1987; 9: 62-73.
79. Liebscher DH, Liebscher DE. Hypertension: the need to form subgroups for magnesium deficiency patients. Trace Elem Electrolytes. 2008; 25: 230.
80. Liebscher DH. Magnesium and tetanic syndrome. Trace Elem Electrolytes. 2008; 24: 120.
81. Micke O, Matzkies F, Mücke R, Schäfer U, Büntzel J, Bruns F, Hausberg M, Kisters K. Magnesium and zinc balance in cisplatinum-based radiochemotherapy in advanced head and neck cancer patients. Trace Elem Electrolytes. 2008; 25: 234.
82. Micke O, Hunger R, Büntzel J, Mücke R, Kisters K. What about magnesium substitution in radiation oncology? Magnesium Research. 2009; 22: 1-2.
83. Möhnle P, Goetz AE. Physiologische Effekte, Pharmakologie und Indikationen zur Gabe von Magnesium. Anaesthesist. 2001; 50: 377-391.
84. Nguyen-Duong H. A rational therapy of tinnitus caused by defective transduction mechanisms with Mg and specific glutamate receptor antagonists. Trace Elem Electrolytes. 2008; 24: 121.
85. + antagonism on biologically active sites: new methodology to study potential dependent ion exchange. Magnesium Research. 2009; 22: 10-20.
86. Porta S, Epple A, Leitner G et al. Impact of stress and triiodothyronine on plasma magnesium fractions. Life Sciences. 1994; 55: 327-332.
87. Porta S. Our opinions about Mg and stress. Trace Elem Electrolytes. 2007; 24: 121.
88. Porta S, Wurzinger S, Wonisch W, Sejak S, Bratu MM, Inzinger M. Correlations between ionized blood magnesium and oxyative state. Trace Elem Electrolytes. 2007; 24: 121.
89. ++ changes and awarded scores in military steeple- chase (HIB). Trace Elem Electrolytes. 2009; 26: 177-180.
90. Rayssiguier Y, Durlach J, Gueux E. Magnesium and ageing. I. Experimental data: importance of oxidative damage. Magnesium Research. 1993; 6: 369-378.
91. Rasmussen H. Clinical intervention studies on magnesium in myocardial infarction. Magnesium. 1989; 8: 316-325.
92. Rasmussen HS, Aurup P, Goldstein K. Influcence of magnesium substitution therapy on blood lipid composition in patients with ischemic heart disease. A double-blind, placebo-controlled study. Arch Int Med. 1989; 149: 1050-1053.
93. Resnick LM, Laragh JH, Sealey JE, Aldemann MH. Divalent cations in essential hypertension: relations between serum ionised calcium magnesium and plasma renin activity. N Engl J Med. 1983; 309: 888-891.
94. Resnick LM, Gupta RK, Laragh JH. Intracellular free magnesium in erythrocytes of essential hypertension: relation to blood pressure and serum divalent cations. Proc Natl Acad Sci USA. 1984; 81: 6511-6515.
95. Resnick LM. Cellular ions in hypertension, insulin resistance, obesity, and diabetes: a unifying theme. J Am Soc Neph. 1992; 3: 78-85.
96. Resnick LM, Militianu D, Cunnings AJ. Direct magnetic resonance determination of aortic distensibility in essential hypertension: relation to age, abdominal visceral fat, and in situ intracellular free magnesium. Hypertension. 1997; 30: 654-659. (Pubitemid 27444249)
97. Rob PM. Magnesium deficiency after kidney transplantation and cyclosporine therapy. Fortschr Med. 1996; 114: 125-126.
98. Rob PM, Lebeau A, Nobiling R, Schmid H, Bley N, Dick K, Weigelt I, Rohwer J, Gobel Y, Sack K, Classen HG. Magnesium metabolism: basic aspects and implications of ciclosporine toxicity in rats. Nephron. 1996; 72: 59-66.
99. Rob PM, Dick K, Bley N, Seyfert T, Brinckmann C, Höllriegel V, Friedrich HJ, Dibbelt L, Seelig MS. Can one really measure magnesium deficiency using the short-term magnesium loading test? J Intern Med. 1999; 246: 373-378.
100. Rob PM, Niederstadt C, Reusche E. Dementia in patients undergoing long-term dialysis: aetiology, differential diagnoses, epidemiology and management. CNS Drugs. 2001; 15: 691-699. (Pubitemid 33701936)
101. Rude RK. Magnesium deficiency and diabetes mellitus. Causes and effects. Postgraduate Medicine. 1992; 92: 217-219.
102. Ryzen E. Magnesium homeostasis in critically ill patients. Magnesium. 1987; 6: 259-263.
103. Ryzen E, Servis KL, Rude RK. Effect of intravenous epinephrine on serum magnesium and free intracellular red blood cell magnesium concentrations measured by nuclear magnetic resonance. J Am Coll Nutr. 1990; 9: 114-119.
104. Sado T, Oi H, Sakata M, Yoshida S, Kawaguchi R, Kanayama S, Shigetomi H, Haruta S, Tsuji Y, Ueda S, Kitanaka T, Yamada Y, Kobayashi H. Aging impairs the protective effect of magnesium supplementation on hypertension in spontaneously hypertensive rats. Magnesium Research. 2007; 20: 196-199.
105. Sauer PMM, Zielmann S, Roth ATP, Frank L, Warneke G, Radke A, Ensink FBM, Kettler D. Untersuchung zur Diagnose eines Magnesiummangels bei Intensivpatienten. Organ der Deutschen Gesellschaft Anästhesiologie und Intensivmedizin. 1996; 31: 31-41.
106. Schäfer U, Anke M. Does the higher magnesium intake of ovolactovegetarians have a potentially positive influence on their magnesium metabolism in comparison to subjects with a mixed diet? Trace Elem Electrolytes. 2008; 25: 232-233.
107. Schweigel M, Kolisek M, Nikolic Z, Kuzinski J. Expression and functional activity of the Na/Mg exchanger, TRPM7 and MagT1 are changed to regulate Mg. Magnesium Research. 2008; 21: 118-123.
108. Seelig MS. Nutritional status and requirements of magnesium. Mag-Bull. 1986; 8: 170-185.
109. Seelig M. The magnesium factor. New York: Penguin Group Inc; 2003.
110. Singh RB, Rastogi SS, Mani UV et al. Does dietary magnesium modulate blood lipids? Biol Trace Elem Res. 1991; 30: 59-64.
111. Sontia B, Ying H, Callera G, Montezano A, Touyz RM. Blood pressure-independent cardiac and renal fibrosis is prevented by magnesium supplementation in aldosterone-infused mice. Trace Elem Electrolytes. 2008; 25: 122.
112. Spätling L, Spätling G. Magnesium supplementation in pregnancy.Adoubleblind study. Br J Obstet Gynaecol. 1988; 95: 120-125.
113. Spätling L, Classen HG, Külpmann WR, Manz F, Rob PM, Schimatschek HF, Vierling W, Vormann J, Weigert A, Wink K. Diagnosing magnesium deficiency. Current recommendations of magnesium research. Fortschr Med Orig. 2000; 118: 49-53.
114. Stendig-Lindberg G, Wacker WE. Long-term effects of peak strenuous effort on serum magnesium, lipids, and blood sugar in apparently healthy young men. Magnesium Research. 1991; 1: 59-65.
115. Stending-Lindberg G, Koeller W, Bauer A, Rob PM. Prolonged magnesium deficiency causes osteoporosis in the rat. J Am Coll Nutr. 2004; 23: 704-711.
116. Stending-Lindberg G, Koeller W, Bauer A, Rob PM. Experimentally induced prolonged magnesium deficiency causes osteoporosis in the rat. Eur J Intern Med. 2004; 15: 97-107.
117. ++ deficiency induces cardiac apoptosis in the rat heart. Magnesium Research. 2007; 20: 208-212.
118. Tokmak F, Kisters K, Hausberg M, Rump LC. Buffer function of the cell membrane for magnesium in chronic kidney disease. Trace Elem Electrolytes. 2008; 25: 234-235.
119. Touyz RM, Milne FJ. Magnesium supplementation attenuates, but does not prevent, development of hypertension in spontaneously hypertensive rats. Am J Hypertens. 1999; 12: 757-765.
120. ++ uptake channels. TRPM6 and TRPM7 in vascular smooth muscle cells from WKY and SHR - differential regulation bei aldosterone and angiotensin II. Am J Hypertens. 2004; 5: 176.
121. Turnbull F. Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively designed overviews of randomised trials. Lancet. 2003; 362: 1527-1535.
122. Vierling W, Stampfl A. Magnesium-dependent calcium efflux in mammalia heart muscle. Cell Calcium. 1994; 15: 715-1182
123. Vierling W. Magnesium, hypertension, arrhythmias and the heart. Trace Elem Electrolytes. 2008; 25: 235.
124. Vierling W. Magnesium and cellular excitability in the cardiovascular systems. Trace Elem Electrolytes. 2008; 25: 123.
125. Vormann J. Magnesium and hearing. Trace Elem Electrolytes. 2008; 25: 236.
126. Wilhelm R, Beckmann V, Vierling W. Influence of magnesium and calcium on current-voltage relationships and the activation and inactivation kinetics on the calcium current of myocardial cell. Trace Elem Electrolytes. 2008; 25: 123.
127. Wink K. Neues über Magnesium in der Kardiologie. Mag-Bull. 1997; 4: 122-124.
128. Wink K. Neuroprotective effects of magnesium in pre-term infants. Trace Elem Electrolytes. 2008; 25: 124.
129. ++ channel TRPM6: insight into themolecular regulation. Magnesium Research. 2009; 22: 127-132.
130. Wolf FI, Trapani V, Cittadini A, Maier JAM. Hypomagnesaemia in oncologic patients: to treat or not to treat? Magnesium Research. 2009; 22: 5-9.
131. Zidek W, Krefting ER, Kisters K, Spieker C, Rahn KH. Electron-probe X-ray microanalysis of sodium ion content in vascular smooth muscle cells from spontaneously hypertensive and normotensive rats. J Hypertens. 1989; 6: 150-151.
132. Zidek W, Zumkley H. Magnesiumstoffwechsel. Hyper- und Hypomagnesiämie. In: Zidek W, Zumkley H (Hrsg). Elektrolytfibel. Stuttgart: Gustav Fischer; 1990, 172-183.