The non-uniformity of microcrystalline cellulose bilayer tablets

Powder Technology

Volumn 188, Issue 3, 2009, Pages 283-294

  Inman, S J ^a   Briscoe, B J ^a   Pitt, K G ^b   Shiu, C ^b  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b Merck Sharp & Dohme Limited   (United Kingdom)

Author keywords

Avicel; Bilayer tablet; Compaction; Interfacial strength; Profilometry

Indexed keywords

CELLULOSE; CELLULOSE DERIVATIVES; COMPACTION; ENERGY DISSIPATION; PROFILOMETRY;

ADJACENT LAYERS; AVICEL; BI LAYERS; BILAYER TABLET; BILAYER TABLETS; COMPACTION STRESSES; EJECTION PHASE; ELASTIC STRAIN ENERGIES; IN HOMOGENEITIES; INDIRECT MEASUREMENTS; INITIAL LAYERS; INTERFACIAL BOUNDARIES; INTERFACIAL STRENGTH; INTERFACIAL ZONES; LOCAL POROSITIES; MANUFACTURING PROCESSES; MATERIAL RESPONSES; MICROCRYSTALLINE CELLULOSES; NON CONTACTS; NON UNIFORMS; OPTICAL PROFILOMETER; PARTICLE DEFORMATIONS; RADIAL DIRECTIONS; SAMPLE SURFACES; STORED ENERGIES; VOLUME EXPANSIONS;

INTERFACIAL ENERGY;

MICROCRYSTALLINE CELLULOSE;

ARTICLE; METHODOLOGY; PARTICLE SIZE; PHYSICAL CHEMISTRY; PROFILOMETRY; STRENGTH; TABLET;

CELLULOSE DERIVATIVES; COMPACTION; DISSIPATION FACTOR; ENERGY; MECHANICAL PROPERTIES; MICROCRYSTALLINE CELLULOSE; MULTILAYERS; OPTICAL INSTRUMENTS; PARTICLES; ROUGHNESS; TABLETS;

EID: 57049092751     PISSN: 00325910     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.powtec.2008.06.002     Document Type: Article

References (33)

1. Abdul S., and Poddar S.S. A flexible technology for modified release of drugs: multi layered tablets. Journal of Controlled Release 97 3 (2004) 393-405
2. Aulton M.E., Tebby H.G., et al. Indentation hardness testing of tablets. Journal of Pharmacy and Pharmacology 26 (1974) 59P-60P Suppl:
3. Aydin I., Briscoe B.J., et al. The internal form of compacted ceramic components: a comparison of a finite element modelling with experiment. Powder Technology 89 3 (1996) 239-254
4. Aydin I., Briscoe B.J., et al. Dimensional variation of die-pressed ceramic green compacts: comparison of a finite element modelling with experiment. Journal of the European Ceramic Society 17 10 (1997) 1201-1212
5. Bashaiwoldu A.B., Podczeck F., et al. The application of non-contact laser profilometry to the determination of permanent structural change induced by compaction of pellets: II. Pellets dried by different techniques. European Journal of Pharmaceutical Sciences 22 1 (2004) 55-61
6. Bashaiwoldu A.B., Podczeck F., et al. The application of non-contact laser profilometry to the determination of permanent structural changes induced by compaction of pellets: I. Pellets of different composition. European Journal of Pharmaceutical Sciences 21 2-3 (2004) 143-154
7. Bolhuis G.K., and Chowhan Z.T. Materials for direct compaction. Pharmaceutical powder compaction technology. In: Alderborn G., and Nystrom C. (Eds) (1996), Marcel Dekker Inc., New York 71
8. Conte U., Maggi L., et al. Multi-layered hydrophilic matrices as constant release devices (GeomatrixTM Systems). Journal of Controlled Release 26 1 (1993) 39-47
9. Eiliazadeh B., Pitt K., et al. Effects of punch geometry on powder movement during pharmaceutical tabletting processes. International Journal of Solids and Structures 41 21 (2004) 5967-5977
10. Fu X. Application of X-ray microtomography and image processing to the investigation of a compacted granular system. Particle & particle systems characterization 23 3-4 (2006) 229-236
11. Inman S.J., Briscoe B.J., et al. Topographic characterisation of bilayered tablets interfaces. Chemical Engineering Research and Design 85 A7 (2007) 1005-1012
12. Inman S.J., Briscoe B.J., et al. Axial tensile fracture of MCC. International Journal of Pharmaceutics (2007)
13. Marshall K., Sixsmith D., et al. Surface geometry of some microcrystalline celluloses. Journal of Pharmacy and Pharmacology 24 (1972) Suppl: 138P.
14. Mashadi A.B., and Newton J.M. The characterisation of the mechanical properties of microcrystalline cellulose: a fracture mechanics approach. Journal of Pharmacy and Pharmacology 39 (1987) 961-965
15. Narayan P., and Hancock B.C. The relationship between the particle properties, mechanical behavior, and surface roughness of some pharmaceutical excipient compacts. Materials Science and Engineering A 355 1-2 (2003) 24-36
16. Narayan P., and Hancock B.C. The influence of particle size on the surface roughness of pharmaceutical excipient compacts. Materials Science and Engineering: A 407 1-2 (2005) 226-233
17. Narayan P., Hancock B.C., et al. Differentiation of the surface topographies of pharmaceutical excipient compacts. Materials Science and Engineering A 430 1-2 (2006) 79-89
18. Ozkan N., and Briscoe B.J. The surface topography of compacted agglomerates; a means to optimize compaction conditions. Powder Technology 86 2 (1996) 201-207
19. Peltonen L., Mannermaa J.P., et al. Roughness analysis from tablet surfaces with a confocal laser scanning microscope. Pharmazie 52 11 (1997) 860-863
20. Podczeck F., Brown S., et al. Monitoring film coating with surface profilometry. Pharmaceutical technology 23 (1999) 48-56
21. Poon C.Y., and Bhushan B. Comparison of surface roughness measurements by stylus profiler, AFM and non-contact optical profiler. Wear 190 1 (1995) 76-88
22. Ragnarsson G. Force-displacement and network measurements. In: Alderborn G., and Nystrom C. (Eds). Pharmaceutical Powder Compaction Technology (1996), Marcel Dekker Inc., New York 71
23. Roberts R.J., and Rowe R.C. Brittle/ductile behaviour in pharmaceutical materials used in tabletting. International Journal of Pharmaceutics 36 2-3 (1987) 205-209
24. Roberts R.J., Rowe R.C., et al. The relationship between the fracture properties, tensile strength and critical stress intensity factor of organic solids and their molecular structure. International Journal of Pharmaceutics 125 1 (1995) 157-162
25. Rowe R.C. The effect of some formulation and process variables on the surface roughness of film-coated tablets. Journal of Pharmacy and Pharmacology 30 (1978) 669-672
26. Seitavuopio P., Rantanen J., et al. Use of roughness maps in visualisation of surfaces. European Journal of Pharmaceutics and Biopharmaceutics 59 2 (2005) 351-358
27. Sinka I.C., Burch S.F., et al. Measurement of density variations in tablets using X-ray computed tomography. International Journal of Pharmaceutics 271 1-2 (2004) 215-224
28. Sinka I.C., Cunningham J.C., et al. The effect of wall friction in the compaction of pharmaceutical tablets with curved faces: a validation study of the Drucker-Prager Cap model. Powder Technology 133 1-3 (2003) 33-43
29. Takeuchi H., Nagira S., et al. Die wall pressure measurement for evaluation of compaction property of pharmaceutical materials. International Journal of Pharmaceutics 274 1-2 (2004) 131-138
30. Train D. Transmission of forces through a powder made during the process of pelleting. Transactions of the Institution of Chemical Engineers 35 (1957) 258-266
31. Whitehouse D.J. Handbook of Surface Metrology (1994), IOP Publishing Ltd, Bristol and Philadelphia
32. Wu C.Y., Best S.M., et al. A simple predictive model for the tensile strength of binary tablets. European Journal of Pharmaceutical Sciences 25 2-3 (2005) 331-336
33. Wu C.Y., Ruddy O.M., et al. Modelling the mechanical behaviour of pharmaceutical powders during compaction. Powder Technology 152 1-3 (2005) 107-117