메뉴 건너뛰기




Volumn 23, Issue 5, 2010, Pages 703-712

Molecular alterations of EGFR and PTEN in prostate cancer: Association with high-grade and advanced-stage carcinomas

Author keywords

EGFR; FISH; Mutation; Overexpression; Prostate cancer; PTEN

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE;

EID: 77952009539     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2010.45     Document Type: Article
Times cited : (55)

References (51)
  • 1
    • 32044464123 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR) signaling in cancer
    • Normanno N, de Luca A, Bianco C, et al. Epidermal growth factor receptor (EGFR) signaling in cancer. Gene 2006;366:2-16.
    • (2006) Gene , vol.366 , pp. 2-16
    • Normanno, N.1    De Luca, A.2    Bianco, C.3
  • 3
    • 36048985044 scopus 로고    scopus 로고
    • The epidermal growth factor receptor: From development to tumorigenesis
    • Sibilia M, Kroismayr R, Lichtenberger BM, et al. The epidermal growth factor receptor: from development to tumorigenesis. Differentiation 2007;75:770-787.
    • (2007) Differentiation , vol.75 , pp. 770-787
    • Sibilia, M.1    Kroismayr, R.2    Lichtenberger, B.M.3
  • 4
    • 33746816120 scopus 로고    scopus 로고
    • The complexity of targeting EGFR signalling in cancer: From expression to turnover
    • Sebastian S, Settleman J, Reshkin SJ, et al. The complexity of targeting EGFR signalling in cancer: from expression to turnover. Biochim Biophys Acta 2006;1766:120-139.
    • (2006) Biochim. Biophys. Acta , vol.1766 , pp. 120-139
    • Sebastian, S.1    Settleman, J.2    Reshkin, S.J.3
  • 5
    • 0036847724 scopus 로고    scopus 로고
    • Expression of epidermal growth factor receptor correlates with disease relapse and progression to androgenindependence in human prostate cancer
    • di Lorenzo G, Tortora G, D'Armiento FP, et al. Expression of epidermal growth factor receptor correlates with disease relapse and progression to androgenindependence in human prostate cancer. Clin Cancer Res 2002;8:3438-3444.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 3438-3444
    • Di Lorenzo, G.1    Tortora, G.2    D'Armiento, F.P.3
  • 6
    • 33847323129 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutations in lung cancer
    • Sharma SV, Bell DW, Settleman J, et al. Epidermal growth factor receptor mutations in lung cancer. Nat Rev Cancer 2007;7:169-181.
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 169-181
    • Sharma, S.V.1    Bell, D.W.2    Settleman, J.3
  • 7
    • 33746933434 scopus 로고    scopus 로고
    • Effect of epidermal growth factor receptor tyrosine kinase domain mutations on the outcome of patients with non-small cell lung cancer treated with epidermal growth factor receptor tyrosine kinase inhibitors
    • Janne PA, Johnson BE. Effect of epidermal growth factor receptor tyrosine kinase domain mutations on the outcome of patients with non-small cell lung cancer treated with epidermal growth factor receptor tyrosine kinase inhibitors. Clin Cancer Res 2006;12:4416s-4420s.
    • (2006) Clin. Cancer Res. , vol.12
    • Janne, P.A.1    Johnson, B.E.2
  • 8
    • 33846220461 scopus 로고    scopus 로고
    • Epidermal growth factor receptor kinase domain mutations in esophageal and pancreatic adenocarcinomas
    • Kwak EL, Jankowski J, Thayer SP, et al. Epidermal growth factor receptor kinase domain mutations in esophageal and pancreatic adenocarcinomas. Clin Cancer Res 2006;12:4283-4287.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 4283-4287
    • Kwak, E.L.1    Jankowski, J.2    Thayer, S.P.3
  • 9
    • 63149108552 scopus 로고    scopus 로고
    • Mutations and response to epidermal growth factor receptor inhibitors
    • Laurent-Puig P, Lievre A, Blons H. Mutations and response to epidermal growth factor receptor inhibitors. Clin Cancer Res 2009;15:1133-1139.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 1133-1139
    • Laurent-Puig, P.1    Lievre, A.2    Blons, H.3
  • 10
    • 34247149803 scopus 로고    scopus 로고
    • Impact of epidermal growth factor receptor (EGFR) kinase mutations, EGFR gene amplifications, and KRAS mutations on survival of pancreatic adenocarcinoma
    • Lee J, Jang KT, Ki CS, et al. Impact of epidermal growth factor receptor (EGFR) kinase mutations, EGFR gene amplifications, and KRAS mutations on survival of pancreatic adenocarcinoma. Cancer 2007;109:1561-1569.
    • (2007) Cancer , vol.109 , pp. 1561-1569
    • Lee, J.1    Jang, K.T.2    Ki, C.S.3
  • 11
    • 20244389231 scopus 로고    scopus 로고
    • Somatic mutations of EGFR gene in squamous cell carcinoma of the head and neck
    • Lee JW, Soung YH, Kim SY, et al. Somatic mutations of EGFR gene in squamous cell carcinoma of the head and neck. Clin Cancer Res 2005;11:2879-2882.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 2879-2882
    • Lee, J.W.1    Soung, Y.H.2    Kim, S.Y.3
  • 13
    • 36749067330 scopus 로고    scopus 로고
    • Clinical significance of epidermal growth factor receptor protein overexpression and gene copy number gains in prostate cancer
    • Schlomm T, Kirstein P, Iwers L, et al. Clinical significance of epidermal growth factor receptor protein overexpression and gene copy number gains in prostate cancer. Clin Cancer Res 2007;13:6579-6584.
    • (2007) Clin. Cancer Res. , vol.13 , pp. 6579-6584
    • Schlomm, T.1    Kirstein, P.2    Iwers, L.3
  • 14
    • 45349087172 scopus 로고    scopus 로고
    • Gene amplification and mutation analysis of epidermal growth factor receptor in hormone refractory prostate cancer
    • Cho KS, Lee JS, Cho NH, et al. Gene amplification and mutation analysis of epidermal growth factor receptor in hormone refractory prostate cancer. Prostate 2008;68:803-808.
    • (2008) Prostate , vol.68 , pp. 803-808
    • Cho, K.S.1    Lee, J.S.2    Cho, N.H.3
  • 15
    • 33744551470 scopus 로고    scopus 로고
    • Novel mutations of epidermal growth factor receptor in localized prostate cancer
    • Douglas DA, Zhong H, Ro JY, et al. Novel mutations of epidermal growth factor receptor in localized prostate cancer. Front Biosci 2006;11:2518-2525.
    • (2006) Front. Biosci. , vol.11 , pp. 2518-2525
    • Douglas, D.A.1    Zhong, H.2    Ro, J.Y.3
  • 16
    • 34948815127 scopus 로고    scopus 로고
    • PI3K/PTEN/AKT signaling regulates prostate adenocarcinoma angiogenesis
    • Fang J, Ding M, Yang L, et al. PI3K/PTEN/AKT signaling regulates prostate adenocarcinoma angiogenesis. Cell Signal 2007;19:2487-2497.
    • (2007) Cell. Signal , vol.19 , pp. 2487-2497
    • Fang, J.1    Ding, M.2    Yang, L.3
  • 17
    • 0141927222 scopus 로고    scopus 로고
    • Role of PI3K/AKT/mTOR signaling in the cell cycle progression of human prostate cancer
    • Gao N, Zhang Z, Jiang BH, et al. Role of PI3K/AKT/mTOR signaling in the cell cycle progression of human prostate cancer. Biochem Biophys Res Commun 2003;310:1124-1132.
    • (2003) Biochem. Biophys. Res. Commun. , vol.310 , pp. 1124-1132
    • Gao, N.1    Zhang, Z.2    Jiang, B.H.3
  • 18
    • 0034681264 scopus 로고    scopus 로고
    • The multiple roles of PTEN in adenocarcinoma suppression
    • di Cristofano A, Pandolfi PP. The multiple roles of PTEN in adenocarcinoma suppression. Cell 2000;100:387-390.
    • (2000) Cell. , vol.100 , pp. 387-390
    • Di Cristofano, A.1    Pandolfi, P.P.2
  • 19
    • 38149015503 scopus 로고    scopus 로고
    • PI3K/PTEN signaling in adenocarcinomaigenesis and angiogenesis
    • Jiang BH, Liu LZ. PI3K/PTEN signaling in adenocarcinomaigenesis and angiogenesis. Biochim Biophys Acta 2008;1784:150-158.
    • (2008) Biochim. Biophys. Acta , vol.1784 , pp. 150-158
    • Jiang, B.H.1    Liu, L.Z.2
  • 20
    • 58149176101 scopus 로고    scopus 로고
    • PTEN mutation: Many birds with one stone in adenocarcinomaigenesis
    • Liu W, Zhou Y, Reske SN, et al. PTEN mutation: many birds with one stone in adenocarcinomaigenesis. Anticancer Res 2008;28:3613-3619.
    • (2008) Anticancer Res. , vol.28 , pp. 3613-3619
    • Liu, W.1    Zhou, Y.2    Reske, S.N.3
  • 21
    • 33745888913 scopus 로고    scopus 로고
    • PTEN function in normal and neoplastic growth
    • Chow LM, Baker SJ. PTEN function in normal and neoplastic growth. Cancer Lett 2006;241:184-196.
    • (2006) Cancer Lett. , vol.241 , pp. 184-196
    • Chow, L.M.1    Baker, S.J.2
  • 22
    • 33748924290 scopus 로고    scopus 로고
    • Comprehensive assessment of DNA copy number alterations in human prostate cancers using Affymetrix 100K SNP mapping array
    • Liu W, Chang B, Sauvageot J, et al. Comprehensive assessment of DNA copy number alterations in human prostate cancers using Affymetrix 100K SNP mapping array. Genes Chromosomes Cancer 2006;45:1018-1032.
    • (2006) Genes Chromosomes Cancer , vol.45 , pp. 1018-1032
    • Liu, W.1    Chang, B.2    Sauvageot, J.3
  • 23
    • 0035949707 scopus 로고    scopus 로고
    • Haploinsufficiency of the Pten adenocarcinoma suppressor gene promotes prostate cancer progression
    • Kwabi-Addo B, Giri D, Schmidt K, et al. Haploinsufficiency of the Pten adenocarcinoma suppressor gene promotes prostate cancer progression. Proc Natl Acad Sci USA 2001;98:11563-11568.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 11563-11568
    • Kwabi-Addo, B.1    Giri, D.2    Schmidt, K.3
  • 24
    • 33846968797 scopus 로고    scopus 로고
    • Complete loss of PTEN expression as a possible early prognostic marker for prostate cancer metastasis
    • Schmitz M, Grignard G, Margue C, et al. Complete loss of PTEN expression as a possible early prognostic marker for prostate cancer metastasis. Int J Cancer 2007;120:1284-1292.
    • (2007) Int. J. Cancer , vol.120 , pp. 1284-1292
    • Schmitz, M.1    Grignard, G.2    Margue, C.3
  • 25
    • 34548299547 scopus 로고    scopus 로고
    • FISH analysis of 107 prostate cancers shows that PTEN genomic deletion is associated with poor clinical outcome
    • Yoshimoto M, Cunha IW, Coudry RA, et al. FISH analysis of 107 prostate cancers shows that PTEN genomic deletion is associated with poor clinical outcome. Br J Cancer 2007;97:678-685.
    • (2007) Br. J. Cancer , vol.97 , pp. 678-685
    • Yoshimoto, M.1    Cunha, I.W.2    Coudry, R.A.3
  • 26
    • 0032532552 scopus 로고    scopus 로고
    • PTEN/MMAC1 is infrequently mutated in pT2 and pT3 carcinomas of the prostate
    • Dong JT, Sipe TW, Hyytinen ER, et al. PTEN/MMAC1 is infrequently mutated in pT2 and pT3 carcinomas of the prostate. Oncogene 1998;17:1979-1982.
    • (1998) Oncogene , vol.17 , pp. 1979-1982
    • Dong, J.T.1    Sipe, T.W.2    Hyytinen, E.R.3
  • 27
    • 33144488630 scopus 로고    scopus 로고
    • Prevalent mutations in prostate cancer
    • Dong JT. Prevalent mutations in prostate cancer. J Cell Biochem 2006;97:433-447.
    • (2006) J. Cell. Biochem. , vol.97 , pp. 433-447
    • Dong, J.T.1
  • 28
    • 27844506524 scopus 로고    scopus 로고
    • Akt-regulated pathways in prostate cancer
    • Majumder PK, Sellers WR. Akt-regulated pathways in prostate cancer. Oncogene 2005;24:7465-7474.
    • (2005) Oncogene , vol.24 , pp. 7465-7474
    • Majumder, P.K.1    Sellers, W.R.2
  • 29
    • 0032482369 scopus 로고    scopus 로고
    • PTEN/MMAC1/TEP1 involvement in primary prostate cancers
    • Pesche S, Latil A, Muzeau F, et al. PTEN/MMAC1/TEP1 involvement in primary prostate cancers. Oncogene 1998;16:2879-2883.
    • (1998) Oncogene , vol.16 , pp. 2879-2883
    • Pesche, S.1    Latil, A.2    Muzeau, F.3
  • 30
    • 0032574718 scopus 로고    scopus 로고
    • Inactivation of the adenocarcinoma suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression
    • Whang YE, Wu X, Suzuki H, et al. Inactivation of the adenocarcinoma suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression. Proc Natl Acad Sci USA 1998;95:5246-5250.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 5246-5250
    • Whang, Y.E.1    Wu, X.2    Suzuki, H.3
  • 31
    • 68049137909 scopus 로고    scopus 로고
    • Targeting the PI3K/AKT pathway for the treatment of prostate cancer
    • Sarker D, Reid AH, Yap TA, et al. Targeting the PI3K/AKT pathway for the treatment of prostate cancer. Clin Cancer Res 2009;15:4799-4805.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 4799-4805
    • Sarker, D.1    Reid, A.H.2    Yap, T.A.3
  • 32
    • 67349105009 scopus 로고    scopus 로고
    • FGFR3 mutations in prostate cancer: Association with lowgrade adenocarcinomas
    • Hernandez S, de Muga S, Agell L, et al. FGFR3 mutations in prostate cancer: association with lowgrade adenocarcinomas. Mod Pathol 2009;22:848-856.
    • (2009) Mod. Pathol. , vol.22 , pp. 848-856
    • Hernandez, S.1    De Muga, S.2    Agell, L.3
  • 33
    • 43749096126 scopus 로고    scopus 로고
    • Epidermal growth factor receptor activation in prostate cancer by three novel missense mutations
    • Cai CQ, Peng Y, Buckley MT, et al. Epidermal growth factor receptor activation in prostate cancer by three novel missense mutations. Oncogene 2008;27:3201-3210.
    • (2008) Oncogene , vol.27 , pp. 3201-3210
    • Cai, C.Q.1    Peng, Y.2    Buckley, M.T.3
  • 34
    • 33644822256 scopus 로고    scopus 로고
    • High frequency of submicroscopic hemizygous deletion is a major mechanism of loss of expression of PTEN in uveal melanoma
    • Abdel-Rahman MH, Yang Y, Zhou XP, et al. High frequency of submicroscopic hemizygous deletion is a major mechanism of loss of expression of PTEN in uveal melanoma. J Clin Oncol 2006;24:288-295.
    • (2006) J. Clin. Oncol. , vol.24 , pp. 288-295
    • Abdel-Rahman, M.H.1    Yang, Y.2    Zhou, X.P.3
  • 35
    • 0030761409 scopus 로고    scopus 로고
    • Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies
    • Tashiro H, Blazes MS, Wu R, et al. Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies. Cancer Res 1997;57:3935-3940.
    • (1997) Cancer Res. , vol.57 , pp. 3935-3940
    • Tashiro, H.1    Blazes, M.S.2    Wu, R.3
  • 36
    • 0030936323 scopus 로고    scopus 로고
    • PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
    • Li J, Yen C, Liaw D, et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997;275:1943-1947.
    • (1997) Science , vol.275 , pp. 1943-1947
    • Li, J.1    Yen, C.2    Liaw, D.3
  • 37
    • 33846252746 scopus 로고    scopus 로고
    • Mechanisms of egfr gene transcription modulation: Relationship to cancer risk and therapy response
    • Brandt B, Meyer-Staeckling S, Schmidt H, et al. Mechanisms of egfr gene transcription modulation: relationship to cancer risk and therapy response. Clin Cancer Res 2006;12:7252-7260.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 7252-7260
    • Brandt, B.1    Meyer-Staeckling, S.2    Schmidt, H.3
  • 38
    • 59249107192 scopus 로고    scopus 로고
    • Impact of EGFR mutation analysis in non-small cell lung cancer
    • Yamamoto H, Toyooka S, Mitsudomi T. Impact of EGFR mutation analysis in non-small cell lung cancer. Lung Cancer 2009;63:315-321.
    • (2009) Lung Cancer , vol.63 , pp. 315-321
    • Yamamoto, H.1    Toyooka, S.2    Mitsudomi, T.3
  • 39
    • 34147095449 scopus 로고    scopus 로고
    • Somatic mutations of the epidermal growth factor receptor and non-small-cell lung cancer
    • Zhang X, Chang A. Somatic mutations of the epidermal growth factor receptor and non-small-cell lung cancer. J Med Genet 2007;44:166-172.
    • (2007) J. Med. Genet. , vol.44 , pp. 166-172
    • Zhang, X.1    Chang, A.2
  • 40
    • 35548962203 scopus 로고    scopus 로고
    • Mutations of the epidermal growth factor receptor gene and related genes as determinants of epidermal growth factor receptor tyrosine kinase inhibitors sensitivity in lung cancer
    • Mitsudomi T, Yatabe Y. Mutations of the epidermal growth factor receptor gene and related genes as determinants of epidermal growth factor receptor tyrosine kinase inhibitors sensitivity in lung cancer. Cancer Sci 2007;98:1817-1824.
    • (2007) Cancer Sci. , vol.98 , pp. 1817-1824
    • Mitsudomi, T.1    Yatabe, Y.2
  • 41
    • 16544382511 scopus 로고    scopus 로고
    • Racial disparity of epidermal growth factor receptor expression in prostate cancer
    • Shuch B, Mikhail M, Satagopan J, et al. Racial disparity of epidermal growth factor receptor expression in prostate cancer. J Clin Oncol 2004;22:4725-4729.
    • (2004) J. Clin. Oncol. , vol.22 , pp. 4725-4729
    • Shuch, B.1    Mikhail, M.2    Satagopan, J.3
  • 42
    • 11144322016 scopus 로고    scopus 로고
    • Expression patterns of potential therapeutic targets in prostate cancer
    • Zellweger T, Ninck C, Bloch M, et al. Expression patterns of potential therapeutic targets in prostate cancer. Int J Cancer 2005;113:619-628.
    • (2005) Int. J. Cancer , vol.113 , pp. 619-628
    • Zellweger, T.1    Ninck, C.2    Bloch, M.3
  • 43
    • 0027403373 scopus 로고
    • Differential immunoreactivity of epidermal growth factor receptor in benign, dysplastic and malignant prostatic tissues
    • Ibrahim GK, Kerns BJ, MacDonald JA, et al. Differential immunoreactivity of epidermal growth factor receptor in benign, dysplastic and malignant prostatic tissues. J Urol 1993;149:170-173.
    • (1993) J. Urol. , vol.149 , pp. 170-173
    • Ibrahim, G.K.1    Kerns, B.J.2    MacDonald, J.A.3
  • 44
    • 0025368191 scopus 로고
    • Epidermal growth factor receptor mRNA levels in human prostatic adenocarcinomas and cell lines
    • Morris GL, Dodd JG. Epidermal growth factor receptor mRNA levels in human prostatic adenocarcinomas and cell lines. J Urol 1990;143:1272-1274.
    • (1990) J. Urol. , vol.143 , pp. 1272-1274
    • Morris, G.L.1    Dodd, J.G.2
  • 45
    • 0028108003 scopus 로고
    • Comparative analysis of epidermal growth factor receptor gene expression and protein product in benign, premalignant, and malignant prostate tissue
    • Turkeri LN, Sakr WA, Wykes SM, et al. Comparative analysis of epidermal growth factor receptor gene expression and protein product in benign, premalignant, and malignant prostate tissue. Prostate 1994;25:199-205.
    • (1994) Prostate , vol.25 , pp. 199-205
    • Turkeri, L.N.1    Sakr, W.A.2    Wykes, S.M.3
  • 47
    • 69849102272 scopus 로고    scopus 로고
    • PTEN-mediated pathways and their association with treatment-resistant prostate cancer
    • Uzoh CC, Perks CM, Bahl A, et al. PTEN-mediated pathways and their association with treatment-resistant prostate cancer. BJU Int 2009;104:556-561.
    • (2009) BJU Int. , vol.104 , pp. 556-561
    • Uzoh, C.C.1    Perks, C.M.2    Bahl, A.3
  • 48
    • 0032473921 scopus 로고    scopus 로고
    • Analysis of PTEN and the 10q23 region in primary prostate carcinomas
    • Feilotter HE, Nagai MA, Boag AH, et al. Analysis of PTEN and the 10q23 region in primary prostate carcinomas. Oncogene 1998;16:1743-1748.
    • (1998) Oncogene , vol.16 , pp. 1743-1748
    • Feilotter, H.E.1    Nagai, M.A.2    Boag, A.H.3
  • 49
    • 0033200172 scopus 로고    scopus 로고
    • Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage
    • McMenamin ME, Soung P, Perera S, et al. Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage. Cancer Res 1999;59:4291-4296.
    • (1999) Cancer Res. , vol.59 , pp. 4291-4296
    • McMenamin, M.E.1    Soung, P.2    Perera, S.3
  • 50
    • 13044250465 scopus 로고    scopus 로고
    • Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems
    • Podsypanina K, Ellenson LH, Nemes A, et al. Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. Proc Natl Acad Sci USA 1999;96:1563-1568.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 1563-1568
    • Podsypanina, K.1    Ellenson, L.H.2    Nemes, A.3
  • 51
    • 40649121309 scopus 로고    scopus 로고
    • Temporally controlled ablation of PTEN in adult mouse prostate epithelium generates a model of invasive prostatic adenocarcinoma
    • Ratnacaram CK, Teletin M, Jiang M, et al. Temporally controlled ablation of PTEN in adult mouse prostate epithelium generates a model of invasive prostatic adenocarcinoma. Proc Natl Acad Sci USA 2008;105:2521-2526.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 2521-2526
    • Ratnacaram, C.K.1    Teletin, M.2    Jiang, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.