Evidence for mitogen-associated protein kinase activation and transduction of mitogenic signals by platelet-derived growth factor in human meningioma cells

Journal of Neurosurgery

Volumn 94, Issue 2, 2001, Pages 293-300

  Johnson, M D ^a   Woodard, A ^a   Kim, P ^a   Frexes Steed, M ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Meningioma; Mitogen associated protein kinase; Platelet derived growth factor

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; MITOGEN ACTIVATED PROTEIN KINASE; PLATELET DERIVED GROWTH FACTOR BB;

ADULT; AGED; ARTICLE; CELL CULTURE; CELL PROLIFERATION; CELL STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MENINGIOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR GROWTH; WESTERN BLOTTING;

EID: 0034876443     PISSN: 00223085     EISSN: None     Source Type: Journal    
DOI: 10.3171/jns.2001.94.2.0293     Document Type: Article

References (25)

1. PD098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
2. Platelet-derived growth factor expression and stimulation in human meningiomas
3. Signal transduction via the MAP kinases: Proceed at your own RSK
4. Constitutively active mutants of MAP kinase kinase (MEK1) induce growth factor-relaxation and oncogenicity when expressed in fibroblasts
5. Differential activation of protein kinase C isoforms by endothelin-1 and phenylephrine and subsequent stimulation of p42 and p44 mitogen-activated protein kinases in ventricular myocytes cultured from neonatal rat hearts
6. Platelet-derived-growthfactor stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle: Role of pertussistoxin-sensitive G-proteins, c-Src tyrosine kinases and phosphoinositide 3-kinase
7. A synthetic inhibitor of the mitogen-activated protein kinase cascade
8. Transforming growth factor-β and transforming growth factor β-receptor expression in human meningioma cells
9. Evidence for transforming growth factor-β expression in human leptomeninges cells and transforming growth factor-β-like activity in human cerebrospinal fluid
10. Enhanced expression of the sis and c-myc oncogenes in human meningiomas
11. Expression of PDGF, PDGF-receptor, EGF-receptor and sex hormone receptors on meningioma
12. Signal transduction through MAP kinase cascades
13. In situ visualization of intratumor growth factor signaling. Immunohistochemical localization of activated ERK/MAP kinase in glial neoplasms
14. Ras target proteins in eukaryotic cells
15. Human meningiomas co-express platelet-derived growth factor (PDGF) and PDGF-receptor genes and their protein products
16. ras in receptor tyrosine kinase signalling
17. Expression of c-sis and c-fos genes in human meningiomas and neurinomas
18. The MAPK signaling cascade
19. Detection of activated platelet-derived growth factor receptors in human meningioma
20. Adenovirus-mediated gene transfer of dominant negative Ha-Ras inhibits proliferation of primary meningioma cells
21. Hyperexpression of mitogen-activated kinase in human breast cancer
22. Autocrine growth stimulation of human meningioma cells by platelet-derived growth factor
23. Platelet-derived growth factor-BB and thrombin activate phosphoinositide 3-kinase and protein kinase B: Role in mediating airway smooth muscle proliferation
24. Expression of PDGF β-receptors in human meningioma cells
25. Regulation of DNA synthesis and growth of cells derived from primary human meningiomas