Use of adenoviral vectors to target chemotherapy to tumor vascular endothelial cells suppresses growth of breast cancer and melanoma

Molecular Therapy

Volumn 18, Issue 5, 2010, Pages 921-928

  Li, Pingchuan ^a   Liu, Yanzheng ^a   Maynard, Jonathan ^a   Tang, Yucheng ^a   Deisseroth, Albert ^a  

^a SIDNEY KIMMEL CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; ANGIOPOIETIN RECEPTOR; CYTOSINE DEAMINASE; FLUCYTOSINE; FLUOROURACIL; HETASTARCH;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; DRUG TARGETING; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; MELANOMA; MOUSE; NONHUMAN; PROMOTER REGION; RECEPTOR BINDING; SINGLE DRUG DOSE; TUMOR REGRESSION; VASCULAR ENDOTHELIUM; VIRAL GENE DELIVERY SYSTEM;

ADENOVIRIDAE;

EID: 77952010527     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2010.5     Document Type: Article

References (29)

1. He, TC, Zhou, S, da Costa, LT, Yu, J, Kinzler, KW and Vogelstein, B (1998). A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci USA 95:2509-2514.
2. Ramnaraine, M, Pan, W, Goblirsch, M, Lynch, C, Lewis, V, Orchard, P et al. (2003). Direct and bystander killing of sarcomas by novel cytosine deaminase fusion gene. Cancer Res 63:6847-6854.
3. Kievit, E, Bershad, E, Ng, E, Sethna, P, Dev, I, Lawrence, TS et al. (1999). Superiority of yeast over bacterial cytosine deaminase for enzyme/prodrug gene therapy in colon cancer xenografts. Cancer Res 59:1417-1421.
4. Kievit, E, Nyati, MK, Ng, E, Stegman, LD, Parsels, J, Ross, BD et al. (2000). Yeast cytosine deaminase improves radiosensitization and bystander effect by 5-fluorocytosine of human colorectal cancer xenografts. Cancer Res 60:6649-6655.
5. Mahan, SD, Ireton, GC, Knoeber, C, Stoddard, BL and Black, ME (2004). Random mutagenesis and selection of Escherichia coli cytosine deaminase for cancer gene therapy. Protein Eng Des Sel 17:625-633.
6. Dong, Y, Wen, P, Manome, Y, Parr, M, Hirshowitz, A, Chen, L et al. (1996). In vivo replication-deficient adenovirus vector-mediated transduction of the cytosine deaminase gene sensitizes glioma cells to 5-fluorocytosine. Hum Gene Ther 7:713-720.
7. Liu, Y, Ye, T, Maynard, J, Akbulut, H and Deisseroth, A (2006). Engineering conditionally replication-competent adenoviral vectors carrying the cytosine deaminase gene increases the infectivity and therapeutic effect for breast cancer gene therapy. Cancer Gene Ther 13:346-356.
8. Martin, V, Liu, D, Fueyo, J and Gomez-Manzano, C (2008). Tie2: a journey from normal angiogenesis to cancer and beyond. Histol Histopathol 23:773-780.
9. Schlaeger, TM, Bartunkova, S, Lawitts, JA, Teichmann, G, Risau, W, Deutsch, U et al. (1997). Uniform vascular-endothelial-cell-specific gene expression in both embryonic and adult transgenic mice. Proc Natl Acad Sci USA 94:3058-3063.
10. Peters, KG, Coogan, A, Berry, D, Marks, J, Iglehart, JD, Kontos, CD et al. (1998). Expression of Tie2/Tek in breast tumour vasculature provides a new marker for evaluation of tumour angiogenesis. Br J Cancer 77:51-56.
11. Tanaka, S, Sugimachi, K, Yamashita Yi, Y, Ohga, T, Shirabe, K, Shimada, M et al. (2002). Tie2 vascular endothelial receptor expression and function in hepatocellular carcinoma. Hepatology 35:861-867.
12. Caine, GJ, Blann, AD, Stonelake, PS, Ryan, P and Lip, GY (2003). Plasma angiopoietin-1, angiopoietin-2 and Tie-2 in breast and prostate cancer: a comparison with VEGF and Flt-1. Eur J Clin Invest 33:883-890.
13. Yu, JL, Rak, JW, Carmeliet, P, Nagy, A, Kerbel, RS and Coomber, BL (2001). Heterogeneous vascular dependence of tumor cell populations. Am J Pathol 158:1325-1334.
14. Brown, LF, Dezube, BJ, Tognazzi, K, Dvorak, HF and Yancopoulos, GD (2000). Expression of Tie1, Tie2, and angiopoietins 1, 2, and 4 in Kaposi's sarcoma and cutaneous angiosarcoma. Am J Pathol 156:2179-2183.
15. Zadeh, G, Qian, B, Okhowat, A, Sabha, N, Kontos, CD and Guha, A. (2004). Targeting the Tie2/Tek receptor in astrocytomas. Am J Pathol 164:467-476.
16. Puri, MC and Bernstein, A (2003). Requirement for the TIE family of receptor tyrosine kinases in adult but not fetal hematopoiesis. Proc Natl Acad Sci USA 100:12753-12758.
17. Arai, F, Hirao, A, Ohmura, M, Sato, H, Matsuoka, S, Takubo, K et al. (2004). Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell 118:149-161.
18. Müller, A, Lange, K, Gaiser, T, Hofmann, M, Bartels, H, Feller, AC et al. (2002). Expression of angiopoietin-1 and its receptor TEK in hematopoietic cells from patients with myeloid leukemia. Leuk Res 26:163-168.
19. Schliemann, C, Bieker, R, Padro, T, Kessler, T, Hintelmann, H, Buchner, T et al. (2006). Expression of angiopoietins and their receptor Tie2 in the bone marrow of patients with acute myeloid leukemia. Haematologica 91:1203-1211.
20. Wang, J, Wu, K, Zhang, D, Tang, H, Xie, H, Hong, L et al. (2005). Expressions and clinical significances of angiopoietin-1,-2 and Tie2 in human gastric cancer. Biochem Biophys Res Commun 337:386-393.
21. Liu, Y and Deisseroth, A (2006). Tumor vascular targeting therapy with viral vectors. Blood 107:3027-3033.
22. Ferrara, N and Kerbel, RS (2005). Angiogenesis as a therapeutic target. Nature 438:967-974.
23. De Palma, M, Venneri, MA, Galli, R, Sergi Sergi, L, Politi, LS, Sampaolesi, M et al. (2005). Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors. Cancer Cell 8:211-226.
24. De Palma, M, Mazzieri, R, Politi, LS, Pucci, F, Zonari, E, Sitia, G et al. (2008). Tumor-targeted interferon-alpha delivery by Tie2-expressing monocytes inhibits tumor growth and metastasis. Cancer Cell 14:299-311.
25. Hood, JD, Bednarski, M, Frausto, R, Guccione, S, Reisfeld, RA, Xiang, R et al. (2002). Tumor regression by targeted gene delivery to the neovasculature. Science 296:2404-2407.
26. Nagel, H, Maag, S, Tassis, A, Nestlé, FO, Greber, UF and Hemmi, S (2003). The alphavbeta5 integrin of hematopoietic and nonhematopoietic cells is a transduction receptor of RGD-4C fiber-modified adenoviruses. Gene Ther 10:1643-1653.
27. Armstrong, RD, Lewis, M, Stern, SG and Cadman, EC (1986). Acute effect of 5-fluorouracil on cytoplasmic and nuclear dihydrofolate reductase messenger RNA metabolism. J Biol Chem 261:7366-7371.
28. Tang, Y, Borgstrom, P, Maynard, J, Koziol, J, Hu, Z, Garen, A et al. (2007). Mapping of angiogenic markers for targeting of vectors to tumor vascular endothelial cells. Cancer Gene Ther 14:346-353.
29. Lyons, M, Onion, D, Green, NK, Aslan, K, Rajaratnam, R, Bazan-Peregrino, M et al. (2006). Adenovirus type 5 interactions with human blood cells may compromise systemic delivery. Mol Ther 14:118-128.