Roller compaction: Application of an in-gap ribbon porosity calculation for the optimization of downstream granule flow and compactability characteristics

Pharmaceutical Development and Technology

Volumn 15, Issue 3, 2010, Pages 223-229

  Gamble, John F ^a   Tobyn, Michael ^a   Dennis, Andrew B ^a   Shah, Trupty ^a,b  

^a BRISTOL MYERS SQUIBB   (United States)

^b University of Bath   (United Kingdom)

Author keywords

Compactability; Dry granulation; Particle size; Porosity; Roller compaction; Work hardening

Indexed keywords

BMS 646256 01; IBIPINABANT; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DOWNSTREAM PROCESSING; DRUG GRANULATION; DRUG GRANULE; PARTICLE SIZE; PRIORITY JOURNAL; PROCESS OPTIMIZATION; TABLET COMPRESSION; TABLET DISINTEGRATION TIME; TABLET POROSITY;

AMIDINES; CHEMISTRY, PHARMACEUTICAL; COMPRESSIVE STRENGTH; PARTICLE SIZE; POROSITY; PYRAZOLES; TABLETS;

EID: 77952031474     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.3109/10837450903095342     Document Type: Article

References (15)

1. Malkowska SK, Khan KA. Effect of recompression on the properties of tablets prepared by dry granulation. Drug Dev Ind Pharm 1983;9(3):331-347.
2. Miller RW. Roller compaction technology. In: Parikh DM, editor. Handbook of pharmaceutical granulation technology. New York: Marcel Dekker;1997:99-150.
3. Sun CC, Himmelspach MW. Reduced tabletability of roller compacted granules as a result of granule size enlargement. J Pharm Sci 2006;95(1):200-206.
4. Heckel RW. Density-pressure relationship in powder compaction. Trans Metall Soc AIME 1961;221:671-675.
5. Sonnergaard JM. A critical evaluation of the Heckel equation. Int J Pharm 1999;193:63-71.
6. Roberts RJ, Rowe RC. Brittle/ductile behaviour in pharmaceutical materials used in tableting. Int J Pharm 1987;36:205-209.
7. Mansa RF, Bridson RH, Greenwood RW, Barker H, Seville JPK. Using intelligent software to predict the effects of formulation and processing parameters on roller compaction. Powder Technol 2008;181(2):217-225.
8. Lammens RF, Portner C. Control of product quality during dry granulation with roller compactors. Proceedings 3rd World Meeting on Pharmaceutics, Biopharmaceutics, Pharmaceutical Technology, Berlin. 2000;67-70.
9. Herting MG, Kleinebudde P. Roll compaction/dry granulation: Effect of raw material particle size on granule and tablet properties. Int J Pharm 2007;338(1-2): 110-118.
10. Nkansah P, Wu S-J, Sobotka S, Yamamoto K, Shao ZJ. A novel method for estimating solid fraction of roller-compacted ribbons. Drug Dev Ind Pharm 2008;34(2):142-148.
11. Alderborn G, Nyström C. Pharmaceutical powder compaction technology. New York: Marcel Decker, Inc.; 1996:318-319.
12. Kuno Y, Kojima M, Nakagami H, Yonemochi E, Terada K. Effect of the type of lubricant on the characteristics of orally disintegrating tablets manufactured using the phase transition of sugar alcohol. Eur J Pharm 2008;69(3):986-992.
13. Kuksa LV. Comparative investigations of the inhomogeneity of elastic and plastic deformation of metals. Strength of Materials 1986;18(3):349-354.
14. Fu X, Elliot JA, Bentham AC, Hancock BC, Cameron RE. Application of X-ray microtomography and image processing to the investigation of a compacted granular system. Part Part Syst Charact 2006;23:229-236.
15. Inman SJ, Briscoe BJ, Pitt KG, Shiu C. The non-uniformity of microcrystalline cellulose bilayer tablets. Powder Technol 2009;188(3):283-294.