Prolonged Magnesium Deficiency Causes Osteoporosis in the Rat

Journal of the American College of Nutrition

Volumn 23, Issue 6, 2004, Pages 704S-711S

  Stendig Lindberg, G ^a   Koeller, W ^a   Bauer, A ^a   Rob, P M ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

Osteoporosis; Prolonged magnesium deficiency; Rats

Indexed keywords

MAGNESIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BIOMECHANICS; BLOOD SAMPLING; BONE DENSITY; BONE FRAGILITY; BONE MINERAL; BONE STRENGTH; CHRONICITY; CONFERENCE PAPER; CONTROLLED STUDY; DIET; DUAL ENERGY X RAY ABSORPTIOMETRY; ELASTICITY; FEMALE; FEMUR; FORCE; MAGNESIUM DEFICIENCY; MICROSCOPY; MORPHOMETRICS; NONHUMAN; OSTEOPOROSIS; POSTMENOPAUSE OSTEOPOROSIS; RAT; TIBIA; TRABECULAR BONE; URINALYSIS; VERTEBRA;

ANIMALS; BONE DENSITY; DENSITOMETRY, X-RAY; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MAGNESIUM; MAGNESIUM DEFICIENCY; OSTEOPOROSIS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; TENSILE STRENGTH;

ANIMALIA;

EID: 11844286403     PISSN: 07315724     EISSN: 15411087     Source Type: Journal    
DOI: 10.1080/07315724.2004.10719413     Document Type: Article

References (14)

1. Stendig-Lindberg G, Tepper R, Leichter I: Trabecular bone density in a two year controlled trial of peroral magnesium in osteoporosis. Magnes Res 6: 155-163, 1993.
2. Stendig-Lindberg G: Long term oral magnesium treatment in postmenopausal osteoporosis. Research Fair, Tel-Aviv University, Sackler Faculty of Medicine. Abstracts. Medicine for the Golden Age T 8: 348, 2001.
3. Tucker KL, Hannan MT, Chen H, Cupples LA, Wilson PWF, Kiel DP: Potassium, magnesium, fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J Clin Nutr 69: 727-738, 1998.
4. Rude RK, Olerich M: Magnesium deficiency: possible role in osteoporosis associated with gluten sensitive enteropathy. Osteoporosis Int 6: 453-461, 1996.
5. Rude K, Kirchen ME, Gruber HE, Stasky AA, Meyer MH: Magnesium deficiency induces bone loss in the rat. Miner Electrolyte Metab 24: 314-320, 1998.
6. Rude RK, Kirchen ME, Gruber HE, Meyer MH, Luck JS, Crawford DL: Magnesium-induced osteoporosis in the rat: uncoupling of bone formation and bone resorption. Magnes Res 12: 257-267, 1999.
7. Riond JL, Hartmann P, Steiner P, Ursprung R, Wanner M, Forrer R, Spichiger UE, Thomsen JS, Mosekilde L: Long-term excessive magnesium supplementation is deleterious whereas suboptimal supply is beneficial for bones in rats. Magnes Res 13: 249-264, 2000.
8. Moshieff R, Kleiner BY, Leichter I, Chaimsky G, Nyska A, Peyser A, Segal D: Use of Dexa to follow mineral contents changes in small ceramic implants in rats. Biomaterials 13: 462-466, 1992.
9. Vogel M, Hahn M, Delling G: Trabecular bone structure in patients with hyperparathyroidism. Virchows Archiv 426: 127-134, 1995.
10. Hahn M, Vogel M, Pompesius Kempa M, Delling G: Trabecular Bone Pattern Factor-a new Parameter for simple Quantification of Bone Microarchitecture. Bone 13: 327-330, 1992.
11. Acil Y, Brinckman J, Nothbohm H, Muller K, Batge B: Changes with age in the urinary excretion of hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP). Scand J Clin Lab Invest 56: 275-283, 1996.
12. Rude RK, Gruber HE, Wei LY, Frausto A, Mills BG: Magnesiumdeficiency: effect on bone and mineral metabolism in the mouse. Calcif Tissue 72: 32-41, 2003.
13. Stendig-Lindberg G, Harsat A, Graff E: Magnesium content of mononuclear cells, erythrocytes and 24-hour urine in carefully screened apparently healthy Israelis. Eur J Clin Chem Clin Biochem 29: 833-835, 1991.
14. Sjogren A, Floren CH, Nilsson A: Magnesium and potassium status in healthy subjects as assessed by analysis of magnesium and potassium in skeletal muscle biopsies and magnesium in mononuclear cells. Magnes 6: 91-99, 1989.